TTF1 | ENSG00000125482 | NCBI 7270

Details for: TTF1

Associated with

Epigenetic regulation of gene expression
(R-HSA-212165)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Gene expression (transcription)
(R-HSA-74160)
Metabolism of proteins
(R-HSA-392499)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Surfactant metabolism
(R-HSA-5683826)
Chromatin binding
(GO:0003682)
Dna-templated transcription termination
(GO:0006353)
Dna binding
(GO:0003677)
Fibrillar center
(GO:0001650)
Negative regulation of dna replication
(GO:0008156)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Termination of rna polymerase i transcription
(GO:0006363)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

tracheobronchial smooth muscle cell CL0019019

CSI 14.36

rCSI 25.33%

PRS 56.65
renal interstitial pericyte CL1001318

CSI 9.52

rCSI 26.24%

PRS 44.77
peripheral nervous system neuron CL2000032

CSI 7.89

rCSI 10.75%

PRS 41.46
regular atrial cardiac myocyte CL0002129

CSI 7.72

rCSI 24.86%

PRS 47.44
group 3 innate lymphoid cell CL0001071

CSI 5.59

rCSI 4.2%

PRS 52.17
epithelial cell of lung CL0000082

CSI 5.42

rCSI 4.49%

PRS 47.08
renal beta-intercalated cell CL0002201

CSI 5.07

rCSI 12.1%

PRS 50.1
granulocyte CL0000094

CSI 4.93

rCSI 7.53%

PRS 57.72
helper T cell CL0000912

CSI 4.31

rCSI 6.1%

PRS 56.31
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 4.19

rCSI 7.4%

PRS 31.21
kidney connecting tubule epithelial cell CL1000768

CSI 3.94

rCSI 10%

PRS 38.65
ionocyte CL0005006

CSI 3.88

rCSI 4.16%

PRS 46.58
VIP GABAergic cortical interneuron CL4023016

CSI 3.84

rCSI 4.58%

PRS 32.04
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.55

rCSI 2.85%

PRS 69.8
Kupffer cell CL0000091

CSI 3.46

rCSI 7.9%

PRS 47.78
double negative thymocyte CL0002489

CSI 3.09

rCSI 2.15%

PRS 57.62
early lymphoid progenitor CL0000936

CSI 3.06

rCSI 2.68%

PRS 53.56
renal alpha-intercalated cell CL0005011

CSI 2.69

rCSI 3.59%

PRS 56.98
acinar cell CL0000622

CSI 2.68

rCSI 3.93%

PRS 59.92
pro-B cell CL0000826

CSI 2.65

rCSI 2.2%

PRS 49.64
cerebellar granule cell CL0001031

CSI 2.56

rCSI 3.76%

PRS 43.54
lung secretory cell CL1000272

CSI 2.51

rCSI 6.21%

PRS 46.36
neural crest cell CL0011012

CSI 2.46

rCSI 1.95%

PRS 36.04
lamp5 GABAergic cortical interneuron CL4023011

CSI 2.45

rCSI 4.11%

PRS 32.17
class switched memory B cell CL0000972

CSI 2.42

rCSI 1.81%

PRS 66.43
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.22

rCSI 3.15%

PRS 45.17
precursor B cell CL0000817

CSI 2.21

rCSI 1.94%

PRS 58.31
hematopoietic multipotent progenitor cell CL0000837

CSI 2.21

rCSI 5.31%

PRS 66.83
alpha-beta T cell CL0000789

CSI 2.16

rCSI 2.53%

PRS 64.17
choroid plexus epithelial cell CL0000706

CSI 2.14

rCSI 3.51%

PRS 38.78
lung neuroendocrine cell CL1000223

CSI 2.13

rCSI 3.16%

PRS 53.63
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.13

rCSI 1.26%

PRS 64.31
plasmablast CL0000980

CSI 2.12

rCSI 1.67%

PRS 54.93
vascular associated smooth muscle cell CL0000359

CSI 2.12

rCSI 6.88%

PRS 50.86
bronchus fibroblast of lung CL2000093

CSI 2.12

rCSI 1.72%

PRS 49.03
plasmacytoid dendritic cell, human CL0001058

CSI 2.09

rCSI 1.46%

PRS 50.42
stem cell CL0000034

CSI 2.07

rCSI 2%

PRS 39.07
fibroblast of lung CL0002553

CSI 2.07

rCSI 1.93%

PRS 48.11
hepatic stellate cell CL0000632

CSI 2.06

rCSI 7.71%

PRS 41.26
BEST4+ enteroycte CL4030026

CSI 2.04

rCSI 2.53%

PRS 51.01
small pre-B-II cell CL0000954

CSI 1.99

rCSI 1.92%

PRS 72.38
interneuron CL0000099

CSI 1.99

rCSI 3.99%

PRS 38.11
cerebral cortex GABAergic interneuron CL0010011

CSI 1.98

rCSI 5.85%

PRS 52.39
astrocyte of the cerebral cortex CL0002605

CSI 1.98

rCSI 4.43%

PRS 32.98
neuroblast (sensu Vertebrata) CL0000031

CSI 1.97

rCSI 2.53%

PRS 46.39
CD4-positive helper T cell CL0000492

CSI 1.9

rCSI 1.43%

PRS 61.23
alveolar type 1 fibroblast cell CL4028004

CSI 1.87

rCSI 2.05%

PRS 52.31
CD14-low, CD16-positive monocyte CL0002396

CSI 1.8

rCSI 1.39%

PRS 47.43
ciliated epithelial cell CL0000067

CSI 1.78

rCSI 1.56%

PRS 37.38
myoepithelial cell CL0000185

CSI 1.78

rCSI 4.5%

PRS 56.82
dendritic cell, human CL0001056

CSI 1.76

rCSI 2.71%

PRS 55.83
double-positive, alpha-beta thymocyte CL0000809

CSI 1.75

rCSI 1.78%

PRS 61.74
hematopoietic precursor cell CL0008001

CSI 1.72

rCSI 1.77%

PRS 66.61
common myeloid progenitor CL0000049

CSI 1.72

rCSI 1.39%

PRS 49.19
rod bipolar cell CL0000751

CSI 1.7

rCSI 3.06%

PRS 41.71
vascular leptomeningeal cell CL4023051

CSI 1.7

rCSI 2.98%

PRS 40.73
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.68

rCSI 2.03%

PRS 56.47
intestinal tuft cell CL0019032

CSI 1.64

rCSI 2.51%

PRS 53.23
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.64

rCSI 1.9%

PRS 42.53
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.64

rCSI 2.15%

PRS 61.82
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.61

rCSI 1.45%

PRS 45.07
fraction A pre-pro B cell CL0002045

CSI 1.59

rCSI 1.82%

PRS 70.96
pvalb GABAergic cortical interneuron CL4023018

CSI 1.58

rCSI 1.97%

PRS 30.56
cardiac muscle cell CL0000746

CSI 1.58

rCSI 2.26%

PRS 39.36
chondrocyte CL0000138

CSI 1.55

rCSI 2.46%

PRS 41.24
ependymal cell CL0000065

CSI 1.51

rCSI 3.06%

PRS 30.48
blood vessel smooth muscle cell CL0019018

CSI 1.5

rCSI 12.23%

PRS 42.6
sst GABAergic cortical interneuron CL4023017

CSI 1.5

rCSI 1.94%

PRS 33.15
OFF-bipolar cell CL0000750

CSI 1.5

rCSI 2.04%

PRS 57.75
placental villous trophoblast CL2000060

CSI 1.49

rCSI 2.3%

PRS 46.18
multi-ciliated epithelial cell CL0005012

CSI 1.46

rCSI 1.46%

PRS 42.45
retinal bipolar neuron CL0000748

CSI 1.45

rCSI 2.72%

PRS 37.87
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.41

rCSI 3.65%

PRS 44.34
cerebral cortex endothelial cell CL1001602

CSI 1.4

rCSI 2.42%

PRS 39.04
glioblast CL0000030

CSI 1.4

rCSI 2.23%

PRS 42.09
fallopian tube secretory epithelial cell CL4030006

CSI 1.39

rCSI 1.34%

PRS 48.73
hematopoietic stem cell CL0000037

CSI 1.39

rCSI 0.92%

PRS 52.09
radial glial cell CL0000681

CSI 1.38

rCSI 1.91%

PRS 47.83
T-helper 17 cell CL0000899

CSI 1.37

rCSI 1.09%

PRS 70.62
intermediate monocyte CL0002393

CSI 1.36

rCSI 2.05%

PRS 50.8
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.35

rCSI 2.7%

PRS 66.49
pancreatic ductal cell CL0002079

CSI 1.35

rCSI 2.63%

PRS 50.66
progenitor cell CL0011026

CSI 1.32

rCSI 2.8%

PRS 51.38
common dendritic progenitor CL0001029

CSI 1.31

rCSI 1.64%

PRS 58.39
myeloid leukocyte CL0000766

CSI 1.27

rCSI 1.17%

PRS 49.17
type B pancreatic cell CL0000169

CSI 1.27

rCSI 2.82%

PRS 45.92
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.27

rCSI 0.86%

PRS 59.46
T-helper 1 cell CL0000545

CSI 1.24

rCSI 2.24%

PRS 73.85
retinal rod cell CL0000604

CSI 1.23

rCSI 2.16%

PRS 46.4
lymphoid lineage restricted progenitor cell CL0000838

CSI 1.2

rCSI 4.67%

PRS 68.93
glycinergic amacrine cell CL4030028

CSI 1.2

rCSI 3.12%

PRS 47.64
lung pericyte CL0009089

CSI 1.12

rCSI 2.95%

PRS 56.39
retina horizontal cell CL0000745

CSI 1.11

rCSI 1.69%

PRS 44.92
sncg GABAergic cortical interneuron CL4023015

CSI 1.08

rCSI 1.74%

PRS 34.34
lung ciliated cell CL1000271

CSI 1

rCSI 1.16%

PRS 38.54
mature alpha-beta T cell CL0000791

CSI 0.98

rCSI 3.56%

PRS 67.86
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.96

rCSI 5.64%

PRS 33.6
mature B cell CL0000785

CSI 0.91

rCSI 0.79%

PRS 58.2
retinal cone cell CL0000573

CSI 0.87

rCSI 1.39%

PRS 38.93
large pre-B-II cell CL0000957

CSI 0.85

rCSI 2.42%

PRS 62.63

medium spiny neuron CL1001474

CSI 0.2

rCSI 1.3%

PRS 35.9%
cytotoxic T cell CL0000910

CSI 0.3

rCSI 1.4%

PRS 59.9%
indirect pathway medium spiny neuron CL4023029

CSI 0.3

rCSI 8.2%

PRS 32.5%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.4

rCSI 1.1%

PRS 35.9%
amacrine cell CL0000561

CSI 0.4

rCSI 1.2%

PRS 39.4%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.4

rCSI 1.5%

PRS 31.0%
regular ventricular cardiac myocyte CL0002131

CSI 0.4

rCSI 2.8%

PRS 40.8%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.5

rCSI 1.8%

PRS 33.1%
erythroid progenitor cell CL0000038

CSI 0.5

rCSI 3.1%

PRS 59.1%
L6b glutamatergic cortical neuron CL4023038

CSI 0.6

rCSI 1.7%

PRS 33.5%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.6

rCSI 1.4%

PRS 31.2%
podocyte CL0000653

CSI 0.6

rCSI 2.9%

PRS 47.3%
microcirculation associated smooth muscle cell CL0008035

CSI 0.7

rCSI 2.0%

PRS 50.6%
promonocyte CL0000559

CSI 0.7

rCSI 1.2%

PRS 57.9%
retinal ganglion cell CL0000740

CSI 0.7

rCSI 1.6%

PRS 36.2%
megakaryocyte CL0000556

CSI 0.7

rCSI 3.2%

PRS 63.9%
dopaminergic neuron CL0000700

CSI 0.8

rCSI 4.3%

PRS 34.7%
forebrain radial glial cell CL0013000

CSI 0.8

rCSI 2.5%

PRS 55.8%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.8

rCSI 1.9%

PRS 46.6%
large pre-B-II cell CL0000957

CSI 0.9

rCSI 2.4%

PRS 62.6%
retinal cone cell CL0000573

CSI 0.9

rCSI 1.4%

PRS 38.9%
mature B cell CL0000785

CSI 0.9

rCSI 0.8%

PRS 58.2%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 1.0

rCSI 5.6%

PRS 33.6%
mature alpha-beta T cell CL0000791

CSI 1.0

rCSI 3.6%

PRS 67.9%
lung ciliated cell CL1000271

CSI 1.0

rCSI 1.2%

PRS 38.5%
sncg GABAergic cortical interneuron CL4023015

CSI 1.1

rCSI 1.7%

PRS 34.3%
retina horizontal cell CL0000745

CSI 1.1

rCSI 1.7%

PRS 44.9%
lung pericyte CL0009089

CSI 1.1

rCSI 3.0%

PRS 56.4%
glycinergic amacrine cell CL4030028

CSI 1.2

rCSI 3.1%

PRS 47.6%
lymphoid lineage restricted progenitor cell CL0000838

CSI 1.2

rCSI 4.7%

PRS 68.9%
retinal rod cell CL0000604

CSI 1.2

rCSI 2.2%

PRS 46.4%
T-helper 1 cell CL0000545

CSI 1.2

rCSI 2.2%

PRS 73.9%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.3

rCSI 0.9%

PRS 59.5%
type B pancreatic cell CL0000169

CSI 1.3

rCSI 2.8%

PRS 45.9%
myeloid leukocyte CL0000766

CSI 1.3

rCSI 1.2%

PRS 49.2%
common dendritic progenitor CL0001029

CSI 1.3

rCSI 1.6%

PRS 58.4%
progenitor cell CL0011026

CSI 1.3

rCSI 2.8%

PRS 51.4%
pancreatic ductal cell CL0002079

CSI 1.4

rCSI 2.6%

PRS 50.7%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.4

rCSI 2.7%

PRS 66.5%
intermediate monocyte CL0002393

CSI 1.4

rCSI 2.1%

PRS 50.8%
T-helper 17 cell CL0000899

CSI 1.4

rCSI 1.1%

PRS 70.6%
radial glial cell CL0000681

CSI 1.4

rCSI 1.9%

PRS 47.8%
hematopoietic stem cell CL0000037

CSI 1.4

rCSI 0.9%

PRS 52.1%
fallopian tube secretory epithelial cell CL4030006

CSI 1.4

rCSI 1.3%

PRS 48.7%
glioblast CL0000030

CSI 1.4

rCSI 2.2%

PRS 42.1%
cerebral cortex endothelial cell CL1001602

CSI 1.4

rCSI 2.4%

PRS 39.0%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.4

rCSI 3.7%

PRS 44.3%
retinal bipolar neuron CL0000748

CSI 1.5

rCSI 2.7%

PRS 37.9%
multi-ciliated epithelial cell CL0005012

CSI 1.5

rCSI 1.5%

PRS 42.5%
placental villous trophoblast CL2000060

CSI 1.5

rCSI 2.3%

PRS 46.2%
OFF-bipolar cell CL0000750

CSI 1.5

rCSI 2.0%

PRS 57.8%
sst GABAergic cortical interneuron CL4023017

CSI 1.5

rCSI 1.9%

PRS 33.2%
blood vessel smooth muscle cell CL0019018

CSI 1.5

rCSI 12.2%

PRS 42.6%
ependymal cell CL0000065

CSI 1.5

rCSI 3.1%

PRS 30.5%
chondrocyte CL0000138

CSI 1.6

rCSI 2.5%

PRS 41.2%
cardiac muscle cell CL0000746

CSI 1.6

rCSI 2.3%

PRS 39.4%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.6

rCSI 2.0%

PRS 30.6%
fraction A pre-pro B cell CL0002045

CSI 1.6

rCSI 1.8%

PRS 71.0%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 1.6

rCSI 1.5%

PRS 45.1%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.6

rCSI 2.2%

PRS 61.8%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.6

rCSI 1.9%

PRS 42.5%
intestinal tuft cell CL0019032

CSI 1.6

rCSI 2.5%

PRS 53.2%
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.7

rCSI 2.0%

PRS 56.5%
vascular leptomeningeal cell CL4023051

CSI 1.7

rCSI 3.0%

PRS 40.7%
rod bipolar cell CL0000751

CSI 1.7

rCSI 3.1%

PRS 41.7%
common myeloid progenitor CL0000049

CSI 1.7

rCSI 1.4%

PRS 49.2%
hematopoietic precursor cell CL0008001

CSI 1.7

rCSI 1.8%

PRS 66.6%
double-positive, alpha-beta thymocyte CL0000809

CSI 1.8

rCSI 1.8%

PRS 61.7%
dendritic cell, human CL0001056

CSI 1.8

rCSI 2.7%

PRS 55.8%
myoepithelial cell CL0000185

CSI 1.8

rCSI 4.5%

PRS 56.8%
ciliated epithelial cell CL0000067

CSI 1.8

rCSI 1.6%

PRS 37.4%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.8

rCSI 1.4%

PRS 47.4%
alveolar type 1 fibroblast cell CL4028004

CSI 1.9

rCSI 2.1%

PRS 52.3%
CD4-positive helper T cell CL0000492

CSI 1.9

rCSI 1.4%

PRS 61.2%
neuroblast (sensu Vertebrata) CL0000031

CSI 2.0

rCSI 2.5%

PRS 46.4%
astrocyte of the cerebral cortex CL0002605

CSI 2.0

rCSI 4.4%

PRS 33.0%
cerebral cortex GABAergic interneuron CL0010011

CSI 2.0

rCSI 5.9%

PRS 52.4%
interneuron CL0000099

CSI 2.0

rCSI 4.0%

PRS 38.1%
small pre-B-II cell CL0000954

CSI 2.0

rCSI 1.9%

PRS 72.4%
BEST4+ enteroycte CL4030026

CSI 2.0

rCSI 2.5%

PRS 51.0%
hepatic stellate cell CL0000632

CSI 2.1

rCSI 7.7%

PRS 41.3%
fibroblast of lung CL0002553

CSI 2.1

rCSI 1.9%

PRS 48.1%
stem cell CL0000034

CSI 2.1

rCSI 2.0%

PRS 39.1%
plasmacytoid dendritic cell, human CL0001058

CSI 2.1

rCSI 1.5%

PRS 50.4%
bronchus fibroblast of lung CL2000093

CSI 2.1

rCSI 1.7%

PRS 49.0%
vascular associated smooth muscle cell CL0000359

CSI 2.1

rCSI 6.9%

PRS 50.9%
plasmablast CL0000980

CSI 2.1

rCSI 1.7%

PRS 54.9%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.1

rCSI 1.3%

PRS 64.3%
lung neuroendocrine cell CL1000223

CSI 2.1

rCSI 3.2%

PRS 53.6%
choroid plexus epithelial cell CL0000706

CSI 2.1

rCSI 3.5%

PRS 38.8%
alpha-beta T cell CL0000789

CSI 2.2

rCSI 2.5%

PRS 64.2%
hematopoietic multipotent progenitor cell CL0000837

CSI 2.2

rCSI 5.3%

PRS 66.8%
precursor B cell CL0000817

CSI 2.2

rCSI 1.9%

PRS 58.3%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.2

rCSI 3.2%

PRS 45.2%
class switched memory B cell CL0000972

CSI 2.4

rCSI 1.8%

PRS 66.4%
lamp5 GABAergic cortical interneuron CL4023011

CSI 2.5

rCSI 4.1%

PRS 32.2%
neural crest cell CL0011012

CSI 2.5

rCSI 2.0%

PRS 36.0%
lung secretory cell CL1000272

CSI 2.5

rCSI 6.2%

PRS 46.4%
cerebellar granule cell CL0001031

CSI 2.6

rCSI 3.8%

PRS 43.5%
pro-B cell CL0000826

CSI 2.7

rCSI 2.2%

PRS 49.6%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [TTF1](/details-gene/7270), or Transcription Termination Factor 1, is a protein-coding gene located on chromosome 9q34.13. Its primary and well-established function is to mediate the termination of transcription by RNA Polymerase I, a crucial step in the biogenesis of ribosomal RNA. Consistent with this fundamental role, [TTF1](/details-gene/7270) is expressed across a wide variety of metabolically active cell types, including [tracheobronchial smooth muscle cell](/details-cell/CL0019019), [renal interstitial pericyte](/details-cell/CL1001318), and various neuronal subtypes. Its function is essential for regulating the rate of ribosome production, thereby controlling the cell's capacity for protein synthesis. The gene is clinically associated with OMIM entry [600777](https://omim.org/entry/600777). ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [TTF1](/details-gene/7270) suggests it is a vital housekeeping gene whose expression level is particularly significant in cells with high metabolic and protein synthesis demands. It displays a high Cell Significance Index (CSI) across multiple, functionally distinct lineages. The highest significance is observed in [tracheobronchial smooth muscle cell](/details-cell/CL0019019) (CSI: 14.36), followed by various cell types in the kidney, including [renal interstitial pericyte](/details-cell/CL1001318) and [renal beta-intercalated cell](/details-cell/CL0002201). This suggests a critical role in maintaining the structural and functional integrity of these tissues. Furthermore, significant expression is noted in the nervous system, with high CSI scores in [peripheral nervous system neuron](/details-cell/CL2000032) and cortical interneurons such as [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064), which is consistent with the high translational demands required for neuronal function and plasticity. The gene also appears important within the immune system, showing relevance in both innate and adaptive lineages, including [group 3 innate lymphoid cell](/details-cell/CL0001071), [granulocyte](/details-cell/CL0000094), and [helper T cell](/details-cell/CL0000912). This broad but significant expression pattern across diverse cell types underscores its fundamental role in ribosome biogenesis, a process essential for cell growth, proliferation, and function. ## Pathways and Molecular Function The molecular functions of [TTF1](/details-gene/7270) are centered on the regulation of gene expression within the nucleus. Gene Ontology annotations confirm its role in [Dna-templated transcription termination](/details-ontology/GO:0006353), specifically the [Termination of rna polymerase i transcription](/details-ontology/GO:0006363). Its molecular activities include [Dna binding](/details-ontology/GO:0003677) and [chromatin binding](/details-ontology/GO:0003682), and it is localized to the [nucleolus](/details-ontology/GO:0005730) and [fibrillar center](/details-ontology/GO:0001650), the primary sites of rRNA synthesis. Reactome pathway analysis further refines this role, placing [TTF1](/details-gene/7270) as a key component of the [Rna polymerase i transcription](/details-pathway/R-HSA-73864) machinery, with specific involvement in [Rna polymerase i transcription termination](/details-pathway/R-HSA-73863). The pathways also indicate its involvement in both [Positive epigenetic regulation of rrna expression](/details-pathway/R-HSA-5250913) and [Negative epigenetic regulation of rrna expression](/details-pathway/R-HSA-5250941), highlighting its function as a critical modulator of ribosome production. Notably, an association with [Surfactant metabolism](/details-pathway/R-HSA-5683826) is listed. This is likely due to a symbol ambiguity with Thyroid Transcription Factor 1 (gene: *NKX2-1*), which is also commonly known as TTF-1 and is a master regulator in the lung. The gene described here, Transcription Termination Factor 1, is functionally distinct, and its link to surfactant metabolism requires careful interpretation and further validation. ## Research Directions The broad and fundamental role of [TTF1](/details-gene/7270) in ribosome biogenesis opens several avenues for investigation, particularly concerning its regulation and therapeutic potential. 1. **Hypothesis 1:** The expression level of [TTF1](/details-gene/7270) is a direct rate-limiting factor for ribosome biogenesis and, consequently, dictates the maximum translational capacity of a cell. Therefore, cell types with high protein synthesis demands, such as neurons or rapidly proliferating immune cells, maintain high constitutive levels of [TTF1](/details-gene/7270) to support their physiological functions. 2. **Hypothesis 2:** While its primary role is in rRNA transcription, [TTF1](/details-gene/7270) may have secondary, cell-type-specific regulatory functions through its chromatin binding activity. In certain contexts, it might be recruited to non-rRNA gene promoters or enhancers to modulate the expression of protein-coding genes involved in specialized cellular processes. **Experimental Approach to Test Hypothesis 1:** To determine if [TTF1](/details-gene/7270) is a rate-limiting factor for protein synthesis, one could use a cell line with high endogenous expression, such as a neuronal or smooth muscle cell line. [TTF1](/details-gene/7270) expression could be titrated down using a CRISPR interference (CRISPRi) system. The consequences would be measured by quantifying (a) nascent rRNA synthesis via 5-ethynyl uridine (EU) labeling, (b) global protein synthesis rates using puromycin-incorporation assays (SUnSET), and (c) downstream effects on cell size, proliferation, and metabolic activity. A dose-dependent reduction in these metrics following [TTF1](/details-gene/7270) knockdown would support the hypothesis. **Therapeutic Potential:** Given its central role in promoting ribosome biogenesis, a process frequently upregulated in cancer to support rapid growth, [TTF1](/details-gene/7270) represents a potential target for anti-cancer therapy. **Inhibition** of [TTF1](/details-gene/7270) could selectively harm cancer cells, which are often highly dependent on robust protein synthesis ("ribosome-addicted"). However, because [TTF1](/details-gene/7270) is essential in healthy, high-turnover tissues, systemic inhibition would likely cause significant toxicity. Therefore, its therapeutic utility may depend on the development of targeted delivery systems (e.g., lipid nanoparticles) that can specifically deliver an inhibitor to tumor cells.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription termination factor 1
A0A087WY09_HUMAN

Genular Protein ID: 2853858673

Symbol: TTF1_HUMAN

Name: Transcription termination factor 1

UniProtKB Accession Codes:

Q15361 A1L160 Q4VXF3 Q58EY2 Q6P5T5

Database IDs:

Citations:

PubMed ID: 7597036

Title: Molecular evolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-1.

PubMed ID: 7597036

DOI: 10.1073/pnas.92.13.5827

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

Length: 905
Mass: 103051
Checksum: 12F829CEFDDF96E8
Sequence:

MEGESSRFEI HTPVSDKKKK KCSIHKERPQ KHSHEIFRDS SLVNEQSQIT RRKKRKKDFQ 
HLISSPLKKS RICDETANAT STLKKRKKRR YSALEVDEEA GVTVVLVDKE NINNTPKHFR 
KDVDVVCVDM SIEQKLPRKP KTDKFQVLAK SHAHKSEALH SKVREKKNKK HQRKAASWES 
QRARDTLPQS ESHQEESWLS VGPGGEITEL PASAHKNKSK KKKKKSSNRE YETLAMPEGS 
QAGREAGTDM QESQPTVGLD DETPQLLGPT HKKKSKKKKK KKSNHQEFEA LAMPEGSQVG 
SEVGADMQES RPAVGLHGET AGIPAPAYKN KSKKKKKKSN HQEFEAVAMP ESLESAYPEG 
SQVGSEVGTV EGSTALKGFK ESNSTKKKSK KRKLTSVKRA RVSGDDFSVP SKNSESTLFD 
SVEGDGAMME EGVKSRPRQK KTQACLASKH VQEAPRLEPA NEEHNVETAE DSEIRYLSAD 
SGDADDSDAD LGSAVKQLQE FIPNIKDRAT STIKRMYRDD LERFKEFKAQ GVAIKFGKFS 
VKENKQLEKN VEDFLALTGI ESADKLLYTD RYPEEKSVIT NLKRRYSFRL HIGRNIARPW 
KLIYYRAKKM FDVNNYKGRY SEGDTEKLKM YHSLLGNDWK TIGEMVARSS LSVALKFSQI 
SSQRNRGAWS KSETRKLIKA VEEVILKKMS PQELKEVDSK LQENPESCLS IVREKLYKGI 
SWVEVEAKVQ TRNWMQCKSK WTEILTKRMT NGRRIYYGMN ALRAKVSLIE RLYEINVEDT 
NEIDWEDLAS AIGDVPPSYV QTKFSRLKAV YVPFWQKKTF PEIIDYLYET TLPLLKEKLE 
KMMEKKGTKI QTPAAPKQVF PFRDIFYYED DSEGEDIEKE SEGQAPCMAH ACNSSTLGGQ 
GRWII

Genular Protein ID: 3388836765

Symbol: A0A087WY09_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WY09

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

Length: 390
Mass: 45622
Checksum: 3D653EB515BA26B8
Sequence:

MYRDDLERFK EFKAQGVAIK FGKFSVKENK QLEKNVEDFL ALTGIESADK LLYTDRYPEE 
KSVITNLKRR YSFRLHIGRN IARPWKLIYY RAKKMFDVNN YKGRYSEGDT EKLKMYHSLL 
GNDWKTIGEM VARSSLSVAL KFSQISSQRN RGAWSKSETR KLIKAVEEVI LKKMSPQELK 
EVDSKLQENP ESCLSIVREK LYKGISWVEV EAKVQTRNWM QCKSKWTEIL TKRMTNGRRI 
YYGMNALRAK VSLIERLYEI NVEDTNEIDW EDLASAIGDV PPSYVQTKFS RLKAVYVPFW 
QKKTFPEIID YLYETTLPLL KEKLEKMMEK KGTKIQTPAA PKQVFPFRDI FYYEDDSEGE 
DIEKESEGQA PCMAHACNSS TLGGQGRWII

	Overall overall
	Acute kidney failure MONDO0002492
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Colon UBERON0001155
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Parkinson disease MONDO0005180
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Small cell lung carcinoma MONDO0008433
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461

Details for: TTF1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Molecular evolution of mammalian ribosomal gene terminator sequences and the transcription termination factor TTF-1. PubMed ID: 7597036

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

PubMed ID: 7597036

PubMed ID: 15164053

PubMed ID: 15489334

PubMed ID: 17081983

PubMed ID: 17525332

PubMed ID: 18669648

PubMed ID: 19413330

PubMed ID: 19690332

PubMed ID: 20068231

PubMed ID: 21406692

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 28112733

PubMed ID: 11237011

PubMed ID: 15164053

PubMed ID: 15496913

PubMed ID: 18669648

PubMed ID: 20068231

PubMed ID: 21406692

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 28112733