Details for: PGK1P2

Gene ID: 5233

Symbol: PGK1P2

Ensembl ID: ENSG00000213290

Description: phosphoglycerate kinase 1, pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.2810
    Cell Significance Index: 3.5300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2760
    Cell Significance Index: 2.8200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2263
    Cell Significance Index: 2.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0942
    Cell Significance Index: 1.3900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0634
    Cell Significance Index: 0.8300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0562
    Cell Significance Index: 0.6800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0448
    Cell Significance Index: 1.1200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0264
    Cell Significance Index: 0.4500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0233
    Cell Significance Index: 0.2600
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0217
    Cell Significance Index: 0.2600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0216
    Cell Significance Index: 0.3000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0170
    Cell Significance Index: 0.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0037
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0014
    Cell Significance Index: 0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.0300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0019
    Cell Significance Index: -0.1000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0117
    Cell Significance Index: -0.4100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0120
    Cell Significance Index: -0.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0124
    Cell Significance Index: -0.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0127
    Cell Significance Index: -0.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0127
    Cell Significance Index: -0.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0171
    Cell Significance Index: -0.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0178
    Cell Significance Index: -0.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0179
    Cell Significance Index: -0.3800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0181
    Cell Significance Index: -0.1600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0186
    Cell Significance Index: -0.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0192
    Cell Significance Index: -0.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0194
    Cell Significance Index: -0.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0195
    Cell Significance Index: -0.3900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0197
    Cell Significance Index: -0.4100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0197
    Cell Significance Index: -0.3900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0216
    Cell Significance Index: -0.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0217
    Cell Significance Index: -0.6400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0219
    Cell Significance Index: -0.3800
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0225
    Cell Significance Index: -0.2500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0227
    Cell Significance Index: -0.2600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0234
    Cell Significance Index: -0.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0237
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0290
    Cell Significance Index: -0.5000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0291
    Cell Significance Index: -0.3100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0295
    Cell Significance Index: -0.3800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0304
    Cell Significance Index: -0.3100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0327
    Cell Significance Index: -0.2800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0338
    Cell Significance Index: -1.0700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0398
    Cell Significance Index: -0.6700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0412
    Cell Significance Index: -0.5200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0435
    Cell Significance Index: -0.3600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0441
    Cell Significance Index: -0.4500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0459
    Cell Significance Index: -0.5400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0472
    Cell Significance Index: -0.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0474
    Cell Significance Index: -0.5700
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0483
    Cell Significance Index: -0.5500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0486
    Cell Significance Index: -0.4700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0498
    Cell Significance Index: -0.5200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0524
    Cell Significance Index: -0.7200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0525
    Cell Significance Index: -0.6100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0551
    Cell Significance Index: -0.6900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0553
    Cell Significance Index: -0.6700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0554
    Cell Significance Index: -0.6700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0566
    Cell Significance Index: -0.7100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0585
    Cell Significance Index: -0.7000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0585
    Cell Significance Index: -0.7700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0590
    Cell Significance Index: -0.7700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0599
    Cell Significance Index: -0.6800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0609
    Cell Significance Index: -0.7600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0627
    Cell Significance Index: -0.6800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0628
    Cell Significance Index: -0.5800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0635
    Cell Significance Index: -0.7800
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0636
    Cell Significance Index: -0.6900
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0637
    Cell Significance Index: -0.7700
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0641
    Cell Significance Index: -0.7700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0660
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0684
    Cell Significance Index: -0.6400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0684
    Cell Significance Index: -1.0400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0692
    Cell Significance Index: -0.6500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0695
    Cell Significance Index: -0.7500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0695
    Cell Significance Index: -0.8200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0705
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0711
    Cell Significance Index: -0.7500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0713
    Cell Significance Index: -0.7900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0717
    Cell Significance Index: -0.6800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0726
    Cell Significance Index: -0.7600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0728
    Cell Significance Index: -0.6900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0728
    Cell Significance Index: -0.3900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0738
    Cell Significance Index: -1.0500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0744
    Cell Significance Index: -0.7700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0772
    Cell Significance Index: -0.6800
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0773
    Cell Significance Index: -0.9200
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.0780
    Cell Significance Index: -0.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0792
    Cell Significance Index: -1.0800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0827
    Cell Significance Index: -0.7700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0836
    Cell Significance Index: -0.7600
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0846
    Cell Significance Index: -0.9400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0849
    Cell Significance Index: -0.7800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0885
    Cell Significance Index: -0.7800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0892
    Cell Significance Index: -0.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PGK1P2 is a pseudogene, meaning it is a non-functional copy of the PGK1 gene, which encodes the enzyme phosphoglycerate kinase. Despite its pseudogenic status, PGK1P2 exhibits significant expression across various cell types, suggesting that it may play a role in regulating cellular metabolism, energy production, or perhaps even influencing cellular behavior. The diverse expression pattern of PGK1P2 across different cell types implies that it may be involved in maintaining cellular homeostasis, particularly in tissues with high metabolic demands, such as skeletal muscle and vascular endothelial cells. **Pathways and Functions:** The functional significance of PGK1P2 remains unclear, but several pathways may be implicated in its regulatory mechanisms. One possible pathway involves the glycolytic pathway, where PGK1P2 could influence energy production and metabolism. Additionally, PGK1P2 may interact with signaling pathways that regulate cellular proliferation, differentiation, and survival. The expression of PGK1P2 in innate lymphoid cells and hematopoietic stem cells suggests its potential involvement in immune responses and hematopoiesis. Furthermore, its presence in epithelial cells and mast cells may indicate a role in regulating cellular responses to environmental stimuli and inflammation. **Clinical Significance:** The clinical significance of PGK1P2 is an area that warrants further investigation. While its pseudogenic status may limit its potential as a therapeutic target, the expression of PGK1P2 in various disease states, such as cancer and inflammatory disorders, suggests its potential as a biomarker or diagnostic tool. For instance, PGK1P2 may be overexpressed in certain types of cancer, where it could contribute to tumor growth and metastasis. Furthermore, its presence in immune cells may indicate an association with autoimmune diseases or immune-related disorders. As research continues to uncover the functional significance of PGK1P2, its potential as a therapeutic target or diagnostic marker becomes increasingly plausible. In conclusion, the PGK1P2 gene, a pseudogene of phosphoglycerate kinase 1, has been identified to be significantly expressed in a diverse range of cell types. While its functional significance remains unclear, its expression pattern suggests a role in regulating cellular metabolism, energy production, and immune responses. Further investigation is necessary to fully elucidate the mechanisms underlying PGK1P2 expression and its implications for our understanding of cellular biology and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.