Details for: TRNA

Gene ID: 4553

Symbol: TRNA

Ensembl ID: ENSG00000210127

Description: tRNA-Ala

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 25.6183
    Cell Significance Index: 197.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 7.0389
    Cell Significance Index: 319.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.9880
    Cell Significance Index: 74.7400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.3986
    Cell Significance Index: 32.8800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.5838
    Cell Significance Index: 22.7700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 2.1923
    Cell Significance Index: 23.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.9096
    Cell Significance Index: 55.0200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.7036
    Cell Significance Index: 17.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.2666
    Cell Significance Index: 18.7000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 1.0435
    Cell Significance Index: 13.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0207
    Cell Significance Index: 47.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7725
    Cell Significance Index: 40.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6274
    Cell Significance Index: 8.5600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.5229
    Cell Significance Index: 13.0600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4797
    Cell Significance Index: 7.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3731
    Cell Significance Index: 10.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2860
    Cell Significance Index: 48.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2237
    Cell Significance Index: 6.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1008
    Cell Significance Index: 11.5500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0730
    Cell Significance Index: 1.0500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0442
    Cell Significance Index: 0.4200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0025
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0147
    Cell Significance Index: -10.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0178
    Cell Significance Index: -10.0200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0348
    Cell Significance Index: -0.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0508
    Cell Significance Index: -10.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0518
    Cell Significance Index: -10.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0716
    Cell Significance Index: -10.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0998
    Cell Significance Index: -6.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1236
    Cell Significance Index: -3.9600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1312
    Cell Significance Index: -1.8200
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1841
    Cell Significance Index: -1.9300
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.1910
    Cell Significance Index: -1.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1921
    Cell Significance Index: -11.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2200
    Cell Significance Index: -7.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2613
    Cell Significance Index: -3.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3526
    Cell Significance Index: -7.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3527
    Cell Significance Index: -11.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3582
    Cell Significance Index: -7.4300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.4029
    Cell Significance Index: -4.7400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.4381
    Cell Significance Index: -3.8300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4487
    Cell Significance Index: -5.6300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4780
    Cell Significance Index: -11.9200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.4799
    Cell Significance Index: -6.1800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4838
    Cell Significance Index: -6.2200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4996
    Cell Significance Index: -4.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5092
    Cell Significance Index: -12.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5125
    Cell Significance Index: -11.0700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.5230
    Cell Significance Index: -5.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5231
    Cell Significance Index: -9.0500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.5236
    Cell Significance Index: -5.2500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5412
    Cell Significance Index: -9.3300
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.5572
    Cell Significance Index: -5.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5700
    Cell Significance Index: -12.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5762
    Cell Significance Index: -14.6800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5902
    Cell Significance Index: -11.6200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5926
    Cell Significance Index: -11.9000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6054
    Cell Significance Index: -11.9700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.6252
    Cell Significance Index: -7.4400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.6283
    Cell Significance Index: -6.4200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.6402
    Cell Significance Index: -7.7600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.6599
    Cell Significance Index: -11.2800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.6657
    Cell Significance Index: -7.0700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.6703
    Cell Significance Index: -9.3000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6740
    Cell Significance Index: -7.1100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.6827
    Cell Significance Index: -9.4400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.6848
    Cell Significance Index: -7.4900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.7061
    Cell Significance Index: -5.8400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.7078
    Cell Significance Index: -9.7200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.7079
    Cell Significance Index: -8.9200
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.7108
    Cell Significance Index: -7.3700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7131
    Cell Significance Index: -10.2400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.7318
    Cell Significance Index: -7.9500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.7562
    Cell Significance Index: -7.7200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.7627
    Cell Significance Index: -8.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7663
    Cell Significance Index: -16.3200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.7665
    Cell Significance Index: -7.0400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.7756
    Cell Significance Index: -8.5900
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.7845
    Cell Significance Index: -8.6500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.7916
    Cell Significance Index: -7.3700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.7920
    Cell Significance Index: -7.9800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.8013
    Cell Significance Index: -10.4600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.8062
    Cell Significance Index: -9.9100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.8268
    Cell Significance Index: -10.8500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.8389
    Cell Significance Index: -10.0600
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.8480
    Cell Significance Index: -10.5300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.8669
    Cell Significance Index: -11.5200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.8786
    Cell Significance Index: -10.3300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.8895
    Cell Significance Index: -8.3400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.9024
    Cell Significance Index: -9.7700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.9299
    Cell Significance Index: -10.7000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.9445
    Cell Significance Index: -10.7300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.9450
    Cell Significance Index: -8.5300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.9801
    Cell Significance Index: -10.1100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.9819
    Cell Significance Index: -9.1900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.9820
    Cell Significance Index: -10.7800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.9846
    Cell Significance Index: -11.6400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.9905
    Cell Significance Index: -12.0400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.9943
    Cell Significance Index: -13.5200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -1.0008
    Cell Significance Index: -11.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression:** tRNA-Ala is highly expressed in cells of the colon and large intestine, including enterocytes, Paneth cells, goblet cells, keratocytes, absorptive cells, duct epithelial cells, intestinal crypt stem cells, transit amplifying cells, abnormal cells, and neoplastic cells. 2. **tRNA molecule:** tRNA-Ala is a component of the tRNA molecule, which plays a central role in the translation of amino acids into proteins. 3. **Amino acid recognition:** tRNA-Ala recognizes and binds to the amino acid alanine, facilitating its incorporation into proteins. 4. **Gene regulation:** tRNA-Ala is regulated by various transcriptional and post-transcriptional mechanisms, including microRNA-mediated downregulation and alternative splicing. **Pathways and Functions:** 1. **Immune system regulation:** tRNA-Ala plays a critical role in regulating the expression of immune cells, including T cells and B cells, which are essential for the maintenance of intestinal homeostasis. 2. **Intestinal epithelial barrier function:** tRNA-Ala contributes to the maintenance of the intestinal epithelial barrier by regulating the expression of tight junction proteins and the production of antimicrobial peptides. 3. **Cell proliferation and differentiation:** tRNA-Ala is involved in the regulation of cell proliferation and differentiation in intestinal stem cells, which are essential for the maintenance of the intestinal epithelium. 4. **Cancer development:** Alterations in tRNA-Ala expression have been linked to cancer development, including colorectal cancer, where it is often downregulated. **Clinical Significance:** 1. **Colorectal cancer:** tRNA-Ala expression is often downregulated in colorectal cancer, suggesting its potential as a biomarker for early detection and diagnosis. 2. **Inflammatory bowel disease (IBD):** tRNA-Ala expression is altered in IBD, including Crohn's disease and ulcerative colitis, highlighting its potential as a therapeutic target. 3. **Gastrointestinal motility disorders:** tRNA-Ala dysregulation may contribute to gastrointestinal motility disorders, such as irritable bowel syndrome (IBS). 4. **Neonatal and pediatric diseases:** tRNA-Ala expression is altered in neonatal and pediatric diseases, including necrotizing enterocolitis (NEC) and short bowel syndrome. In conclusion, tRNA-Ala plays a critical role in maintaining intestinal homeostasis by regulating the expression of various cell types and pathways. Its dysregulation has been linked to various diseases, including colorectal cancer, IBD, and gastrointestinal motility disorders. Further research is necessary to elucidate the mechanisms underlying tRNA-Ala's functions and to explore its potential as a therapeutic target in the treatment of intestinal diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.