Details for: OIP5 AS1

Gene ID: 729082

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: OIP5 AS1

Ensembl ID: ENSG00000247556

Description: OIP5 antisense RNA 1

Cell Significance Landscape

Associated with

  • Lncrna-mediated post-transcriptional gene silencing
    (GO:0000512)
  • Mirna inhibitor activity via base-pairing
    (GO:0140869)
  • Target-directed mirna degradation
    (GO:0140958)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • innate lymphoid cell CL0001065
    CSI 24.77
    rCSI 51.14%
    PRS 79.16
  • alpha-beta T cell CL0000789
    CSI 16.36
    rCSI 19.18%
    PRS 93.96
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 16.26
    rCSI 20.22%
    PRS 63.5
  • erythroblast CL0000765
    CSI 12.37
    rCSI 32.82%
    PRS 87.15
  • sst GABAergic cortical interneuron CL4023017
    CSI 10.86
    rCSI 14%
    PRS 66.75
  • VIP GABAergic cortical interneuron CL4023016
    CSI 9.78
    rCSI 11.69%
    PRS 65.67
  • conjunctival epithelial cell CL1000432
    CSI 9.27
    rCSI 14.15%
    PRS 82.74
  • transit amplifying cell of colon CL0009011
    CSI 9.17
    rCSI 10.77%
    PRS 84.23
  • enteroendocrine cell CL0000164
    CSI 8.55
    rCSI 11.68%
    PRS 82.18
  • lung ciliated cell CL1000271
    CSI 8.33
    rCSI 9.64%
    PRS 75.5
  • BEST4+ enteroycte CL4030026
    CSI 8.33
    rCSI 10.36%
    PRS 83.36
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 8.14
    rCSI 6.1%
    PRS 95.7
  • choroid plexus epithelial cell CL0000706
    CSI 8.08
    rCSI 13.24%
    PRS 72.81
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 7.61
    rCSI 5.34%
    PRS 93.47
  • interneuron CL0000099
    CSI 7.3
    rCSI 14.65%
    PRS 73.84
  • epithelial cell CL0000066
    CSI 6.86
    rCSI 10.53%
    PRS 71.75
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 6.58
    rCSI 15.73%
    PRS 69.83
  • Mueller cell CL0000636
    CSI 6.5
    rCSI 14.84%
    PRS 74.57
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 6.27
    rCSI 5.02%
    PRS 93.38
  • glial cell CL0000125
    CSI 6.24
    rCSI 23.78%
    PRS 74.19
  • Schwann cell CL0002573
    CSI 6.17
    rCSI 17.55%
    PRS 78.45
  • stem cell CL0000034
    CSI 5.77
    rCSI 5.56%
    PRS 76.82
  • cerebral cortex neuron CL0010012
    CSI 5.41
    rCSI 22.04%
    PRS 74.62
  • helper T cell CL0000912
    CSI 5.08
    rCSI 7.19%
    PRS 81.1
  • basal cell CL0000646
    CSI 4.95
    rCSI 6.62%
    PRS 80.98
  • cerebellar granule cell CL0001031
    CSI 4.52
    rCSI 6.65%
    PRS 75.98
  • ciliated epithelial cell CL0000067
    CSI 4.34
    rCSI 3.82%
    PRS 72.49
  • ON-bipolar cell CL0000749
    CSI 4.17
    rCSI 6.2%
    PRS 82.25
  • deuterosomal cell CL4033044
    CSI 3.89
    rCSI 13.16%
    PRS 79.44
  • group 3 innate lymphoid cell CL0001071
    CSI 3.87
    rCSI 2.9%
    PRS 88.06
  • alveolar macrophage CL0000583
    CSI 3.77
    rCSI 6.2%
    PRS 86.27
  • erythroid lineage cell CL0000764
    CSI 3.74
    rCSI 24.06%
    PRS 89.96
  • mature T cell CL0002419
    CSI 3.7
    rCSI 2.88%
    PRS 94.07
  • cardiac muscle cell CL0000746
    CSI 3.65
    rCSI 5.24%
    PRS 73.07
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 3.62
    rCSI 2.79%
    PRS 85.78
  • naive B cell CL0000788
    CSI 3.47
    rCSI 2.98%
    PRS 88.25
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.39
    rCSI 8.76%
    PRS 78.48
  • ependymal cell CL0000065
    CSI 3.39
    rCSI 6.87%
    PRS 61.94
  • retinal rod cell CL0000604
    CSI 3.28
    rCSI 5.78%
    PRS 78.11
  • retinal pigment epithelial cell CL0002586
    CSI 3.26
    rCSI 6.47%
    PRS 78.63
  • paneth cell of epithelium of small intestine CL1000343
    CSI 3.22
    rCSI 9.01%
    PRS 88.54
  • mesothelial cell CL0000077
    CSI 3.21
    rCSI 12.54%
    PRS 61.96
  • mononuclear phagocyte CL0000113
    CSI 3.16
    rCSI 6.96%
    PRS 86.1
  • pancreatic acinar cell CL0002064
    CSI 3.1
    rCSI 4.12%
    PRS 87.67
  • ciliated cell CL0000064
    CSI 3.06
    rCSI 4.95%
    PRS 77.6
  • precursor B cell CL0000817
    CSI 2.99
    rCSI 2.62%
    PRS 89.18
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 2.96
    rCSI 3.58%
    PRS 89.45
  • rod bipolar cell CL0000751
    CSI 2.88
    rCSI 5.17%
    PRS 76.43
  • M cell of gut CL0000682
    CSI 2.83
    rCSI 3.01%
    PRS 87.03
  • adipocyte CL0000136
    CSI 2.8
    rCSI 3.59%
    PRS 73.27
  • cardiac endothelial cell CL0010008
    CSI 2.65
    rCSI 10.7%
    PRS 82.87
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.5
    rCSI 6.53%
    PRS 83.8
  • OFF-bipolar cell CL0000750
    CSI 2.5
    rCSI 3.42%
    PRS 83.79
  • epithelial cell of proximal tubule CL0002306
    CSI 2.48
    rCSI 6.07%
    PRS 75.2
  • cerebral cortex endothelial cell CL1001602
    CSI 2.47
    rCSI 4.27%
    PRS 74.93
  • common myeloid progenitor CL0000049
    CSI 2.39
    rCSI 1.93%
    PRS 84.79
  • pulmonary alveolar type 2 cell CL0002063
    CSI 2.39
    rCSI 3.7%
    PRS 85.86
  • retina horizontal cell CL0000745
    CSI 2.36
    rCSI 3.59%
    PRS 79.62
  • mucosal invariant T cell CL0000940
    CSI 2.36
    rCSI 1.9%
    PRS 90.35
  • lung secretory cell CL1000272
    CSI 2.32
    rCSI 5.75%
    PRS 82.86
  • amacrine cell CL0000561
    CSI 2.22
    rCSI 6.42%
    PRS 72.54
  • acinar cell CL0000622
    CSI 2.17
    rCSI 3.18%
    PRS 90.84
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 2.13
    rCSI 5.18%
    PRS 63.55
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.1
    rCSI 2.97%
    PRS 79.71
  • goblet cell CL0000160
    CSI 2.07
    rCSI 1.96%
    PRS 81.15
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.03
    rCSI 4.55%
    PRS 66.5
  • inhibitory interneuron CL0000498
    CSI 2.01
    rCSI 4.65%
    PRS 71.13
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.99
    rCSI 3.21%
    PRS 66.97
  • respiratory basal cell CL0002633
    CSI 1.99
    rCSI 2.06%
    PRS 86.29
  • primordial germ cell CL0000670
    CSI 1.96
    rCSI 9.78%
    PRS 93.51
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.92
    rCSI 46.32%
    PRS 64.2
  • naive thymus-derived CD4-positive, alpha-beta T cell CL0000895
    CSI 1.89
    rCSI 2.38%
    PRS 94.52
  • granulocyte CL0000094
    CSI 1.83
    rCSI 2.8%
    PRS 89.01
  • intermediate monocyte CL0002393
    CSI 1.81
    rCSI 2.74%
    PRS 87.62
  • direct pathway medium spiny neuron CL4023026
    CSI 1.81
    rCSI 43.38%
    PRS 63.63
  • intestinal tuft cell CL0019032
    CSI 1.81
    rCSI 2.76%
    PRS 86.01
  • alveolar adventitial fibroblast CL4028006
    CSI 1.75
    rCSI 2.76%
    PRS 84.15
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.72
    rCSI 9.91%
    PRS 79.16
  • transit amplifying cell of small intestine CL0009012
    CSI 1.67
    rCSI 7.32%
    PRS 89.3
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.61
    rCSI 2.71%
    PRS 65.6
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.6
    rCSI 2.83%
    PRS 65.15
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 1.55
    rCSI 2.12%
    PRS 95.84
  • L6b glutamatergic cortical neuron CL4023038
    CSI 1.53
    rCSI 4.79%
    PRS 67.26
  • regulatory T cell CL0000815
    CSI 1.51
    rCSI 1.75%
    PRS 81.71
  • ventricular cardiac muscle cell CL2000046
    CSI 1.49
    rCSI 5.12%
    PRS 89.35
  • pancreatic ductal cell CL0002079
    CSI 1.38
    rCSI 2.68%
    PRS 85.63
  • club cell CL0000158
    CSI 1.36
    rCSI 1.99%
    PRS 77.6
  • Bergmann glial cell CL0000644
    CSI 1.33
    rCSI 1.81%
    PRS 74.21
  • retinal cone cell CL0000573
    CSI 1.22
    rCSI 1.97%
    PRS 73.33
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.17
    rCSI 3.15%
    PRS 86.56
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 1.12
    rCSI 6.6%
    PRS 66.19
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.12
    rCSI 2.84%
    PRS 73.72
  • parietal epithelial cell CL1000452
    CSI 1.07
    rCSI 2.86%
    PRS 75.14
  • endothelial cell of vascular tree CL0002139
    CSI 1.04
    rCSI 5.69%
    PRS 79.41
  • ON midget ganglion cell CL4033046
    CSI 0.98
    rCSI 19.87%
    PRS 72.82
  • glutamatergic neuron CL0000679
    CSI 0.96
    rCSI 1.98%
    PRS 70.18
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.92
    rCSI 9.73%
    PRS 78.75
  • stromal cell of ovary CL0002132
    CSI 0.89
    rCSI 2.46%
    PRS 88.6
  • enterocyte of epithelium of small intestine CL1000334
    CSI 0.87
    rCSI 13.42%
    PRS 89.07
  • retinal ganglion cell CL0000740
    CSI 0.86
    rCSI 1.89%
    PRS 69.23
  • intestinal crypt stem cell of colon CL0009043
    CSI 0.5
    rCSI 3.7%
    PRS 90.6%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.5
    rCSI 1.9%
    PRS 63.5%
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.6
    rCSI 2.2%
    PRS 66.2%
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 0.8
    rCSI 2.5%
    PRS 68.9%
  • GABAergic neuron CL0000617
    CSI 0.8
    rCSI 2.6%
    PRS 67.0%
  • GABAergic amacrine cell CL4030027
    CSI 0.8
    rCSI 2.7%
    PRS 68.9%
  • OFF midget ganglion cell CL4033047
    CSI 0.8
    rCSI 16.4%
    PRS 73.8%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.8
    rCSI 2.6%
    PRS 69.5%
  • ON parasol ganglion cell CL4033052
    CSI 0.8
    rCSI 11.9%
    PRS 74.2%
  • retinal ganglion cell CL0000740
    CSI 0.9
    rCSI 1.9%
    PRS 69.2%
  • enterocyte of epithelium of small intestine CL1000334
    CSI 0.9
    rCSI 13.4%
    PRS 89.1%
  • stromal cell of ovary CL0002132
    CSI 0.9
    rCSI 2.5%
    PRS 88.6%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.9
    rCSI 9.7%
    PRS 78.8%
  • glutamatergic neuron CL0000679
    CSI 1.0
    rCSI 2.0%
    PRS 70.2%
  • ON midget ganglion cell CL4033046
    CSI 1.0
    rCSI 19.9%
    PRS 72.8%
  • endothelial cell of vascular tree CL0002139
    CSI 1.0
    rCSI 5.7%
    PRS 79.4%
  • parietal epithelial cell CL1000452
    CSI 1.1
    rCSI 2.9%
    PRS 75.1%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.1
    rCSI 2.8%
    PRS 73.7%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 1.1
    rCSI 6.6%
    PRS 66.2%
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 1.2
    rCSI 3.2%
    PRS 86.6%
  • retinal cone cell CL0000573
    CSI 1.2
    rCSI 2.0%
    PRS 73.3%
  • Bergmann glial cell CL0000644
    CSI 1.3
    rCSI 1.8%
    PRS 74.2%
  • club cell CL0000158
    CSI 1.4
    rCSI 2.0%
    PRS 77.6%
  • pancreatic ductal cell CL0002079
    CSI 1.4
    rCSI 2.7%
    PRS 85.6%
  • ventricular cardiac muscle cell CL2000046
    CSI 1.5
    rCSI 5.1%
    PRS 89.4%
  • regulatory T cell CL0000815
    CSI 1.5
    rCSI 1.8%
    PRS 81.7%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 1.5
    rCSI 4.8%
    PRS 67.3%
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 1.6
    rCSI 2.1%
    PRS 95.8%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.6
    rCSI 2.8%
    PRS 65.2%
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.6
    rCSI 2.7%
    PRS 65.6%
  • transit amplifying cell of small intestine CL0009012
    CSI 1.7
    rCSI 7.3%
    PRS 89.3%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.7
    rCSI 9.9%
    PRS 79.2%
  • alveolar adventitial fibroblast CL4028006
    CSI 1.8
    rCSI 2.8%
    PRS 84.2%
  • intestinal tuft cell CL0019032
    CSI 1.8
    rCSI 2.8%
    PRS 86.0%
  • direct pathway medium spiny neuron CL4023026
    CSI 1.8
    rCSI 43.4%
    PRS 63.6%
  • intermediate monocyte CL0002393
    CSI 1.8
    rCSI 2.7%
    PRS 87.6%
  • granulocyte CL0000094
    CSI 1.8
    rCSI 2.8%
    PRS 89.0%
  • naive thymus-derived CD4-positive, alpha-beta T cell CL0000895
    CSI 1.9
    rCSI 2.4%
    PRS 94.5%
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.9
    rCSI 46.3%
    PRS 64.2%
  • primordial germ cell CL0000670
    CSI 2.0
    rCSI 9.8%
    PRS 93.5%
  • respiratory basal cell CL0002633
    CSI 2.0
    rCSI 2.1%
    PRS 86.3%
  • sncg GABAergic cortical interneuron CL4023015
    CSI 2.0
    rCSI 3.2%
    PRS 67.0%
  • inhibitory interneuron CL0000498
    CSI 2.0
    rCSI 4.7%
    PRS 71.1%
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.0
    rCSI 4.6%
    PRS 66.5%
  • goblet cell CL0000160
    CSI 2.1
    rCSI 2.0%
    PRS 81.2%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.1
    rCSI 3.0%
    PRS 79.7%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 2.1
    rCSI 5.2%
    PRS 63.6%
  • acinar cell CL0000622
    CSI 2.2
    rCSI 3.2%
    PRS 90.8%
  • amacrine cell CL0000561
    CSI 2.2
    rCSI 6.4%
    PRS 72.5%
  • lung secretory cell CL1000272
    CSI 2.3
    rCSI 5.8%
    PRS 82.9%
  • mucosal invariant T cell CL0000940
    CSI 2.4
    rCSI 1.9%
    PRS 90.4%
  • retina horizontal cell CL0000745
    CSI 2.4
    rCSI 3.6%
    PRS 79.6%
  • pulmonary alveolar type 2 cell CL0002063
    CSI 2.4
    rCSI 3.7%
    PRS 85.9%
  • common myeloid progenitor CL0000049
    CSI 2.4
    rCSI 1.9%
    PRS 84.8%
  • cerebral cortex endothelial cell CL1001602
    CSI 2.5
    rCSI 4.3%
    PRS 74.9%
  • epithelial cell of proximal tubule CL0002306
    CSI 2.5
    rCSI 6.1%
    PRS 75.2%
  • OFF-bipolar cell CL0000750
    CSI 2.5
    rCSI 3.4%
    PRS 83.8%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.5
    rCSI 6.5%
    PRS 83.8%
  • cardiac endothelial cell CL0010008
    CSI 2.7
    rCSI 10.7%
    PRS 82.9%
  • adipocyte CL0000136
    CSI 2.8
    rCSI 3.6%
    PRS 73.3%
  • M cell of gut CL0000682
    CSI 2.8
    rCSI 3.0%
    PRS 87.0%
  • rod bipolar cell CL0000751
    CSI 2.9
    rCSI 5.2%
    PRS 76.4%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 3.0
    rCSI 3.6%
    PRS 89.5%
  • precursor B cell CL0000817
    CSI 3.0
    rCSI 2.6%
    PRS 89.2%
  • ciliated cell CL0000064
    CSI 3.1
    rCSI 5.0%
    PRS 77.6%
  • pancreatic acinar cell CL0002064
    CSI 3.1
    rCSI 4.1%
    PRS 87.7%
  • mononuclear phagocyte CL0000113
    CSI 3.2
    rCSI 7.0%
    PRS 86.1%
  • mesothelial cell CL0000077
    CSI 3.2
    rCSI 12.5%
    PRS 62.0%
  • paneth cell of epithelium of small intestine CL1000343
    CSI 3.2
    rCSI 9.0%
    PRS 88.5%
  • retinal pigment epithelial cell CL0002586
    CSI 3.3
    rCSI 6.5%
    PRS 78.6%
  • retinal rod cell CL0000604
    CSI 3.3
    rCSI 5.8%
    PRS 78.1%
  • ependymal cell CL0000065
    CSI 3.4
    rCSI 6.9%
    PRS 61.9%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.4
    rCSI 8.8%
    PRS 78.5%
  • naive B cell CL0000788
    CSI 3.5
    rCSI 3.0%
    PRS 88.3%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 3.6
    rCSI 2.8%
    PRS 85.8%
  • cardiac muscle cell CL0000746
    CSI 3.7
    rCSI 5.2%
    PRS 73.1%
  • mature T cell CL0002419
    CSI 3.7
    rCSI 2.9%
    PRS 94.1%
  • erythroid lineage cell CL0000764
    CSI 3.7
    rCSI 24.1%
    PRS 90.0%
  • alveolar macrophage CL0000583
    CSI 3.8
    rCSI 6.2%
    PRS 86.3%
  • group 3 innate lymphoid cell CL0001071
    CSI 3.9
    rCSI 2.9%
    PRS 88.1%
  • deuterosomal cell CL4033044
    CSI 3.9
    rCSI 13.2%
    PRS 79.4%
  • ON-bipolar cell CL0000749
    CSI 4.2
    rCSI 6.2%
    PRS 82.3%
  • ciliated epithelial cell CL0000067
    CSI 4.3
    rCSI 3.8%
    PRS 72.5%
  • cerebellar granule cell CL0001031
    CSI 4.5
    rCSI 6.7%
    PRS 76.0%
  • basal cell CL0000646
    CSI 5.0
    rCSI 6.6%
    PRS 81.0%
  • helper T cell CL0000912
    CSI 5.1
    rCSI 7.2%
    PRS 81.1%
  • cerebral cortex neuron CL0010012
    CSI 5.4
    rCSI 22.0%
    PRS 74.6%
  • stem cell CL0000034
    CSI 5.8
    rCSI 5.6%
    PRS 76.8%
  • Schwann cell CL0002573
    CSI 6.2
    rCSI 17.6%
    PRS 78.5%
  • glial cell CL0000125
    CSI 6.2
    rCSI 23.8%
    PRS 74.2%
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 6.3
    rCSI 5.0%
    PRS 93.4%
  • Mueller cell CL0000636
    CSI 6.5
    rCSI 14.8%
    PRS 74.6%
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 6.6
    rCSI 15.7%
    PRS 69.8%
  • epithelial cell CL0000066
    CSI 6.9
    rCSI 10.5%
    PRS 71.8%
  • interneuron CL0000099
    CSI 7.3
    rCSI 14.7%
    PRS 73.8%
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 7.6
    rCSI 5.3%
    PRS 93.5%
  • choroid plexus epithelial cell CL0000706
    CSI 8.1
    rCSI 13.2%
    PRS 72.8%
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 8.1
    rCSI 6.1%
    PRS 95.7%
  • BEST4+ enteroycte CL4030026
    CSI 8.3
    rCSI 10.4%
    PRS 83.4%
  • lung ciliated cell CL1000271
    CSI 8.3
    rCSI 9.6%
    PRS 75.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [OIP5-AS1](/details-gene/729082) is a long non-coding RNA (lncRNA) located on chromosome 15q15.1. Its primary annotated function is to act as a microRNA (miRNA) inhibitor, engaging in post-transcriptional gene silencing by sequestering specific miRNAs. This mechanism suggests a role as a critical regulator of gene expression across a wide array of biological contexts. **Overall**, its expression profile indicates high significance in remarkably diverse cell populations, including immune cells like [innate lymphoid cell](/details-cell/CL0001065)s and [alpha-beta T cell](/details-cell/CL0000789)s, specific neuronal subtypes such as [pvalb GABAergic cortical interneuron](/details-cell/CL4023018)s, and highly proliferative cells like [erythroblast](/details-cell/CL0000765)s, pointing to a fundamental role in multiple distinct cellular lineages. ## Cellular Roles and Expression Landscape The expression pattern of [OIP5-AS1](/details-gene/729082) highlights its importance across several major biological systems, suggesting it is not a lineage-specific marker but rather a functional regulator active in various cell states. - **Immune System:** The gene shows its highest overall significance in [innate lymphoid cell](/details-cell/CL0001065) (CSI: 24.77), followed by strong signals in [alpha-beta T cell](/details-cell/CL0000789)s and [CD16-negative, CD56-bright natural killer cell, human](/details-cell/CL0000938). This suggests a potential role in the regulation of both innate and adaptive lymphocyte development, activation, or function. - **Nervous System:** [OIP5-AS1](/details-gene/729082) is a highly significant transcript in several distinct subtypes of cortical interneurons, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018)s, [sst GABAergic cortical interneuron](/details-cell/CL4023017)s, and [VIP GABAergic cortical interneuron](/details-cell/CL4023016). This specific but broad expression across inhibitory neuron classes may indicate a role in establishing or maintaining neuronal identity or regulating synaptic activity. - **Proliferative and Differentiating Tissues:** High significance in [erythroblast](/details-cell/CL0000765)s and [transit amplifying cell of colon](/details-cell/CL0009011) suggests a function in cell cycle control or differentiation in rapidly dividing progenitor populations. Its activity in these cells may be linked to the precise regulation of protein expression required for hematopoiesis and tissue renewal. - **Specialized Epithelial Cells:** The gene is also prominent in diverse specialized epithelial cells, including [conjunctival epithelial cell](/details-cell/CL1000432), [lung ciliated cell](/details-cell/CL1000271), and [choroid plexus epithelial cell](/details-cell/CL0000706), indicating a potential contribution to the unique functions of these barrier and secretory tissues. ## Pathways and Molecular Function The molecular function of [OIP5-AS1](/details-gene/729082) is directly tied to its role as a competitive endogenous RNA (ceRNA). According to its functional annotations, it exhibits '[Mirna inhibitor activity via base-pairing](/details-go/GO0140869)', a process also described as '[Lncrna-mediated post-transcriptional gene silencing](/details-go/GO0000512)'. This mechanism involves [OIP5-AS1](/details-gene/729082) acting as a "sponge" that binds to and sequesters specific miRNAs, thereby preventing these miRNAs from binding to and degrading their target messenger RNAs (mRNAs). By regulating miRNA availability, [OIP5-AS1](/details-gene/729082) can indirectly fine-tune the expression levels of a multitude of protein-coding genes. This function is consistent with its broad expression pattern, as the specific miRNAs it sponges and the resulting downstream effects would be highly context-dependent. For instance, in [alpha-beta T cell](/details-cell/CL0000789)s, it might regulate miRNAs that target key transcription factors for T cell activation, whereas in [pvalb GABAergic cortical interneuron](/details-cell/CL4023018)s, it could modulate miRNAs controlling synaptic protein synthesis. ## Research Directions The widespread yet significant expression of [OIP5-AS1](/details-gene/729082) across functionally distinct cell types, combined with its role as a miRNA sponge, opens up several avenues for future investigation. **Proposed Hypotheses:** 1. Given its high significance in both innate and adaptive lymphocytes, we hypothesize that **[OIP5-AS1](/details-gene/729082) is a critical regulator of immune cell quiescence and activation.** By sequestering specific miRNAs (e.g., those targeting cell cycle inhibitors or pro-inflammatory cytokines), it may act as a molecular switch that permits rapid transcriptional changes upon immune stimulation. 2. The prominent expression of [OIP5-AS1](/details-gene/729082) in multiple, distinct interneuron subtypes suggests a role in maintaining neuronal identity or function. We hypothesize that **[OIP5-AS1](/details-gene/729082) stabilizes interneuron-specific gene expression programs** by sponging miRNAs that would otherwise repress key transcription factors or ion channels essential for the electrophysiological properties of these neurons. **Experimental Approach:** To test the first hypothesis regarding its role in T cell activation, a compelling experiment would be the **targeted degradation of [OIP5-AS1](/details-gene/729082) in primary human T cells using antisense oligonucleotides (ASOs)**. Following ASO-mediated knockdown, T cells would be activated via TCR stimulation. The functional consequences could be assessed by measuring proliferation (e.g., CFSE dilution assay), cytokine secretion (e.g., IL-2, IFN-gamma via ELISA), and expression of activation markers (CD25, CD69 via flow cytometry). Parallel RNA-sequencing and miRNA-sequencing of knockdown versus control cells would help identify the specific miRNAs it sponges and the downstream mRNA targets that are subsequently dysregulated. **Therapeutic Potential:** As a non-coding RNA, [OIP5-AS1](/details-gene/729082) presents a non-traditional but potentially valuable therapeutic target. Its function as a regulator of miRNA activity makes **inhibition** a plausible therapeutic strategy, achievable with technologies like ASOs. However, its broad expression across many healthy cell types, including immune and neuronal cells, raises significant concerns about potential on-target toxicities with systemic administration. Consequently, its therapeutic potential is likely highest in contexts where it is aberrantly overexpressed, such as in certain cancers or autoimmune conditions. In these scenarios, targeting [OIP5-AS1](/details-gene/729082) could restore normal miRNA function and suppress pathological cell activity, assuming a sufficient therapeutic window exists.