Details for: RYR3

Gene ID: 6263

Symbol: RYR3

Ensembl ID: ENSG00000198838

Description: ryanodine receptor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 7.4
    Marker Score: 38798
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 6.98
    Marker Score: 37516
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 5.64
    Marker Score: 3713
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 5.6
    Marker Score: 12876
  • Cell Name: granule cell (CL0000120)
    Fold Change: 5.55
    Marker Score: 41823
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.73
    Marker Score: 15853
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.25
    Marker Score: 69322.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.21
    Marker Score: 1438
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.87
    Marker Score: 4819
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.79
    Marker Score: 1566
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.79
    Marker Score: 3843.5
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.77
    Marker Score: 1329
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.67
    Marker Score: 2315
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.38
    Marker Score: 756
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.33
    Marker Score: 1364
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.2
    Marker Score: 9162
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.03
    Marker Score: 781
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2
    Marker Score: 631
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.95
    Marker Score: 4883
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18305
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.91
    Marker Score: 19762
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16136
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.83
    Marker Score: 1954
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.83
    Marker Score: 69468.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.73
    Marker Score: 13283
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.69
    Marker Score: 10161
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.66
    Marker Score: 2006
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.64
    Marker Score: 1250
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.57
    Marker Score: 2865
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2335
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.42
    Marker Score: 824
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.41
    Marker Score: 2862
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.26
    Marker Score: 2966
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.21
    Marker Score: 447
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.18
    Marker Score: 4806
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.18
    Marker Score: 23415
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.15
    Marker Score: 70861.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.13
    Marker Score: 353
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.11
    Marker Score: 666
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16321
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.97
    Marker Score: 2775
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.94
    Marker Score: 431.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.9
    Marker Score: 863
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 649
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.85
    Marker Score: 3929
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.8
    Marker Score: 2753
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8
    Marker Score: 3345
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.79
    Marker Score: 526.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.77
    Marker Score: 7243
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.75
    Marker Score: 3137
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.73
    Marker Score: 187
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.73
    Marker Score: 348
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.72
    Marker Score: 972
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.72
    Marker Score: 187
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.72
    Marker Score: 328
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.64
    Marker Score: 4265
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.63
    Marker Score: 697
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.62
    Marker Score: 195
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.6
    Marker Score: 217.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.58
    Marker Score: 434.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.58
    Marker Score: 1263
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.56
    Marker Score: 600
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.56
    Marker Score: 202
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.5
    Marker Score: 625
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.5
    Marker Score: 460
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.5
    Marker Score: 220
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.49
    Marker Score: 277
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.48
    Marker Score: 16370.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.48
    Marker Score: 196
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.46
    Marker Score: 1921
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.46
    Marker Score: 16840
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.44
    Marker Score: 575
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.44
    Marker Score: 291
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.44
    Marker Score: 280.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.44
    Marker Score: 3832
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.44
    Marker Score: 124
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.43
    Marker Score: 6499

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** RYR3 exhibits several key characteristics that distinguish it from other ryanodine receptors: 1. **High calcium affinity**: RYR3 has a high affinity for calcium ions, allowing it to regulate calcium release from the SR with precision. 2. **Calcium channel activity**: RYR3 functions as a calcium channel, enabling the controlled release of calcium ions into the cytosol. 3. **Sarcoplasmic reticulum membrane localization**: RYR3 is primarily localized to the SR membrane, where it regulates calcium release in response to various stimuli. 4. **Homotetramerization**: RYR3 can form homotetramers, a four-subunit structure that enhances its calcium channel activity. **Pathways and Functions:** RYR3 is involved in various cellular pathways, including: 1. **Calcium-induced calcium release activity**: RYR3 regulates calcium release from the SR in response to increased intracellular calcium concentrations. 2. **Calcium-mediated signaling**: RYR3 plays a crucial role in calcium-mediated signaling pathways, including those involved in muscle contraction, neuronal signaling, and cellular response to stimuli. 3. **Intracellular calcium ion homeostasis**: RYR3 helps maintain calcium homeostasis within cells by regulating calcium release and uptake. 4. **Muscle contraction**: RYR3 is essential for muscle contraction, as it regulates calcium release from the SR in striated muscle cells. 5. **Neuronal signaling**: RYR3 is involved in neuronal signaling, including synaptic transmission and neuronal plasticity. **Clinical Significance:** Dysregulation of RYR3 has been implicated in various diseases and disorders, including: 1. **Malignant hyperthermia**: RYR3 mutations can cause malignant hyperthermia, a life-threatening condition characterized by muscle rigidity and hyperthermia. 2. **Myasthenia gravis**: RYR3 has been linked to myasthenia gravis, an autoimmune disorder characterized by muscle weakness and fatigue. 3. **Neurodegenerative diseases**: RYR3 has been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Cardiac arrhythmias**: RYR3 has been linked to cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. In conclusion, RYR3 is a critical protein that regulates calcium signaling and homeostasis within cells. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of RYR3 in maintaining cellular health and function.

Genular Protein ID: 1170661471

Symbol: RYR3_HUMAN

Name: Brain ryanodine receptor-calcium release channel

UniProtKB Accession Codes:

Q15413 O15175 Q15412

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 22 Gene3D 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 22 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 9 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9395096

Title: Molecular cloning and characterization of a human brain ryanodine receptor.

PubMed ID: 9395096

DOI: 10.1016/s0014-5793(97)01275-1

PubMed ID: 9515741

Title: cDNA cloning and sequencing of the human ryanodine receptor type 3 (RYR3) reveals a novel alternative splice site in the RYR3 gene.

PubMed ID: 9515741

DOI: 10.1016/s0014-5793(98)00124-0

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 9607712

Title: Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

PubMed ID: 9607712

DOI: 10.1016/s0306-4522(97)00612-x

PubMed ID: 7523185

Title: Involvement of the brain type of ryanodine receptor in T-cell proliferation.

PubMed ID: 7523185

DOI: 10.1016/0014-5793(94)00955-4

PubMed ID: 8276408

Title: Localization of a novel ryanodine receptor gene (RYR3) to human chromosome 15q14-q15 by in situ hybridization.

PubMed ID: 8276408

DOI: 10.1006/geno.1993.1446

PubMed ID: 7556644

Title: Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.

PubMed ID: 7556644

DOI: 10.1016/0014-5793(95)00924-x

PubMed ID: 12354756

Title: Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex.

PubMed ID: 12354756

DOI: 10.1074/jbc.m209061200

PubMed ID: 22100703

Title: Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.

PubMed ID: 22100703

DOI: 10.1016/j.abb.2011.11.004

PubMed ID: 22705209

Title: Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain.

PubMed ID: 22705209

DOI: 10.1016/j.str.2012.04.015

PubMed ID: 29498452

Title: Ryanodine receptor type 3 (RYR3) as a novel gene associated with a myopathy with nemaline bodies.

PubMed ID: 29498452

DOI: 10.1111/ene.13607

PubMed ID: 31230720

Title: The Genomics of Arthrogryposis, a Complex Trait: Candidate Genes and Further Evidence for Oligogenic Inheritance.

PubMed ID: 31230720

DOI: 10.1016/j.ajhg.2019.05.015

Sequence Information:

  • Length: 4870
  • Mass: 552042
  • Checksum: B953487A89FD480F
  • Sequence:
    • MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP 
PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAVL LRHSFSGMYL 
TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER 
YLHLSVSNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD 
QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED 
QGLILQDRAK SDTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS 
GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ 
FVSGNNRTAA PITLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG 
MLALVLNCID RLNVYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN 
NLDWLISKLD RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI 
LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW 
YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW 
SGRIPRAVAS INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS 
FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGIRDLLGT 
TQFLSQASFI PCPVDTSQVI LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR 
QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS 
NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV 
PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD SAVEKVSIDK IRFFRVERSY 
AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DVELGADDQA FVFEGNRGQR WHQGSGYFGR 
TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR 
MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVMRID 
GTMDSPPCLK VTHKTFGTQN SNADMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI 
LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE 
SVKRSNCYMV WGGDIVASSQ RSNRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN 
TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFRSEEK NPVPQCPPRL DVQTIQPVLW 
SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMRFHYH 
TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLASAKE 
RKLMMKNEYI IPITSTTRNI RLFPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTGEDHQ 
KQSPEIPLES LRTKALSMLT EAVQCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD 
DDVRQILLLI DPSVFGEHSA GTEEGAEKEE VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP 
ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ ALNMSAALTA 
RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH EDLLLHCGVP LEEEEEEEED 
TSWTGKLCAL VYKIKGPPKP EKEQPTEEEE RCPTTLKELI SQTMICWAQE DQIQDSELVR 
MMFNLLRRQY DSIGELLQAL RKTYTISHTS VSDTINLLAA LGQIRSLLSV RMGKEEELLM 
INGLGDIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF 
CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL ALSLEEPDLE 
KVVTYLAGCG LQSCPMLLAK GYPDVGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL 
LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKREVSTG DDEEEEEIVH 
MGNAIMSFYS ALIDLLGRCA PEMHLIQTGK GEAIRIRSIL RSLVPTEDLV GIISIPLKLP 
SLNKDGSVSE PDMAANFCPD HKAPMVLFLD RVYGIKDQTF LLHLLEVGFL PDLRASASLD 
TVSLSTTEAA LALNRYICSA VLPLLTRCAP LFAGTEHCTS LIDSTLQTIY RLSKGRSLTK 
AQRDTIEECL LAICNHLRPS MLQQLLRRLV FDVPQLNEYC KMPLKLLTNH YEQCWKYYCL 
PSGWGSYGLA VEEELHLTEK LFWGIFDSLS HKKYDPDLFR MALPCLSAIA GALPPDYLDT 
RITATLEKQI SVDADGNFDP KPINTMNFSL PEKLEYIVTK YAEHSHDKWA CDKSQSGWKY 
GISLDENVKT HPLIRPFKTL TEKEKEIYRW PARESLKTML AVGWTVERTK EGEALVQQRE 
NEKLRSVSQA NQGNSYSPAP LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK KKLELESKGG 
GSHPLLVPYD TLTAKEKFKD REKAQDLFKF LQVNGIIVSR GMKDMELDAS SMEKRFAYKF 
LKKILKYVDS AQEFIAHLEA IVSSGKTEKS PRDQEIKFFA KVLLPLVDQY FTSHCLYFLS 
SPLKPLSSSG YASHKEKEMV AGLFCKLAAL VRHRISLFGS DSTTMVSCLH ILAQTLDTRT 
VMKSGSELVK AGLRAFFENA AEDLEKTSEN LKLGKFTHSR TQIKGVSQNI NYTTVALLPI 
LTSIFEHVTQ HQFGMDLLLG DVQISCYHIL CSLYSLGTGK NIYVERQRPA LGECLASLAA 
AIPVAFLEPT LNRYNPLSVF NTKTPRERSI LGMPDTVEDM CPDIPQLEGL MKEINDLAES 
GARYTEMPHV IEVILPMLCN YLSYWWERGP ENLPPSTGPC CTKVTSEHLS LILGNILKII 
NNNLGIDEAS WMKRIAVYAQ PIISKARPDL LRSHFIPTLE KLKKKAVKTV QEEEQLKADG 
KGDTQEAELL ILDEFAVLCR DLYAFYPMLI RYVDNNRSNW LKSPDADSDQ LFRMVAEVFI 
LWCKSHNFKR EEQNFVIQNE INNLAFLTGD SKSKMSKAMQ VKSGGQDQER KKTKRRGDLY 
SIQTSLIVAA LKKMLPIGLN MCTPGDQELI SLAKSRYSHR DTDEEVREHL RNNLHLQEKS 
DDPAVKWQLN LYKDVLKSEE PFNPEKTVER VQRISAAVFH LEQVEQPLRS KKAVWHKLLS 
KQRKRAVVAC FRMAPLYNLP RHRSINLFLH GYQRFWIETE EYSFEEKLVQ DLAKSPKVEE 
EEEEETEKQP DPLHQIILYF SRNALTERSK LEDDPLYTSY SSMMAKSCQS GEDEEEDEDK 
EKTFEEKEME KQKTLYQQAR LHERGAAEMV LQMISASKGE MSPMVVETLK LGIAILNGGN 
AGVQQKMLDY LKEKKDAGFF QSLSGLMQSC SVLDLNAFER QNKAEGLGMV TEEGTLIVRE 
RGEKVLQNDE FTRDLFRFLQ LLCEGHNSDF QNFLRTQMGN TTTVNVIIST VDYLLRLQES 
ISDFYWYYSG KDIIDESGQH NFSKALAVTK QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV 
VGFLHVFANM QMKLSQDSSQ IELLKELLDL LQDMVVMLLS LLEGNVVNGT IGKQMVDTLV 
ESSTNVEMIL KFFDMFLKLK DLTSSDTFKE YDPDGKGIIS KKEFQKAMEG QKQYTQSEID 
FLLSCAEADE NDMFNYVDFV DRFHEPAKDI GFNVAVLLTN LSEHMPNDSR LKCLLDPAES 
VLNYFEPYLG RIEIMGGAKK IERVYFEISE SSRTQWEKPQ VKESKRQFIF DVVNEGGEQE 
KMELFVNFCE DTIFEMQLAS QISESDSADR PEEEEEDEDS SYVLEIAGEE EEDGSLEPAS 
AFAMACASVK RNVTDFLKRA TLKNLRKQYR NVKKMTAKEL VKVLFSFFWM LFVGLFQLLF 
TILGGIFQIL WSTVFGGGLV EGAKNIRVTK ILGDMPDPTQ FGIHDDTMEA ERAEVMEPGI 
TTELVHFIKG EKGDTDIMSD LFGLHPKKEG SLKHGPEVGL GDLSEIIGKD EPPTLESTVQ 
KKRKAQAAEM KAANEAEGKV ESEKADMEDG EKEDKDKEEE QAEYLWTEVT KKKKRRCGQK 
VEKPEAFTAN FFKGLEIYQT KLLHYLARNF YNLRFLALFV AFAINFILLF YKVTEEPLEE 
ETEDVANLWN SFNDEEEEEA MVFFVLQEST GYMAPTLRAL AIIHTIISLV CVVGYYCLKV 
PLVVFKREKE IARKLEFDGL YITEQPSEDD IKGQWDRLVI NTPSFPNNYW DKFVKRKVIN 
KYGDLYGAER IAELLGLDKN ALDFSPVEET KAEAASLVSW LSSIDMKYHI WKLGVVFTDN 
SFLYLAWYTT MSVLGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV 
VYLYTVVAFN FFRKFYNKSE DDDEPDMKCD DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD 
PYEMYRIVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVREDMETK CFICGIGNDY 
FDTTPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWDFFPAGDC 
FRKQYEDQLG

Genular Protein ID: 3842231908

Symbol: A0A0U1RRH1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0U1RRH1

Database IDs:

ARBA 17 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 7 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 21 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PeptideAtlas 2 Pfam 9 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 SAM 2 SMART 2 SMR 1 SUPFAM 4 VEuPathDB 1

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 4859
  • Mass: 550825
  • Checksum: B32C375E0117149B
  • Sequence:
    • MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP 
PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAVL LRHSFSGMYL 
TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER 
YLHLSVSNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD 
QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED 
QGLILQDRAK SDTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS 
GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ 
FVSGNNRTAA PITLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG 
MLALVLNCID RLNVYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN 
NLDWLISKLD RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI 
LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW 
YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW 
SGRIPRAVAS INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS 
FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGIRDLLGT 
TQFLSQASFI PCPVDTSQVI LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR 
QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS 
NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV 
PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD SAVEKVSIDK IRFFRVERSY 
AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DVELGADDQA FVFEGNRGQR WHQGSGYFGR 
TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR 
MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVMRID 
GTMDSPPCLK VTHKTFGTQN SNADMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI 
LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE 
SVKRSNCYMV WGGDIVASSQ RSNRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN 
TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFRSEEK NPVPQCPPRL DVQTIQPVLW 
SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMRFHYH 
TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLASAKE 
RKLMMKNEYI IPITSTTRNI RLFPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTGEDHQ 
KQSPEIPLES LRTKALSMLT EAVQCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD 
DDVRQILLLI DPSVFGEHSA GTEEGAEKEE VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP 
ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ ALNMSAALTA 
RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH EDLLLHCGVP LEEEEEEEED 
TSWTGKLCAL VYKIKGPPKP EKEQPTEEEE RCPTTLKELI SQTMICWAQE DQIQDSELVR 
MMFNLLRRQY DSIGELLQAL RKTYTISHTS VSDTINLLAA LGQIRSLLSV RMGKEEELLM 
INGLGDIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF 
CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL ALSLEEPDLE 
KVVTYLAGCG LQSCPMLLAK GYPDVGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL 
LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKREVTGD DEEEEEIVHM 
GNAIMSFYSA LIDLLGRCAP EMHLIQTGKG EAIRIRSILR SLVPTEDLVG IISIPLKLPS 
LNKDGSVSEP DMAANFCPDH KAPMVLFLDR VYGIKDQTFL LHLLEVGFLP DLRASASLDT 
VSLSTTEAAL ALNRYICSAV LPLLTRCAPL FAGTEHCTSL IDSTLQTIYR LSKGRSLTKA 
QRDTIEECLL AICNHLRPSM LQQLLRRLVF DVPQLNEYCK MPLKLLTNHY EQCWKYYCLP 
SGWGSYGLAV EEELHLTEKL FWGIFDSLSH KKYDPDLFRM ALPCLSAIAG ALPPDYLDTR 
ITATLEKQIS VDADGNFDPK PINTMNFSLP EKLEYIVTKY AEHSHDKWAC DKSQSGWKYG 
ISLDENVKTH PLIRPFKTLT EKEKEIYRWP ARESLKTMLA VGWTVERTKE GEALVQQREN 
EKLRSVSQAN QGNSYSPAPL DLSNVVLSRE LQGMVEVVAE NYHNIWAKKK KLELESKGGG 
SHPLLVPYDT LTAKEKFKDR EKAQDLFKFL QVNGIIVSRG MKDMELDASS MEKRFAYKFL 
KKILKYVDSA QEFIAHLEAI VSSGKTEKSP RDQEIKFFAK VLLPLVDQYF TSHCLYFLSS 
PLKPLSSSGY ASHKEKEMVA GLFCKLAALV RHRISLFGSD STTMVSCLHI LAQTLDTRTV 
MKSGSELVKA GLRAFFENAA EDLEKTSENL KLGKFTHSRT QIKGVSQNIN YTTVALLPIL 
TSIFEHVTQH QFGMDLLLGD VQISCYHILC SLYSLGTGKN IYVERQRPAL GECLASLAAA 
IPVAFLEPTL NRYNPLSVFN TKTPRERSIL GMPDTVEDMC PDIPQLEGLM KEINDLAESG 
ARYTEMPHVI EVILPMLCNY LSYWWERGPE NLPPSTGPCC TKVTSEHLSL ILGNILKIIN 
NNLGIDEASW MKRIAVYAQP IISKARPDLL RSHFIPTLEK LKKKAVKTVQ EEEQLKADGK 
GDTQEAELLI LDEFAVLCRD LYAFYPMLIR YVDNNRSNWL KSPDADSDQL FRMVAEVFIL 
WCKSHNFKRE EQNFVIQNEI NNLAFLTGDS KSKMSKSGGQ DQERKKTKRR GDLYSIQTSL 
IVAALKKMLP IGLNMCTPGD QELISLAKSR YSHRDTDEEV REHLRNNLHL QEKSDDPAVK 
WQLNLYKDVL KSEEPFNPEK TVERVQRISA AVFHLEQVEQ PLRSKKAVWH KLLSKQRKRA 
VVACFRMAPL YNLPRHKINN FFLSTFQQVW LEKVNEKTQY DRLIPILMKS PKVEEEEEEE 
TEKQPDPLHQ IILYFSRNAL TERSKLEDDP LYTSYSSMMA KSCQSGEDEE EDEDKEKTFE 
EKEMEKQKTL YQQARLHERG AAEMVLQMIS ASKGEMSPMV VETLKLGIAI LNGGNAGVQQ 
KMLDYLKEKK DAGFFQSLSG LMQSCSVLDL NAFERQNKAE GLGMVTEEGT REKVLQNDEF 
TRDLFRFLQL LCEGHNSDFQ NFLRTQMGNT TTVNVIISTV DYLLRLQESI SDFYWYYSGK 
DIIDESGQHN FSKALAVTKQ IFNSLTEYIQ GPCIGNQQSL AHSRLWDAVV GFLHVFANMQ 
MKLSQDSSQI ELLKELLDLL QDMVVMLLSL LEGNVVNGTI GKQMVDTLVE SSTNVEMILK 
FFDMFLKLKD LTSSDTFKEY DPDGKGIISK KEFQKAMEGQ KQYTQSEIDF LLSCAEADEN 
DMFNYVDFVD RFHEPAKDIG FNVAVLLTNL SEHMPNDSRL KCLLDPAESV LNYFEPYLGR 
IEIMGGAKKI ERVYFEISES SRTQWEKPQV KESKRQFIFD VVNEGGEQEK MELFVNFCED 
TIFEMQLASQ ISESDSADRP EEEEEDEDSS YVLEIAGEEE EDGSLEPASA FAMACASVKR 
NVTDFLKRAT LKNLRKQYRN VKKMTAKELV KVLFSFFWML FVGLFQLLFT ILGGIFQILW 
STVFGGGLVE GAKNIRVTKI LGDMPDPTQF GIHDDTMEAE RAEVMEPGIT TELVHFIKGE 
KGDTDIMSDL FGLHPKKEGS LKHGPEVGLG DLSEIIGKDE PPTLESTVQK KRKAQAAEMK 
AANEAEGKVE SEKADMEDGE KEDKDKEEEQ AEYLWTEVTK KKKRRCGQKV EKPEAFTANF 
FKGLEIYQTK LLHYLARNFY NLRFLALFVA FAINFILLFY KVTEEPLEEE TEDVANLWNS 
FNDEEEEEAM VFFVLQESTG YMAPTLRALA IIHTIISLVC VVGYYCLKVP LVVFKREKEI 
ARKLEFDGLY ITEQPSEDDI KGQWDRLVIN TPSFPNNYWD KFVKRKVINK YGDLYGAERI 
AELLGLDKNA LDFSPVEETK AEAASLVSWL SSIDMKYHIW KLGVVFTDNS FLYLAWYTTM 
SVLGHYNNFF FAAHLLDIAM GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF 
FRKFYNKSED DDEPDMKCDD MMTCYLFHMY VGVRAGGGIG DEIEDPAGDP YEMYRIVFDI 
TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVREDMETKC FICGIGNDYF DTTPHGFETH 
TLQEHNLANY LFFLMYLINK DETEHTGQES YVWKMYQERC WDFFPAGDCF RKQYEDQLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.