Gene JAK2 - ENSG00000096968 | NCBI Gene ID: 3717

Details for: JAK2

Gene ID: 3717

Symbol: JAK2

Ensembl ID: ENSG00000096968

Description: Janus kinase 2

Associated with

Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Cyclin d associated events in g1
(R-HSA-69231)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Erythropoietin activates phosphoinositide-3-kinase (pi3k)
(R-HSA-9027276)
Erythropoietin activates phospholipase c gamma (plcg)
(R-HSA-9027277)
Erythropoietin activates ras
(R-HSA-9027284)
Erythropoietin activates stat5
(R-HSA-9027283)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
G1 phase
(R-HSA-69236)
Growth hormone receptor signaling
(R-HSA-982772)
Hemostasis
(R-HSA-109582)
Ifng signaling activates mapks
(R-HSA-9732724)
Il-6-type cytokine receptor ligand interactions
(R-HSA-6788467)
Immune system
(R-HSA-168256)
Inactivation of csf3 (g-csf) signaling
(R-HSA-9705462)
Infectious disease
(R-HSA-5663205)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-6 family signaling
(R-HSA-6783589)
Interleukin-6 signaling
(R-HSA-1059683)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
Interleukin-20 family signaling
(R-HSA-8854691)
Interleukin-23 signaling
(R-HSA-9020933)
Interleukin-27 signaling
(R-HSA-9020956)
Interleukin-35 signalling
(R-HSA-8984722)
Interleukin receptor shc signaling
(R-HSA-912526)
Mapk1 (erk2) activation
(R-HSA-112411)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk3 (erk1) activation
(R-HSA-110056)
Mapk family signaling cascades
(R-HSA-5683057)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Potential therapeutics for sars
(R-HSA-9679191)
Prolactin receptor signaling
(R-HSA-1170546)
Raf-independent mapk1/3 activation
(R-HSA-112409)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Regulation of ifng signaling
(R-HSA-877312)
Rmts methylate histone arginines
(R-HSA-3214858)
Sars-cov infections
(R-HSA-9679506)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by interleukins
(R-HSA-449147)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by leptin
(R-HSA-2586552)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain kit mutants
(R-HSA-9670439)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signaling downstream of ras mutants
(R-HSA-9649948)
Viral infection pathways
(R-HSA-9824446)
Acetylcholine receptor binding
(GO:0033130)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Adaptive immune response
(GO:0002250)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Chromatin remodeling
(GO:0006338)
Enzyme-linked receptor protein signaling pathway
(GO:0007167)
G protein-coupled receptor signaling pathway
(GO:0007186)
Growth hormone receptor binding
(GO:0005131)
Heme binding
(GO:0020037)
Histone binding
(GO:0042393)
Histone h3y41 kinase activity
(GO:0035401)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Insulin receptor substrate binding
(GO:0043560)
Interleukin-12 receptor binding
(GO:0005143)
Metal ion binding
(GO:0046872)
Microglial cell activation
(GO:0001774)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Peptide hormone receptor binding
(GO:0051428)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Receptor signaling pathway via jak-stat
(GO:0007259)
Sh2 domain binding
(GO:0042169)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Transcription by rna polymerase ii
(GO:0006366)
Type 1 angiotensin receptor binding
(GO:0031702)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.27
Marker Score: 1128
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.21
Marker Score: 33083
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.1
Marker Score: 16084
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.1
Marker Score: 2413
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.06
Marker Score: 41045
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.96
Marker Score: 72172
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.89
Marker Score: 7297
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.88
Marker Score: 71279
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.87
Marker Score: 814
Cell Name: neuron (CL0000540)
Fold Change: 1.84
Marker Score: 7499
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.83
Marker Score: 1019
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.8
Marker Score: 7471
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8
Marker Score: 110705
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.8
Marker Score: 1073
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.74
Marker Score: 16529
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.73
Marker Score: 17900
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.73
Marker Score: 3331
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.71
Marker Score: 619
Cell Name: fat cell (CL0000136)
Fold Change: 1.67
Marker Score: 933
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.62
Marker Score: 4611
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.61
Marker Score: 15130
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.61
Marker Score: 35938
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.56
Marker Score: 7216
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.55
Marker Score: 13355
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.52
Marker Score: 2352
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.48
Marker Score: 49948
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.47
Marker Score: 1406
Cell Name: interneuron (CL0000099)
Fold Change: 1.38
Marker Score: 629
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.34
Marker Score: 1030
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.32
Marker Score: 73662
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.3
Marker Score: 543
Cell Name: podocyte (CL0000653)
Fold Change: 1.29
Marker Score: 477
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.25
Marker Score: 366
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.25
Marker Score: 26644
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.24
Marker Score: 4404
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.22
Marker Score: 5102.5
Cell Name: contractile cell (CL0000183)
Fold Change: 1.21
Marker Score: 656
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.18
Marker Score: 622
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.18
Marker Score: 18461
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.17
Marker Score: 1289
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.12
Marker Score: 2814
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.11
Marker Score: 321
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.1
Marker Score: 401
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.09
Marker Score: 2395
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.08
Marker Score: 634
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.07
Marker Score: 4149
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.07
Marker Score: 410
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.06
Marker Score: 359
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.05
Marker Score: 509
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.04
Marker Score: 270
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.04
Marker Score: 604
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.04
Marker Score: 2115
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.01
Marker Score: 277
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71713
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47938
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.99
Marker Score: 1232
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.99
Marker Score: 1923
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.98
Marker Score: 590
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30395
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.98
Marker Score: 1209
Cell Name: lactocyte (CL0002325)
Fold Change: 0.96
Marker Score: 15474
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.96
Marker Score: 2263
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.96
Marker Score: 1605
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2401
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.94
Marker Score: 484
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.94
Marker Score: 955
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.93
Marker Score: 612
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 439
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.92
Marker Score: 297
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.92
Marker Score: 1040
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.91
Marker Score: 286
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2711
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.89
Marker Score: 2224
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.89
Marker Score: 235
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.88
Marker Score: 511
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5293
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.87
Marker Score: 428
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 311
Cell Name: germ cell (CL0000586)
Fold Change: 0.86
Marker Score: 1507
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.86
Marker Score: 4893
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.85
Marker Score: 268
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.83
Marker Score: 5014
Cell Name: astrocyte (CL0000127)
Fold Change: 0.82
Marker Score: 714
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.82
Marker Score: 1164
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.81
Marker Score: 207
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.81
Marker Score: 1180
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.81
Marker Score: 549
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.8
Marker Score: 862
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.8
Marker Score: 856
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.79
Marker Score: 792.5
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.79
Marker Score: 316
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 602
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.78
Marker Score: 436
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.77
Marker Score: 931
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.77
Marker Score: 544
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.77
Marker Score: 2733
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.75
Marker Score: 799
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.75
Marker Score: 1814
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.75
Marker Score: 1215
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.75
Marker Score: 901

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**Key characteristics:** - JAK2 is a Janus kinase, which means it can act as a kinase or a phosphatase. - It is a key regulator of the cell cycle, cell cycle progression, and apoptosis. - It is involved in inflammation, leukocyte differentiation, and platelet production. - It is also involved in the regulation of erythropoietin signaling and the development of the central nervous system. **Pathways and functions:** - JAK2 is involved in the regulation of cell cycle progression through phosphorylation of various substrates. - It is essential for the G1/S transition and the G2/M transition of the cell cycle. - It also plays a role in cell survival, proliferation, and differentiation. - JAK2 is involved in inflammation through the activation of the mitogen-activated protein kinase (MAPK) signaling pathway. - It is also involved in the regulation of platelet production and function. **Clinical significance:** - Mutations in JAK2 have been linked to a number of human diseases, including cancer, autoimmune disorders, and inflammatory diseases. - JAK2 inhibitors are being investigated as potential treatments for these diseases. - Understanding the role of JAK2 in disease may lead to the development of new therapeutic strategies. **Additional notes:** - JAK2 is a highly conserved kinase that is found in all eukaryotic cells. - It is a key regulator of cell growth, differentiation, and survival. - Its activity is regulated by a variety of factors, including growth factors, cytokines, and hormones.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 797839445

Symbol: JAK2_HUMAN

Name: Janus kinase 2

UniProtKB Accession Codes:

O60674 O14636 O75297

Database IDs:

Citations:

PubMed ID: 9618263

Title: Cloning and characterization of human Jak-2 kinase: high mRNA expression in immune cells and muscle tissue.

PubMed ID: 9618263

DOI: 10.1006/bbrc.1998.8685

PubMed ID: 9446644

Title: Cloning and characterization of the human homolog of mouse Jak2.

PubMed ID: 9446644

PubMed ID: 9326218

Title: Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia.

PubMed ID: 9326218

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 7615558

Title: The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors.

PubMed ID: 7615558

DOI: 10.1074/jbc.270.29.17528

PubMed ID: 7673114

Title: Interaction between the components of the interferon gamma receptor complex.

PubMed ID: 7673114

DOI: 10.1074/jbc.270.36.20915

PubMed ID: 10531356

Title: The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.

PubMed ID: 10531356

DOI: 10.1074/jbc.274.44.31531

PubMed ID: 10899310

Title: STAM2, a new member of the STAM family, binding to the Janus kinases.

PubMed ID: 10899310

DOI: 10.1016/s0014-5793(00)01760-9

PubMed ID: 12023369

Title: A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.

PubMed ID: 12023369

DOI: 10.4049/jimmunol.168.11.5699

PubMed ID: 15805263

Title: The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2.

PubMed ID: 15805263

DOI: 10.1158/0008-5472.can-04-4263

PubMed ID: 16034466

Title: PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation.

PubMed ID: 16034466

DOI: 10.1038/sj.leu.2403879

PubMed ID: 16091753

Title: The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene.

PubMed ID: 16091753

DOI: 10.1038/sj.onc.1208850

PubMed ID: 16769584

Title: A combination of cytomorphology, cytogenetic analysis, fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction for establishing clonality in cases of persisting hypereosinophilia.

PubMed ID: 16769584

PubMed ID: 16424865

Title: A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma.

PubMed ID: 16424865

DOI: 10.1038/sj.leu.2404104

PubMed ID: 19783980

Title: JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.

PubMed ID: 19783980

DOI: 10.1038/nature08448

PubMed ID: 21036157

Title: Heme controls the regulation of protein tyrosine kinases Jak2 and Src.

PubMed ID: 21036157

DOI: 10.1016/j.bbrc.2010.10.101

PubMed ID: 20353823

Title: Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response.

PubMed ID: 20353823

DOI: 10.1016/j.cellsig.2010.03.012

PubMed ID: 20098430

Title: The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.

PubMed ID: 20098430

DOI: 10.1038/nm.2079

PubMed ID: 21423214

Title: Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.

PubMed ID: 21423214

DOI: 10.1038/onc.2011.68

PubMed ID: 21368206

Title: Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses.

PubMed ID: 21368206

DOI: 10.1073/pnas.1011115108

PubMed ID: 16456223

Title: Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?

PubMed ID: 16456223

DOI: 10.1385/cbb:44:2:213

PubMed ID: 19290934

Title: Janus kinases in immune cell signaling.

PubMed ID: 19290934

DOI: 10.1111/j.1600-065x.2008.00754.x

PubMed ID: 21119685

Title: Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.

PubMed ID: 21119685

DOI: 10.1038/cr.2010.165

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25092874

Title: RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development.

PubMed ID: 25092874

DOI: 10.1084/jem.20130624

PubMed ID: 16174768

Title: The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor.

PubMed ID: 16174768

DOI: 10.1182/blood-2005-06-2413

PubMed ID: 15781101

Title: Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.

PubMed ID: 15781101

DOI: 10.1016/s0140-6736(05)71142-9

PubMed ID: 16325696

Title: Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study.

PubMed ID: 16325696

DOI: 10.1016/s0140-6736(05)67785-9

PubMed ID: 15793561

Title: A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.

PubMed ID: 15793561

DOI: 10.1038/nature03546

PubMed ID: 15858187

Title: A gain-of-function mutation of JAK2 in myeloproliferative disorders.

PubMed ID: 15858187

DOI: 10.1056/nejmoa051113

PubMed ID: 16707754

Title: Case records of the Massachusetts General Hospital. Case 15-2006: a 46-year-old woman with sudden onset of abdominal distention.

PubMed ID: 16707754

DOI: 10.1056/nejmcpc069006

PubMed ID: 16247455

Title: The JAK2 V617F mutation in de novo acute myelogenous leukemias.

PubMed ID: 16247455

DOI: 10.1038/sj.onc.1209163

PubMed ID: 16603627

Title: The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation.

PubMed ID: 16603627

DOI: 10.1073/pnas.0601462103

PubMed ID: 17267906

Title: JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis.

PubMed ID: 17267906

DOI: 10.1056/nejmoa065202

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 22397670

Title: Germline JAK2 mutation in a family with hereditary thrombocytosis.

PubMed ID: 22397670

DOI: 10.1056/nejmc1200349

Sequence Information:

Length: 1132
Mass: 130674
Checksum: C30669EF1A7DA80C
Sequence:

MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLQ VYLYHSLGKS EADYLTFPSG 
EYVAEEICIA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NVLYRIRFYF 
PRWYCSGSNR AYRHGISRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG 
MAVLDMMRIA KENDQTPLAI YNSISYKTFL PKCIRAKIQD YHILTRKRIR YRFRRFIQQF 
SQCKATARNL KLKYLINLET LQSAFYTEKF EVKEPGSGPS GEEIFATIII TGNGGIQWSR 
GKHKESETLT EQDLQLYCDF PNIIDVSIKQ ANQEGSNESR VVTIHKQDGK NLEIELSSLR 
EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIQSNC HGPISMDFAI SKLKKAGNQT 
GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENE EYNLSGTKKN FSSLKDLLNC 
YQMETVRSDN IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV PTSPTLQRPT HMNQMVFHKI 
RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM 
MSKLSHKHLV LNYGVCVCGD ENILVQEFVK FGSLDTYLKK NKNCINILWK LEVAKQLAWA 
MHFLEENTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 
PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDRH QLPAPKWAEL 
ANLINNCMDY EPDFRPSFRA IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD 
PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 
ILKSLQHDNI VKYKGVCYSA GRRNLKLIME YLPYGSLRDY LQKHKERIDH IKLLQYTSQI 
CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW 
YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPAE FMRMIGNDKQ GQMIVFHLIE 
LLKNNGRLPR PDGCPDEIYM IMTECWNNNV NQRPSFRDLA LRVDQIRDNM AG

Genular Protein ID: 833429521

Symbol: A8K910_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K910

Database IDs:

Sequence Information:

Length: 1132
Mass: 130700
Checksum: 9A1BA832F3496B43
Sequence:

MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLQ VYLYHSLGKS EADYLTFPSG 
EYVAEEICIA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NVLYRIRFYF 
PRWYCSGSNR AYRHGISRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG 
MAVLDMMRIA KENDQTPLAI YNSISYKTFL PKCIRAKIQD YHILTRKRIR YRFRRFIQQF 
SQCKATARNL KLKYLINLET LQSAFYTEKF EVKEPGSGPS GEEIFATIII TGNGGIQWSR 
GKHKESETLT EQDLQLYCDF PNIIDVSIKQ ANQEGSNESR VVTIHKQDGK NLEIELSSLR 
EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIQSNC YGPISMDFAI SKLKKAGNQT 
GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENE EYNLSGTKKN FSSLKDLLNC 
YQMETVRSDN IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV PTSPTLQRPT HMNQMVFHKI 
RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM 
MSKLSHKHLV LNYGVCVCGD ENILVQEFVK FGSLDTYLKK NKNCINILWK LEVAKQLAWA 
MHFLEENTLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 
PECIENPKNL NLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDRH QLPAPKWAEL 
ANLINNCMDY EPDFRPSFRA IIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD 
PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 
ILKSLQHDNI VKYKGVCYSA GRRNLKLIME YLPYGSLRDY LQKHKERIDH IKLLQYTSQI 
CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW 
YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPAE FMRMIGNDKQ GQMIVFHLIE 
LLKNNGRLPR PDGCPDEIYM IMTECWNNNV NQRPSFRDLA LRVDQIRDNM AG

Genular Protein ID: 3060005687

Symbol: B4DYV1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DYV1

Database IDs:

Sequence Information:

Length: 983
Mass: 113747
Checksum: E5276939A8BC26A5
Sequence:

MSYLFAQWRH DFVHGWIKVP VTHETQEECL GMAVLDMMRI AKENDQTPLA IYNSISYKTF 
LPKCIRAKIQ DYHILTRKRI RYRFRRFIQQ FSQCKATARN LKLKYLINLE TLQSAFYTEK 
FEVKEPGSGP SGEEIFATII ITGNGGIQWS RGKHKESETL TEQDLQLYCD FPNIIDVSIK 
QANQEGSNES RVVTIHKQDG KNLEIELSSL REALSFVSLI DGYYRLTADA HHYLCKEVAP 
PAVLENIQSN CHGPISMDFA ISKLKKAGNQ TGLYVLRCSP KDFNKYFLTF AVERENVIEY 
KHCLITKNEN EEYNLSGTKK NFSSLKDLLN CYQMETVRSD NIIFQFTKCC PPKPKDKSNL 
LVFRTNGVSD VPTSPTLQRP THMNQMVFHK IRNEDLIFNE SLGQGTFTKI FKGVRREVGD 
YGQLHETEVL LKVLDKAHRN YSESFFEAAS MMSKLSHKHL VLNYGVCVCG DENILVQEFV 
KFGSLDTYLK KNKNCINILW KLEVAKQLAW AMHFLEENTL IHGNVCAKNI LLIREEDRKT 
GNPPFIKLSD PGISITVLPK DILQERIPWV PPECIENPKN LNLATDKWSF GTTLWEICSG 
GDKPLSALDS QRKLQFYEDR HQLPAPKWAE LANLINNCMD YEPDFRPSFR AIIRDLNSLF 
TPDYELLTEN DMLPNMRIGA LGFSGAFEDR DPTQFEERHL KFLQQLGKGN FGSVEMCRYD 
PLQDNTGEVV AVKKLQHSTE EHLRDFEREI EILKSLQHDN IVKYKGVCYS AGRRNLKLIM 
EYLPYGSLRD YLQKHKERID HIKLLQYTSQ ICKGMEYLGT KRYIHRDLAT RNILVENENR 
VKIGDFGLTK VLPQDKEYYK VKEPGESPIF WYAPESLTES KFSVASDVWS FGVVLYELFT 
YIEKSKSPPA EFMHMIGNDK QGQMIVFHLI ELLKNNGRLP RPDGCPDEIY MIMTECWNNN 
VNQRPSFRDL ALRVDQIRDN MAG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: JAK2

Associated with

Cells (max top 100)

Other Information

Cloning and characterization of human Jak-2 kinase: high mRNA expression in immune cells and muscle tissue. PubMed ID: 9618263

Cloning and characterization of the human homolog of mouse Jak2. PubMed ID: 9446644

Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. PubMed ID: 9326218

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors. PubMed ID: 7615558

Interaction between the components of the interferon gamma receptor complex. PubMed ID: 7673114

The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. PubMed ID: 10531356

STAM2, a new member of the STAM family, binding to the Janus kinases. PubMed ID: 10899310

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. PubMed ID: 12023369

The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2. PubMed ID: 15805263

PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation. PubMed ID: 16034466

The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. PubMed ID: 16091753

A combination of cytomorphology, cytogenetic analysis, fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction for establishing clonality in cases of persisting hypereosinophilia. PubMed ID: 16769584

A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma. PubMed ID: 16424865

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. PubMed ID: 19783980

Heme controls the regulation of protein tyrosine kinases Jak2 and Src. PubMed ID: 21036157

Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. PubMed ID: 20353823

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. PubMed ID: 20098430

Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. PubMed ID: 21423214

Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. PubMed ID: 21368206

Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression? PubMed ID: 16456223

Janus kinases in immune cell signaling. PubMed ID: 19290934

Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. PubMed ID: 21119685

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development. PubMed ID: 25092874

The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. PubMed ID: 16174768

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. PubMed ID: 15781101

Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study. PubMed ID: 16325696

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. PubMed ID: 15793561

A gain-of-function mutation of JAK2 in myeloproliferative disorders. PubMed ID: 15858187

Case records of the Massachusetts General Hospital. Case 15-2006: a 46-year-old woman with sudden onset of abdominal distention. PubMed ID: 16707754

The JAK2 V617F mutation in de novo acute myelogenous leukemias. PubMed ID: 16247455

The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation. PubMed ID: 16603627

JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. PubMed ID: 17267906

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Germline JAK2 mutation in a family with hereditary thrombocytosis. PubMed ID: 22397670

Database document:

PubMed ID: 9618263

PubMed ID: 9446644

PubMed ID: 9326218

PubMed ID: 15164053

PubMed ID: 7615558

PubMed ID: 7673114

PubMed ID: 10531356

PubMed ID: 10899310

PubMed ID: 12023369

PubMed ID: 15805263

PubMed ID: 16034466

PubMed ID: 16091753

PubMed ID: 16769584

PubMed ID: 16424865

PubMed ID: 19783980

PubMed ID: 21036157

PubMed ID: 20353823

PubMed ID: 20098430

PubMed ID: 21423214

PubMed ID: 21368206

PubMed ID: 16456223

PubMed ID: 19290934

PubMed ID: 21119685

PubMed ID: 23186163

PubMed ID: 25092874

PubMed ID: 16174768

PubMed ID: 15781101

PubMed ID: 16325696

PubMed ID: 15793561

PubMed ID: 15858187

PubMed ID: 16707754

PubMed ID: 16247455

PubMed ID: 16603627

PubMed ID: 17267906

PubMed ID: 17344846

PubMed ID: 22397670