Details for: SNX1

Gene ID: 6642

Symbol: SNX1

Ensembl ID: ENSG00000028528

Description: sorting nexin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.35
    Marker Score: 10898
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.08
    Marker Score: 8708.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.85
    Marker Score: 4428
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.77
    Marker Score: 39664
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.73
    Marker Score: 521
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.67
    Marker Score: 5920
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.55
    Marker Score: 909
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.51
    Marker Score: 92888
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.51
    Marker Score: 57197
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.5
    Marker Score: 12859
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.48
    Marker Score: 13921.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.47
    Marker Score: 13946.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.46
    Marker Score: 3980.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.46
    Marker Score: 2250
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.44
    Marker Score: 503.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.44
    Marker Score: 1740
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.42
    Marker Score: 1761
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.42
    Marker Score: 14652
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.4
    Marker Score: 51753
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.38
    Marker Score: 5332
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.37
    Marker Score: 1575.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.37
    Marker Score: 20462
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.37
    Marker Score: 29180
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.36
    Marker Score: 660
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.36
    Marker Score: 430
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.35
    Marker Score: 15653.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.34
    Marker Score: 13501
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.33
    Marker Score: 1402
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.33
    Marker Score: 5409
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.32
    Marker Score: 21190
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.31
    Marker Score: 1928
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.3
    Marker Score: 9994.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.29
    Marker Score: 4763.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.27
    Marker Score: 25361
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.27
    Marker Score: 372
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.27
    Marker Score: 3451
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.27
    Marker Score: 1347.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.27
    Marker Score: 8154
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.26
    Marker Score: 1363
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.25
    Marker Score: 2407.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.25
    Marker Score: 318
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.25
    Marker Score: 619
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.24
    Marker Score: 683.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.24
    Marker Score: 1602
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.24
    Marker Score: 1336
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.24
    Marker Score: 2027.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.23
    Marker Score: 5107
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.23
    Marker Score: 68852
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.22
    Marker Score: 673
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.22
    Marker Score: 729
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.22
    Marker Score: 1229
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.22
    Marker Score: 681
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.21
    Marker Score: 5218
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.19
    Marker Score: 868
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.19
    Marker Score: 1093.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.19
    Marker Score: 21085.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.18
    Marker Score: 3514.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.18
    Marker Score: 1484.5
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.18
    Marker Score: 1158
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.18
    Marker Score: 2594
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.18
    Marker Score: 2780
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.18
    Marker Score: 4637
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.18
    Marker Score: 8777
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.16
    Marker Score: 430
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.16
    Marker Score: 6236
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.16
    Marker Score: 18123.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.16
    Marker Score: 1104
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.15
    Marker Score: 2240
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.15
    Marker Score: 1528
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.15
    Marker Score: 465
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.14
    Marker Score: 1919
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.13
    Marker Score: 708
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.13
    Marker Score: 2817.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.13
    Marker Score: 278
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.12
    Marker Score: 267
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.11
    Marker Score: 1338.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.11
    Marker Score: 964
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.11
    Marker Score: 738
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.11
    Marker Score: 357
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.1
    Marker Score: 1294
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.1
    Marker Score: 1177
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.1
    Marker Score: 411
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.1
    Marker Score: 1747
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.1
    Marker Score: 1764
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.09
    Marker Score: 1209
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.09
    Marker Score: 1098.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.09
    Marker Score: 576
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.08
    Marker Score: 4667
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.08
    Marker Score: 1298
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.08
    Marker Score: 373
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.07
    Marker Score: 714
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.06
    Marker Score: 590.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.06
    Marker Score: 335
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.06
    Marker Score: 1931
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.06
    Marker Score: 1099
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.06
    Marker Score: 515
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.05
    Marker Score: 613
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.05
    Marker Score: 358
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.05
    Marker Score: 717
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.04
    Marker Score: 294

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Other Information

**Key Characteristics:** SNX1 is a small, evolutionarily conserved protein that belongs to the sorting nexin family. It contains a PH (phosphoinositide-binding) domain, which enables it to interact with phosphatidylinositol molecules and regulate membrane trafficking. SNX1 is primarily localized to the early endosome and Golgi apparatus, where it regulates the transport of proteins and lipids between these organelles. Its ability to bind to specific proteins and lipids, such as the epidermal growth factor receptor (EGFR) and transferrin receptor, allows it to modulate signaling pathways and regulate cellular processes. **Pathways and Functions:** SNX1 is involved in several cellular processes, including: 1. **Endocytosis and Exocytosis:** SNX1 regulates the transport of proteins and lipids between the early endosome and Golgi apparatus, which is essential for endocytosis and exocytosis. 2. **Retrograde Transport:** SNX1 is involved in retrograde transport of proteins and lipids from the Golgi apparatus to the early endosome, which is essential for protein degradation and recycling. 3. **Protein Degradation:** SNX1 regulates the transport of proteins to the lysosome for degradation, which is essential for maintaining protein homeostasis. 4. **Signaling Pathways:** SNX1 modulates signaling pathways, including the EGFR and leptin receptor pathways, which are involved in cell growth, differentiation, and survival. **Clinical Significance:** Dysregulation of SNX1 has been implicated in various diseases, including: 1. **Cancer:** SNX1 is involved in the regulation of cell growth and survival, and its dysregulation has been implicated in cancer development and progression. 2. **Neurodegenerative Diseases:** SNX1 has been implicated in the regulation of protein degradation and transport, and its dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Cardiovascular Disease:** SNX1 has been implicated in the regulation of protein transport and signaling pathways, and its dysregulation has been implicated in cardiovascular disease. In conclusion, SNX1 is a multifunctional protein that plays a crucial role in regulating membrane trafficking and protein transport within cells. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and regulation. Further research is needed to fully elucidate the role of SNX1 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 687702922

Symbol: SNX1_HUMAN

Name: Sorting nexin-1

UniProtKB Accession Codes:

Q13596 A6NM19 A8K6T7 H0Y2M5 O60750 O60751 Q6ZRJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EMDB 1 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 2 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8638121

Title: Enhanced degradation of EGF receptors by a sorting nexin, SNX1.

PubMed ID: 8638121

DOI: 10.1126/science.272.5264.1008

PubMed ID: 9819414

Title: Identification of a family of sorting nexin molecules and characterization of their association with receptors.

PubMed ID: 9819414

DOI: 10.1128/mcb.18.12.7278

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11102511

Title: Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes.

PubMed ID: 11102511

DOI: 10.1091/mbc.11.12.4105

PubMed ID: 12198132

Title: The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation.

PubMed ID: 12198132

DOI: 10.1074/jbc.m206986200

PubMed ID: 11997453

Title: Endosomal localization and function of sorting nexin 1.

PubMed ID: 11997453

DOI: 10.1073/pnas.092142699

PubMed ID: 15498486

Title: Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.

PubMed ID: 15498486

DOI: 10.1016/j.cub.2004.09.077

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16407403

Title: An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins.

PubMed ID: 16407403

DOI: 10.1091/mbc.e05-09-0899

PubMed ID: 17550970

Title: The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network.

PubMed ID: 17550970

DOI: 10.1242/jcs.003111

PubMed ID: 17101778

Title: Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.

PubMed ID: 17101778

DOI: 10.1128/mcb.00156-06

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18088323

Title: SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors.

PubMed ID: 18088323

DOI: 10.1111/j.1600-0854.2007.00686.x

PubMed ID: 19935774

Title: The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport.

PubMed ID: 19935774

DOI: 10.1038/cr.2009.130

PubMed ID: 19619496

Title: The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network.

PubMed ID: 19619496

DOI: 10.1016/j.devcel.2009.04.016

PubMed ID: 19816406

Title: Amphipathic motifs in BAR domains are essential for membrane curvature sensing.

PubMed ID: 19816406

DOI: 10.1038/emboj.2009.261

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19874558

Title: Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes.

PubMed ID: 19874558

DOI: 10.1111/j.1600-0854.2009.00993.x

PubMed ID: 21040701

Title: Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking.

PubMed ID: 21040701

DOI: 10.1016/j.bbrc.2010.10.121

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20604901

Title: A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling.

PubMed ID: 20604901

DOI: 10.1111/j.1600-0854.2010.01100.x

PubMed ID: 20070609

Title: Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent.

PubMed ID: 20070609

DOI: 10.1111/j.1600-0854.2010.01035.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22431521

Title: The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.

PubMed ID: 22431521

DOI: 10.1128/mcb.06726-11

PubMed ID: 23152498

Title: Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.

PubMed ID: 23152498

DOI: 10.1074/jbc.m112.428458

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 15673616

Title: Determinants of the endosomal localization of sorting nexin 1.

PubMed ID: 15673616

DOI: 10.1091/mbc.e04-06-0504

PubMed ID: 23085988

Title: Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules.

PubMed ID: 23085988

DOI: 10.1038/emboj.2012.283

Sequence Information:

  • Length: 522
  • Mass: 59070
  • Checksum: 6AC8AA0A589513E3
  • Sequence:
    • MASGGGGCSA SERLPPPFPG LEPESEGAAG GSEPEAGDSD TEGEDIFTGA AVVSKHQSPK 
ITTSLLPINN GSKENGIHEE QDQEPQDLFA DATVELSLDS TQNNQKKVLA KTLISLPPQE 
ATNSSKPQPT YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ TSLPLFRSKQ 
FAVKRRFSDF LGLYEKLSEK HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA 
ALERYLQRIV NHPTMLQDPD VREFLEKEEL PRAVGTQTLS GAGLLKMFNK ATDAVSKMTI 
KMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTAQFAKS LAMLGSSEDN 
TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI RLLAIVRAAF DQRMKTWQRW 
QDAQATLQKK REAEARLLWA NKPDKLQQAK DEILEWESRV TQYERDFERI STVVRKEVIR 
FEKEKSKDFK NHVIKYLETL LYSQQQLAKY WEAFLPEAKA IS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.