Details for: PTK2

Gene ID: 5747

Symbol: PTK2

Ensembl ID: ENSG00000169398

Description: protein tyrosine kinase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granule cell (CL0000120)
    Fold Change: 6.58
    Marker Score: 49597
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.61
    Marker Score: 29413
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.28
    Marker Score: 28371
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 4.95
    Marker Score: 6163
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.88
    Marker Score: 11211
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.69
    Marker Score: 4048
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 4.62
    Marker Score: 4099
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.39
    Marker Score: 77891
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.22
    Marker Score: 10098
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 4.21
    Marker Score: 2282
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.05
    Marker Score: 136875
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.97
    Marker Score: 16537.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.85
    Marker Score: 5176
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.84
    Marker Score: 12877
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.75
    Marker Score: 2603
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.69
    Marker Score: 2780
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.68
    Marker Score: 4459
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.64
    Marker Score: 2990
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.61
    Marker Score: 3446
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.61
    Marker Score: 2778.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.57
    Marker Score: 7830
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.52
    Marker Score: 3983
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.49
    Marker Score: 14592
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.3
    Marker Score: 1915
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.29
    Marker Score: 6327
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.27
    Marker Score: 3764
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.19
    Marker Score: 1680
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.11
    Marker Score: 66400
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 3
    Marker Score: 865.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 3
    Marker Score: 11617
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3
    Marker Score: 8553
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.98
    Marker Score: 9752
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.96
    Marker Score: 1420
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.95
    Marker Score: 1654
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.93
    Marker Score: 1926
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.91
    Marker Score: 13440
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.9
    Marker Score: 848
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.9
    Marker Score: 64714
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.89
    Marker Score: 1683
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.82
    Marker Score: 1857
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.79
    Marker Score: 4057
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.74
    Marker Score: 4597
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.71
    Marker Score: 861
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.69
    Marker Score: 1607
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.67
    Marker Score: 53185
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.67
    Marker Score: 6683
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.65
    Marker Score: 836
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.64
    Marker Score: 1544
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.63
    Marker Score: 39266
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.6
    Marker Score: 19921
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.6
    Marker Score: 98675
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.52
    Marker Score: 1401
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.5
    Marker Score: 10349
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.48
    Marker Score: 900
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.46
    Marker Score: 2656
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.44
    Marker Score: 1023
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.43
    Marker Score: 39028
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.36
    Marker Score: 87244
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.34
    Marker Score: 1213
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.26
    Marker Score: 2497
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.24
    Marker Score: 580
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.23
    Marker Score: 8632
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.23
    Marker Score: 19533
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.22
    Marker Score: 3117
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.18
    Marker Score: 1890.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.18
    Marker Score: 2630
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.15
    Marker Score: 20238
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.14
    Marker Score: 790.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.14
    Marker Score: 2644
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.13
    Marker Score: 3062
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.12
    Marker Score: 817
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.07
    Marker Score: 1158
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127283
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.07
    Marker Score: 7343
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.06
    Marker Score: 1024
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.03
    Marker Score: 732.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 2
    Marker Score: 8145
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.97
    Marker Score: 20349
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.96
    Marker Score: 970
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.96
    Marker Score: 740
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.96
    Marker Score: 2099
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.95
    Marker Score: 6917.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.92
    Marker Score: 18200
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.87
    Marker Score: 2641
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15987
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.86
    Marker Score: 508
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.83
    Marker Score: 465
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.81
    Marker Score: 662
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8
    Marker Score: 2658
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.79
    Marker Score: 567
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.72
    Marker Score: 3236
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.71
    Marker Score: 641
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.67
    Marker Score: 553
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.65
    Marker Score: 664
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.64
    Marker Score: 793
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.63
    Marker Score: 556
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.63
    Marker Score: 1656
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.62
    Marker Score: 507
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.61
    Marker Score: 2478
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.6
    Marker Score: 323

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Other Information

**Key Characteristics** PTK2 is a non-receptor tyrosine kinase that belongs to the Src family of kinases. It is characterized by its ability to phosphorylate and activate various downstream targets, including FAK1, Src, and Stat3, which are involved in signaling pathways that regulate cell migration, proliferation, and survival. PTK2 is also known for its ability to interact with various proteins, including integrins, focal adhesion proteins, and cytoskeletal components, which are essential for cell adhesion and migration. **Pathways and Functions** PTK2 is involved in various signaling pathways that regulate cell migration, proliferation, and survival. Some of the key pathways and functions of PTK2 include: 1. **Integrin-mediated signaling**: PTK2 is a key regulator of integrin-mediated signaling pathways, which are essential for cell adhesion, migration, and interaction with the extracellular matrix. 2. **Cell migration**: PTK2 is involved in the regulation of cell migration, including the migration of epithelial cells, macrophages, and neurons. 3. **Proliferation**: PTK2 is involved in the regulation of cell proliferation, including the proliferation of epithelial cells and macrophages. 4. **Survival**: PTK2 is involved in the regulation of cell survival, including the survival of neurons and macrophages. 5. **Apoptosis**: PTK2 is involved in the regulation of apoptosis, including the inhibition of apoptosis in neurons and macrophages. 6. **Cytoskeletal regulation**: PTK2 is involved in the regulation of cytoskeletal dynamics, including the regulation of actin dynamics and microtubule stability. **Clinical Significance** PTK2 has been implicated in various diseases, including: 1. **Cancer**: PTK2 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Cardiovascular disease**: PTK2 is involved in the regulation of vascular smooth muscle cell migration and proliferation, and is associated with cardiovascular disease. 3. **Neurodegenerative disorders**: PTK2 is involved in the regulation of neuronal migration and survival, and is associated with neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: PTK2 is involved in the regulation of immune cell migration and proliferation, and is associated with infectious diseases, including leishmaniasis and malaria. In conclusion, PTK2 is a non-receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell migration, proliferation, survival, and differentiation. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. Further research is needed to fully understand the mechanisms of PTK2 and its role in disease.

Genular Protein ID: 1395446821

Symbol: FAK1_HUMAN

Name: Focal adhesion kinase-related nonkinase

UniProtKB Accession Codes:

Q05397 B4E2N6 F5H4S4 J3QT16 Q14291 Q8IYN9 Q9UD85

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 ELM 1 EMBL 10 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 70 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 45 PDBsum 39 PIR 2 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 16 RefSeq 3 Rhea 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7692878

Title: Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK.

PubMed ID: 7692878

DOI: 10.1089/dna.1993.12.823

PubMed ID: 8422239

Title: Expression of an N-terminally truncated form of human focal adhesion kinase in brain.

PubMed ID: 8422239

DOI: 10.1006/bbrc.1993.1022

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8247543

Title: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

PubMed ID: 8247543

PubMed ID: 9360983

Title: Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.

PubMed ID: 9360983

DOI: 10.1074/jbc.272.46.29083

PubMed ID: 9422762

Title: Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.

PubMed ID: 9422762

DOI: 10.1074/jbc.273.2.1003

PubMed ID: 9756887

Title: Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase.

PubMed ID: 9756887

DOI: 10.1074/jbc.273.41.26516

PubMed ID: 10655584

Title: Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation.

PubMed ID: 10655584

DOI: 10.1038/35000008

PubMed ID: 11331870

Title: Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.

PubMed ID: 11331870

DOI: 10.1038/35074500

PubMed ID: 11980671

Title: Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples.

PubMed ID: 11980671

PubMed ID: 12221124

Title: Regulation of focal adhesion kinase by a novel protein inhibitor FIP200.

PubMed ID: 12221124

DOI: 10.1091/mbc.e02-05-0295

PubMed ID: 12387730

Title: Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein.

PubMed ID: 12387730

DOI: 10.1042/bj20020410

PubMed ID: 15166238

Title: Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway.

PubMed ID: 15166238

DOI: 10.1074/jbc.m313265200

PubMed ID: 15561106

Title: The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.

PubMed ID: 15561106

DOI: 10.1016/j.yexcr.2004.09.005

PubMed ID: 15855171

Title: Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.

PubMed ID: 15855171

DOI: 10.1074/jbc.m414172200

PubMed ID: 15895076

Title: Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase.

PubMed ID: 15895076

DOI: 10.1038/ncb1262

PubMed ID: 16452200

Title: Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells.

PubMed ID: 16452200

DOI: 10.1158/0008-5472.can-05-1661

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16998626

Title: Expression of FAK-related non-kinase (FRNK) coincides with morphological change in the early stage of cell adhesion.

PubMed ID: 16998626

DOI: 10.1007/s00795-006-0325-8

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18006843

Title: Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma.

PubMed ID: 18006843

DOI: 10.1158/0008-5472.can-07-2667

PubMed ID: 17395594

Title: Cellular characterization of a novel focal adhesion kinase inhibitor.

PubMed ID: 17395594

DOI: 10.1074/jbc.m606695200

PubMed ID: 16927379

Title: Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5.

PubMed ID: 16927379

DOI: 10.1002/jcb.21074

PubMed ID: 17431114

Title: Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo.

PubMed ID: 17431114

DOI: 10.1158/1535-7163.mct-06-0476

PubMed ID: 18497331

Title: The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.

PubMed ID: 18497331

DOI: 10.1161/circresaha.107.170357

PubMed ID: 18292575

Title: Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways.

PubMed ID: 18292575

DOI: 10.4049/jimmunol.180.5.3485

PubMed ID: 18256281

Title: A novel Cas family member, HEPL, regulates FAK and cell spreading.

PubMed ID: 18256281

DOI: 10.1091/mbc.e07-09-0953

PubMed ID: 18206965

Title: Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.

PubMed ID: 18206965

DOI: 10.1016/j.molcel.2007.11.031

PubMed ID: 18657504

Title: Regulation of estrogen rapid signaling through arginine methylation by PRMT1.

PubMed ID: 18657504

DOI: 10.1016/j.molcel.2008.05.025

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19339212

Title: Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes.

PubMed ID: 19339212

DOI: 10.1016/j.bbamcr.2009.01.015

PubMed ID: 19138410

Title: Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.

PubMed ID: 19138410

DOI: 10.1186/1471-2407-9-12

PubMed ID: 19787193

Title: STEAP4 regulates focal adhesion kinase activation and CpG motifs within STEAP4 promoter region are frequently methylated in DU145, human androgen-independent prostate cancer cells.

PubMed ID: 19787193

DOI: 10.3892/ijmm_00000270

PubMed ID: 19494199

Title: Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2).

PubMed ID: 19494199

DOI: 10.1167/iovs.08-3315

PubMed ID: 19147981

Title: Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.

PubMed ID: 19147981

DOI: 10.1172/jci37160

PubMed ID: 19118217

Title: EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.

PubMed ID: 19118217

DOI: 10.1242/jcs.036467

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20495381

Title: Bioluminescent imaging study: FAK inhibitor, PF-562,271, preclinical study in PC3M-luc-C6 local implant and metastasis xenograft models.

PubMed ID: 20495381

DOI: 10.4161/cbt.10.1.11993

PubMed ID: 19917054

Title: LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin.

PubMed ID: 19917054

DOI: 10.1111/j.1349-7006.2009.01398.x

PubMed ID: 20109444

Title: Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts.

PubMed ID: 20109444

DOI: 10.1016/j.yexcr.2010.01.021

PubMed ID: 20439989

Title: ZF21 protein regulates cell adhesion and motility.

PubMed ID: 20439989

DOI: 10.1074/jbc.m110.106443

PubMed ID: 20798394

Title: Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK.

PubMed ID: 20798394

DOI: 10.1074/mcp.m110.003665

PubMed ID: 20037584

Title: CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.

PubMed ID: 20037584

DOI: 10.1038/ni.1836

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21454698

Title: Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.

PubMed ID: 21454698

DOI: 10.1074/jbc.m110.168500

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23503467

Title: A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis.

PubMed ID: 23503467

DOI: 10.1038/onc.2013.43

PubMed ID: 10354709

Title: Signaling through focal adhesion kinase.

PubMed ID: 10354709

DOI: 10.1016/s0079-6107(98)00052-2

PubMed ID: 15725728

Title: Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning.

PubMed ID: 15725728

PubMed ID: 16919435

Title: Integrin-regulated FAK-Src signaling in normal and cancer cells.

PubMed ID: 16919435

DOI: 10.1016/j.ceb.2006.08.011

PubMed ID: 17968709

Title: Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions.

PubMed ID: 17968709

DOI: 10.1080/15216540701694245

PubMed ID: 18677107

Title: FERM control of FAK function: implications for cancer therapy.

PubMed ID: 18677107

DOI: 10.4161/cc.6367

PubMed ID: 19525103

Title: Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility.

PubMed ID: 19525103

DOI: 10.1016/j.ceb.2009.05.006

PubMed ID: 19224453

Title: Focal adhesion kinase and cancer.

PubMed ID: 19224453

DOI: 10.14670/hh-24.503

PubMed ID: 20515733

Title: Focal adhesion kinase and p53 signal transduction pathways in cancer.

PubMed ID: 20515733

DOI: 10.2741/3653

PubMed ID: 20552554

Title: The role of focal adhesion kinase in early development.

PubMed ID: 20552554

DOI: 10.14670/hh-25.1039

PubMed ID: 20101634

Title: Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer.

PubMed ID: 20101634

DOI: 10.1002/iub.303

PubMed ID: 20332118

Title: Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions.

PubMed ID: 20332118

DOI: 10.1242/jcs.045112

PubMed ID: 21482413

Title: Focal adhesion kinase: exploring Fak structure to gain insight into function.

PubMed ID: 21482413

DOI: 10.1016/b978-0-12-386041-5.00005-4

PubMed ID: 23509069

Title: MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.

PubMed ID: 23509069

DOI: 10.1083/jcb.201207050

PubMed ID: 29069646

Title: The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly.

PubMed ID: 29069646

DOI: 10.1159/000484298

PubMed ID: 31630787

Title: De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry.

PubMed ID: 31630787

DOI: 10.1016/j.ajhg.2019.09.022

PubMed ID: 12005431

Title: The structural basis of localization and signaling by the focal adhesion targeting domain.

PubMed ID: 12005431

DOI: 10.1016/s0969-2126(02)00717-7

PubMed ID: 12467573

Title: Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.

PubMed ID: 12467573

DOI: 10.1016/s0969-2126(02)00907-3

PubMed ID: 14527389

Title: Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain.

PubMed ID: 14527389

DOI: 10.1016/j.str.2003.08.010

PubMed ID: 18339875

Title: Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.

PubMed ID: 18339875

DOI: 10.1158/0008-5472.can-07-5155

PubMed ID: 18078954

Title: Structural basis for the interaction between focal adhesion kinase and CD4.

PubMed ID: 18078954

DOI: 10.1016/j.jmb.2007.11.040

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1052
  • Mass: 119233
  • Checksum: D8A4C15138AB0243
  • Sequence:
    • MAAAYLDPNL NHTPNSSTKT HLGTGMERSP GAMERVLKVF HYFESNSEPT TWASIIRHGD 
ATDVRGIIQK IVDSHKVKHV ACYGFRLSHL RSEEVHWLHV DMGVSSVREK YELAHPPEEW 
KYELRIRYLP KGFLNQFTED KPTLNFFYQQ VKSDYMLEIA DQVDQEIALK LGCLEIRRSY 
WEMRGNALEK KSNYEVLEKD VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI 
LKFFEILSPV YRFDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGCNP THLADFTQVQ 
TIQYSNSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL VNGTSQSFII 
RPQKEGERAL PSIPKLANSE KQGMRTHAVS VSETDDYAEI IDEEDTYTMP STRDYEIQRE 
RIELGRCIGE GQFGDVHQGI YMSPENPALA VAIKTCKNCT SDSVREKFLQ EALTMRQFDH 
PHIVKLIGVI TENPVWIIME LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK 
RFVHRDIAAR NVLVSSNDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT 
SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT LYSLMTKCWA 
YDPSRRPRFT ELKAQLSTIL EEEKAQQEER MRMESRRQAT VSWDSGGSDE APPKPSRPGY 
PSPRSSEGFY PSPQHMVQTN HYQVSGYPGS HGITAMAGSI YPGQASLLDQ TDSWNHRPQE 
IAMWQPNVED STVLDLRGIG QVLPTHLMEE RLIRQQQEME EDQRWLEKEE RFLKPDVRLS 
RGSIDREDGS LQGPIGNQHI YQPVGKPDPA APPKKPPRPG APGHLGSLAS LSSPADSYNE 
GVKLQPQEIS PPPTANLDRS NDKVYENVTG LVKAVIEMSS KIQPAPPEEY VPMVKEVGLA 
LRTLLATVDE TIPLLPASTH REIEMAQKLL NSDLGELINK MKLAQQYVMT SLQQEYKKQM 
LTAAHALAVD AKNLLDVIDQ ARLKMLGQTR PH

Genular Protein ID: 2972634751

Symbol: Q658W2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q658W2

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 6 DNASU 1 EC 1 EMBL 2 GO 18 Gene3D 5 Genevisible 1 GenomeRNAi 1 InterPro 18 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 3 Rhea 3 SAM 1 SMART 2 SUPFAM 5 iPTMnet 1

Sequence Information:

  • Length: 1074
  • Mass: 121721
  • Checksum: 49E165262172ADE7
  • Sequence:
    • MISADCNLCL PEYDRYLASS KIMAAAYLDP NLNHTPNSST KTHLGTGMER SPGAMERVLK 
VFHYFESNSE PTTWASIIRH GDATDVRGII QKIVDSHKVK HVACYGFRLS HLRSEEVHWL 
HVDMGVSSVR EKYELAHPPE EWKYELRIRY LPKGFLNQFT EDKPTLNFFY QQVKSDYMLE 
IADQVDQEIA LKLGCLEIRR SYWEMRGNAL EKKSNYEVLE KDVGLKRFFP KSLLDSVKAK 
TLRKLIQQTF RQFANLNREE SILKFFEILS PVYRFDKECF KCALGSSWII SVELAIGPEE 
GISYLTDKGC NPTHLADFTQ VQTIQYSNSE DKDRKGMLQL KIAGAPEPLT VTAPSLTIAE 
NMADLIDGYC RLVNGTSQSF IIRPQKEGER ALPSIPKLAN SEKQGMRTHA VSVSETDDYA 
EIIDEEDTYT MPSTRDYEIQ RERIELGRCI GEGQFGDVHQ GIYMSPENPA LAVAIKTCKN 
CTSDSVREKF LQEALTMRQF DHPHIVKLIG VITENPVWII MELCTLGELR SFLQVRKYSL 
DLASLILYAY QLSTALAYLE SKRFVHRDIA ARNVLVSSND CVKLGDFGLS RYMEDSTYYK 
ASKGKLPIKW MAPESINFRR FTSASDVWMF GVCMWEILMH GVKPFQGVKN NDVIGRIENG 
ERLPMPPNCP PTLYSLMTKC WAYDPSRRPR FTELKAQLST ILEEEKAQQE ERMRMESRRQ 
ATVSWDSGGS DEAPPKPSRP GYPSPRSSEG FYPSPQHMVQ TNHYQVSGYP GSHGITAMAG 
SIYPGQASLL DQTDSWNHRP QEIAMWQPNV EDSTVLDLRG IGQVLPTHLM EERLIRQQQE 
MEEDQRWLEK EERFLKPDVR LSRGSIDRED GSLQGPIGNQ HIYQPVGKPD PAAPPKKPPR 
PGAPGHLGSL ASLSSPADSY NEGVKLQPQE ISPPPTANLD RSNDKVYENV TGLVKAVIEM 
SSKIQPAPPE EYVPMVKEVG LALRTLLATV DETIPLLPAS THREIEMAQK LLNSDLGELI 
NKMKLAQQYV MTSLQQEYKK QMLTAAHALA VDAKNLLDVI DQARLKMLGQ TRPH

Genular Protein ID: 3808189954

Symbol: Q59GN8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GN8

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 6 DNASU 1 EC 1 EMBL 2 GO 15 Gene3D 5 GenomeRNAi 1 InterPro 16 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 1 Rhea 3 SAM 1 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 975
  • Mass: 110234
  • Checksum: 7C93F34BA129B5E7
  • Sequence:
    • RSFIILKAIV SQPPGPVLSG MEMLLMSGYE LRIRYLPKGF LNQFTEDKPT LNFFYQQVKS 
DYMLEIADQV DQEIALKLGC LEIRRSYWEM RGNALEKKSN YEVLEKDVGL KRFFPKSLLD 
SVKAKTLRKL IQQTFRQFAN LNREESILKF FEILSPVYRF DKECFKCALG SSWIISVELA 
IGPEEGISYL TDKGCNPTHL ADFTQVQTIQ YSNSEDKDRK GMLQLKIAGA PEPLTVTAPS 
LTIAENMADL IDGYCRLVNG TSQSFIIRPQ KEGERALPSI PKLANSEKQG MRTHAVSVSD 
EISGDETDDY AEIIDEEDTY TMPSKSYGID EARDYEIQRE RIELGRCIGE GQFGDVHQGI 
YMSPENPALA VAIKTCKNCT SDSVREKFLQ EALTMRQFDH PHIVKLIGVI TENPVWIIME 
LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK RFVHRDIAAR NVLVSSNDCV 
KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT SASDVWMFGV CMWEILMHGV 
KPFQGVKNND VIGRIENGER LPMPPNCPPT LYSLMTKCWA YDPSRRPRFT ELKAQLSTIL 
EEEKAQQEER MRMESRRQAT VSWDSGGSDE APPKPSRPGY PSPRSSEGFY PSPQHMVQTN 
HYQVSGYPGS HGITAMAGSI YPGQASLLDQ TDSWNHRPQE IAMWQPNVED STVLDLRGIG 
QVLPTHLMEE RLIRQQQEME EDQRWLEKEE RFLKPDVRLS RGSIDREDGS LQGPIGNQHI 
YQPVGKPDPA APPKKPPRPG APGHLGSLAS LSSPADSYNE GVKPWRLQPQ EISPPPTANL 
DRSNDKVYEN VTGLVKAVIE MSSKIQPAPP EEYVPMVKEV GLALRTLLAT VDETIPLLPA 
STHREIEMAQ KLLNSDLGEL INKMKLAQQY VMTSLQQEYK KQMLTAAHAL AVDAKNLLDV 
IDQARLKMLG QTRPH

Genular Protein ID: 516626567

Symbol: Q59GM6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GM6

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 6 DNASU 1 EC 1 EMBL 2 GO 15 Gene3D 5 Genevisible 1 GenomeRNAi 1 InterPro 16 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 3 Rhea 3 SAM 1 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 1007
  • Mass: 114157
  • Checksum: 40109858F52472C9
  • Sequence:
    • RKGEYDRYLA SSKIMAAAYL DPNLNHTPEE WKYELRIRYL PKGFLNQFTE DKPTLNFFYQ 
QVKSDYMLEI ADQVDQEIAL KLGCLEIRRS YWEMRGNALE KKSNYEVLEK DVGLKRFFPK 
SLLDSVKAKT LRKLIQQTFR QFANLNREES ILKFFEILSP VYRFDKECFK CALGSSWIIS 
VELAIGPEEG ISYLTDKGCN PTHLADFTQV QTIQYSNSED KDRKGMLQLK IAGAPEPLTV 
TAPSLTIAEN MADLIDGYCR LVNGTSQSFI IRPQKEGERA LPSIPKLANS EKQGMRTHAV 
SVSGVSHCQH KVKKARRFLP LVFCSHDPPS ADEISGDETD DYAEIIDEED TYTMPSKSYG 
IDEARDYEIQ RERIELGRCI GEGQFGDVHQ GIYMSPENPA LAVAIKTCKN CTSDSVREKF 
LQEALTMRQF DHPHIVKLIG VITENPVWII MELCTLGELR SFLQVRKYSL DLASLILYAY 
QLSTALAYLE SKRFVHRDIA ARNVLVSSND CVKLGDFGLS RYMEDSTYYK ASKGKLPIKW 
MAPESINFRR FTSASDVWMF GVCMWEILMH GVKPFQGVKN NDVIGRIENG ERLPMPPNCP 
PTLYSLMTKC WAYDPSRRPR FTELKAQLST ILEEEKAQQE ERMRMESRRQ ATVSWDSGGS 
DEAPPKPSRP GYPSPRSSEG FYPSPQHMVQ TNHYQVSGYP GSHGITAMAG SIYPGQASLL 
DQTDSWNHRP QEIAMWQPNV EDSTVLDLRG IGQVLPTHLM EERLIRQQQE MEEDQRWLEK 
EERFLKPDVR LSRGSIDRED GSLQGPIGNQ HIYQPVGKPD PAAPPKKPPR PGAPGHLGSL 
ASLSSPADSY NEGVKPWRLQ PQEISPPPTA NLDRSNDKVY ENVTGLVKAV IEMSSKIQPA 
PPEEYVPMVK EVGLALRTLL ATVDETIPLL PASTHREIEM AQKLLNSDLG ELINKMKLAQ 
QYVMTSLQQE YKKQMLTAAH ALAVDAKNLL DVIDQARLKM LGQTRPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.