Details for: CCDC171

Gene ID: 203238

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CCDC171

Ensembl ID: ENSG00000164989

Description: coiled-coil domain containing 171

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 16.02
    rCSI 38.93%
    PRS 72.01
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 15.96
    rCSI 26.78%
    PRS 74.3
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 12.46
    rCSI 44.85%
    PRS 72.25
  • alveolar adventitial fibroblast CL4028006
    CSI 10.47
    rCSI 16.54%
    PRS 89.46
  • blood vessel endothelial cell CL0000071
    CSI 10.32
    rCSI 21.41%
    PRS 86.61
  • retinal ganglion cell CL0000740
    CSI 10.07
    rCSI 22.25%
    PRS 77.05
  • ciliated epithelial cell CL0000067
    CSI 9.47
    rCSI 8.33%
    PRS 79.53
  • L6b glutamatergic cortical neuron CL4023038
    CSI 9.46
    rCSI 29.56%
    PRS 75.72
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 9.4
    rCSI 35.51%
    PRS 74.6
  • adipocyte CL0000136
    CSI 8.89
    rCSI 11.42%
    PRS 79.81
  • radial glial cell CL0000681
    CSI 8.07
    rCSI 11.22%
    PRS 86.95
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 7.37
    rCSI 43.39%
    PRS 74.75
  • retinal rod cell CL0000604
    CSI 6.95
    rCSI 12.25%
    PRS 84.38
  • GABAergic amacrine cell CL4030027
    CSI 6.85
    rCSI 23.46%
    PRS 75.6
  • melanocyte CL0000148
    CSI 6.28
    rCSI 4.65%
    PRS 84.28
  • mesothelial cell CL0000077
    CSI 6.2
    rCSI 24.24%
    PRS 70.46
  • central nervous system neuron CL2000029
    CSI 5.99
    rCSI 44.01%
    PRS 79.08
  • glioblast CL0000030
    CSI 5.67
    rCSI 9.05%
    PRS 80.81
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 5.63
    rCSI 6.5%
    PRS 81.29
  • sncg GABAergic cortical interneuron CL4023015
    CSI 5.51
    rCSI 8.87%
    PRS 75.47
  • small intestine goblet cell CL1000495
    CSI 5.32
    rCSI 11.66%
    PRS 91.36
  • ependymal cell CL0000065
    CSI 5.32
    rCSI 10.79%
    PRS 70.1
  • neural crest cell CL0011012
    CSI 5.26
    rCSI 4.16%
    PRS 80.63
  • neuron CL0000540
    CSI 5.23
    rCSI 13.92%
    PRS 76.36
  • neural cell CL0002319
    CSI 4.85
    rCSI 18.28%
    PRS 73.04
  • cerebral cortex endothelial cell CL1001602
    CSI 4.83
    rCSI 8.36%
    PRS 82.54
  • Mueller cell CL0000636
    CSI 4.82
    rCSI 11%
    PRS 81.46
  • interneuron CL0000099
    CSI 4.81
    rCSI 9.66%
    PRS 81.76
  • sst GABAergic cortical interneuron CL4023017
    CSI 4.66
    rCSI 6.01%
    PRS 75.45
  • regular ventricular cardiac myocyte CL0002131
    CSI 4.59
    rCSI 28.67%
    PRS 81.82
  • pulmonary alveolar type 2 cell CL0002063
    CSI 4.51
    rCSI 7%
    PRS 90.04
  • inhibitory interneuron CL0000498
    CSI 4.4
    rCSI 10.15%
    PRS 78.83
  • retinal bipolar neuron CL0000748
    CSI 4.38
    rCSI 8.2%
    PRS 79.3
  • endocardial cell CL0002350
    CSI 4.15
    rCSI 19.88%
    PRS 84.61
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 4.13
    rCSI 10.77%
    PRS 89.87
  • hematopoietic precursor cell CL0008001
    CSI 4.08
    rCSI 4.19%
    PRS 95.07
  • glial cell CL0000125
    CSI 4.04
    rCSI 15.38%
    PRS 81.45
  • chondrocyte CL0000138
    CSI 4.03
    rCSI 6.4%
    PRS 83.44
  • VIP GABAergic cortical interneuron CL4023016
    CSI 3.98
    rCSI 4.76%
    PRS 74.43
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 3.96
    rCSI 7%
    PRS 73.8
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 3.94
    rCSI 3.56%
    PRS 87.44
  • cardiac neuron CL0010022
    CSI 3.9
    rCSI 12.47%
    PRS 86.74
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 3.72
    rCSI 8.89%
    PRS 77.38
  • vascular leptomeningeal cell CL4023051
    CSI 3.71
    rCSI 6.51%
    PRS 84.43
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 3.71
    rCSI 10.01%
    PRS 91
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 3.64
    rCSI 31.44%
    PRS 82.88
  • choroid plexus epithelial cell CL0000706
    CSI 3.64
    rCSI 5.95%
    PRS 80.66
  • peripheral nervous system neuron CL2000032
    CSI 3.63
    rCSI 4.94%
    PRS 81.85
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.57
    rCSI 4.44%
    PRS 72.08
  • cerebellar granule cell CL0001031
    CSI 3.5
    rCSI 5.15%
    PRS 82.83
  • rod bipolar cell CL0000751
    CSI 3.43
    rCSI 6.16%
    PRS 83.11
  • cardiac endothelial cell CL0010008
    CSI 3.12
    rCSI 12.6%
    PRS 89.16
  • hematopoietic stem cell CL0000037
    CSI 3.11
    rCSI 2.07%
    PRS 90.37
  • hepatic stellate cell CL0000632
    CSI 3.1
    rCSI 11.62%
    PRS 83.28
  • pulmonary alveolar type 1 cell CL0002062
    CSI 3.05
    rCSI 17.57%
    PRS 85.34
  • GABAergic neuron CL0000617
    CSI 3
    rCSI 10.04%
    PRS 74.48
  • epithelial cell of proximal tubule CL0002306
    CSI 2.93
    rCSI 7.15%
    PRS 81.51
  • ciliated cell CL0000064
    CSI 2.91
    rCSI 4.72%
    PRS 82.97
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.87
    rCSI 6.44%
    PRS 74.93
  • alveolar type 1 fibroblast cell CL4028004
    CSI 2.87
    rCSI 3.14%
    PRS 90.01
  • Bergmann glial cell CL0000644
    CSI 2.8
    rCSI 3.83%
    PRS 80.54
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.79
    rCSI 7.07%
    PRS 81.54
  • common myeloid progenitor CL0000049
    CSI 2.74
    rCSI 2.22%
    PRS 90.28
  • glutamatergic neuron CL0000679
    CSI 2.72
    rCSI 5.58%
    PRS 76.58
  • glycinergic amacrine cell CL4030028
    CSI 2.71
    rCSI 7.05%
    PRS 82.54
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.66
    rCSI 3.77%
    PRS 85.94
  • renal beta-intercalated cell CL0002201
    CSI 2.65
    rCSI 6.33%
    PRS 88.55
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 2.65
    rCSI 8.7%
    PRS 76.31
  • multi-ciliated epithelial cell CL0005012
    CSI 2.54
    rCSI 2.53%
    PRS 82.91
  • lung secretory cell CL1000272
    CSI 2.53
    rCSI 6.27%
    PRS 88.89
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 2.53
    rCSI 6.53%
    PRS 85.17
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.52
    rCSI 1.95%
    PRS 91.37
  • fibroblast of cardiac tissue CL0002548
    CSI 2.4
    rCSI 11.51%
    PRS 89.14
  • myoepithelial cell CL0000185
    CSI 2.34
    rCSI 5.92%
    PRS 91.42
  • ON midget ganglion cell CL4033046
    CSI 2.29
    rCSI 46.72%
    PRS 79.39
  • cardiac muscle cell CL0000746
    CSI 2.29
    rCSI 3.29%
    PRS 80.18
  • parietal epithelial cell CL1000452
    CSI 2.22
    rCSI 5.93%
    PRS 82.45
  • retinal pigment epithelial cell CL0002586
    CSI 2.21
    rCSI 4.4%
    PRS 84.78
  • direct pathway medium spiny neuron CL4023026
    CSI 2.2
    rCSI 52.56%
    PRS 71.95
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 2.19
    rCSI 6.86%
    PRS 77.62
  • OFF midget ganglion cell CL4033047
    CSI 2.13
    rCSI 43.31%
    PRS 80.22
  • H2 horizontal cell CL0004218
    CSI 2.09
    rCSI 10.37%
    PRS 82.92
  • deuterosomal cell CL4033044
    CSI 2.05
    rCSI 6.93%
    PRS 83.93
  • conjunctival epithelial cell CL1000432
    CSI 2.04
    rCSI 3.12%
    PRS 87.9
  • retinal cone cell CL0000573
    CSI 1.96
    rCSI 3.16%
    PRS 80.34
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 1.93
    rCSI 4.41%
    PRS 81.79
  • renal principal cell CL0005009
    CSI 1.92
    rCSI 4.98%
    PRS 88.01
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 1.88
    rCSI 3.42%
    PRS 81.77
  • neural progenitor cell CL0011020
    CSI 1.86
    rCSI 8.2%
    PRS 77.64
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 1.83
    rCSI 3.98%
    PRS 77.14
  • stromal cell CL0000499
    CSI 1.8
    rCSI 5.07%
    PRS 84.33
  • amacrine cell CL0000561
    CSI 1.73
    rCSI 5.01%
    PRS 79.59
  • lung ciliated cell CL1000271
    CSI 1.66
    rCSI 1.92%
    PRS 82.71
  • macroglial cell CL0000126
    CSI 1.6
    rCSI 4.11%
    PRS 84.55
  • podocyte CL0000653
    CSI 1.59
    rCSI 7.07%
    PRS 89.11
  • ON parasol ganglion cell CL4033052
    CSI 1.58
    rCSI 22.48%
    PRS 80.61
  • renal interstitial pericyte CL1001318
    CSI 1.5
    rCSI 4.12%
    PRS 85.35
  • microcirculation associated smooth muscle cell CL0008035
    CSI 1.49
    rCSI 4.31%
    PRS 87.65
  • extravillous trophoblast CL0008036
    CSI 1.45
    rCSI 1.8%
    PRS 87.12
  • S cone cell CL0003050
    CSI 1.33
    rCSI 5.85%
    PRS 83.46
  • medium spiny neuron CL1001474
    CSI 0.3
    rCSI 2.6%
    PRS 79.7%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.5
    rCSI 4.9%
    PRS 84.5%
  • starburst amacrine cell CL0004232
    CSI 0.7
    rCSI 5.4%
    PRS 75.6%
  • flat midget bipolar cell CL4033033
    CSI 0.7
    rCSI 4.6%
    PRS 78.8%
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 0.7
    rCSI 3.5%
    PRS 96.8%
  • invaginating midget bipolar cell CL4033034
    CSI 0.8
    rCSI 4.6%
    PRS 79.9%
  • diffuse bipolar 3b cell CL4033030
    CSI 0.8
    rCSI 5.3%
    PRS 82.4%
  • blood vessel smooth muscle cell CL0019018
    CSI 0.8
    rCSI 6.5%
    PRS 84.9%
  • diffuse bipolar 3a cell CL4033029
    CSI 1.0
    rCSI 6.4%
    PRS 80.6%
  • H1 horizontal cell CL0004217
    CSI 1.0
    rCSI 4.0%
    PRS 82.6%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 1.0
    rCSI 2.5%
    PRS 96.1%
  • keratocyte CL0002363
    CSI 1.1
    rCSI 2.6%
    PRS 89.9%
  • basal cell of epidermis CL0002187
    CSI 1.1
    rCSI 2.0%
    PRS 59.1%
  • mesangial cell CL0000650
    CSI 1.1
    rCSI 4.6%
    PRS 93.8%
  • regular atrial cardiac myocyte CL0002129
    CSI 1.2
    rCSI 3.8%
    PRS 85.2%
  • OFFx cell CL4033036
    CSI 1.2
    rCSI 5.8%
    PRS 79.2%
  • S cone cell CL0003050
    CSI 1.3
    rCSI 5.9%
    PRS 83.5%
  • extravillous trophoblast CL0008036
    CSI 1.5
    rCSI 1.8%
    PRS 87.1%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 1.5
    rCSI 4.3%
    PRS 87.7%
  • renal interstitial pericyte CL1001318
    CSI 1.5
    rCSI 4.1%
    PRS 85.4%
  • ON parasol ganglion cell CL4033052
    CSI 1.6
    rCSI 22.5%
    PRS 80.6%
  • podocyte CL0000653
    CSI 1.6
    rCSI 7.1%
    PRS 89.1%
  • macroglial cell CL0000126
    CSI 1.6
    rCSI 4.1%
    PRS 84.6%
  • lung ciliated cell CL1000271
    CSI 1.7
    rCSI 1.9%
    PRS 82.7%
  • amacrine cell CL0000561
    CSI 1.7
    rCSI 5.0%
    PRS 79.6%
  • stromal cell CL0000499
    CSI 1.8
    rCSI 5.1%
    PRS 84.3%
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 1.8
    rCSI 4.0%
    PRS 77.1%
  • neural progenitor cell CL0011020
    CSI 1.9
    rCSI 8.2%
    PRS 77.6%
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 1.9
    rCSI 3.4%
    PRS 81.8%
  • renal principal cell CL0005009
    CSI 1.9
    rCSI 5.0%
    PRS 88.0%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 1.9
    rCSI 4.4%
    PRS 81.8%
  • retinal cone cell CL0000573
    CSI 2.0
    rCSI 3.2%
    PRS 80.3%
  • conjunctival epithelial cell CL1000432
    CSI 2.0
    rCSI 3.1%
    PRS 87.9%
  • deuterosomal cell CL4033044
    CSI 2.1
    rCSI 6.9%
    PRS 83.9%
  • H2 horizontal cell CL0004218
    CSI 2.1
    rCSI 10.4%
    PRS 82.9%
  • OFF midget ganglion cell CL4033047
    CSI 2.1
    rCSI 43.3%
    PRS 80.2%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 2.2
    rCSI 6.9%
    PRS 77.6%
  • direct pathway medium spiny neuron CL4023026
    CSI 2.2
    rCSI 52.6%
    PRS 72.0%
  • retinal pigment epithelial cell CL0002586
    CSI 2.2
    rCSI 4.4%
    PRS 84.8%
  • parietal epithelial cell CL1000452
    CSI 2.2
    rCSI 5.9%
    PRS 82.5%
  • cardiac muscle cell CL0000746
    CSI 2.3
    rCSI 3.3%
    PRS 80.2%
  • ON midget ganglion cell CL4033046
    CSI 2.3
    rCSI 46.7%
    PRS 79.4%
  • myoepithelial cell CL0000185
    CSI 2.3
    rCSI 5.9%
    PRS 91.4%
  • fibroblast of cardiac tissue CL0002548
    CSI 2.4
    rCSI 11.5%
    PRS 89.1%
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.5
    rCSI 2.0%
    PRS 91.4%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 2.5
    rCSI 6.5%
    PRS 85.2%
  • lung secretory cell CL1000272
    CSI 2.5
    rCSI 6.3%
    PRS 88.9%
  • multi-ciliated epithelial cell CL0005012
    CSI 2.5
    rCSI 2.5%
    PRS 82.9%
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 2.7
    rCSI 8.7%
    PRS 76.3%
  • renal beta-intercalated cell CL0002201
    CSI 2.7
    rCSI 6.3%
    PRS 88.6%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.7
    rCSI 3.8%
    PRS 85.9%
  • glycinergic amacrine cell CL4030028
    CSI 2.7
    rCSI 7.1%
    PRS 82.5%
  • glutamatergic neuron CL0000679
    CSI 2.7
    rCSI 5.6%
    PRS 76.6%
  • common myeloid progenitor CL0000049
    CSI 2.7
    rCSI 2.2%
    PRS 90.3%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.8
    rCSI 7.1%
    PRS 81.5%
  • Bergmann glial cell CL0000644
    CSI 2.8
    rCSI 3.8%
    PRS 80.5%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 2.9
    rCSI 3.1%
    PRS 90.0%
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.9
    rCSI 6.4%
    PRS 74.9%
  • ciliated cell CL0000064
    CSI 2.9
    rCSI 4.7%
    PRS 83.0%
  • epithelial cell of proximal tubule CL0002306
    CSI 2.9
    rCSI 7.2%
    PRS 81.5%
  • GABAergic neuron CL0000617
    CSI 3.0
    rCSI 10.0%
    PRS 74.5%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 3.1
    rCSI 17.6%
    PRS 85.3%
  • hepatic stellate cell CL0000632
    CSI 3.1
    rCSI 11.6%
    PRS 83.3%
  • hematopoietic stem cell CL0000037
    CSI 3.1
    rCSI 2.1%
    PRS 90.4%
  • cardiac endothelial cell CL0010008
    CSI 3.1
    rCSI 12.6%
    PRS 89.2%
  • rod bipolar cell CL0000751
    CSI 3.4
    rCSI 6.2%
    PRS 83.1%
  • cerebellar granule cell CL0001031
    CSI 3.5
    rCSI 5.2%
    PRS 82.8%
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 3.6
    rCSI 4.4%
    PRS 72.1%
  • peripheral nervous system neuron CL2000032
    CSI 3.6
    rCSI 4.9%
    PRS 81.9%
  • choroid plexus epithelial cell CL0000706
    CSI 3.6
    rCSI 6.0%
    PRS 80.7%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 3.6
    rCSI 31.4%
    PRS 82.9%
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 3.7
    rCSI 10.0%
    PRS 91.0%
  • vascular leptomeningeal cell CL4023051
    CSI 3.7
    rCSI 6.5%
    PRS 84.4%
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 3.7
    rCSI 8.9%
    PRS 77.4%
  • cardiac neuron CL0010022
    CSI 3.9
    rCSI 12.5%
    PRS 86.7%
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 3.9
    rCSI 3.6%
    PRS 87.4%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 4.0
    rCSI 7.0%
    PRS 73.8%
  • VIP GABAergic cortical interneuron CL4023016
    CSI 4.0
    rCSI 4.8%
    PRS 74.4%
  • chondrocyte CL0000138
    CSI 4.0
    rCSI 6.4%
    PRS 83.4%
  • glial cell CL0000125
    CSI 4.0
    rCSI 15.4%
    PRS 81.5%
  • hematopoietic precursor cell CL0008001
    CSI 4.1
    rCSI 4.2%
    PRS 95.1%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 4.1
    rCSI 10.8%
    PRS 89.9%
  • endocardial cell CL0002350
    CSI 4.2
    rCSI 19.9%
    PRS 84.6%
  • retinal bipolar neuron CL0000748
    CSI 4.4
    rCSI 8.2%
    PRS 79.3%
  • inhibitory interneuron CL0000498
    CSI 4.4
    rCSI 10.2%
    PRS 78.8%
  • pulmonary alveolar type 2 cell CL0002063
    CSI 4.5
    rCSI 7.0%
    PRS 90.0%
  • regular ventricular cardiac myocyte CL0002131
    CSI 4.6
    rCSI 28.7%
    PRS 81.8%
  • sst GABAergic cortical interneuron CL4023017
    CSI 4.7
    rCSI 6.0%
    PRS 75.5%
  • interneuron CL0000099
    CSI 4.8
    rCSI 9.7%
    PRS 81.8%
  • Mueller cell CL0000636
    CSI 4.8
    rCSI 11.0%
    PRS 81.5%
  • cerebral cortex endothelial cell CL1001602
    CSI 4.8
    rCSI 8.4%
    PRS 82.5%
  • neural cell CL0002319
    CSI 4.9
    rCSI 18.3%
    PRS 73.0%
  • neuron CL0000540
    CSI 5.2
    rCSI 13.9%
    PRS 76.4%
  • neural crest cell CL0011012
    CSI 5.3
    rCSI 4.2%
    PRS 80.6%
  • ependymal cell CL0000065
    CSI 5.3
    rCSI 10.8%
    PRS 70.1%
  • small intestine goblet cell CL1000495
    CSI 5.3
    rCSI 11.7%
    PRS 91.4%
  • sncg GABAergic cortical interneuron CL4023015
    CSI 5.5
    rCSI 8.9%
    PRS 75.5%
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 5.6
    rCSI 6.5%
    PRS 81.3%
  • glioblast CL0000030
    CSI 5.7
    rCSI 9.1%
    PRS 80.8%
  • central nervous system neuron CL2000029
    CSI 6.0
    rCSI 44.0%
    PRS 79.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CCDC171](/details-gene/203238), or Coiled-coil domain-containing protein 171, is a protein-coding gene located on human chromosome 9p22.3. The gene was initially identified and characterized through large-scale cDNA sequencing projects ([Link](https://doi.org/10.1038/ng1285), [Link](https://doi.org/10.1101/gr.2596504)). Expression data indicates that [CCDC171](/details-gene/203238) is a significant gene within the central nervous system. Its expression is particularly prominent in a wide range of neuronal subtypes, including various glutamatergic and GABAergic neurons, suggesting a fundamental role in neuronal biology. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [CCDC171](/details-gene/203238) demonstrates a strong association with the nervous system. The gene shows its highest significance in multiple classes of cortical neurons, including [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 16.02), [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 15.96), and [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041) (CSI: 12.46). Its role in neural tissue extends to the visual system, with high significance in [retinal ganglion cell](/details-cell/CL0000740) (CSI: 10.07) and [retinal rod cell](/details-cell/CL0000604) (CSI: 6.95). Beyond the central nervous system, [CCDC171](/details-gene/203238) is also expressed in several non-neuronal cell types, although with a lower CSI score. These include structural and barrier cells such as [alveolar adventitial fibroblast](/details-cell/CL4028006) (CSI: 10.47), [blood vessel endothelial cell](/details-cell/CL0000071) (CSI: 10.32), and [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 9.47). This broader expression pattern suggests that while its primary role may be in neuronal function, it could also contribute to more generalized cellular processes in other tissues. ## Pathways and Molecular Function Functional annotation for [CCDC171](/details-gene/203238) is currently limited. The gene's name indicates that its protein product contains at least one coiled-coil domain. These structural motifs are well-known mediators of protein-protein interactions, oligomerization, and the formation of stable structural scaffolds. This suggests that the CCDC171 protein may function as an adapter or scaffolding component, potentially assembling protein complexes or contributing to the organization of the cytoskeleton. This putative function is consistent with its high expression in neurons, which rely heavily on a complex and stable cytoarchitecture for processes like axonal transport and synaptic maintenance. ## Research Directions Given the high and specific expression of [CCDC171](/details-gene/203238) in diverse neuronal subtypes, research should focus on elucidating its specific role in the central nervous system. The lack of functional data presents several opportunities for investigation. Based on its expression profile and predicted protein structure, several testable hypotheses can be proposed: 1. **Hypothesis 1:** [CCDC171](/details-gene/203238) acts as a scaffolding protein at the synapse, organizing signaling complexes necessary for either glutamatergic or GABAergic neurotransmission, consistent with its high expression in both neuron types. 2. **Hypothesis 2:** The CCDC171 protein is involved in the maintenance of neuronal cytoskeletal architecture, interacting with microtubule- or actin-associated proteins to support axonal and dendritic structure. 3. **Hypothesis 3:** In non-neuronal cells like [endothelial cells](/details-cell/CL0000071) and [fibroblasts](/details-cell/CL4028006), [CCDC171](/details-gene/203238) may play a role in cell-cell adhesion or focal adhesion dynamics, leveraging its predicted protein-protein interaction domains. To test the first hypothesis regarding its role as a synaptic scaffolding protein, a key experiment would be to identify its binding partners in a neuronal context. Co-immunoprecipitation of endogenous or tagged CCDC171 from primary cortical neuron lysates, followed by mass spectrometry (Co-IP/MS), would reveal its interactome. The identified interacting proteins (e.g., synaptic vesicle proteins, postsynaptic density components) would provide direct evidence of its involvement in synaptic function. Subsequently, shRNA-mediated knockdown of [CCDC171](/details-gene/203238) in cultured neurons, followed by electrophysiological analysis (e.g., patch-clamp recording of miniature excitatory or inhibitory postsynaptic currents), could directly assess its impact on synaptic transmission. From a therapeutic standpoint, the potential of [CCDC171](/details-gene/203238) is highly speculative. However, its specific expression pattern in distinct neuronal populations suggests it could be investigated as a biomarker or potential target for neurological or psychiatric disorders characterized by the dysfunction of specific cortical circuits. If its function is essential for neuronal viability, it could be a target for neuroprotective strategies, while if it is involved in pathological protein aggregation, inhibition might be considered.

Genular Protein ID: 542653211

Symbol: CC171_HUMAN

Name: Coiled-coil domain-containing protein 171

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1326
  • Mass: 152810
  • Checksum: 27116BFFDBBD46F8
  • Sequence:
  • MNLNTSSNTG DTQRLKIASL DVKQILKNET ELDITDNLRK KLHWAKKEKL EITTKHNAEL 
    ASYESQIAKL RSEVEKGEAL RQSLEYDLAV ARKEAGLGRR AAEERLAEAH RIQEKLCAQN 
    SELQAKTNET EKAFQTSQQK WKEECRRFEH DLEERDNMIQ NCNREYDLLM KEKSRLEKTL 
    QEALEKHQRE KNEMESHIRE TALEEFRLQE EQWEAERREL QFIVQEQDTA VQNMHKKVEK 
    LETEHMDCSD LLRRQTSELE FSTQREERLR KEFEATTLRV RKLEENIEAE RAAHLESKFN 
    SEIIQLRIRD LEGALQVEKA SQAEAVADLE IIKNEFKEVE SAYEREKHNA QESFAKLNLL 
    EKEYFSKNKK LNEDIEEQKK VIIDLSKRLQ YNEKSCSELQ EELVMAKKHQ AFLVETCENN 
    VKELESILDS FTVSGQWTSG IHKDKDKPPS FSVVLERLRR TLTDYQNKLE DASNEEKACN 
    ELDSTKQKID SHTKNIKELQ DKLADVNKEL SHLHTKCADR EALISTLKVE LQNVLHCWEK 
    EKAQAAQSES ELQKLSQAFH KDAEEKLTFL HTLYQHLVAG CVLIKQPEGM LDKFSWSELC 
    AVLQENVDAL IADLNRANEK IRHLEYICKN KSDTMRELQQ TQEDTFTKVA EQIKAQESCW 
    HRQKKELELQ YSELFLEVQK RAQKFQEIAE KNMEKLNHIE KSHEQLVLEN SHFKKLLSQT 
    QREQMSLLAA CALMAGALYP LYSRSCALST QRDFLQEQVN TFELFKLEIR TLAQALSTVE 
    EKKQEEAKMK KKTFKGLIRI FRKGVIAVLA ANRLKILGQS CASLFTWMES FKEGIGMLVC 
    TGEPQDKHKF PKHQKEQLRC LQALSWLTSS DLLAAIISSM AELQDVIGKA DPNSRICGHL 
    LIGAAKNSFA KLMDKISLVM ECIPLHSSRS ITYVEKDSLV QRLAHGLHKV NTLALKYGLR 
    GHVPITKSTA SLQKQILGFT QRLHAAEVER RSLRLEVTEF KRSVNEMKKE LDKAQGLQMQ 
    LNEFKQSKLI THEKFESACE ELNNALLREE QAQMLLNEQA QQLQELNYKL ELHSSEEADK 
    NQTLGEAVKS LSEAKMELRR KDQSLRQLNR HLTQLEQDKR RLEENIHDAE SALRMAAKDK 
    ECVANHMRAV ENTLHKVRDQ ISLSWSAASR NDFTLQLPKL HLETFAMEGL KGGPEVVACQ 
    AMIKSFMDVY QLASTRIMTL EKEMTSHRSH IAALKSELHT ACLRENASLQ SIGSRDHSNL 
    SIPSRAPLPA DTTGIGDFLP LKAELDTTYT FLKETFINTV PHALTSSHSS PVTMSANANR 
    PTQIGL