Details for: PSMC3P1

Gene ID: 5703

Symbol: PSMC3P1

Ensembl ID: ENSG00000236680

Description: proteasome 26S subunit, ATPase 3 pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.3009
    Cell Significance Index: 3.7800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1549
    Cell Significance Index: 3.8700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.1071
    Cell Significance Index: 1.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0971
    Cell Significance Index: 1.0100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0071
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0025
    Cell Significance Index: -0.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0030
    Cell Significance Index: -1.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0040
    Cell Significance Index: -0.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0054
    Cell Significance Index: -2.4600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0096
    Cell Significance Index: -1.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0125
    Cell Significance Index: -1.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0176
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0177
    Cell Significance Index: -0.1700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0182
    Cell Significance Index: -0.8500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0295
    Cell Significance Index: -0.4200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0332
    Cell Significance Index: -0.4000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0371
    Cell Significance Index: -0.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0407
    Cell Significance Index: -1.2000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0493
    Cell Significance Index: -0.5200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0560
    Cell Significance Index: -0.7200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0565
    Cell Significance Index: -0.9500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0595
    Cell Significance Index: -0.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0621
    Cell Significance Index: -1.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0632
    Cell Significance Index: -1.7200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0667
    Cell Significance Index: -1.1400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0682
    Cell Significance Index: -0.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0721
    Cell Significance Index: -1.2400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0728
    Cell Significance Index: -0.8100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0744
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0822
    Cell Significance Index: -1.0400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0832
    Cell Significance Index: -0.9300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0955
    Cell Significance Index: -1.1100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0982
    Cell Significance Index: -1.0700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1005
    Cell Significance Index: -1.2400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1025
    Cell Significance Index: -1.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1088
    Cell Significance Index: -1.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1107
    Cell Significance Index: -1.3200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1109
    Cell Significance Index: -1.1800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1159
    Cell Significance Index: -1.3900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1174
    Cell Significance Index: -1.2000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1244
    Cell Significance Index: -1.4800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1267
    Cell Significance Index: -1.7400
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1331
    Cell Significance Index: -1.1000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1370
    Cell Significance Index: -1.3900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1387
    Cell Significance Index: -1.7500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1398
    Cell Significance Index: -1.8000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1401
    Cell Significance Index: -0.7500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1428
    Cell Significance Index: -1.6600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1455
    Cell Significance Index: -1.4700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1467
    Cell Significance Index: -1.9300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1518
    Cell Significance Index: -1.5500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1523
    Cell Significance Index: -1.7200
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1537
    Cell Significance Index: -1.7500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1564
    Cell Significance Index: -1.8700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1566
    Cell Significance Index: -1.4700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1584
    Cell Significance Index: -1.9200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1586
    Cell Significance Index: -2.0700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1599
    Cell Significance Index: -1.7600
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1635
    Cell Significance Index: -1.7800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1646
    Cell Significance Index: -2.1600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1647
    Cell Significance Index: -1.8700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1648
    Cell Significance Index: -1.8300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1660
    Cell Significance Index: -1.9100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1662
    Cell Significance Index: -2.0800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1669
    Cell Significance Index: -2.0900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1670
    Cell Significance Index: -2.5400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1674
    Cell Significance Index: -2.1000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.1675
    Cell Significance Index: -1.5500
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1687
    Cell Significance Index: -1.9700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1704
    Cell Significance Index: -1.9500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1708
    Cell Significance Index: -2.2300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1735
    Cell Significance Index: -2.0500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1745
    Cell Significance Index: -1.5400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1757
    Cell Significance Index: -1.4500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1759
    Cell Significance Index: -2.1400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1760
    Cell Significance Index: -2.1400
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.1778
    Cell Significance Index: -1.9300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1804
    Cell Significance Index: -1.9400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1821
    Cell Significance Index: -2.1500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1831
    Cell Significance Index: -2.0800
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1836
    Cell Significance Index: -1.7200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1842
    Cell Significance Index: -2.0400
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1875
    Cell Significance Index: -2.1500
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.1906
    Cell Significance Index: -2.1000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1915
    Cell Significance Index: -2.1200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1918
    Cell Significance Index: -2.1300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1940
    Cell Significance Index: -2.0800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1943
    Cell Significance Index: -2.1900
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1965
    Cell Significance Index: -2.1300
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.1978
    Cell Significance Index: -2.1600
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.2021
    Cell Significance Index: -1.8600
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.2024
    Cell Significance Index: -2.1600
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.2050
    Cell Significance Index: -2.1700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2063
    Cell Significance Index: -1.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PSMC3P1 is a pseudogene, meaning that it lacks a functional coding sequence and is unable to produce a protein. However, its expression is widespread, suggesting that it may play a regulatory or non-coding role in the cells where it is detected. Notably, PSMC3P1 is expressed in cells that are typically associated with immune function, such as CD4-positive and CD8-positive alpha-beta thymocytes, as well as in cells involved in hematopoiesis, such as common myeloid progenitors and hematopoietic stem cells. **Pathways and Functions:** While the exact mechanisms by which PSMC3P1 influences cellular function remain unclear, several theories have emerged based on its expression patterns and the biological processes it is involved in. One possibility is that PSMC3P1 plays a role in regulating the proteasome, the protein complex responsible for degrading damaged or misfolded proteins. The proteasome is a critical component of the ubiquitin-proteasome pathway, which is involved in various cellular processes, including cell cycle regulation, apoptosis, and immune response. Given its expression in cells involved in immune function, it is possible that PSMC3P1 influences the regulation of the proteasome, thereby modulating immune responses and cellular homeostasis. Another theory is that PSMC3P1 is involved in the regulation of RNA processing and splicing. Pseudogenes often act as decoys, binding to RNA-binding proteins and preventing them from interacting with their target mRNAs. This could lead to changes in RNA processing and splicing patterns, influencing gene expression and cellular differentiation. **Clinical Significance:** The clinical significance of PSMC3P1 is still unclear, but its expression in various cell types suggests that it may play a role in human disease. For example, alterations in the proteasome have been implicated in various cancers, including multiple myeloma and lymphoma. If PSMC3P1 is involved in regulating the proteasome, its dysregulation could contribute to tumorigenesis. Additionally, pseudogenes like PSMC3P1 may be involved in the regulation of immune responses, and their dysregulation could contribute to autoimmune diseases or immunodeficiencies. In conclusion, while the exact functions of PSMC3P1 remain unclear, its widespread expression across diverse cell types suggests that it may play a significant role in regulating cellular homeostasis and immune function. Further research is needed to elucidate the mechanisms by which PSMC3P1 influences cellular processes and to explore its clinical significance in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.