Details for: PTK2
Gene ID: 5747
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PTK2
Ensembl ID: ENSG00000169398
Description: protein tyrosine kinase 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 55.49rCSI 66.29%PRS 44.06
-
CSI 54.05rCSI 67.24%PRS 42.42
-
CSI 47.18rCSI 60.83%PRS 45.61
-
CSI 44.74rCSI 71.96%PRS 46.33
-
CSI 42.8rCSI 71.85%PRS 44.32
-
CSI 41.68rCSI 100%PRS 61.18
-
CSI 38.97rCSI 68.82%PRS 43.39
-
CSI 37.61rCSI 81.58%PRS 50.45
-
CSI 36.67rCSI 56%PRS 63.41
-
CSI 34.8rCSI 56.99%PRS 51.85
-
CSI 32.43rCSI 44.37%PRS 55.91
-
CSI 32.15rCSI 27.58%PRS 70.64
-
CSI 31.58rCSI 69.76%PRS 48.77
-
CSI 30.51rCSI 74.14%PRS 42.9
-
CSI 29.79rCSI 66.79%PRS 45.04
-
CSI 29.35rCSI 59.56%PRS 41.93
-
CSI 28.82rCSI 68.94%PRS 49.84
-
CSI 27.9rCSI 48.92%PRS 54.54
-
CSI 27.5rCSI 49.97%PRS 54.42
-
CSI 27.47rCSI 38.94%PRS 58.95
-
CSI 25.98rCSI 23.06%PRS 60.62
-
CSI 25.85rCSI 69.09%PRS 53.58
-
CSI 25.13rCSI 34.8%PRS 63.7
-
CSI 24.85rCSI 54.67%PRS 45.41
-
CSI 24.5rCSI 76.62%PRS 48.48
-
CSI 24.43rCSI 65.06%PRS 51.75
-
CSI 24.38rCSI 76.18%PRS 45.97
-
CSI 24.18rCSI 79.47%PRS 49.55
-
CSI 23.23rCSI 49.5%PRS 34.91
-
CSI 22.73rCSI 26.25%PRS 55.8
-
CSI 22.61rCSI 32.44%PRS 52.17
-
CSI 22.29rCSI 35.46%PRS 55.04
-
CSI 21.49rCSI 37.16%PRS 52.77
-
CSI 21.34rCSI 29.15%PRS 64.44
-
CSI 21.01rCSI 75.59%PRS 42.69
-
CSI 20.57rCSI 77.74%PRS 45.04
-
CSI 20.13rCSI 55.48%PRS 58.13
-
CSI 19.72rCSI 67.53%PRS 51.38
-
CSI 19.32rCSI 57.1%PRS 52.84
-
CSI 18.96rCSI 49.39%PRS 59.97
-
CSI 18.91rCSI 47.96%PRS 52.14
-
CSI 18.41rCSI 25.58%PRS 61.29
-
CSI 17.96rCSI 46.65%PRS 66.22
-
CSI 17.87rCSI 51.75%PRS 63.98
-
CSI 17.64rCSI 35.42%PRS 51.73
-
CSI 17.4rCSI 15.13%PRS 73.47
-
CSI 17.34rCSI 21.45%PRS 59.37
-
CSI 16.87rCSI 31.6%PRS 50.89
-
CSI 16.85rCSI 26.89%PRS 55.23
-
CSI 16.84rCSI 21.62%PRS 54.99
-
CSI 16.36rCSI 15.77%PRS 53.37
-
CSI 16.24rCSI 64.33%PRS 61.76
-
CSI 16.21rCSI 30.92%PRS 77.22
-
CSI 16.18rCSI 51.78%PRS 59.73
-
CSI 16.15rCSI 29.6%PRS 73.75
-
CSI 15.8rCSI 21.6%PRS 68.83
-
CSI 15.45rCSI 16.56%PRS 62.32
-
CSI 15.07rCSI 30.97%PRS 52.84
-
CSI 14.94rCSI 11.81%PRS 49.53
-
CSI 14.77rCSI 36.07%PRS 56
-
CSI 14.76rCSI 35.49%PRS 70.06
-
CSI 14.63rCSI 19.9%PRS 74.37
-
CSI 14.63rCSI 22.48%PRS 58.43
-
CSI 14.25rCSI 25.42%PRS 76.2
-
CSI 14.23rCSI 19.38%PRS 54.45
-
CSI 14.03rCSI 18.01%PRS 59.89
-
CSI 13.81rCSI 31.87%PRS 51.67
-
CSI 13.74rCSI 10.18%PRS 55.16
-
CSI 13.71rCSI 13.19%PRS 62.71
-
CSI 13.7rCSI 40.43%PRS 61.25
-
CSI 13.61rCSI 31.13%PRS 62.62
-
CSI 13.51rCSI 55.06%PRS 56.91
-
CSI 13.5rCSI 50.96%PRS 48.87
-
CSI 12.95rCSI 76.25%PRS 45.52
-
CSI 12.93rCSI 48.46%PRS 54.63
-
CSI 12.66rCSI 18.62%PRS 56.08
-
CSI 12.66rCSI 15.75%PRS 64.42
-
CSI 12.4rCSI 32.33%PRS 62.35
-
CSI 11.88rCSI 52.21%PRS 59.24
-
CSI 11.77rCSI 55.37%PRS 57.33
-
CSI 11.77rCSI 48.83%PRS 65.73
-
CSI 11.57rCSI 30.71%PRS 73.85
-
CSI 11.4rCSI 36.98%PRS 62.9
-
CSI 11.39rCSI 33.02%PRS 52.28
-
CSI 11.29rCSI 13.55%PRS 60.79
-
CSI 11.17rCSI 17.98%PRS 52.18
-
CSI 11.15rCSI 12.93%PRS 70.38
-
CSI 10.97rCSI 32.55%PRS 72.69
-
CSI 10.82rCSI 17.53%PRS 59.34
-
CSI 10.8rCSI 36.59%PRS 56.24
-
CSI 10.79rCSI 28.47%PRS 71.52
-
CSI 10.79rCSI 53.17%PRS 73.75
-
CSI 10.57rCSI 18.91%PRS 61.74
-
CSI 10.54rCSI 15.46%PRS 74.41
-
CSI 10.49rCSI 18.85%PRS 55.78
-
CSI 10.39rCSI 10.84%PRS 63.05
-
CSI 10.35rCSI 76.09%PRS 49.16
-
CSI 10.35rCSI 14.77%PRS 64.96
-
CSI 10.35rCSI 15.39%PRS 64.07
-
CSI 10.29rCSI 51.8%PRS 63.52
-
CSI 0.2rCSI 2.3%PRS 74.9%
-
CSI 0.2rCSI 3.4%PRS 77.0%
-
CSI 0.4rCSI 2.8%PRS 75.4%
-
CSI 0.5rCSI 2.7%PRS 71.6%
-
CSI 0.6rCSI 2.4%PRS 75.0%
-
CSI 0.7rCSI 3.6%PRS 78.0%
-
CSI 0.7rCSI 1.3%PRS 65.7%
-
CSI 0.7rCSI 2.9%PRS 75.2%
-
CSI 0.7rCSI 6.5%PRS 79.1%
-
CSI 0.8rCSI 11.9%PRS 76.4%
-
CSI 0.9rCSI 22.6%PRS 60.5%
-
CSI 0.9rCSI 14.1%PRS 79.1%
-
CSI 1.1rCSI 3.0%PRS 75.2%
-
CSI 1.1rCSI 8.5%PRS 69.4%
-
CSI 1.1rCSI 1.2%PRS 66.3%
-
CSI 1.2rCSI 6.1%PRS 72.1%
-
CSI 1.3rCSI 2.9%PRS 76.2%
-
CSI 1.4rCSI 5.9%PRS 77.0%
-
CSI 1.4rCSI 10.2%PRS 78.5%
-
CSI 1.5rCSI 2.8%PRS 73.1%
-
CSI 1.6rCSI 2.3%PRS 78.5%
-
CSI 1.6rCSI 2.3%PRS 66.1%
-
CSI 1.6rCSI 7.0%PRS 75.3%
-
CSI 1.8rCSI 10.6%PRS 69.6%
-
CSI 1.8rCSI 3.4%PRS 80.7%
-
CSI 1.8rCSI 4.7%PRS 78.1%
-
CSI 1.8rCSI 1.8%PRS 65.3%
-
CSI 1.9rCSI 6.4%PRS 83.6%
-
CSI 1.9rCSI 5.6%PRS 75.8%
-
CSI 2.0rCSI 2.1%PRS 72.8%
-
CSI 2.0rCSI 12.4%PRS 77.0%
-
CSI 2.1rCSI 2.0%PRS 71.6%
-
CSI 2.2rCSI 3.9%PRS 77.7%
-
CSI 2.2rCSI 6.3%PRS 83.7%
-
CSI 2.3rCSI 3.7%PRS 73.8%
-
CSI 2.4rCSI 4.9%PRS 80.6%
-
CSI 2.4rCSI 3.1%PRS 67.7%
-
CSI 2.5rCSI 3.8%PRS 61.0%
-
CSI 2.5rCSI 8.8%PRS 71.2%
-
CSI 2.6rCSI 12.3%PRS 78.7%
-
CSI 2.6rCSI 3.6%PRS 69.3%
-
CSI 2.7rCSI 6.4%PRS 72.5%
-
CSI 2.7rCSI 7.6%PRS 59.4%
-
CSI 2.7rCSI 12.4%PRS 73.1%
-
CSI 2.7rCSI 17.6%PRS 64.3%
-
CSI 2.8rCSI 65.3%PRS 81.2%
-
CSI 2.9rCSI 16.0%PRS 72.0%
-
CSI 2.9rCSI 26.7%PRS 72.7%
-
CSI 3.0rCSI 4.0%PRS 69.2%
-
CSI 3.0rCSI 16.7%PRS 77.7%
-
CSI 3.0rCSI 13.5%PRS 79.0%
-
CSI 3.0rCSI 8.1%PRS 69.8%
-
CSI 3.1rCSI 7.0%PRS 59.0%
-
CSI 3.1rCSI 74.3%PRS 44.2%
-
CSI 3.1rCSI 74.6%PRS 43.3%
-
CSI 3.1rCSI 16.8%PRS 74.8%
-
CSI 3.1rCSI 27.5%PRS 49.7%
-
CSI 3.2rCSI 8.2%PRS 66.0%
-
CSI 3.2rCSI 35.8%PRS 80.3%
-
CSI 3.2rCSI 34.0%PRS 60.8%
-
CSI 3.3rCSI 15.5%PRS 79.1%
-
CSI 3.5rCSI 4.4%PRS 69.1%
-
CSI 3.6rCSI 56.5%PRS 67.7%
-
CSI 3.7rCSI 7.2%PRS 78.9%
-
CSI 3.7rCSI 42.3%PRS 53.6%
-
CSI 3.7rCSI 75.6%PRS 54.7%
-
CSI 3.7rCSI 8.9%PRS 71.1%
-
CSI 3.7rCSI 76.0%PRS 53.3%
-
CSI 3.8rCSI 32.5%PRS 59.6%
-
CSI 4.0rCSI 24.8%PRS 44.6%
-
CSI 4.0rCSI 41.4%PRS 55.8%
-
CSI 4.0rCSI 8.8%PRS 70.7%
-
CSI 4.1rCSI 3.4%PRS 67.1%
-
CSI 4.1rCSI 33.5%PRS 55.9%
-
CSI 4.2rCSI 10.6%PRS 56.9%
-
CSI 4.3rCSI 12.2%PRS 74.8%
-
CSI 4.3rCSI 4.4%PRS 68.5%
-
CSI 4.4rCSI 5.5%PRS 73.6%
-
CSI 4.4rCSI 6.4%PRS 58.8%
-
CSI 4.4rCSI 17.2%PRS 39.3%
-
CSI 4.4rCSI 5.2%PRS 65.0%
-
CSI 4.4rCSI 19.2%PRS 74.8%
-
CSI 4.5rCSI 10.0%PRS 75.2%
-
CSI 4.6rCSI 10.7%PRS 80.0%
-
CSI 4.6rCSI 12.1%PRS 80.7%
-
CSI 4.7rCSI 18.1%PRS 76.9%
-
CSI 4.7rCSI 7.4%PRS 65.0%
-
CSI 4.8rCSI 11.3%PRS 66.3%
-
CSI 4.8rCSI 11.4%PRS 71.5%
-
CSI 4.9rCSI 10.8%PRS 60.7%
-
CSI 4.9rCSI 30.6%PRS 54.4%
-
CSI 4.9rCSI 4.7%PRS 62.2%
-
CSI 5.0rCSI 18.9%PRS 53.4%
-
CSI 5.0rCSI 71.4%PRS 53.6%
-
CSI 5.2rCSI 7.6%PRS 67.6%
-
CSI 5.3rCSI 8.2%PRS 70.0%
-
CSI 5.4rCSI 8.2%PRS 76.0%
-
CSI 5.4rCSI 10.7%PRS 60.3%
-
CSI 5.4rCSI 5.4%PRS 56.1%
-
CSI 5.4rCSI 31.3%PRS 61.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1395446821
Symbol: FAK1_HUMAN
Name: Focal adhesion kinase-related nonkinase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7692878
Title: Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK.
PubMed ID: 7692878
PubMed ID: 8422239
Title: Expression of an N-terminally truncated form of human focal adhesion kinase in brain.
PubMed ID: 8422239
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8247543
Title: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.
PubMed ID: 8247543
PubMed ID: 9360983
Title: Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.
PubMed ID: 9360983
PubMed ID: 9422762
Title: Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions.
PubMed ID: 9422762
PubMed ID: 9756887
Title: Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase.
PubMed ID: 9756887
PubMed ID: 10655584
Title: Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation.
PubMed ID: 10655584
DOI: 10.1038/35000008
PubMed ID: 11331870
Title: Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.
PubMed ID: 11331870
DOI: 10.1038/35074500
PubMed ID: 11980671
Title: Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples.
PubMed ID: 11980671
PubMed ID: 12221124
Title: Regulation of focal adhesion kinase by a novel protein inhibitor FIP200.
PubMed ID: 12221124
PubMed ID: 12387730
Title: Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein.
PubMed ID: 12387730
DOI: 10.1042/bj20020410
PubMed ID: 15166238
Title: Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway.
PubMed ID: 15166238
PubMed ID: 15561106
Title: The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
PubMed ID: 15561106
PubMed ID: 15855171
Title: Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.
PubMed ID: 15855171
PubMed ID: 15895076
Title: Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase.
PubMed ID: 15895076
DOI: 10.1038/ncb1262
PubMed ID: 16452200
Title: Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells.
PubMed ID: 16452200
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16998626
Title: Expression of FAK-related non-kinase (FRNK) coincides with morphological change in the early stage of cell adhesion.
PubMed ID: 16998626
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18006843
Title: Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma.
PubMed ID: 18006843
PubMed ID: 17395594
Title: Cellular characterization of a novel focal adhesion kinase inhibitor.
PubMed ID: 17395594
PubMed ID: 16927379
Title: Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5.
PubMed ID: 16927379
DOI: 10.1002/jcb.21074
PubMed ID: 17431114
Title: Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo.
PubMed ID: 17431114
PubMed ID: 18497331
Title: The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.
PubMed ID: 18497331
PubMed ID: 18292575
Title: Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways.
PubMed ID: 18292575
PubMed ID: 18256281
Title: A novel Cas family member, HEPL, regulates FAK and cell spreading.
PubMed ID: 18256281
PubMed ID: 18206965
Title: Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.
PubMed ID: 18206965
PubMed ID: 18657504
Title: Regulation of estrogen rapid signaling through arginine methylation by PRMT1.
PubMed ID: 18657504
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19339212
Title: Specific tyrosine phosphorylation of focal adhesion kinase mediated by Fer tyrosine kinase in suspended hepatocytes.
PubMed ID: 19339212
PubMed ID: 19138410
Title: Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.
PubMed ID: 19138410
PubMed ID: 19787193
Title: STEAP4 regulates focal adhesion kinase activation and CpG motifs within STEAP4 promoter region are frequently methylated in DU145, human androgen-independent prostate cancer cells.
PubMed ID: 19787193
PubMed ID: 19494199
Title: Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2).
PubMed ID: 19494199
DOI: 10.1167/iovs.08-3315
PubMed ID: 19147981
Title: Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.
PubMed ID: 19147981
DOI: 10.1172/jci37160
PubMed ID: 19118217
Title: EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility.
PubMed ID: 19118217
DOI: 10.1242/jcs.036467
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20495381
Title: Bioluminescent imaging study: FAK inhibitor, PF-562,271, preclinical study in PC3M-luc-C6 local implant and metastasis xenograft models.
PubMed ID: 20495381
PubMed ID: 19917054
Title: LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin.
PubMed ID: 19917054
PubMed ID: 20109444
Title: Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts.
PubMed ID: 20109444
PubMed ID: 20439989
Title: ZF21 protein regulates cell adhesion and motility.
PubMed ID: 20439989
PubMed ID: 20798394
Title: Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK.
PubMed ID: 20798394
PubMed ID: 20037584
Title: CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
PubMed ID: 20037584
DOI: 10.1038/ni.1836
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21454698
Title: Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.
PubMed ID: 21454698
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23503467
Title: A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis.
PubMed ID: 23503467
DOI: 10.1038/onc.2013.43
PubMed ID: 10354709
Title: Signaling through focal adhesion kinase.
PubMed ID: 10354709
PubMed ID: 15725728
Title: Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning.
PubMed ID: 15725728
PubMed ID: 16919435
Title: Integrin-regulated FAK-Src signaling in normal and cancer cells.
PubMed ID: 16919435
PubMed ID: 17968709
Title: Focal adhesion kinase: an essential kinase in the regulation of cardiovascular functions.
PubMed ID: 17968709
PubMed ID: 18677107
Title: FERM control of FAK function: implications for cancer therapy.
PubMed ID: 18677107
DOI: 10.4161/cc.6367
PubMed ID: 19525103
Title: Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility.
PubMed ID: 19525103
PubMed ID: 19224453
PubMed ID: 20515733
Title: Focal adhesion kinase and p53 signal transduction pathways in cancer.
PubMed ID: 20515733
DOI: 10.2741/3653
PubMed ID: 20552554
Title: The role of focal adhesion kinase in early development.
PubMed ID: 20552554
DOI: 10.14670/hh-25.1039
PubMed ID: 20101634
Title: Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer.
PubMed ID: 20101634
DOI: 10.1002/iub.303
PubMed ID: 20332118
Title: Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions.
PubMed ID: 20332118
DOI: 10.1242/jcs.045112
PubMed ID: 21482413
Title: Focal adhesion kinase: exploring Fak structure to gain insight into function.
PubMed ID: 21482413
PubMed ID: 23509069
Title: MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
PubMed ID: 23509069
PubMed ID: 29069646
Title: The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly.
PubMed ID: 29069646
DOI: 10.1159/000484298
PubMed ID: 31630787
Title: De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry.
PubMed ID: 31630787
PubMed ID: 12005431
Title: The structural basis of localization and signaling by the focal adhesion targeting domain.
PubMed ID: 12005431
PubMed ID: 12467573
Title: Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography.
PubMed ID: 12467573
PubMed ID: 14527389
Title: Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain.
PubMed ID: 14527389
PubMed ID: 18339875
Title: Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.
PubMed ID: 18339875
PubMed ID: 18078954
Title: Structural basis for the interaction between focal adhesion kinase and CD4.
PubMed ID: 18078954
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 1052
- Mass: 119233
- Checksum: D8A4C15138AB0243
- Sequence:
MAAAYLDPNL NHTPNSSTKT HLGTGMERSP GAMERVLKVF HYFESNSEPT TWASIIRHGD ATDVRGIIQK IVDSHKVKHV ACYGFRLSHL RSEEVHWLHV DMGVSSVREK YELAHPPEEW KYELRIRYLP KGFLNQFTED KPTLNFFYQQ VKSDYMLEIA DQVDQEIALK LGCLEIRRSY WEMRGNALEK KSNYEVLEKD VGLKRFFPKS LLDSVKAKTL RKLIQQTFRQ FANLNREESI LKFFEILSPV YRFDKECFKC ALGSSWIISV ELAIGPEEGI SYLTDKGCNP THLADFTQVQ TIQYSNSEDK DRKGMLQLKI AGAPEPLTVT APSLTIAENM ADLIDGYCRL VNGTSQSFII RPQKEGERAL PSIPKLANSE KQGMRTHAVS VSETDDYAEI IDEEDTYTMP STRDYEIQRE RIELGRCIGE GQFGDVHQGI YMSPENPALA VAIKTCKNCT SDSVREKFLQ EALTMRQFDH PHIVKLIGVI TENPVWIIME LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK RFVHRDIAAR NVLVSSNDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT LYSLMTKCWA YDPSRRPRFT ELKAQLSTIL EEEKAQQEER MRMESRRQAT VSWDSGGSDE APPKPSRPGY PSPRSSEGFY PSPQHMVQTN HYQVSGYPGS HGITAMAGSI YPGQASLLDQ TDSWNHRPQE IAMWQPNVED STVLDLRGIG QVLPTHLMEE RLIRQQQEME EDQRWLEKEE RFLKPDVRLS RGSIDREDGS LQGPIGNQHI YQPVGKPDPA APPKKPPRPG APGHLGSLAS LSSPADSYNE GVKLQPQEIS PPPTANLDRS NDKVYENVTG LVKAVIEMSS KIQPAPPEEY VPMVKEVGLA LRTLLATVDE TIPLLPASTH REIEMAQKLL NSDLGELINK MKLAQQYVMT SLQQEYKKQM LTAAHALAVD AKNLLDVIDQ ARLKMLGQTR PH
Genular Protein ID: 2972634751
Symbol: Q658W2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1074
- Mass: 121721
- Checksum: 49E165262172ADE7
- Sequence:
MISADCNLCL PEYDRYLASS KIMAAAYLDP NLNHTPNSST KTHLGTGMER SPGAMERVLK VFHYFESNSE PTTWASIIRH GDATDVRGII QKIVDSHKVK HVACYGFRLS HLRSEEVHWL HVDMGVSSVR EKYELAHPPE EWKYELRIRY LPKGFLNQFT EDKPTLNFFY QQVKSDYMLE IADQVDQEIA LKLGCLEIRR SYWEMRGNAL EKKSNYEVLE KDVGLKRFFP KSLLDSVKAK TLRKLIQQTF RQFANLNREE SILKFFEILS PVYRFDKECF KCALGSSWII SVELAIGPEE GISYLTDKGC NPTHLADFTQ VQTIQYSNSE DKDRKGMLQL KIAGAPEPLT VTAPSLTIAE NMADLIDGYC RLVNGTSQSF IIRPQKEGER ALPSIPKLAN SEKQGMRTHA VSVSETDDYA EIIDEEDTYT MPSTRDYEIQ RERIELGRCI GEGQFGDVHQ GIYMSPENPA LAVAIKTCKN CTSDSVREKF LQEALTMRQF DHPHIVKLIG VITENPVWII MELCTLGELR SFLQVRKYSL DLASLILYAY QLSTALAYLE SKRFVHRDIA ARNVLVSSND CVKLGDFGLS RYMEDSTYYK ASKGKLPIKW MAPESINFRR FTSASDVWMF GVCMWEILMH GVKPFQGVKN NDVIGRIENG ERLPMPPNCP PTLYSLMTKC WAYDPSRRPR FTELKAQLST ILEEEKAQQE ERMRMESRRQ ATVSWDSGGS DEAPPKPSRP GYPSPRSSEG FYPSPQHMVQ TNHYQVSGYP GSHGITAMAG SIYPGQASLL DQTDSWNHRP QEIAMWQPNV EDSTVLDLRG IGQVLPTHLM EERLIRQQQE MEEDQRWLEK EERFLKPDVR LSRGSIDRED GSLQGPIGNQ HIYQPVGKPD PAAPPKKPPR PGAPGHLGSL ASLSSPADSY NEGVKLQPQE ISPPPTANLD RSNDKVYENV TGLVKAVIEM SSKIQPAPPE EYVPMVKEVG LALRTLLATV DETIPLLPAS THREIEMAQK LLNSDLGELI NKMKLAQQYV MTSLQQEYKK QMLTAAHALA VDAKNLLDVI DQARLKMLGQ TRPH
Genular Protein ID: 3808189954
Symbol: Q59GN8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 975
- Mass: 110234
- Checksum: 7C93F34BA129B5E7
- Sequence:
RSFIILKAIV SQPPGPVLSG MEMLLMSGYE LRIRYLPKGF LNQFTEDKPT LNFFYQQVKS DYMLEIADQV DQEIALKLGC LEIRRSYWEM RGNALEKKSN YEVLEKDVGL KRFFPKSLLD SVKAKTLRKL IQQTFRQFAN LNREESILKF FEILSPVYRF DKECFKCALG SSWIISVELA IGPEEGISYL TDKGCNPTHL ADFTQVQTIQ YSNSEDKDRK GMLQLKIAGA PEPLTVTAPS LTIAENMADL IDGYCRLVNG TSQSFIIRPQ KEGERALPSI PKLANSEKQG MRTHAVSVSD EISGDETDDY AEIIDEEDTY TMPSKSYGID EARDYEIQRE RIELGRCIGE GQFGDVHQGI YMSPENPALA VAIKTCKNCT SDSVREKFLQ EALTMRQFDH PHIVKLIGVI TENPVWIIME LCTLGELRSF LQVRKYSLDL ASLILYAYQL STALAYLESK RFVHRDIAAR NVLVSSNDCV KLGDFGLSRY MEDSTYYKAS KGKLPIKWMA PESINFRRFT SASDVWMFGV CMWEILMHGV KPFQGVKNND VIGRIENGER LPMPPNCPPT LYSLMTKCWA YDPSRRPRFT ELKAQLSTIL EEEKAQQEER MRMESRRQAT VSWDSGGSDE APPKPSRPGY PSPRSSEGFY PSPQHMVQTN HYQVSGYPGS HGITAMAGSI YPGQASLLDQ TDSWNHRPQE IAMWQPNVED STVLDLRGIG QVLPTHLMEE RLIRQQQEME EDQRWLEKEE RFLKPDVRLS RGSIDREDGS LQGPIGNQHI YQPVGKPDPA APPKKPPRPG APGHLGSLAS LSSPADSYNE GVKPWRLQPQ EISPPPTANL DRSNDKVYEN VTGLVKAVIE MSSKIQPAPP EEYVPMVKEV GLALRTLLAT VDETIPLLPA STHREIEMAQ KLLNSDLGEL INKMKLAQQY VMTSLQQEYK KQMLTAAHAL AVDAKNLLDV IDQARLKMLG QTRPH
Genular Protein ID: 516626567
Symbol: Q59GM6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1007
- Mass: 114157
- Checksum: 40109858F52472C9
- Sequence:
RKGEYDRYLA SSKIMAAAYL DPNLNHTPEE WKYELRIRYL PKGFLNQFTE DKPTLNFFYQ QVKSDYMLEI ADQVDQEIAL KLGCLEIRRS YWEMRGNALE KKSNYEVLEK DVGLKRFFPK SLLDSVKAKT LRKLIQQTFR QFANLNREES ILKFFEILSP VYRFDKECFK CALGSSWIIS VELAIGPEEG ISYLTDKGCN PTHLADFTQV QTIQYSNSED KDRKGMLQLK IAGAPEPLTV TAPSLTIAEN MADLIDGYCR LVNGTSQSFI IRPQKEGERA LPSIPKLANS EKQGMRTHAV SVSGVSHCQH KVKKARRFLP LVFCSHDPPS ADEISGDETD DYAEIIDEED TYTMPSKSYG IDEARDYEIQ RERIELGRCI GEGQFGDVHQ GIYMSPENPA LAVAIKTCKN CTSDSVREKF LQEALTMRQF DHPHIVKLIG VITENPVWII MELCTLGELR SFLQVRKYSL DLASLILYAY QLSTALAYLE SKRFVHRDIA ARNVLVSSND CVKLGDFGLS RYMEDSTYYK ASKGKLPIKW MAPESINFRR FTSASDVWMF GVCMWEILMH GVKPFQGVKN NDVIGRIENG ERLPMPPNCP PTLYSLMTKC WAYDPSRRPR FTELKAQLST ILEEEKAQQE ERMRMESRRQ ATVSWDSGGS DEAPPKPSRP GYPSPRSSEG FYPSPQHMVQ TNHYQVSGYP GSHGITAMAG SIYPGQASLL DQTDSWNHRP QEIAMWQPNV EDSTVLDLRG IGQVLPTHLM EERLIRQQQE MEEDQRWLEK EERFLKPDVR LSRGSIDRED GSLQGPIGNQ HIYQPVGKPD PAAPPKKPPR PGAPGHLGSL ASLSSPADSY NEGVKPWRLQ PQEISPPPTA NLDRSNDKVY ENVTGLVKAV IEMSSKIQPA PPEEYVPMVK EVGLALRTLL ATVDETIPLL PASTHREIEM AQKLLNSDLG ELINKMKLAQ QYVMTSLQQE YKKQMLTAAH ALAVDAKNLL DVIDQARLKM LGQTRPH