MTMR6 | ENSG00000139505 | NCBI 9107

Details for: MTMR6

Gene ID: 9107

Symbol: MTMR6

Ensembl ID: ENSG00000139505

Description: myotubularin related protein 6

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phospholipid metabolism
(R-HSA-1483257)
Pi metabolism
(R-HSA-1483255)
Synthesis of pips at the plasma membrane
(R-HSA-1660499)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endocytosis
(GO:0006897)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
Nuclear envelope
(GO:0005635)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
(GO:0052629)
Phosphatidylinositol-3,5-bisphosphate phosphatase activity
(GO:0106018)
Phosphatidylinositol-3-phosphate phosphatase activity
(GO:0004438)
Phosphatidylinositol biosynthetic process
(GO:0006661)
Phosphatidylinositol dephosphorylation
(GO:0046856)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein serine/threonine phosphatase activity
(GO:0004722)
Protein tyrosine phosphatase activity
(GO:0004725)
Ruffle membrane
(GO:0032587)

Other Information

Proteins

MTMR6_HUMAN

Genular Protein ID: 160797113

Symbol: MTMR6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y217 B2RBB5 B3KSB4 Q5JRG6 Q86TB7 Q86YH4 Q96P80

Database IDs:

Citations:

PubMed ID: 12890864

Title: Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.

PubMed ID: 12890864

DOI: 10.1073/pnas.1333958100

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9736772

Title: Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.

PubMed ID: 9736772

DOI: 10.1093/hmg/7.11.1703

PubMed ID: 12646134

Title: Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.

PubMed ID: 12646134

DOI: 10.1016/s0960-9822(03)00132-5

PubMed ID: 15831468

Title: The phosphatidylinositol 3-phosphate phosphatase myotubularin-related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1.

PubMed ID: 15831468

DOI: 10.1128/mcb.25.9.3630-3638.2005

PubMed ID: 16787938

Title: Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.

PubMed ID: 16787938

DOI: 10.1242/jcs.03040

PubMed ID: 16847315

Title: Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells.

PubMed ID: 16847315

DOI: 10.1128/mcb.00352-06

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19038970

Title: MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis.

PubMed ID: 19038970

DOI: 10.1074/jbc.m804292200

PubMed ID: 23145062

Title: Human ALKBH4 interacts with proteins associated with transcription.

PubMed ID: 23145062

DOI: 10.1371/journal.pone.0049045

PubMed ID: 22647598

Title: Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8.

PubMed ID: 22647598

DOI: 10.1073/pnas.1207021109

PubMed ID: 23188820

Title: Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways.

PubMed ID: 23188820

DOI: 10.1074/jbc.m112.395087

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24591580

Title: Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.

PubMed ID: 24591580

DOI: 10.1073/pnas.1311029111

Sequence Information:

Length: 621
Mass: 71968
Checksum: 1F34608F99DCEA39
Sequence:

MEHIRTTKVE QVKLLDRFST SNKSLTGTLY LTATHLLFID SHQKETWILH HHIASVEKLA 
LTTSGCPLVI QCKNFRTVHF IVPRERDCHD IYNSLLQLSK QAKYEDLYAF SYNPKQNDSE 
RLQGWQLIDL AEEYKRMGVP NSHWQLSDAN RDYKICETYP RELYVPRIAS KPIIVGSSKF 
RSKGRFPVLS YYHQDKEAAI CRCSQPLSGF SARCLEDEHL LQAISKANPV NRYMYVMDTR 
PKLNAMANRA AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVNGT KGLSVNDFYS 
GLESSGWLRH IKAVMDAAIF LAKAITVENA SVLVHCSDGW DRTSQVCSLG SLLLDSYYRT 
IKGFMVLIEK DWISFGHKFS ERCGQLDGDP KEVSPVFTQF LECVWHLTEQ FPQAFEFSEA 
FLLQIHEHIH SCQFGNFLGN CQKEREELKL KEKTYSLWPF LLEDQKKYLN PLYSSESHRF 
TVLEPNTVSF NFKFWRNMYH QFDRTLHPRQ SVFNIIMNMN EQNKQLEKDI KDLESKIKQR 
KNKQTDGILT KELLHSVHPE SPNLKTSLCF KEQTLLPVND ALRTIEGSSP ADNRYSEYAE 
EFSKSEPAVV SLEYGVARMT C

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MTMR6

Associated with

Other Information

Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. PubMed ID: 12890864

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. PubMed ID: 9736772

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases. PubMed ID: 12646134

The phosphatidylinositol 3-phosphate phosphatase myotubularin-related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1. PubMed ID: 15831468

Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. PubMed ID: 16787938

Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. PubMed ID: 16847315

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis. PubMed ID: 19038970

Human ALKBH4 interacts with proteins associated with transcription. PubMed ID: 23145062

Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8. PubMed ID: 22647598

Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. PubMed ID: 23188820

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis. PubMed ID: 24591580