Genular: Defining Cellular Identity and Function

Details for: PSME4

Gene ID: 23198

Symbol: PSME4

Ensembl ID: ENSG00000068878

Description: proteasome activator subunit 4

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
P53-dependent g1/s dna damage checkpoint
(R-HSA-69580)
P53-independent g1/s dna damage checkpoint
(R-HSA-69613)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Pten regulation
(R-HSA-6807070)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Synthesis of dna
(R-HSA-69239)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by runx2
(R-HSA-8878166)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Ubiquitin-dependent degradation of cyclin d
(R-HSA-75815)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.76
Marker Score: 6,912
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.62
Marker Score: 9,305
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.56
Marker Score: 5,625
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.54
Marker Score: 56,697
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.28
Marker Score: 9,534
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.21
Marker Score: 697
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.17
Marker Score: 1,264
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.15
Marker Score: 2,379
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.14
Marker Score: 2,254
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.04
Marker Score: 43,491
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.99
Marker Score: 582
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.89
Marker Score: 996
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.87
Marker Score: 1,992
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.85
Marker Score: 1,076
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.84
Marker Score: 2,228
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.83
Marker Score: 1,271
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.83
Marker Score: 527
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.83
Marker Score: 67,330
Cell Name: neuron (CL0000540)
Fold Change: 1.82
Marker Score: 7,412
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.82
Marker Score: 4,348
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.81
Marker Score: 1,607
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.8
Marker Score: 10,654
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.78
Marker Score: 2,021
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.78
Marker Score: 2,396
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.77
Marker Score: 1,527
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.75
Marker Score: 66,482
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.74
Marker Score: 2,005
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.74
Marker Score: 107,119
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.72
Marker Score: 2,889
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.7
Marker Score: 2,501
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.69
Marker Score: 535
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.67
Marker Score: 976
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.66
Marker Score: 822
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.65
Marker Score: 17,064
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.64
Marker Score: 14,062
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.64
Marker Score: 15,548
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.58
Marker Score: 6,547
Cell Name: fat cell (CL0000136)
Fold Change: 1.58
Marker Score: 881
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.57
Marker Score: 2,275
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.55
Marker Score: 2,984
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.55
Marker Score: 23,190
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.55
Marker Score: 11,849
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.54
Marker Score: 764
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.54
Marker Score: 14,454
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.53
Marker Score: 30,484
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.53
Marker Score: 642
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.53
Marker Score: 2,362
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.53
Marker Score: 850
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.47
Marker Score: 7,238
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.47
Marker Score: 1,778
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.47
Marker Score: 1,131
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.47
Marker Score: 499
Cell Name: astrocyte (CL0000127)
Fold Change: 1.45
Marker Score: 1,260
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.45
Marker Score: 5,619
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.44
Marker Score: 1,138
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.41
Marker Score: 683
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.37
Marker Score: 1,479
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.37
Marker Score: 815
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.34
Marker Score: 8,644
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.34
Marker Score: 3,269
Cell Name: lymphocyte (CL0000542)
Fold Change: 1.34
Marker Score: 675
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.33
Marker Score: 23,620
Cell Name: lactocyte (CL0002325)
Fold Change: 1.27
Marker Score: 20,462
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.27
Marker Score: 43,315
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.24
Marker Score: 5,369
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.24
Marker Score: 467
Cell Name: Unknown (CL0002371)
Fold Change: 1.21
Marker Score: 1,290
Cell Name: basal cell (CL0000646)
Fold Change: 1.21
Marker Score: 1,564
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.2
Marker Score: 1,705
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 1.19
Marker Score: 429
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.19
Marker Score: 445
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.19
Marker Score: 6,396
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.19
Marker Score: 2,705
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.18
Marker Score: 323
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.18
Marker Score: 777
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.18
Marker Score: 30,115
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.16
Marker Score: 5,381
Cell Name: podocyte (CL0000653)
Fold Change: 1.16
Marker Score: 429
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.16
Marker Score: 1,105
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.16
Marker Score: 774
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.15
Marker Score: 504
Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.15
Marker Score: 364
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.15
Marker Score: 17,950
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.15
Marker Score: 2,032
Cell Name: papillary tips cell (CL1000597)
Fold Change: 1.14
Marker Score: 231
Cell Name: club cell (CL0000158)
Fold Change: 1.13
Marker Score: 1,316
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.13
Marker Score: 3,870
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.12
Marker Score: 285
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.11
Marker Score: 520
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.1
Marker Score: 907
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.09
Marker Score: 1,155
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.09
Marker Score: 4,194
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.09
Marker Score: 344
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.08
Marker Score: 1,341
Cell Name: melanocyte (CL0000148)
Fold Change: 1.07
Marker Score: 432
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.06
Marker Score: 1,139
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.05
Marker Score: 969
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.05
Marker Score: 1,299
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.05
Marker Score: 542
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.04
Marker Score: 585

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** 1. **Proteasome subunit**: PSME4 is a subunit of the 20S proteasome, a large protein complex responsible for protein degradation. 2. **Ubiquitin-proteasome system**: PSME4 is part of the UPS, a highly conserved cellular machinery that regulates protein degradation and cellular homeostasis. 3. **Highly expressed**: PSME4 is highly expressed in multiple cell types, including skeletal muscle fibers, cardiac myocytes, and epithelial cells. 4. **Regulatory function**: PSME4 regulates protein degradation, cell cycle progression, and immune responses, highlighting its importance in maintaining cellular homeostasis. **Pathways and Functions** 1. **Protein degradation**: PSME4 is involved in the degradation of damaged or misfolded proteins, regulating cellular homeostasis. 2. **Cell cycle regulation**: PSME4 regulates cell cycle progression by degrading proteins involved in the cell cycle, such as cyclin D. 3. **Immune responses**: PSME4 plays a role in regulating immune responses by degrading proteins involved in the immune response, such as MHC class I molecules. 4. **Apoptosis regulation**: PSME4 regulates apoptosis by degrading proteins involved in the apoptotic pathway, such as Bcl-2. 5. **Signal transduction**: PSME4 is involved in signal transduction pathways, including the Wnt/β-catenin pathway and the Hedgehog pathway. **Clinical Significance** 1. **Cancer**: Alterations in PSME4 expression have been associated with cancer development and progression, highlighting its potential as a therapeutic target. 2. **Neurodegenerative diseases**: PSME4 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where protein aggregation and degradation are disrupted. 3. **Infectious diseases**: PSME4 plays a role in regulating immune responses to infectious diseases, such as HIV and tuberculosis. 4. **Cardiac diseases**: PSME4 has been associated with cardiac diseases, such as heart failure and coronary artery disease, where protein degradation and cell cycle regulation are disrupted. In conclusion, PSME4 is a critical gene involved in regulating protein degradation, cell cycle progression, and immune responses. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully understand the role of PSME4 in human disease and to develop effective therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Proteasome activator complex subunit 4

Genular Protein ID: 1847118801

Symbol: PSME4_HUMAN

Name: Proteasome activator complex subunit 4

UniProtKB Accession Codes:

Q14997 Q1XBG4 Q1XBG5 Q1XBG6 Q2M1Z0 Q6IPR2 Q86XF8

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 12093752

Title: PA200, a nuclear proteasome activator involved in DNA repair.

PubMed ID: 12093752

DOI: 10.1093/emboj/cdf333

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18845680

Title: Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability.

PubMed ID: 18845680

DOI: 10.1073/pnas.0803145105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22550082

Title: The proteasome activator PA200 regulates tumor cell responsiveness to glutamine and resistance to ionizing radiation.

PubMed ID: 22550082

DOI: 10.1158/1541-7786.mcr-11-0493-t

PubMed ID: 23706739

Title: Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.

PubMed ID: 23706739

DOI: 10.1016/j.cell.2013.04.032

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 1843
Mass: 211334
Checksum: 2D2C3A594E4FA4E7
Sequence:

MEPAERAGVG EPPEPGGRPE PGPRGFVPQK EIVYNKLLPY AERLDAESDL QLAQIKCNLG 
RAVQLQELWP GGLFWTRKLS TYIRLYGRKF SKEDHVLFIK LLYELVSIPK LEISMMQGFA 
RLLINLLKKK ELLSRADLEL PWRPLYDMVE RILYSKTEHL GLNWFPNSVE NILKTLVKSC 
RPYFPADATA EMLEEWRPLM CPFDVTMQKA ITYFEIFLPT SLPPELHHKG FKLWFDELIG 
LWVSVQNLPQ WEGQLVNLFA RLATDNIGYI DWDPYVPKIF TRILRSLNLP VGSSQVLVPR 
FLTNAYDIGH AVIWITAMMG GPSKLVQKHL AGLFNSITSF YHPSNNGRWL NKLMKLLQRL 
PNSVVRRLHR ERYKKPSWLT PVPDSHKLTD QDVTDFVQCI IQPVLLAMFS KTGSLEAAQA 
LQNLALMRPE LVIPPVLERT YPALETLTEP HQLTATLSCV IGVARSLVSG GRWFPEGPTH 
MLPLLMRALP GVDPNDFSKC MITFQFIATF STLVPLVDCS SVLQERNDLT EVERELCSAT 
AEFEDFVLQF MDRCFGLIES STLEQTREET ETEKMTHLES LVELGLSSTF STILTQCSKE 
IFMVALQKVF NFSTSHIFET RVAGRMVADM CRAAVKCCPE ESLKLFVPHC CSVITQLTMN 
DDVLNDEELD KELLWNLQLL SEITRVDGRK LLLYREQLVK ILQRTLHLTC KQGYTLSCNL 
LHHLLRSTTL IYPTEYCSVP GGFDKPPSEY FPIKDWGKPG DLWNLGIQWH VPSSEEVSFA 
FYLLDSFLQP ELVKLQHCGD GKLEMSRDDI LQSLTIVHNC LIGSGNLLPP LKGEPVTNLV 
PSMVSLEETK LYTGLEYDLS RENHREVIAT VIRKLLNHIL DNSEDDTKSL FLIIKIIGDL 
LQFQGSHKHE FDSRWKSFNL VKKSMENRLH GKKQHIRALL IDRVMLQHEL RTLTVEGCEY 
KKIHQDMIRD LLRLSTSSYS QVRNKAQQTF FAALGAYNFC CRDIIPLVLE FLRPDRQGVT 
QQQFKGALYC LLGNHSGVCL ANLHDWDCIV QTWPAIVSSG LSQAMSLEKP SIVRLFDDLA 
EKIHRQYETI GLDFTIPKSC VEIAELLQQS KNPSINQILL SPEKIKEGIK RQQEKNADAL 
RNYENLVDTL LDGVEQRNLP WKFEHIGIGL LSLLLRDDRV LPLRAIRFFV ENLNHDAIVV 
RKMAISAVAG ILKQLKRTHK KLTINPCEIS GCPKPTQIIA GDRPDNHWLH YDSKTIPRTK 
KEWESSCFVE KTHWGYYTWP KNMVVYAGVE EQPKLGRSRE DMTEAEQIIF DHFSDPKFVE 
QLITFLSLED RKGKDKFNPR RFCLFKGIFR NFDDAFLPVL KPHLEHLVAD SHESTQRCVA 
EIIAGLIRGS KHWTFEKVEK LWELLCPLLR TALSNITVET YNDWGACIAT SCESRDPRKL 
HWLFELLLES PLSGEGGSFV DACRLYVLQG GLAQQEWRVP ELLHRLLKYL EPKLTQVYKN 
VRERIGSVLT YIFMIDVSLP NTTPTISPHV PEFTARILEK LKPLMDVDEE IQNHVMEENG 
IGEEDERTQG IKLLKTILKW LMASAGRSFS TAVTEQLQLL PLFFKIAPVE NDNSYDELKR 
DAKLCLSLMS QGLLYPHQVP LVLQVLKQTA RSSSWHARYT VLTYLQTMVF YNLFIFLNNE 
DAVKDIRWLV ISLLEDEQLE VREMAATTLS GLLQCNFLTM DSPMQIHFEQ LCKTKLPKKR 
KRDPGSVGDT IPSAELVKRH AGVLGLGACV LSSPYDVPTW MPQLLMNLSA HLNDPQPIEM 
TVKKTLSNFR RTHHDNWQEH KQQFTDDQLL VLTDLLVSPC YYA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSME4

Associated with

Cells (max top 100)

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 7584044

PA200, a nuclear proteasome activator involved in DNA repair. PubMed ID: 12093752

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability. PubMed ID: 18845680

Initial characterization of the human central proteome. PubMed ID: 21269460

The proteasome activator PA200 regulates tumor cell responsiveness to glutamine and resistance to ionizing radiation. PubMed ID: 22550082

Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. PubMed ID: 23706739

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163