PRKAR2B | ENSG00000005249 | NCBI 5577

Details for: PRKAR2B

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Aurka activation by tpx2
(R-HSA-8854518)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Cam pathway
(R-HSA-111997)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Centrosome maturation
(R-HSA-380287)
Cilium assembly
(R-HSA-5617833)
Creb1 phosphorylation through the activation of adenylate cyclase
(R-HSA-442720)
Dag and ip3 signaling
(R-HSA-1489509)
Darpp-32 events
(R-HSA-180024)
Disease
(R-HSA-1643685)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
G2/m transition
(R-HSA-69275)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gper1 signaling
(R-HSA-9634597)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Infectious disease
(R-HSA-5663205)
Integration of energy metabolism
(R-HSA-163685)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Metabolism
(R-HSA-1430728)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Parasitic infection pathways
(R-HSA-9824443)
Pka-mediated phosphorylation of creb
(R-HSA-111931)
Pka activation
(R-HSA-163615)
Pka activation in glucagon signalling
(R-HSA-164378)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of insulin secretion
(R-HSA-422356)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signal transduction
(R-HSA-162582)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Camp-dependent protein kinase complex
(GO:0005952)
Camp-dependent protein kinase inhibitor activity
(GO:0004862)
Camp-dependent protein kinase regulator activity
(GO:0008603)
Camp binding
(GO:0030552)
Centrosome
(GO:0005813)
Ciliary base
(GO:0097546)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendritic shaft
(GO:0043198)
Dendritic spine
(GO:0043197)
Extracellular exosome
(GO:0070062)
Fatty acid metabolic process
(GO:0006631)
Glutamatergic synapse
(GO:0098978)
Intracellular signal transduction
(GO:0035556)
Learning
(GO:0007612)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of camp/pka signal transduction
(GO:0141162)
Neuronal cell body
(GO:0043025)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase a catalytic subunit binding
(GO:0034236)
Regulation of protein phosphorylation
(GO:0001932)
Response to antipsychotic drug
(GO:0097332)
Ubiquitin protein ligase binding
(GO:0031625)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

adipocyte CL0000136

CSI 54.92

rCSI 70.52%

PRS 70.46
lamp5 GABAergic cortical interneuron CL4023011

CSI 29.41

rCSI 49.37%

PRS 62.44
sncg GABAergic cortical interneuron CL4023015

CSI 26.83

rCSI 43.14%

PRS 64
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 22.58

rCSI 54.89%

PRS 60.44
epicardial adipocyte CL1000309

CSI 19.74

rCSI 64.23%

PRS 77.84
L6b glutamatergic cortical neuron CL4023038

CSI 16.22

rCSI 50.68%

PRS 64.12
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 15.32

rCSI 33.24%

PRS 68.01
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 14.82

rCSI 48.72%

PRS 66.47
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 14.07

rCSI 50.64%

PRS 60.36
epithelial cell CL0000066

CSI 12.68

rCSI 19.48%

PRS 69.72
secretory cell CL0000151

CSI 12.49

rCSI 13.03%

PRS 79.66
platelet CL0000233

CSI 11.96

rCSI 49.62%

PRS 77.9
peripheral nervous system neuron CL2000032

CSI 11.83

rCSI 16.12%

PRS 71.96
club cell CL0000158

CSI 11.8

rCSI 17.28%

PRS 74.95
erythrocyte CL0000232

CSI 10.28

rCSI 23.33%

PRS 80.71
near-projecting glutamatergic cortical neuron CL4023012

CSI 9.87

rCSI 37.32%

PRS 62.92
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 9.41

rCSI 55.42%

PRS 63.16
myofibroblast cell CL0000186

CSI 9.12

rCSI 12.63%

PRS 77.55
glioblast CL0000030

CSI 8.59

rCSI 13.71%

PRS 71.9
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 8.54

rCSI 9.87%

PRS 72.44
cerebellar granule cell CL0001031

CSI 8.51

rCSI 12.51%

PRS 73.29
megakaryocyte CL0000556

CSI 8.45

rCSI 36.66%

PRS 85.48
hematopoietic precursor cell CL0008001

CSI 7.93

rCSI 8.16%

PRS 90.93
subcutaneous adipocyte CL0002521

CSI 7.76

rCSI 39.74%

PRS 83.33
megakaryocyte-erythroid progenitor cell CL0000050

CSI 7.55

rCSI 6.82%

PRS 78.45
nasal mucosa goblet cell CL0002480

CSI 7.34

rCSI 8.52%

PRS 84.06
retinal cone cell CL0000573

CSI 7.27

rCSI 11.71%

PRS 70.5
pvalb GABAergic cortical interneuron CL4023018

CSI 7.22

rCSI 8.98%

PRS 60.4
neuron CL0000540

CSI 7.15

rCSI 19.04%

PRS 67.97
radial glial cell CL0000681

CSI 7.06

rCSI 9.81%

PRS 78.79
astrocyte of the cerebral cortex CL0002605

CSI 7.02

rCSI 15.74%

PRS 63.28
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 6.64

rCSI 15.88%

PRS 67.27
hepatic stellate cell CL0000632

CSI 6.24

rCSI 23.38%

PRS 72.83
ependymal cell CL0000065

CSI 6.22

rCSI 12.62%

PRS 58.9
amacrine cell CL0000561

CSI 6.03

rCSI 17.47%

PRS 69.87
neural cell CL0002319

CSI 5.99

rCSI 22.61%

PRS 63.2
neuroblast (sensu Vertebrata) CL0000031

CSI 5.92

rCSI 7.6%

PRS 76.37
endothelial cell of placenta CL0009092

CSI 5.89

rCSI 29.05%

PRS 87.55
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 5.87

rCSI 8.32%

PRS 77.01
interstitial cell of Cajal CL0002088

CSI 5.83

rCSI 7.42%

PRS 85.15
interneuron CL0000099

CSI 5.76

rCSI 11.56%

PRS 70.58
cerebral cortex endothelial cell CL1001602

CSI 5.74

rCSI 9.93%

PRS 72.01
hematopoietic multipotent progenitor cell CL0000837

CSI 5.73

rCSI 13.8%

PRS 92.08
duct epithelial cell CL0000068

CSI 5.73

rCSI 8.38%

PRS 85
alveolar macrophage CL0000583

CSI 5.54

rCSI 9.12%

PRS 84
retinal bipolar neuron CL0000748

CSI 5.51

rCSI 10.31%

PRS 68.81
retinal rod cell CL0000604

CSI 5.28

rCSI 9.31%

PRS 75.88
vascular associated smooth muscle cell CL0000359

CSI 5.11

rCSI 16.58%

PRS 78.44
epithelial cell of lower respiratory tract CL0002632

CSI 5.04

rCSI 3.9%

PRS 83.89
inhibitory interneuron CL0000498

CSI 4.74

rCSI 10.95%

PRS 68.32
stromal cell CL0000499

CSI 4.73

rCSI 13.31%

PRS 75.36
rod bipolar cell CL0000751

CSI 4.59

rCSI 8.26%

PRS 73.73
diffuse bipolar 1 cell CL4033027

CSI 4.48

rCSI 33.69%

PRS 70.71
vascular leptomeningeal cell CL4023051

CSI 4.39

rCSI 7.69%

PRS 74.27
mesenchymal cell CL0008019

CSI 4.36

rCSI 11.07%

PRS 73.68
lung pericyte CL0009089

CSI 4.29

rCSI 11.33%

PRS 86.67
VIP GABAergic cortical interneuron CL4023016

CSI 4.29

rCSI 5.12%

PRS 62.56
sst GABAergic cortical interneuron CL4023017

CSI 4.22

rCSI 5.44%

PRS 63.6
cerebral cortex GABAergic interneuron CL0010011

CSI 4.2

rCSI 12.41%

PRS 81.12
common myeloid progenitor CL0000049

CSI 4.17

rCSI 3.37%

PRS 82.38
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 4.01

rCSI 7.09%

PRS 61.78
melanocyte of skin CL1000458

CSI 3.91

rCSI 5.33%

PRS 47.41
plasmacytoid dendritic cell, human CL0001058

CSI 3.7

rCSI 2.59%

PRS 83.51
medium spiny neuron CL1001474

CSI 3.7

rCSI 31.84%

PRS 68.6
cerebral cortex neuron CL0010012

CSI 3.65

rCSI 14.85%

PRS 72.37
tracheobronchial smooth muscle cell CL0019019

CSI 3.41

rCSI 6.02%

PRS 85.28
erythroblast CL0000765

CSI 3.35

rCSI 8.89%

PRS 85.77
glutamatergic neuron CL0000679

CSI 3.32

rCSI 6.81%

PRS 67.73
ON-bipolar cell CL0000749

CSI 3.15

rCSI 4.69%

PRS 80.27
CD1c-positive myeloid dendritic cell CL0002399

CSI 3.1

rCSI 3.75%

PRS 87.45
midbrain dopaminergic neuron CL2000097

CSI 3.07

rCSI 19.66%

PRS 76.28
Kupffer cell CL0000091

CSI 2.88

rCSI 6.59%

PRS 81.01
perivascular cell CL4033054

CSI 2.83

rCSI 3.87%

PRS 84.66
OFF-bipolar cell CL0000750

CSI 2.82

rCSI 3.86%

PRS 82.21
mesodermal cell CL0000222

CSI 2.81

rCSI 3.37%

PRS 78.13
megakaryocyte progenitor cell CL0000553

CSI 2.67

rCSI 48.91%

PRS 94.84
glycinergic amacrine cell CL4030028

CSI 2.57

rCSI 6.69%

PRS 75.01
direct pathway medium spiny neuron CL4023026

CSI 2.53

rCSI 60.57%

PRS 60.76
indirect pathway medium spiny neuron CL4023029

CSI 2.49

rCSI 60.15%

PRS 61.33
enteric smooth muscle cell CL0002504

CSI 2.49

rCSI 3.55%

PRS 81.11
microcirculation associated smooth muscle cell CL0008035

CSI 2.47

rCSI 7.16%

PRS 79.74
cardiac muscle cell CL0000746

CSI 2.38

rCSI 3.41%

PRS 70.17
GABAergic neuron CL0000617

CSI 2.32

rCSI 7.76%

PRS 64.19
promyelocyte CL0000836

CSI 2.31

rCSI 3.32%

PRS 85.63
pancreatic ductal cell CL0002079

CSI 2.17

rCSI 4.22%

PRS 83.21
endocardial cell CL0002350

CSI 2.13

rCSI 10.21%

PRS 76.71
dendritic cell, human CL0001056

CSI 2.05

rCSI 3.14%

PRS 88.32
podocyte CL0000653

CSI 2.02

rCSI 9%

PRS 80.87
granulocyte monocyte progenitor cell CL0000557

CSI 1.94

rCSI 1.68%

PRS 84.07
acinar cell CL0000622

CSI 1.9

rCSI 2.79%

PRS 89.15
lung secretory cell CL1000272

CSI 1.79

rCSI 4.42%

PRS 80.1
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.56

rCSI 2.83%

PRS 71.83
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.55

rCSI 4.02%

PRS 75.77
CD14-low, CD16-positive monocyte CL0002396

CSI 1.55

rCSI 1.2%

PRS 83.16
type B pancreatic cell CL0000169

CSI 1.4

rCSI 3.11%

PRS 79.81
S cone cell CL0003050

CSI 1.38

rCSI 6.09%

PRS 75.36
dopaminergic neuron CL0000700

CSI 1.31

rCSI 7.42%

PRS 66.45
ON parasol ganglion cell CL4033052

CSI 1.31

rCSI 18.59%

PRS 71.37
primitive red blood cell CL0002355

CSI 1.28

rCSI 6.92%

PRS 86.12
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 1.28

rCSI 4.01%

PRS 66.43

GABAergic interneuron CL0011005

CSI 0.4

rCSI 6.2%

PRS 81.2%
blood vessel smooth muscle cell CL0019018

CSI 0.4

rCSI 3.6%

PRS 74.6%
erythroid progenitor cell CL0000038

CSI 0.6

rCSI 3.2%

PRS 85.3%
H2 horizontal cell CL0004218

CSI 0.6

rCSI 3.0%

PRS 75.0%
diffuse bipolar 3a cell CL4033029

CSI 0.9

rCSI 5.8%

PRS 73.0%
diffuse bipolar 6 cell CL4033032

CSI 1.0

rCSI 5.3%

PRS 71.5%
central nervous system neuron CL2000029

CSI 1.1

rCSI 7.9%

PRS 67.8%
CD14-positive monocyte CL0001054

CSI 1.2

rCSI 1.5%

PRS 88.9%
OFFx cell CL4033036

CSI 1.2

rCSI 5.8%

PRS 71.6%
GABAergic amacrine cell CL4030027

CSI 1.2

rCSI 4.2%

PRS 66.6%
retinal ganglion cell CL0000740

CSI 1.2

rCSI 2.7%

PRS 66.1%
stromal cell of ovary CL0002132

CSI 1.3

rCSI 3.4%

PRS 86.9%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 1.3

rCSI 4.0%

PRS 66.4%
primitive red blood cell CL0002355

CSI 1.3

rCSI 6.9%

PRS 86.1%
ON parasol ganglion cell CL4033052

CSI 1.3

rCSI 18.6%

PRS 71.4%
dopaminergic neuron CL0000700

CSI 1.3

rCSI 7.4%

PRS 66.5%
S cone cell CL0003050

CSI 1.4

rCSI 6.1%

PRS 75.4%
type B pancreatic cell CL0000169

CSI 1.4

rCSI 3.1%

PRS 79.8%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.6

rCSI 1.2%

PRS 83.2%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.6

rCSI 4.0%

PRS 75.8%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.6

rCSI 2.8%

PRS 71.8%
lung secretory cell CL1000272

CSI 1.8

rCSI 4.4%

PRS 80.1%
acinar cell CL0000622

CSI 1.9

rCSI 2.8%

PRS 89.2%
granulocyte monocyte progenitor cell CL0000557

CSI 1.9

rCSI 1.7%

PRS 84.1%
podocyte CL0000653

CSI 2.0

rCSI 9.0%

PRS 80.9%
dendritic cell, human CL0001056

CSI 2.1

rCSI 3.1%

PRS 88.3%
endocardial cell CL0002350

CSI 2.1

rCSI 10.2%

PRS 76.7%
pancreatic ductal cell CL0002079

CSI 2.2

rCSI 4.2%

PRS 83.2%
promyelocyte CL0000836

CSI 2.3

rCSI 3.3%

PRS 85.6%
GABAergic neuron CL0000617

CSI 2.3

rCSI 7.8%

PRS 64.2%
cardiac muscle cell CL0000746

CSI 2.4

rCSI 3.4%

PRS 70.2%
microcirculation associated smooth muscle cell CL0008035

CSI 2.5

rCSI 7.2%

PRS 79.7%
enteric smooth muscle cell CL0002504

CSI 2.5

rCSI 3.6%

PRS 81.1%
indirect pathway medium spiny neuron CL4023029

CSI 2.5

rCSI 60.2%

PRS 61.3%
direct pathway medium spiny neuron CL4023026

CSI 2.5

rCSI 60.6%

PRS 60.8%
glycinergic amacrine cell CL4030028

CSI 2.6

rCSI 6.7%

PRS 75.0%
megakaryocyte progenitor cell CL0000553

CSI 2.7

rCSI 48.9%

PRS 94.8%
mesodermal cell CL0000222

CSI 2.8

rCSI 3.4%

PRS 78.1%
OFF-bipolar cell CL0000750

CSI 2.8

rCSI 3.9%

PRS 82.2%
perivascular cell CL4033054

CSI 2.8

rCSI 3.9%

PRS 84.7%
Kupffer cell CL0000091

CSI 2.9

rCSI 6.6%

PRS 81.0%
midbrain dopaminergic neuron CL2000097

CSI 3.1

rCSI 19.7%

PRS 76.3%
CD1c-positive myeloid dendritic cell CL0002399

CSI 3.1

rCSI 3.8%

PRS 87.5%
ON-bipolar cell CL0000749

CSI 3.2

rCSI 4.7%

PRS 80.3%
glutamatergic neuron CL0000679

CSI 3.3

rCSI 6.8%

PRS 67.7%
erythroblast CL0000765

CSI 3.4

rCSI 8.9%

PRS 85.8%
tracheobronchial smooth muscle cell CL0019019

CSI 3.4

rCSI 6.0%

PRS 85.3%
cerebral cortex neuron CL0010012

CSI 3.7

rCSI 14.9%

PRS 72.4%
medium spiny neuron CL1001474

CSI 3.7

rCSI 31.8%

PRS 68.6%
plasmacytoid dendritic cell, human CL0001058

CSI 3.7

rCSI 2.6%

PRS 83.5%
melanocyte of skin CL1000458

CSI 3.9

rCSI 5.3%

PRS 47.4%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 4.0

rCSI 7.1%

PRS 61.8%
common myeloid progenitor CL0000049

CSI 4.2

rCSI 3.4%

PRS 82.4%
cerebral cortex GABAergic interneuron CL0010011

CSI 4.2

rCSI 12.4%

PRS 81.1%
sst GABAergic cortical interneuron CL4023017

CSI 4.2

rCSI 5.4%

PRS 63.6%
VIP GABAergic cortical interneuron CL4023016

CSI 4.3

rCSI 5.1%

PRS 62.6%
lung pericyte CL0009089

CSI 4.3

rCSI 11.3%

PRS 86.7%
mesenchymal cell CL0008019

CSI 4.4

rCSI 11.1%

PRS 73.7%
vascular leptomeningeal cell CL4023051

CSI 4.4

rCSI 7.7%

PRS 74.3%
diffuse bipolar 1 cell CL4033027

CSI 4.5

rCSI 33.7%

PRS 70.7%
rod bipolar cell CL0000751

CSI 4.6

rCSI 8.3%

PRS 73.7%
stromal cell CL0000499

CSI 4.7

rCSI 13.3%

PRS 75.4%
inhibitory interneuron CL0000498

CSI 4.7

rCSI 11.0%

PRS 68.3%
epithelial cell of lower respiratory tract CL0002632

CSI 5.0

rCSI 3.9%

PRS 83.9%
vascular associated smooth muscle cell CL0000359

CSI 5.1

rCSI 16.6%

PRS 78.4%
retinal rod cell CL0000604

CSI 5.3

rCSI 9.3%

PRS 75.9%
retinal bipolar neuron CL0000748

CSI 5.5

rCSI 10.3%

PRS 68.8%
alveolar macrophage CL0000583

CSI 5.5

rCSI 9.1%

PRS 84.0%
duct epithelial cell CL0000068

CSI 5.7

rCSI 8.4%

PRS 85.0%
hematopoietic multipotent progenitor cell CL0000837

CSI 5.7

rCSI 13.8%

PRS 92.1%
cerebral cortex endothelial cell CL1001602

CSI 5.7

rCSI 9.9%

PRS 72.0%
interneuron CL0000099

CSI 5.8

rCSI 11.6%

PRS 70.6%
interstitial cell of Cajal CL0002088

CSI 5.8

rCSI 7.4%

PRS 85.2%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 5.9

rCSI 8.3%

PRS 77.0%
endothelial cell of placenta CL0009092

CSI 5.9

rCSI 29.1%

PRS 87.6%
neuroblast (sensu Vertebrata) CL0000031

CSI 5.9

rCSI 7.6%

PRS 76.4%
neural cell CL0002319

CSI 6.0

rCSI 22.6%

PRS 63.2%
amacrine cell CL0000561

CSI 6.0

rCSI 17.5%

PRS 69.9%
ependymal cell CL0000065

CSI 6.2

rCSI 12.6%

PRS 58.9%
hepatic stellate cell CL0000632

CSI 6.2

rCSI 23.4%

PRS 72.8%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 6.6

rCSI 15.9%

PRS 67.3%
astrocyte of the cerebral cortex CL0002605

CSI 7.0

rCSI 15.7%

PRS 63.3%
radial glial cell CL0000681

CSI 7.1

rCSI 9.8%

PRS 78.8%
neuron CL0000540

CSI 7.2

rCSI 19.0%

PRS 68.0%
pvalb GABAergic cortical interneuron CL4023018

CSI 7.2

rCSI 9.0%

PRS 60.4%
retinal cone cell CL0000573

CSI 7.3

rCSI 11.7%

PRS 70.5%
nasal mucosa goblet cell CL0002480

CSI 7.3

rCSI 8.5%

PRS 84.1%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 7.6

rCSI 6.8%

PRS 78.5%
subcutaneous adipocyte CL0002521

CSI 7.8

rCSI 39.7%

PRS 83.3%
hematopoietic precursor cell CL0008001

CSI 7.9

rCSI 8.2%

PRS 90.9%
megakaryocyte CL0000556

CSI 8.5

rCSI 36.7%

PRS 85.5%
cerebellar granule cell CL0001031

CSI 8.5

rCSI 12.5%

PRS 73.3%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 8.5

rCSI 9.9%

PRS 72.4%
glioblast CL0000030

CSI 8.6

rCSI 13.7%

PRS 71.9%
myofibroblast cell CL0000186

CSI 9.1

rCSI 12.6%

PRS 77.6%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 9.4

rCSI 55.4%

PRS 63.2%
near-projecting glutamatergic cortical neuron CL4023012

CSI 9.9

rCSI 37.3%

PRS 62.9%
erythrocyte CL0000232

CSI 10.3

rCSI 23.3%

PRS 80.7%
club cell CL0000158

CSI 11.8

rCSI 17.3%

PRS 75.0%
peripheral nervous system neuron CL2000032

CSI 11.8

rCSI 16.1%

PRS 72.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [PRKAR2B](/details-gene/5577) (protein kinase cAMP-dependent type II regulatory subunit beta) encodes a key regulatory subunit of Protein Kinase A (PKA), a central enzyme in the cAMP signaling cascade. As a type II beta regulatory subunit, it binds to and inhibits the catalytic subunit of PKA in the absence of cAMP. Upon cAMP binding, this inhibition is released, activating the kinase to phosphorylate downstream targets. **Overall**, expression data reveals that [PRKAR2B](/details-gene/5577) is a highly significant gene in [adipocyte](/details-cell/CL0000136)s and a diverse range of neuronal subtypes, suggesting critical roles in both metabolic regulation and synaptic function. Genetic variants in this gene are associated with a multiple congenital malformation syndrome ([OMIM: 176912](https://omim.org/entry/176912)), underscoring its importance in development [Link](https://doi.org/10.1016/j.ajhg.2020.09.005). ## Cellular Roles and Expression Landscape The expression profile of [PRKAR2B](/details-gene/5577) highlights its dual specialization in metabolic and neuronal tissues. The gene's most significant expression is observed in [adipocyte](/details-cell/CL0000136)s (CSI: 54.92), where its high abundance suggests it is a crucial component of the cellular machinery regulating energy storage and release. Beyond its metabolic role, [PRKAR2B](/details-gene/5577) is a prominent marker across various neuronal populations in the central nervous system. It shows high significance in both inhibitory and excitatory neurons, including [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 29.41), [sncg GABAergic cortical interneuron](/details-cell/CL4023015) (CSI: 26.83), and multiple subtypes of glutamatergic neurons such as [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 22.58). This broad yet specific expression pattern in the brain points towards a fundamental role in modulating neuronal excitability and synaptic communication. Additionally, notable expression in [platelet](/details-cell/CL0000233)s suggests a potential role in hemostasis, consistent with PKA's involvement in platelet activation. ## Pathways and Molecular Function The functions of [PRKAR2B](/details-gene/5577) are centered on its role as a regulator of PKA. Gene Ontology annotations confirm its molecular function in [cAMP binding](/details-go/GO:0030552), [cAMP-dependent protein kinase regulator activity](/details-go/GO:0008603), and binding to the [PKA catalytic subunit](/details-go/GO:0034236). Its cellular localization is diverse, including the [cytoplasm](/details-go/GO:0005737), [dendritic spine](/details-go/GO:0043197), and [centrosome](/details-go/GO:0005813), positioning it to respond to localized cAMP signals. Pathway analysis reinforces the cellular expression data. Its high significance in neurons is supported by its involvement in numerous neuronal processes, including '[Neuronal system](/details-pathway/R-HSA-112316)', '[Transmission across chemical synapses](/details-pathway/R-HSA-112315)', and '[Activation of nmda receptors and postsynaptic events](/details-pathway/R-HSA-442755)'. This is consistent with a role in learning and synaptic plasticity ([GO:0007612](/details-go/GO:0007612)). Similarly, its top expression in adipocytes aligns with its participation in metabolic pathways such as '[Fatty acid metabolic process](/details-go/GO:0006631)', '[Glucagon signaling in metabolic regulation](/details-pathway/R-HSA-163359)', and '[Integration of energy metabolism](/details-pathway/R-HSA-163685)'. The extensive list of associated pathways, from '[Cell cycle](/details-pathway/R-HSA-1640170)' to '[Hemostasis](/details-pathway/R-HSA-109582)', illustrates the ubiquitous nature of PKA signaling, which [PRKAR2B](/details-gene/5577) helps to regulate. ## Research Directions The specific and high-level expression of [PRKAR2B](/details-gene/5577) in distinct cell types offers clear avenues for future investigation into its physiological roles and potential contributions to disease. **Proposed Hypotheses:** 1. Given its exceptional expression in [adipocyte](/details-cell/CL0000136)s and its link to glucagon signaling pathways, we hypothesize that **[PRKAR2B](/details-gene/5577) is a primary determinant of lipolytic response rates in adipose tissue.** Its abundance may set the threshold for PKA activation following hormonal stimulation, thereby controlling the mobilization of fatty acids. Dysregulation or altered expression of this subunit could be a contributing factor to metabolic diseases characterized by impaired lipolysis, such as obesity or type 2 diabetes. 2. Based on its high significance in multiple glutamatergic and GABAergic neuron subtypes and its association with synaptic transmission pathways ([GO:0050804](/details-go/GO:0050804)), we hypothesize that **[PRKAR2B](/details-gene/5577) is essential for specific forms of synaptic plasticity and memory formation.** Its localization to dendritic spines and involvement in NMDA receptor signaling suggests it fine-tunes the postsynaptic response to neurotransmitters, a process critical for learning. **Key Experimental Approach:** To test the first hypothesis regarding its role in adipocyte metabolism, an ideal experiment would be: * **Generate a conditional knockout mouse model** using an Adipoq-Cre driver to specifically delete [PRKAR2B](/details-gene/5577) in adipocytes. * **Isolate primary adipocytes** from both knockout and wild-type control mice. * **Perform ex vivo lipolysis assays** by stimulating the cells with a beta-adrenergic agonist (e.g., isoproterenol) and measuring the release of glycerol and free fatty acids into the media. * **Conduct phosphoproteomic analysis** on stimulated adipocytes to identify how the loss of [PRKAR2B](/details-gene/5577) alters the landscape of PKA-mediated phosphorylation events on downstream targets involved in lipid metabolism. **Therapeutic Potential:** As a regulatory subunit, [PRKAR2B](/details-gene/5577) itself is not a direct enzymatic target but represents a key node for modulating PKA activity. Its high expression in adipocytes and neurons suggests that cell-type-specific targeting would be necessary to avoid widespread side effects. For metabolic disorders involving excessive PKA signaling (e.g., certain lipodystrophies or hormone-secreting tumors), developing small molecules that stabilize the inhibitory interaction between [PRKAR2B](/details-gene/5577) and the catalytic subunit could be a viable strategy for inhibition. Conversely, in conditions of deficient PKA signaling, agents that promote its dissociation might serve to activate the pathway. The linkage to a congenital syndrome ([OMIM: 176912](https://omim.org/entry/176912)) highlights the critical importance of its function, suggesting that any therapeutic modulation would require a precise and carefully controlled approach.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

cAMP-dependent protein kinase type II-beta regulatory subunit
B3KY43_HUMAN

Genular Protein ID: 2526073384

Symbol: KAP3_HUMAN

Name: cAMP-dependent protein kinase type II-beta regulatory subunit

UniProtKB Accession Codes:

P31323 A4D0R9

Database IDs:

Citations:

PubMed ID: 2851102

Title: Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis.

PubMed ID: 2851102

DOI: 10.1210/mend-2-12-1364

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21423175

Title: Control of PKA stability and signalling by the RING ligase praja2.

PubMed ID: 21423175

DOI: 10.1038/ncb2209

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25920809

Title: GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation.

PubMed ID: 25920809

DOI: 10.1016/j.bbamcr.2015.04.013

PubMed ID: 33058759

Title: Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.

PubMed ID: 33058759

DOI: 10.1016/j.ajhg.2020.09.005

Sequence Information:

Length: 418
Mass: 46302
Checksum: 83F402CCFFEFD186
Sequence:

MSIEIPAGLT ELLQGFTVEV LRHQPADLLE FALQHFTRLQ QENERKGTAR FGHEGRTWGD 
LGAAAGGGTP SKGVNFAEEP MQSDSEDGEE EEAAPADAGA FNAPVINRFT RRASVCAEAY 
NPDEEEDDAE SRIIHPKTDD QRNRLQEACK DILLFKNLDP EQMSQVLDAM FEKLVKDGEH 
VIDQGDDGDN FYVIDRGTFD IYVKCDGVGR CVGNYDNRGS FGELALMYNT PRAATITATS 
PGALWGLDRV TFRRIIVKNN AKKRKMYESF IESLPFLKSL EFSERLKVVD VIGTKVYNDG 
EQIIAQGDSA DSFFIVESGE VKITMKRKGK SEVEENGAVE IARCSRGQYF GELALVTNKP 
RAASAHAIGT VKCLAMDVQA FERLLGPCME IMKRNIATYE EQLVALFGTN MDIVEPTA

Genular Protein ID: 203057116

Symbol: B3KY43_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KY43

Database IDs:

Sequence Information:

Length: 405
Mass: 44867
Checksum: 165B480722FDD14F
Sequence:

MSIEIPAGLT ELLQGFTVEV LRHQPADLLE FALQHFTRLQ QENERKGTAR FGHEGRTWGD 
LGAAAGGGTP SKGVNFAEEA APADAGAFNA PVINRFTRRA SVCAEAYNPD EEEDDAESRI 
IHPKTDDQRN RLQEACKDIL LFKNLDPEQM SQVLDAMFEK LVKDGEHVID QGDDGDNFYV 
IDRGTFDIYV KCDGVGRCVG NYDNRGSFGE LALMYNTPRA ATITATSPGA LWGLDRVTFR 
RIIVKNNAKK RKMYESFIES LPFLKSLEFS ERLKVVDVIG TKVYNDGEQI IAQGDSADSF 
FIVESGEVKI TMKRKGKSEV EENGVVEIAR CSRGQYFGEL ALVTNKPRAA SAHAIGTVKC 
LAMDVQAFER LLGPCMEIMK RNIATYEEQL VALFGTNMDI VEPTA

	Overall overall
	Alzheimer disease MONDO0004975
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	Interventricular septum UBERON0002094
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	Lymph node UBERON0000029
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: PRKAR2B

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis. PubMed ID: 2851102

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. PubMed ID: 18318008

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

Control of PKA stability and signalling by the RING ligase praja2. PubMed ID: 21423175

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation. PubMed ID: 25920809

Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. PubMed ID: 33058759