Details for: PNMA2

Gene ID: 10687

Symbol: PNMA2

Ensembl ID: ENSG00000240694

Description: PNMA family member 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.89
    Marker Score: 37,623
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.77
    Marker Score: 6,833
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.73
    Marker Score: 65,707
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.68
    Marker Score: 62,024
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.67
    Marker Score: 15,730
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.66
    Marker Score: 102,390
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.66
    Marker Score: 17,117
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.66
    Marker Score: 24,756
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.62
    Marker Score: 12,412
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,167
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.6
    Marker Score: 15,230
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.57
    Marker Score: 6,524
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.56
    Marker Score: 13,398
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.46
    Marker Score: 2,972
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.46
    Marker Score: 854
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.44
    Marker Score: 5,854
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.41
    Marker Score: 2,179
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,809
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.13
    Marker Score: 420
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 500
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.05
    Marker Score: 237
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.02
    Marker Score: 960
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1
    Marker Score: 421
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,041
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.99
    Marker Score: 1,198
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.97
    Marker Score: 403
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,350
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.89
    Marker Score: 4,135
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,284
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.86
    Marker Score: 1,046
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.86
    Marker Score: 346
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.85
    Marker Score: 959
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.74
    Marker Score: 201
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.73
    Marker Score: 581
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.72
    Marker Score: 1,017
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.71
    Marker Score: 2,941
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.67
    Marker Score: 224
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.66
    Marker Score: 344
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 417
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 386
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.57
    Marker Score: 297
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 230
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.55
    Marker Score: 360
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.54
    Marker Score: 11,453
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.51
    Marker Score: 964
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.51
    Marker Score: 3,292
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.49
    Marker Score: 795
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.49
    Marker Score: 2,053
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.46
    Marker Score: 1,316
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.46
    Marker Score: 157
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.45
    Marker Score: 612
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.45
    Marker Score: 1,522
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.45
    Marker Score: 621
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.43
    Marker Score: 143
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.42
    Marker Score: 416
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.41
    Marker Score: 13,702
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 394
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.4
    Marker Score: 343
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.38
    Marker Score: 646
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.38
    Marker Score: 182
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.38
    Marker Score: 145
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.37
    Marker Score: 163
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.37
    Marker Score: 173
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.36
    Marker Score: 3,605
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.35
    Marker Score: 368
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.35
    Marker Score: 430
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.34
    Marker Score: 200
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.33
    Marker Score: 1,740
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.32
    Marker Score: 1,697
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.31
    Marker Score: 182
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.31
    Marker Score: 111
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.3
    Marker Score: 380
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.29
    Marker Score: 537
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.29
    Marker Score: 89
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.29
    Marker Score: 164
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.28
    Marker Score: 676
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.28
    Marker Score: 84
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.28
    Marker Score: 634
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.27
    Marker Score: 302

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** PNMA2 is highly expressed in GABAergic cortical interneurons, caudal ganglionic eminence-derived GABAergic cortical interneurons, and other neuronal cell types, suggesting a crucial role in their development and function. 2. **Apoptosis Regulation:** PNMA2 is involved in the positive regulation of the apoptotic process, which is essential for maintaining tissue homeostasis and preventing cancer. 3. **Protein Binding:** PNMA2 interacts with various proteins, including those involved in apoptosis, cell signaling, and protein degradation, highlighting its potential involvement in multiple cellular processes. 4. **Neurological and Cancer Associations:** The PNMA2 protein has been identified as a paraneoplastic antigen, suggesting its potential role in neurodegenerative diseases and cancer. **Pathways and Functions:** 1. **Nucleolus:** PNMA2 is involved in the regulation of ribosome biogenesis and protein synthesis, highlighting its role in cellular growth and development. 2. **Positive Regulation of Apoptotic Process:** PNMA2 promotes apoptosis by interacting with pro-apoptotic proteins, thereby maintaining tissue homeostasis and preventing cancer. 3. **Protein Binding:** PNMA2 interacts with various proteins, including those involved in apoptosis, cell signaling, and protein degradation, suggesting its involvement in multiple cellular processes. 4. **Neurotransmitter Signaling:** PNMA2 is expressed in GABAergic cortical interneurons, suggesting its potential role in regulating neurotransmitter signaling and neuronal communication. **Clinical Significance:** 1. **Neurodegenerative Diseases:** The identification of PNMA2 as a paraneoplastic antigen suggests its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 2. **Cancer:** PNMA2's involvement in apoptosis regulation and protein binding suggests its potential as a therapeutic target in cancer treatment. 3. **Neurological Disorders:** PNMA2's expression in GABAergic cortical interneurons and other neuronal cell types highlights its potential role in regulating neuronal function and development. 4. **Gene Therapy:** Further research is needed to explore the potential of PNMA2 as a gene therapy target for treating neurodegenerative diseases and cancer. In conclusion, the PNMA2 gene plays a crucial role in regulating apoptosis and protein binding, and its expression in various cell types highlights its potential involvement in multiple cellular processes. Further research is needed to fully elucidate the role of PNMA2 in regulating cellular function and development, and its potential as a therapeutic target in neurodegenerative diseases and cancer.

Genular Protein ID: 2559677840

Symbol: PNMA2_HUMAN

Name: Paraneoplastic antigen Ma2

UniProtKB Accession Codes:

Q9UL42 B3KNY9 O94959 O95145 Q49A18 Q9UL43

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10362822

Title: A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer.

PubMed ID: 10362822

DOI: 10.1056/nejm199906103402303

PubMed ID: 11558790

Title: Molecular and clinical diversity in paraneoplastic immunity to Ma proteins.

PubMed ID: 11558790

DOI: 10.1002/ana.1288.abs

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10050892

Title: Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders.

PubMed ID: 10050892

DOI: 10.1093/brain/122.1.27

PubMed ID: 19366867

Title: Paraneoplastic antigen-like 5 gene (PNMA5) is preferentially expressed in the association areas in a primate specific manner.

PubMed ID: 19366867

DOI: 10.1093/cercor/bhp062

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 364
  • Mass: 41509
  • Checksum: 6E417AD96E3F0E93
  • Sequence:
    • MALALLEDWC RIMSVDEQKS LMVTGIPADF EEAEIQEVLQ ETLKSLGRYR LLGKIFRKQE 
NANAVLLELL EDTDVSAIPS EVQGKGGVWK VIFKTPNQDT EFLERLNLFL EKEGQTVSGM 
FRALGQEGVS PATVPCISPE LLAHLLGQAM AHAPQPLLPM RYRKLRVFSG SAVPAPEEES 
FEVWLEQATE IVKEWPVTEA EKKRWLAESL RGPALDLMHI VQADNPSISV EECLEAFKQV 
FGSLESRRTA QVRYLKTYQE EGEKVSAYVL RLETLLRRAV EKRAIPRRIA DQVRLEQVMA 
GATLNQMLWC RLRELKDQGP PPSFLELMKV IREEEEEEAS FENESIEEPE ERDGYGRWNH 
EGDD

Genular Protein ID: 1118430131

Symbol: Q5U5Z3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5U5Z3

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 364
  • Mass: 41440
  • Checksum: 9B403E9C6E3F0F22
  • Sequence:
    • MALALLEDWC RIMSVDEQKS LMVTGIPADF EEAEIQEVLQ ETLKSLGRYR LLGKIFRKQE 
NANAVLLELL EDTDVSAIPS EVQGKGGVWK VIFKTPNQDT EFLERLNLFL EKEGQTVSGM 
FRALGQEGVS PATVPCISPE LLAHLLGQAM AHAPQPLLPM RYRKLRVFSG SAVPAPEEES 
FEVWLEQATE IVKEWPVTEA EKKRWLAESL RGPALDLMHI VQADNPSISV EECLEAFKQV 
FGSLESRRTA QVRYLKTYQE EGEKVSAYVL RLETLLRRAV EKRAIPRRIA DQVSLEQVMA 
GATLNQMLWC RLRELKDQGP PPSFLELMKV IREEEEEEAS FENESIEEPE ERDGYGRWNH 
EGDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.