Details for: RNU5E 1

Gene ID: 26829

Symbol: RNU5E 1

Ensembl ID: ENSG00000199347

Description: RNA, U5E small nuclear 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3526
    Cell Significance Index: 3.6500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1903
    Cell Significance Index: 2.3200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1828
    Cell Significance Index: 2.3100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.1490
    Cell Significance Index: 1.4200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0753
    Cell Significance Index: 0.8000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0468
    Cell Significance Index: 0.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0137
    Cell Significance Index: 0.2300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0107
    Cell Significance Index: 0.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0082
    Cell Significance Index: 0.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0002
    Cell Significance Index: -0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0014
    Cell Significance Index: -0.1600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0085
    Cell Significance Index: -0.0700
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0113
    Cell Significance Index: -0.1100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0119
    Cell Significance Index: -0.1100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0148
    Cell Significance Index: -0.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0166
    Cell Significance Index: -0.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0166
    Cell Significance Index: -0.6100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0176
    Cell Significance Index: -0.2300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0182
    Cell Significance Index: -0.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0186
    Cell Significance Index: -0.2800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0273
    Cell Significance Index: -0.3300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0288
    Cell Significance Index: -0.3600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0292
    Cell Significance Index: -0.4200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0294
    Cell Significance Index: -0.5000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0294
    Cell Significance Index: -0.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0305
    Cell Significance Index: -1.0000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0334
    Cell Significance Index: -0.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0344
    Cell Significance Index: -0.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0353
    Cell Significance Index: -1.2400
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0356
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0358
    Cell Significance Index: -0.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0368
    Cell Significance Index: -0.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0384
    Cell Significance Index: -0.8400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0386
    Cell Significance Index: -0.5300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0394
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0406
    Cell Significance Index: -0.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0407
    Cell Significance Index: -1.2900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0408
    Cell Significance Index: -0.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0409
    Cell Significance Index: -1.0200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0422
    Cell Significance Index: -0.4000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0442
    Cell Significance Index: -0.9500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0452
    Cell Significance Index: -0.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0460
    Cell Significance Index: -0.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0467
    Cell Significance Index: -1.1700
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0473
    Cell Significance Index: -0.4200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0477
    Cell Significance Index: -0.5200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0481
    Cell Significance Index: -0.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0482
    Cell Significance Index: -0.9700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0508
    Cell Significance Index: -0.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0509
    Cell Significance Index: -1.0100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0509
    Cell Significance Index: -1.0200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0513
    Cell Significance Index: -1.0100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0515
    Cell Significance Index: -0.7000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0542
    Cell Significance Index: -0.7200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0543
    Cell Significance Index: -0.7100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0552
    Cell Significance Index: -0.6900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0560
    Cell Significance Index: -0.6200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0578
    Cell Significance Index: -0.7100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0584
    Cell Significance Index: -0.6900
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0584
    Cell Significance Index: -0.6700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0590
    Cell Significance Index: -0.7400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0595
    Cell Significance Index: -0.7500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0600
    Cell Significance Index: -0.6900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0602
    Cell Significance Index: -0.6200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0609
    Cell Significance Index: -0.7200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0609
    Cell Significance Index: -0.7300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0627
    Cell Significance Index: -0.7600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0628
    Cell Significance Index: -0.7100
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0629
    Cell Significance Index: -0.3900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0630
    Cell Significance Index: -0.5700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0635
    Cell Significance Index: -0.6700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0636
    Cell Significance Index: -0.8300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0638
    Cell Significance Index: -0.8400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0641
    Cell Significance Index: -0.6200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0647
    Cell Significance Index: -0.7700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0650
    Cell Significance Index: -0.7900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0652
    Cell Significance Index: -0.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0652
    Cell Significance Index: -1.1300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0653
    Cell Significance Index: -0.7300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0654
    Cell Significance Index: -0.7600
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: -0.0659
    Cell Significance Index: -0.8000
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0665
    Cell Significance Index: -0.7200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0668
    Cell Significance Index: -0.7600
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0669
    Cell Significance Index: -0.7300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0671
    Cell Significance Index: -0.6300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0676
    Cell Significance Index: -0.8200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0679
    Cell Significance Index: -0.6700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0680
    Cell Significance Index: -0.6200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0687
    Cell Significance Index: -0.6400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0691
    Cell Significance Index: -0.8400
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0705
    Cell Significance Index: -0.7600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0709
    Cell Significance Index: -0.7900
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0714
    Cell Significance Index: -0.7400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0716
    Cell Significance Index: -0.9400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0719
    Cell Significance Index: -0.7300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0722
    Cell Significance Index: -0.5700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0724
    Cell Significance Index: -0.7400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0726
    Cell Significance Index: -0.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU5E1 is a small nuclear RNA (snRNA) that belongs to the U5 family of snRNAs, which are involved in the assembly of spliceosomal complexes. The gene encodes a 62 nucleotide-long RNA molecule that is highly conserved across species. RNU5E1 is expressed in multiple cell types, including those involved in tissue development, immune responses, and cancer. The gene's expression patterns suggest a critical role in regulating gene expression and maintaining cellular homeostasis. **Pathways and Functions:** RNU5E1 is involved in several key RNA processing pathways, including: 1. **Formation of quadruple snRNP complex**: RNU5E1 plays a crucial role in the assembly of the quadruple snRNP complex, which is composed of U4, U5, U6, and U5 snRNAs. This complex is essential for the recognition and excision of introns from pre-mRNA. 2. **Spliceosomal tri-snRNP complex assembly**: RNU5E1 is also involved in the assembly of spliceosomal tri-snRNP complexes, which are composed of U4, U6, and U5 snRNAs. These complexes are responsible for the recognition and excision of introns from pre-mRNA. 3. **U4/U6 x U5 tri-snRNP complex formation**: RNU5E1 is required for the formation of the U4/U6 x U5 tri-snRNP complex, which is a critical intermediate in the splicing of pre-mRNA. 4. **U5 snRNP**: RNU5E1 is also involved in the assembly of the U5 snRNP, which is responsible for the recognition and excision of introns from pre-mRNA. **Clinical Significance:** The RNU5E1 gene's involvement in RNA processing pathways has significant implications for our understanding of disease mechanisms. Alterations in RNU5E1 expression have been linked to various diseases, including: 1. **Cancer**: RNU5E1 expression is often downregulated in cancer cells, leading to aberrant splicing and altered gene expression. 2. **Immune disorders**: RNU5E1 plays a critical role in regulating immune responses, and alterations in its expression have been linked to autoimmune diseases. 3. **Neurological disorders**: RNU5E1 has been implicated in the regulation of gene expression in the nervous system, and alterations in its expression have been linked to neurological disorders such as Alzheimer's disease. In conclusion, the RNU5E1 gene plays a critical role in RNA processing pathways, and its involvement in disease mechanisms has significant implications for our understanding of cellular function and disease. Further research is needed to fully elucidate the role of RNU5E1 in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.