Details for: LINC00513

Gene ID: 100506860

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC00513

Ensembl ID: ENSG00000233559

Description: long intergenic non-protein coding RNA 513

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 24.12
    rCSI 33.14%
    PRS 94.44
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 23.56
    rCSI 28.13%
    PRS 94.03
  • respiratory basal cell CL0002633
    CSI 18.46
    rCSI 19.12%
    PRS 84.7
  • pulmonary alveolar type 2 cell CL0002063
    CSI 16.18
    rCSI 25.1%
    PRS 84.73
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 11.42
    rCSI 10.4%
    PRS 91.48
  • T follicular helper cell CL0002038
    CSI 11.35
    rCSI 8.49%
    PRS 92.28
  • cardiac muscle cell CL0000746
    CSI 8.06
    rCSI 11.56%
    PRS 70.78
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 7.33
    rCSI 5.87%
    PRS 92.79
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 7.24
    rCSI 26.05%
    PRS 61.08
  • blood vessel endothelial cell CL0000071
    CSI 6.81
    rCSI 14.14%
    PRS 77.49
  • epithelial cell of lower respiratory tract CL0002632
    CSI 6.54
    rCSI 5.07%
    PRS 84.49
  • inhibitory interneuron CL0000498
    CSI 5.92
    rCSI 13.68%
    PRS 68.92
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 5.89
    rCSI 5.45%
    PRS 93.62
  • glial cell CL0000125
    CSI 5.89
    rCSI 22.44%
    PRS 72.06
  • stromal cell of ovary CL0002132
    CSI 5.84
    rCSI 16.06%
    PRS 87.28
  • retinal rod cell CL0000604
    CSI 5.04
    rCSI 8.88%
    PRS 76.36
  • retinal cone cell CL0000573
    CSI 4.96
    rCSI 7.98%
    PRS 71.16
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 4.76
    rCSI 2.81%
    PRS 94.19
  • melanocyte CL0000148
    CSI 4.71
    rCSI 3.49%
    PRS 74.6
  • mesothelial cell CL0000077
    CSI 4.69
    rCSI 18.35%
    PRS 59.41
  • helper T cell CL0000912
    CSI 4.69
    rCSI 6.63%
    PRS 79.82
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 4.48
    rCSI 6.11%
    PRS 95.34
  • conjunctival epithelial cell CL1000432
    CSI 4.32
    rCSI 6.6%
    PRS 80.96
  • myeloid dendritic cell CL0000782
    CSI 4.18
    rCSI 6.06%
    PRS 92.19
  • retinal ganglion cell CL0000740
    CSI 4.12
    rCSI 9.1%
    PRS 66.8
  • alveolar adventitial fibroblast CL4028006
    CSI 4.09
    rCSI 6.46%
    PRS 82.24
  • rod bipolar cell CL0000751
    CSI 3.84
    rCSI 6.89%
    PRS 74.21
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 3.8
    rCSI 3.73%
    PRS 92.75
  • neuron CL0000540
    CSI 3.79
    rCSI 10.1%
    PRS 68.39
  • glutamatergic neuron CL0000679
    CSI 3.72
    rCSI 7.64%
    PRS 68.19
  • L6b glutamatergic cortical neuron CL4023038
    CSI 3.61
    rCSI 11.27%
    PRS 64.8
  • chondrocyte CL0000138
    CSI 3.45
    rCSI 5.49%
    PRS 74.04
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 3.28
    rCSI 4.65%
    PRS 77.61
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 3.28
    rCSI 7.97%
    PRS 61.13
  • ON parasol ganglion cell CL4033052
    CSI 3.26
    rCSI 46.27%
    PRS 71.94
  • lung pericyte CL0009089
    CSI 3.19
    rCSI 8.42%
    PRS 87.05
  • adipocyte CL0000136
    CSI 3.19
    rCSI 4.1%
    PRS 70.95
  • mural cell CL0008034
    CSI 3.19
    rCSI 10.79%
    PRS 76.83
  • retinal bipolar neuron CL0000748
    CSI 3.17
    rCSI 5.94%
    PRS 69.39
  • epicardial adipocyte CL1000309
    CSI 3.09
    rCSI 10.06%
    PRS 78.42
  • IgG plasma cell CL0000985
    CSI 3.08
    rCSI 3.68%
    PRS 90.03
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.07
    rCSI 3.82%
    PRS 61.03
  • myofibroblast cell CL0000186
    CSI 3.06
    rCSI 4.23%
    PRS 78.1
  • fibroblast of lung CL0002553
    CSI 2.93
    rCSI 2.73%
    PRS 81.56
  • choroid plexus epithelial cell CL0000706
    CSI 2.92
    rCSI 4.79%
    PRS 70.5
  • alveolar macrophage CL0000583
    CSI 2.88
    rCSI 4.74%
    PRS 84.36
  • intermediate monocyte CL0002393
    CSI 2.84
    rCSI 4.28%
    PRS 85.78
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.82
    rCSI 3.63%
    PRS 64.31
  • mucosal invariant T cell CL0000940
    CSI 2.79
    rCSI 2.26%
    PRS 88.87
  • brush cell of tracheobronchial tree CL0002075
    CSI 2.73
    rCSI 8.11%
    PRS 88.91
  • Mueller cell CL0000636
    CSI 2.7
    rCSI 6.16%
    PRS 72.49
  • Kupffer cell CL0000091
    CSI 2.65
    rCSI 6.07%
    PRS 81.62
  • myoepithelial cell CL0000185
    CSI 2.59
    rCSI 6.54%
    PRS 85.62
  • hepatic stellate cell CL0000632
    CSI 2.55
    rCSI 9.57%
    PRS 73.54
  • endocardial cell CL0002350
    CSI 2.49
    rCSI 11.92%
    PRS 77.16
  • ON midget ganglion cell CL4033046
    CSI 2.48
    rCSI 50.42%
    PRS 70.73
  • cerebellar granule cell CL0001031
    CSI 2.47
    rCSI 3.63%
    PRS 73.9
  • bronchus fibroblast of lung CL2000093
    CSI 2.46
    rCSI 2%
    PRS 80.15
  • lung secretory cell CL1000272
    CSI 2.42
    rCSI 5.98%
    PRS 80.76
  • OFF midget ganglion cell CL4033047
    CSI 2.42
    rCSI 49.2%
    PRS 71.85
  • fibroblast of cardiac tissue CL0002548
    CSI 2.41
    rCSI 11.55%
    PRS 80.67
  • glioblast CL0000030
    CSI 2.33
    rCSI 3.72%
    PRS 72.45
  • interneuron CL0000099
    CSI 2.3
    rCSI 4.62%
    PRS 71.28
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.23
    rCSI 53.92%
    PRS 61.94
  • mononuclear phagocyte CL0000113
    CSI 2.23
    rCSI 4.9%
    PRS 84.38
  • Schwann cell CL0002573
    CSI 2.21
    rCSI 6.27%
    PRS 76.56
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.19
    rCSI 3.98%
    PRS 72.43
  • direct pathway medium spiny neuron CL4023026
    CSI 2.12
    rCSI 50.8%
    PRS 61.37
  • renal interstitial pericyte CL1001318
    CSI 2.09
    rCSI 5.77%
    PRS 76.04
  • CD4-positive helper T cell CL0000492
    CSI 2.07
    rCSI 1.56%
    PRS 91.76
  • alveolar type 1 fibroblast cell CL4028004
    CSI 2.06
    rCSI 2.25%
    PRS 82.62
  • paneth cell of epithelium of small intestine CL1000343
    CSI 2.01
    rCSI 5.65%
    PRS 87.33
  • amacrine cell CL0000561
    CSI 2.01
    rCSI 5.84%
    PRS 70.48
  • T-helper 17 cell CL0000899
    CSI 1.99
    rCSI 1.58%
    PRS 95.46
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.96
    rCSI 2.34%
    PRS 63.24
  • lung neuroendocrine cell CL1000223
    CSI 1.94
    rCSI 2.88%
    PRS 84.62
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.94
    rCSI 3.1%
    PRS 84.36
  • IgA plasma cell CL0000987
    CSI 1.94
    rCSI 1.98%
    PRS 87.77
  • cardiac endothelial cell CL0010008
    CSI 1.93
    rCSI 7.8%
    PRS 80.56
  • cardiac neuron CL0010022
    CSI 1.91
    rCSI 6.1%
    PRS 78.37
  • memory T cell CL0000813
    CSI 1.89
    rCSI 3.64%
    PRS 95.58
  • endothelial cell of vascular tree CL0002139
    CSI 1.88
    rCSI 10.29%
    PRS 77.18
  • contractile cell CL0000183
    CSI 1.86
    rCSI 5.48%
    PRS 79.66
  • Hofbauer cell CL3000001
    CSI 1.81
    rCSI 3.41%
    PRS 88.18
  • basal cell CL0000646
    CSI 1.8
    rCSI 2.41%
    PRS 79.13
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 1.8
    rCSI 1.88%
    PRS 92.51
  • T-helper 1 cell CL0000545
    CSI 1.78
    rCSI 3.22%
    PRS 94.39
  • stromal cell CL0000499
    CSI 1.71
    rCSI 4.81%
    PRS 75.83
  • granulocyte CL0000094
    CSI 1.71
    rCSI 2.61%
    PRS 87.6
  • BEST4+ enteroycte CL4030026
    CSI 1.66
    rCSI 2.07%
    PRS 81.62
  • vascular leptomeningeal cell CL4023051
    CSI 1.66
    rCSI 2.91%
    PRS 75
  • small intestine goblet cell CL1000495
    CSI 1.61
    rCSI 3.52%
    PRS 86.03
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.53
    rCSI 1.18%
    PRS 83.61
  • luminal epithelial cell of mammary gland CL0002326
    CSI 1.49
    rCSI 2.71%
    PRS 90.21
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.49
    rCSI 2.63%
    PRS 62.52
  • macroglial cell CL0000126
    CSI 1.49
    rCSI 3.83%
    PRS 77.49
  • Bergmann glial cell CL0000644
    CSI 1.47
    rCSI 2.02%
    PRS 72.33
  • retina horizontal cell CL0000745
    CSI 1.45
    rCSI 2.21%
    PRS 77.68
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 1.44
    rCSI 8.49%
    PRS 63.81
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.43
    rCSI 3.69%
    PRS 76.35
  • blood vessel smooth muscle cell CL0019018
    CSI 0.6
    rCSI 5.2%
    PRS 75.2%
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 0.7
    rCSI 2.8%
    PRS 63.7%
  • invaginating midget bipolar cell CL4033034
    CSI 0.8
    rCSI 4.6%
    PRS 72.4%
  • enteroglial cell CL4040002
    CSI 0.8
    rCSI 4.1%
    PRS 82.1%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.8
    rCSI 2.5%
    PRS 67.1%
  • regular atrial cardiac myocyte CL0002129
    CSI 0.8
    rCSI 2.6%
    PRS 77.6%
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.8
    rCSI 5.2%
    PRS 72.7%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 0.9
    rCSI 1.9%
    PRS 74.5%
  • GABAergic amacrine cell CL4030027
    CSI 0.9
    rCSI 3.2%
    PRS 67.0%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.0
    rCSI 1.2%
    PRS 61.8%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.0
    rCSI 6.0%
    PRS 77.4%
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.1
    rCSI 1.8%
    PRS 63.1%
  • mesenchymal stem cell of adipose tissue CL0002570
    CSI 1.1
    rCSI 6.1%
    PRS 83.7%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 1.1
    rCSI 3.2%
    PRS 95.2%
  • natural T-regulatory cell CL0000903
    CSI 1.2
    rCSI 2.2%
    PRS 96.7%
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 1.3
    rCSI 2.8%
    PRS 68.5%
  • endothelial cell of placenta CL0009092
    CSI 1.3
    rCSI 6.6%
    PRS 87.9%
  • keratocyte CL0002363
    CSI 1.4
    rCSI 3.3%
    PRS 83.8%
  • lung ciliated cell CL1000271
    CSI 1.4
    rCSI 1.7%
    PRS 73.3%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.4
    rCSI 3.7%
    PRS 76.4%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 1.4
    rCSI 8.5%
    PRS 63.8%
  • retina horizontal cell CL0000745
    CSI 1.5
    rCSI 2.2%
    PRS 77.7%
  • Bergmann glial cell CL0000644
    CSI 1.5
    rCSI 2.0%
    PRS 72.3%
  • macroglial cell CL0000126
    CSI 1.5
    rCSI 3.8%
    PRS 77.5%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.5
    rCSI 2.6%
    PRS 62.5%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 1.5
    rCSI 2.7%
    PRS 90.2%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.5
    rCSI 1.2%
    PRS 83.6%
  • small intestine goblet cell CL1000495
    CSI 1.6
    rCSI 3.5%
    PRS 86.0%
  • vascular leptomeningeal cell CL4023051
    CSI 1.7
    rCSI 2.9%
    PRS 75.0%
  • BEST4+ enteroycte CL4030026
    CSI 1.7
    rCSI 2.1%
    PRS 81.6%
  • granulocyte CL0000094
    CSI 1.7
    rCSI 2.6%
    PRS 87.6%
  • stromal cell CL0000499
    CSI 1.7
    rCSI 4.8%
    PRS 75.8%
  • T-helper 1 cell CL0000545
    CSI 1.8
    rCSI 3.2%
    PRS 94.4%
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 1.8
    rCSI 1.9%
    PRS 92.5%
  • basal cell CL0000646
    CSI 1.8
    rCSI 2.4%
    PRS 79.1%
  • Hofbauer cell CL3000001
    CSI 1.8
    rCSI 3.4%
    PRS 88.2%
  • contractile cell CL0000183
    CSI 1.9
    rCSI 5.5%
    PRS 79.7%
  • endothelial cell of vascular tree CL0002139
    CSI 1.9
    rCSI 10.3%
    PRS 77.2%
  • memory T cell CL0000813
    CSI 1.9
    rCSI 3.6%
    PRS 95.6%
  • cardiac neuron CL0010022
    CSI 1.9
    rCSI 6.1%
    PRS 78.4%
  • cardiac endothelial cell CL0010008
    CSI 1.9
    rCSI 7.8%
    PRS 80.6%
  • IgA plasma cell CL0000987
    CSI 1.9
    rCSI 2.0%
    PRS 87.8%
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.9
    rCSI 3.1%
    PRS 84.4%
  • lung neuroendocrine cell CL1000223
    CSI 1.9
    rCSI 2.9%
    PRS 84.6%
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.0
    rCSI 2.3%
    PRS 63.2%
  • T-helper 17 cell CL0000899
    CSI 2.0
    rCSI 1.6%
    PRS 95.5%
  • amacrine cell CL0000561
    CSI 2.0
    rCSI 5.8%
    PRS 70.5%
  • paneth cell of epithelium of small intestine CL1000343
    CSI 2.0
    rCSI 5.7%
    PRS 87.3%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 2.1
    rCSI 2.3%
    PRS 82.6%
  • CD4-positive helper T cell CL0000492
    CSI 2.1
    rCSI 1.6%
    PRS 91.8%
  • renal interstitial pericyte CL1001318
    CSI 2.1
    rCSI 5.8%
    PRS 76.0%
  • direct pathway medium spiny neuron CL4023026
    CSI 2.1
    rCSI 50.8%
    PRS 61.4%
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.2
    rCSI 4.0%
    PRS 72.4%
  • Schwann cell CL0002573
    CSI 2.2
    rCSI 6.3%
    PRS 76.6%
  • mononuclear phagocyte CL0000113
    CSI 2.2
    rCSI 4.9%
    PRS 84.4%
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.2
    rCSI 53.9%
    PRS 61.9%
  • interneuron CL0000099
    CSI 2.3
    rCSI 4.6%
    PRS 71.3%
  • glioblast CL0000030
    CSI 2.3
    rCSI 3.7%
    PRS 72.5%
  • fibroblast of cardiac tissue CL0002548
    CSI 2.4
    rCSI 11.6%
    PRS 80.7%
  • OFF midget ganglion cell CL4033047
    CSI 2.4
    rCSI 49.2%
    PRS 71.9%
  • lung secretory cell CL1000272
    CSI 2.4
    rCSI 6.0%
    PRS 80.8%
  • bronchus fibroblast of lung CL2000093
    CSI 2.5
    rCSI 2.0%
    PRS 80.2%
  • cerebellar granule cell CL0001031
    CSI 2.5
    rCSI 3.6%
    PRS 73.9%
  • ON midget ganglion cell CL4033046
    CSI 2.5
    rCSI 50.4%
    PRS 70.7%
  • endocardial cell CL0002350
    CSI 2.5
    rCSI 11.9%
    PRS 77.2%
  • hepatic stellate cell CL0000632
    CSI 2.6
    rCSI 9.6%
    PRS 73.5%
  • myoepithelial cell CL0000185
    CSI 2.6
    rCSI 6.5%
    PRS 85.6%
  • Kupffer cell CL0000091
    CSI 2.7
    rCSI 6.1%
    PRS 81.6%
  • Mueller cell CL0000636
    CSI 2.7
    rCSI 6.2%
    PRS 72.5%
  • brush cell of tracheobronchial tree CL0002075
    CSI 2.7
    rCSI 8.1%
    PRS 88.9%
  • mucosal invariant T cell CL0000940
    CSI 2.8
    rCSI 2.3%
    PRS 88.9%
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.8
    rCSI 3.6%
    PRS 64.3%
  • intermediate monocyte CL0002393
    CSI 2.8
    rCSI 4.3%
    PRS 85.8%
  • alveolar macrophage CL0000583
    CSI 2.9
    rCSI 4.7%
    PRS 84.4%
  • choroid plexus epithelial cell CL0000706
    CSI 2.9
    rCSI 4.8%
    PRS 70.5%
  • fibroblast of lung CL0002553
    CSI 2.9
    rCSI 2.7%
    PRS 81.6%
  • myofibroblast cell CL0000186
    CSI 3.1
    rCSI 4.2%
    PRS 78.1%
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.1
    rCSI 3.8%
    PRS 61.0%
  • IgG plasma cell CL0000985
    CSI 3.1
    rCSI 3.7%
    PRS 90.0%
  • epicardial adipocyte CL1000309
    CSI 3.1
    rCSI 10.1%
    PRS 78.4%
  • retinal bipolar neuron CL0000748
    CSI 3.2
    rCSI 5.9%
    PRS 69.4%
  • mural cell CL0008034
    CSI 3.2
    rCSI 10.8%
    PRS 76.8%
  • adipocyte CL0000136
    CSI 3.2
    rCSI 4.1%
    PRS 71.0%
  • lung pericyte CL0009089
    CSI 3.2
    rCSI 8.4%
    PRS 87.1%
  • ON parasol ganglion cell CL4033052
    CSI 3.3
    rCSI 46.3%
    PRS 71.9%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 3.3
    rCSI 8.0%
    PRS 61.1%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 3.3
    rCSI 4.7%
    PRS 77.6%
  • chondrocyte CL0000138
    CSI 3.5
    rCSI 5.5%
    PRS 74.0%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 3.6
    rCSI 11.3%
    PRS 64.8%
  • glutamatergic neuron CL0000679
    CSI 3.7
    rCSI 7.6%
    PRS 68.2%
  • neuron CL0000540
    CSI 3.8
    rCSI 10.1%
    PRS 68.4%
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 3.8
    rCSI 3.7%
    PRS 92.8%
  • rod bipolar cell CL0000751
    CSI 3.8
    rCSI 6.9%
    PRS 74.2%
  • alveolar adventitial fibroblast CL4028006
    CSI 4.1
    rCSI 6.5%
    PRS 82.2%
  • retinal ganglion cell CL0000740
    CSI 4.1
    rCSI 9.1%
    PRS 66.8%
  • myeloid dendritic cell CL0000782
    CSI 4.2
    rCSI 6.1%
    PRS 92.2%
  • conjunctival epithelial cell CL1000432
    CSI 4.3
    rCSI 6.6%
    PRS 81.0%
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 4.5
    rCSI 6.1%
    PRS 95.3%
  • helper T cell CL0000912
    CSI 4.7
    rCSI 6.6%
    PRS 79.8%
  • mesothelial cell CL0000077
    CSI 4.7
    rCSI 18.4%
    PRS 59.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC00513](/details-gene/100506860) is a long intergenic non-protein coding RNA (lncRNA) located on chromosome 7. Expression data strongly indicates a primary role in the immune system, particularly within cytotoxic T lymphocyte populations. It is most significantly expressed in both [CD4-positive, alpha-beta cytotoxic T cell](/details-cell/CL0000934) and [CD8-positive, alpha-beta cytotoxic T cell](/details-cell/CL0000794), suggesting a function related to T cell effector mechanisms. Additionally, [LINC00513](/details-gene/100506860) shows significant expression in various epithelial cells of the respiratory system, including [respiratory basal cell](/details-cell/CL0002633) and [pulmonary alveolar type 2 cell](/details-cell/CL0002063), pointing to potential roles in lung tissue homeostasis or response to environmental stimuli. ## Cellular Roles and Expression Landscape The expression profile of [LINC00513](/details-gene/100506860) highlights its specialized function in distinct cellular contexts. **Overall**, the gene's significance is highest in mature, cytotoxic T cell lineages. * **Immune System:** The gene is a prominent marker for cytotoxic lymphocytes, with the highest significance scores observed in [CD4-positive, alpha-beta cytotoxic T cell](/details-cell/CL0000934) (CSI: 24.12) and [CD8-positive, alpha-beta cytotoxic T cell](/details-cell/CL0000794) (CSI: 23.56). Its relevance extends to other T cell subsets, including [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913), [T follicular helper cell](/details-cell/CL0002038), and developing [CD4-positive, alpha-beta thymocyte](/details-cell/CL0000810), which is consistent with a role in T cell differentiation, activation, and effector function. * **Respiratory System:** A secondary but highly significant expression pattern is observed in the lung epithelium. [LINC00513](/details-gene/100506860) is highly expressed in [respiratory basal cell](/details-cell/CL0002633) (CSI: 18.46) and [pulmonary alveolar type 2 cell](/details-cell/CL0002063) (CSI: 16.18). This dual-expression pattern in both immune and epithelial compartments suggests it may be involved in immune-epithelial crosstalk, host defense, or tissue repair processes within the lung. * **Other Tissues:** Moderate expression is also noted in a diverse set of other cell types, such as [cardiac muscle cell](/details-cell/CL0000746), various neurons including [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041), and [blood vessel endothelial cell](/details-cell/CL0000071). This suggests that while its primary role appears to be in immunology and lung biology, it may have broader, albeit less prominent, functions in other tissues. ## Pathways and Molecular Function Detailed functional annotation for [LINC00513](/details-gene/100506860) is not available in the provided dataset. However, its strong and specific expression pattern allows for functional inference. Given its high significance in cytotoxic and memory T cells, [LINC00513](/details-gene/100506860) may function as a regulatory lncRNA involved in molecular pathways governing T cell activation, differentiation into effector lineages, or the execution of cytotoxic programs. Its presence in respiratory epithelial cells suggests a potential role in pathways related to cellular stress response, barrier function, or inflammatory signaling in the lung. ## Research Directions The distinct expression pattern of [LINC00513](/details-gene/100506860) in both cytotoxic T cells and respiratory epithelium presents several avenues for future investigation. Its function as a lncRNA suggests it may act by regulating the expression of nearby or distal protein-coding genes critical to these cell types. **Testable Hypotheses:** 1. [LINC00513](/details-gene/100506860) is a positive regulator of gene programs essential for T cell cytotoxicity. Its upregulation during T cell activation may be required for the full expression of effector molecules like granzymes and perforin. 2. In the lung, [LINC00513](/details-gene/100506860) expression in [respiratory basal cell](/details-cell/CL0002633) and [pulmonary alveolar type 2 cell](/details-cell/CL0002063) is induced by viral infection or tissue damage, where it helps orchestrate the local immune response or tissue repair processes. **Proposed Experimental Approach:** To test the first hypothesis regarding its role in T cell function, a loss-of-function study could be performed. Primary human CD8+ T cells could be isolated and transduced with lentiviral vectors expressing shRNAs or a CRISPR-interference (CRISPRi) system targeting [LINC00513](/details-gene/100506860). Following T cell activation, the impact of its knockdown on cell proliferation, cytokine production (e.g., IFN-gamma, TNF-alpha), and cytotoxic potential could be measured using flow cytometry and in vitro killing assays against target tumor cells. RNA-sequencing of knockdown versus control cells would further identify the specific gene expression pathways regulated by [LINC00513](/details-gene/100506860). **Therapeutic Potential:** As a lncRNA, [LINC00513](/details-gene/100506860) presents a potential target for RNA-based therapeutics, such as antisense oligonucleotides (ASOs). If it is confirmed to be a positive regulator of T cell cytotoxicity, developing strategies to enhance its expression or activity could be a novel approach to boost anti-tumor immunity in cancer immunotherapy. Conversely, if its expression in the lung is found to drive pathological inflammation in diseases like asthma or chronic obstructive pulmonary disease (COPD), ASO-mediated inhibition of [LINC00513](/details-gene/100506860) could represent a targeted anti-inflammatory strategy. Its therapeutic utility is therefore highly context-dependent and warrants further investigation.