MTMR6 | ENSG00000139505 | NCBI 9107

Details for: MTMR6

Gene ID: 9107

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MTMR6

Ensembl ID: ENSG00000139505

Description: myotubularin related protein 6

Cell Significance Landscape

Display Count:

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phospholipid metabolism
(R-HSA-1483257)
Pi metabolism
(R-HSA-1483255)
Synthesis of pips at the plasma membrane
(R-HSA-1660499)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endocytosis
(GO:0006897)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
Nuclear envelope
(GO:0005635)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
(GO:0052629)
Phosphatidylinositol-3,5-bisphosphate phosphatase activity
(GO:0106018)
Phosphatidylinositol-3-phosphate phosphatase activity
(GO:0004438)
Phosphatidylinositol biosynthetic process
(GO:0006661)
Phosphatidylinositol dephosphorylation
(GO:0046856)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein serine/threonine phosphatase activity
(GO:0004722)
Protein tyrosine phosphatase activity
(GO:0004725)
Ruffle membrane
(GO:0032587)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

astrocyte of the cerebral cortex CL0002605

CSI 6.76

rCSI 15.16%

PRS 30.89
type B pancreatic cell CL0000169

CSI 6.63

rCSI 14.67%

PRS 43.1
erythrocyte CL0000232

CSI 6.33

rCSI 14.37%

PRS 51.04
enteric smooth muscle cell CL0002504

CSI 4.98

rCSI 7.11%

PRS 48.34
ependymal cell CL0000065

CSI 4.87

rCSI 9.87%

PRS 28.41
ionocyte CL0005006

CSI 4

rCSI 4.29%

PRS 43.67
pancreatic D cell CL0000173

CSI 3.57

rCSI 3.51%

PRS 48.12
cerebral cortex endothelial cell CL1001602

CSI 3.24

rCSI 5.6%

PRS 36.6
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.2

rCSI 2.44%

PRS 57.04
unswitched memory B cell CL0000970

CSI 2.86

rCSI 2.41%

PRS 62.94
group 3 innate lymphoid cell CL0001071

CSI 2.71

rCSI 2.04%

PRS 49.19
hepatic stellate cell CL0000632

CSI 2.69

rCSI 10.06%

PRS 38.81
plasmablast CL0000980

CSI 2.63

rCSI 2.07%

PRS 52.11
peripheral nervous system neuron CL2000032

CSI 2.62

rCSI 3.57%

PRS 39.04
Kupffer cell CL0000091

CSI 2.6

rCSI 5.95%

PRS 45.06
alpha-beta T cell CL0000789

CSI 2.46

rCSI 2.89%

PRS 61.22
mucus secreting cell CL0000319

CSI 2.19

rCSI 3.48%

PRS 56.35
pro-B cell CL0000826

CSI 2.15

rCSI 1.78%

PRS 46.63
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.14

rCSI 1.54%

PRS 58.64
duct epithelial cell CL0000068

CSI 2.11

rCSI 3.09%

PRS 48.75
pulmonary capillary endothelial cell CL4028001

CSI 2.09

rCSI 3.98%

PRS 62.44
pancreatic A cell CL0000171

CSI 2.06

rCSI 2.16%

PRS 48.53
neural crest cell CL0011012

CSI 2.04

rCSI 1.61%

PRS 33.58
VIP GABAergic cortical interneuron CL4023016

CSI 2.03

rCSI 2.43%

PRS 30.07
alternatively activated macrophage CL0000890

CSI 2

rCSI 2.52%

PRS 59.18
perivascular cell CL4033054

CSI 1.94

rCSI 2.65%

PRS 50.68
double-positive, alpha-beta thymocyte CL0000809

CSI 1.91

rCSI 1.95%

PRS 58.92
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.89

rCSI 1.28%

PRS 56.12
retina horizontal cell CL0000745

CSI 1.89

rCSI 2.88%

PRS 42.37
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.87

rCSI 3.31%

PRS 29.16
melanocyte CL0000148

CSI 1.85

rCSI 1.37%

PRS 39.26
precursor B cell CL0000817

CSI 1.79

rCSI 1.56%

PRS 55.27
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.78

rCSI 2.33%

PRS 58.76
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 1.76

rCSI 1.04%

PRS 60.95
granulocyte monocyte progenitor cell CL0000557

CSI 1.75

rCSI 1.52%

PRS 49.44
common myeloid progenitor CL0000049

CSI 1.75

rCSI 1.41%

PRS 46.28
CD14-positive monocyte CL0001054

CSI 1.75

rCSI 2.18%

PRS 56.88
ciliated cell CL0000064

CSI 1.72

rCSI 2.79%

PRS 44.11
retinal rod cell CL0000604

CSI 1.72

rCSI 3.03%

PRS 43.93
epithelial cell of lung CL0000082

CSI 1.71

rCSI 1.41%

PRS 44.16
ON-bipolar cell CL0000749

CSI 1.67

rCSI 2.48%

PRS 48.04
mature B cell CL0000785

CSI 1.67

rCSI 1.45%

PRS 55.19
early lymphoid progenitor CL0000936

CSI 1.66

rCSI 1.46%

PRS 50.68
vascular leptomeningeal cell CL4023051

CSI 1.65

rCSI 2.9%

PRS 38.19
activated CD4-positive, alpha-beta T cell CL0000896

CSI 1.65

rCSI 1.53%

PRS 65.71
conjunctival epithelial cell CL1000432

CSI 1.64

rCSI 2.5%

PRS 46.17
dendritic cell, human CL0001056

CSI 1.63

rCSI 2.5%

PRS 52.76
granulocyte CL0000094

CSI 1.61

rCSI 2.46%

PRS 54.89
multi-ciliated epithelial cell CL0005012

CSI 1.6

rCSI 1.6%

PRS 39.95
rod bipolar cell CL0000751

CSI 1.6

rCSI 2.88%

PRS 39.11
blood vessel endothelial cell CL0000071

CSI 1.58

rCSI 3.27%

PRS 43.6
plasmacytoid dendritic cell, human CL0001058

CSI 1.56

rCSI 1.09%

PRS 47.47
cerebral cortex GABAergic interneuron CL0010011

CSI 1.55

rCSI 4.59%

PRS 49.68
elicited macrophage CL0000861

CSI 1.54

rCSI 1.42%

PRS 53.12
alveolar macrophage CL0000583

CSI 1.51

rCSI 2.48%

PRS 51.13
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.51

rCSI 2.53%

PRS 30.15
OFF-bipolar cell CL0000750

CSI 1.51

rCSI 2.06%

PRS 55.11
CD4-positive helper T cell CL0000492

CSI 1.49

rCSI 1.13%

PRS 58.03
T follicular helper cell CL0002038

CSI 1.47

rCSI 1.1%

PRS 60.32
common dendritic progenitor CL0001029

CSI 1.43

rCSI 1.79%

PRS 55.52
interneuron CL0000099

CSI 1.43

rCSI 2.87%

PRS 35.69
retinal bipolar neuron CL0000748

CSI 1.4

rCSI 2.62%

PRS 35.59
ciliated epithelial cell CL0000067

CSI 1.39

rCSI 1.23%

PRS 34.96
extravillous trophoblast CL0008036

CSI 1.38

rCSI 1.71%

PRS 41.6
myeloid dendritic cell CL0000782

CSI 1.37

rCSI 1.98%

PRS 61.79
sst GABAergic cortical interneuron CL4023017

CSI 1.35

rCSI 1.74%

PRS 31.03
neuroblast (sensu Vertebrata) CL0000031

CSI 1.35

rCSI 1.73%

PRS 43.63
retinal cone cell CL0000573

CSI 1.33

rCSI 2.14%

PRS 36.41
Mueller cell CL0000636

CSI 1.32

rCSI 3.01%

PRS 39.15
cardiac endothelial cell CL0010008

CSI 1.31

rCSI 5.3%

PRS 44.19
cerebral cortex neuron CL0010012

CSI 1.31

rCSI 5.35%

PRS 42.94
retinal blood vessel endothelial cell CL0002585

CSI 1.28

rCSI 2.04%

PRS 49.52
myeloid leukocyte CL0000766

CSI 1.27

rCSI 1.17%

PRS 46.56
inhibitory interneuron CL0000498

CSI 1.25

rCSI 2.9%

PRS 37.35
stem cell CL0000034

CSI 1.22

rCSI 1.18%

PRS 36.51
pvalb GABAergic cortical interneuron CL4023018

CSI 1.2

rCSI 1.49%

PRS 28.58
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.19

rCSI 1.38%

PRS 40.03
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.12

rCSI 1.36%

PRS 53.53
enteroendocrine cell CL0000164

CSI 1.05

rCSI 1.44%

PRS 48.3
glycinergic amacrine cell CL4030028

CSI 1.01

rCSI 2.64%

PRS 45.16
goblet cell CL0000160

CSI 0.98

rCSI 0.93%

PRS 46.41
promonocyte CL0000559

CSI 0.96

rCSI 1.64%

PRS 55
CD14-low, CD16-positive monocyte CL0002396

CSI 0.95

rCSI 0.73%

PRS 44.53
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.95

rCSI 2.96%

PRS 33.59
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.93

rCSI 3.34%

PRS 28.99
lung ciliated cell CL1000271

CSI 0.91

rCSI 1.05%

PRS 36
lung pericyte CL0009089

CSI 0.86

rCSI 2.28%

PRS 53.47
intermediate monocyte CL0002393

CSI 0.82

rCSI 1.24%

PRS 47.68
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.8

rCSI 1.6%

PRS 63.43
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.8

rCSI 1.92%

PRS 35.12
amacrine cell CL0000561

CSI 0.78

rCSI 2.26%

PRS 37.13
Hofbauer cell CL3000001

CSI 0.75

rCSI 1.41%

PRS 55.94
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.75

rCSI 1.81%

PRS 29.25
GABAergic neuron CL0000617

CSI 0.74

rCSI 2.48%

PRS 34.07
retinal ganglion cell CL0000740

CSI 0.73

rCSI 1.6%

PRS 34.12
lung macrophage CL1001603

CSI 0.71

rCSI 1.59%

PRS 52.25
microcirculation associated smooth muscle cell CL0008035

CSI 0.7

rCSI 2.04%

PRS 48.12
central nervous system neuron CL2000029

CSI 0.69

rCSI 5.06%

PRS 33.91
hepatocyte CL0000182

CSI 0.67

rCSI 1.2%

PRS 44.06
sncg GABAergic cortical interneuron CL4023015

CSI 0.61

rCSI 0.97%

PRS 32.21

ON parasol ganglion cell CL4033052

CSI 0.2

rCSI 3.2%

PRS 38.1%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.2

rCSI 1.4%

PRS 31.5%
indirect pathway medium spiny neuron CL4023029

CSI 0.3

rCSI 6.0%

PRS 30.4%
direct pathway medium spiny neuron CL4023026

CSI 0.3

rCSI 6.7%

PRS 29.5%
medium spiny neuron CL1001474

CSI 0.3

rCSI 3.0%

PRS 33.4%
blood vessel smooth muscle cell CL0019018

CSI 0.4

rCSI 2.9%

PRS 40.3%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.4

rCSI 1.6%

PRS 31.0%
L6b glutamatergic cortical neuron CL4023038

CSI 0.4

rCSI 1.3%

PRS 31.3%
endothelial cell of placenta CL0009092

CSI 0.4

rCSI 2.1%

PRS 57.6%
colon macrophage CL0009038

CSI 0.5

rCSI 2.5%

PRS 67.8%
GABAergic amacrine cell CL4030027

CSI 0.6

rCSI 1.9%

PRS 37.1%
sncg GABAergic cortical interneuron CL4023015

CSI 0.6

rCSI 1.0%

PRS 32.2%
hepatocyte CL0000182

CSI 0.7

rCSI 1.2%

PRS 44.1%
central nervous system neuron CL2000029

CSI 0.7

rCSI 5.1%

PRS 33.9%
microcirculation associated smooth muscle cell CL0008035

CSI 0.7

rCSI 2.0%

PRS 48.1%
lung macrophage CL1001603

CSI 0.7

rCSI 1.6%

PRS 52.3%
retinal ganglion cell CL0000740

CSI 0.7

rCSI 1.6%

PRS 34.1%
GABAergic neuron CL0000617

CSI 0.7

rCSI 2.5%

PRS 34.1%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.8

rCSI 1.8%

PRS 29.3%
Hofbauer cell CL3000001

CSI 0.8

rCSI 1.4%

PRS 55.9%
amacrine cell CL0000561

CSI 0.8

rCSI 2.3%

PRS 37.1%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.8

rCSI 1.9%

PRS 35.1%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.8

rCSI 1.6%

PRS 63.4%
intermediate monocyte CL0002393

CSI 0.8

rCSI 1.2%

PRS 47.7%
lung pericyte CL0009089

CSI 0.9

rCSI 2.3%

PRS 53.5%
lung ciliated cell CL1000271

CSI 0.9

rCSI 1.1%

PRS 36.0%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.9

rCSI 3.3%

PRS 29.0%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 1.0

rCSI 3.0%

PRS 33.6%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.0

rCSI 0.7%

PRS 44.5%
promonocyte CL0000559

CSI 1.0

rCSI 1.6%

PRS 55.0%
goblet cell CL0000160

CSI 1.0

rCSI 0.9%

PRS 46.4%
glycinergic amacrine cell CL4030028

CSI 1.0

rCSI 2.6%

PRS 45.2%
enteroendocrine cell CL0000164

CSI 1.1

rCSI 1.4%

PRS 48.3%
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.1

rCSI 1.4%

PRS 53.5%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.2

rCSI 1.4%

PRS 40.0%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.2

rCSI 1.5%

PRS 28.6%
stem cell CL0000034

CSI 1.2

rCSI 1.2%

PRS 36.5%
inhibitory interneuron CL0000498

CSI 1.3

rCSI 2.9%

PRS 37.4%
myeloid leukocyte CL0000766

CSI 1.3

rCSI 1.2%

PRS 46.6%
retinal blood vessel endothelial cell CL0002585

CSI 1.3

rCSI 2.0%

PRS 49.5%
cerebral cortex neuron CL0010012

CSI 1.3

rCSI 5.4%

PRS 42.9%
cardiac endothelial cell CL0010008

CSI 1.3

rCSI 5.3%

PRS 44.2%
Mueller cell CL0000636

CSI 1.3

rCSI 3.0%

PRS 39.2%
retinal cone cell CL0000573

CSI 1.3

rCSI 2.1%

PRS 36.4%
neuroblast (sensu Vertebrata) CL0000031

CSI 1.4

rCSI 1.7%

PRS 43.6%
sst GABAergic cortical interneuron CL4023017

CSI 1.4

rCSI 1.7%

PRS 31.0%
myeloid dendritic cell CL0000782

CSI 1.4

rCSI 2.0%

PRS 61.8%
extravillous trophoblast CL0008036

CSI 1.4

rCSI 1.7%

PRS 41.6%
ciliated epithelial cell CL0000067

CSI 1.4

rCSI 1.2%

PRS 35.0%
retinal bipolar neuron CL0000748

CSI 1.4

rCSI 2.6%

PRS 35.6%
interneuron CL0000099

CSI 1.4

rCSI 2.9%

PRS 35.7%
common dendritic progenitor CL0001029

CSI 1.4

rCSI 1.8%

PRS 55.5%
T follicular helper cell CL0002038

CSI 1.5

rCSI 1.1%

PRS 60.3%
CD4-positive helper T cell CL0000492

CSI 1.5

rCSI 1.1%

PRS 58.0%
OFF-bipolar cell CL0000750

CSI 1.5

rCSI 2.1%

PRS 55.1%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.5

rCSI 2.5%

PRS 30.2%
alveolar macrophage CL0000583

CSI 1.5

rCSI 2.5%

PRS 51.1%
elicited macrophage CL0000861

CSI 1.5

rCSI 1.4%

PRS 53.1%
cerebral cortex GABAergic interneuron CL0010011

CSI 1.6

rCSI 4.6%

PRS 49.7%
plasmacytoid dendritic cell, human CL0001058

CSI 1.6

rCSI 1.1%

PRS 47.5%
blood vessel endothelial cell CL0000071

CSI 1.6

rCSI 3.3%

PRS 43.6%
rod bipolar cell CL0000751

CSI 1.6

rCSI 2.9%

PRS 39.1%
multi-ciliated epithelial cell CL0005012

CSI 1.6

rCSI 1.6%

PRS 40.0%
granulocyte CL0000094

CSI 1.6

rCSI 2.5%

PRS 54.9%
dendritic cell, human CL0001056

CSI 1.6

rCSI 2.5%

PRS 52.8%
conjunctival epithelial cell CL1000432

CSI 1.6

rCSI 2.5%

PRS 46.2%
activated CD4-positive, alpha-beta T cell CL0000896

CSI 1.7

rCSI 1.5%

PRS 65.7%
vascular leptomeningeal cell CL4023051

CSI 1.7

rCSI 2.9%

PRS 38.2%
early lymphoid progenitor CL0000936

CSI 1.7

rCSI 1.5%

PRS 50.7%
mature B cell CL0000785

CSI 1.7

rCSI 1.5%

PRS 55.2%
ON-bipolar cell CL0000749

CSI 1.7

rCSI 2.5%

PRS 48.0%
epithelial cell of lung CL0000082

CSI 1.7

rCSI 1.4%

PRS 44.2%
retinal rod cell CL0000604

CSI 1.7

rCSI 3.0%

PRS 43.9%
ciliated cell CL0000064

CSI 1.7

rCSI 2.8%

PRS 44.1%
CD14-positive monocyte CL0001054

CSI 1.8

rCSI 2.2%

PRS 56.9%
common myeloid progenitor CL0000049

CSI 1.8

rCSI 1.4%

PRS 46.3%
granulocyte monocyte progenitor cell CL0000557

CSI 1.8

rCSI 1.5%

PRS 49.4%
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 1.8

rCSI 1.0%

PRS 61.0%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.8

rCSI 2.3%

PRS 58.8%
precursor B cell CL0000817

CSI 1.8

rCSI 1.6%

PRS 55.3%
melanocyte CL0000148

CSI 1.9

rCSI 1.4%

PRS 39.3%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.9

rCSI 3.3%

PRS 29.2%
retina horizontal cell CL0000745

CSI 1.9

rCSI 2.9%

PRS 42.4%
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.9

rCSI 1.3%

PRS 56.1%
double-positive, alpha-beta thymocyte CL0000809

CSI 1.9

rCSI 2.0%

PRS 58.9%
perivascular cell CL4033054

CSI 1.9

rCSI 2.7%

PRS 50.7%
alternatively activated macrophage CL0000890

CSI 2.0

rCSI 2.5%

PRS 59.2%
VIP GABAergic cortical interneuron CL4023016

CSI 2.0

rCSI 2.4%

PRS 30.1%
neural crest cell CL0011012

CSI 2.0

rCSI 1.6%

PRS 33.6%
pancreatic A cell CL0000171

CSI 2.1

rCSI 2.2%

PRS 48.5%
pulmonary capillary endothelial cell CL4028001

CSI 2.1

rCSI 4.0%

PRS 62.4%
duct epithelial cell CL0000068

CSI 2.1

rCSI 3.1%

PRS 48.8%
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.1

rCSI 1.5%

PRS 58.6%
pro-B cell CL0000826

CSI 2.2

rCSI 1.8%

PRS 46.6%
mucus secreting cell CL0000319

CSI 2.2

rCSI 3.5%

PRS 56.4%
alpha-beta T cell CL0000789

CSI 2.5

rCSI 2.9%

PRS 61.2%
Kupffer cell CL0000091

CSI 2.6

rCSI 6.0%

PRS 45.1%
peripheral nervous system neuron CL2000032

CSI 2.6

rCSI 3.6%

PRS 39.0%
plasmablast CL0000980

CSI 2.6

rCSI 2.1%

PRS 52.1%
hepatic stellate cell CL0000632

CSI 2.7

rCSI 10.1%

PRS 38.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Myotubularin-related protein 6 ([MTMR6](/details-gene/9107)) is a protein-coding gene located on chromosome 13q12.13. It belongs to the myotubularin family of dual-specificity phosphatases, which are crucial regulators of phosphoinositide (PI) signaling. Functionally, [MTMR6](/details-gene/9107) acts as a phosphatase that specifically dephosphorylates phosphatidylinositol-3-phosphate (PI(3)P) and phosphatidylinositol-3,5-bisphosphate (PI(3,5)P2) ([Link](https://doi.org/10.1016/s0960-9822(03)00132-5)). This activity implicates it in fundamental cellular processes including endocytosis, autophagic pathways, and phospholipid metabolism ([Link](https://doi.org/10.1074/jbc.m112.395087)). **Overall**, expression data reveals its significance in a diverse array of cell types, including [astrocyte of the cerebral cortex](/details-cell/CL0002605) and [type B pancreatic cell](/details-cell/CL0000169), suggesting a broad role in maintaining cellular homeostasis through the precise regulation of lipid-based signaling pathways. ## Cellular Roles and Expression Landscape The expression profile of [MTMR6](/details-gene/9107) indicates its importance across multiple, functionally distinct cell lineages rather than serving as a marker for a single tissue type. **Overall**, it shows the highest significance in cells with high metabolic or signaling activity. Its top significance in [astrocyte of the cerebral cortex](/details-cell/CL0002605) and [ependymal cell](/details-cell/CL0000065) suggests a role in central nervous system homeostasis, potentially related to membrane trafficking and cellular support. Concurrently, high significance in endocrine cells, such as [type B pancreatic cell](/details-cell/CL0000169) and [pancreatic D cell](/details-cell/CL0000173), points towards a function in the regulation of hormone secretion, a process heavily dependent on phosphoinositide signaling. Furthermore, [MTMR6](/details-gene/9107) is significant in various immune cells, including [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050), [unswitched memory B cell](/details-cell/CL0000970), [group 3 innate lymphoid cell](/details-cell/CL0001071), and [Kupffer cell](/details-cell/CL0000091). This is consistent with published research identifying [MTMR6](/details-gene/9107) as a negative regulator of CD4 T cell activation ([Link](https://doi.org/10.1128/mcb.00352-06)) and ion channel function ([Link](https://doi.org/10.1128/mcb.25.9.3630-3638.2005)), highlighting its role in modulating immune responses. The broad but specific expression pattern across neural, endocrine, and immune systems underscores its role as a key regulator of fundamental PI-dependent cellular events. ## Pathways and Molecular Function The molecular function of [MTMR6](/details-gene/9107) is centered on its phosphatase activity. Gene Ontology annotations confirm its role as a [phosphatidylinositol-3-phosphate phosphatase](/details-go/GO:0004438) and [phosphatidylinositol-3,5-bisphosphate 3-phosphatase](/details-go/GO:0052629). This enzymatic activity is integral to several major biological processes, including [endocytosis](/details-go/GO:0006897) and the broader [phosphatidylinositol biosynthetic process](/details-go/GO:0006661). Reactome pathway analysis further situates [MTMR6](/details-gene/9107) within the context of [Metabolism of lipids](/details-pathway/R-HSA-556833), specifically [Pi metabolism](/details-pathway/R-HSA-1483255). By controlling the levels of key phosphoinositide species, [MTMR6](/details-gene/9107) influences the dynamics of membrane trafficking and signal transduction. Its annotated cellular components, including the [cytoplasm](/details-go/GO:0005737), [endoplasmic reticulum](/details-go/GO:0005783), and [ruffle membrane](/details-go/GO:0032587), are consistent with a protein involved in dynamic signaling events at various subcellular locations. Studies have shown that its enzymatic activity and stability can be modulated by interactions with other myotubularin family members, such as MTMR9, which enhances its role in apoptosis ([Link](https://doi.org/10.1074/jbc.m804292200)). ## Research Directions The widespread yet significant expression of [MTMR6](/details-gene/9107) in physiologically critical cells, combined with its function as a key signaling node, presents several avenues for future investigation. **Testable Hypotheses:** 1. Given its high significance in [type B pancreatic cell](/details-cell/CL0000169) and its role in regulating phosphoinositide levels, it is hypothesized that [MTMR6](/details-gene/9107) is a critical regulator of insulin exocytosis by controlling the PI(3)P-dependent trafficking of insulin granules to the plasma membrane. 2. Based on evidence that [MTMR6](/details-gene/9107) is a negative regulator of T cell activation ([Link](https://doi.org/10.1128/mcb.00352-06)) and its noted expression in [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050), we hypothesize that [MTMR6](/details-gene/9107) acts as an intrinsic checkpoint protein that fine-tunes the threshold for T cell receptor signaling to prevent autoimmunity and limit immunopathology. 3. Considering its high CSI in [astrocyte of the cerebral cortex](/details-cell/CL0002605) and its function in [endocytosis](/details-go/GO:0006897), it is proposed that [MTMR6](/details-gene/9107) regulates synaptic plasticity by modulating the endocytic recycling of neurotransmitter receptors and transporters at the astrocytic perisynaptic process. **Experimental Approach for Hypothesis 2:** To test the role of [MTMR6](/details-gene/9107) as a T cell checkpoint, a conditional knockout mouse model could be employed (e.g., *Mtmr6*^fl/fl x *Cd4-Cre*). T cells isolated from these knockout mice and wild-type littermates would be stimulated *in vitro* with anti-CD3/CD28 antibodies. The functional consequences of [MTMR6](/details-gene/9107) deletion would be assessed by measuring T cell proliferation (via CFSE dilution), cytokine secretion (e.g., IL-2, IFN-gamma by ELISA), and the phosphorylation status of key downstream signaling molecules like AKT and ERK using flow cytometry or western blotting. An observation of hyper-proliferation and enhanced cytokine production in knockout T cells would support the hypothesis. **Therapeutic Potential:** As an intracellular enzyme, [MTMR6](/details-gene/9107) is a viable target for small molecule inhibitors. Its demonstrated role as a negative regulator of T cell function suggests that its **inhibition** could serve as a novel immunotherapeutic strategy. By blocking [MTMR6](/details-gene/9107) activity, it may be possible to lower the activation threshold of tumor-infiltrating lymphocytes, thereby enhancing anti-cancer immune responses. This positions [MTMR6](/details-gene/9107) as a potential target for developing next-generation cancer immunotherapies, conceptually similar to established immune checkpoint inhibitors but with a distinct intracellular mechanism of action.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

MTMR6_HUMAN

Genular Protein ID: 160797113

Symbol: MTMR6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y217 B2RBB5 B3KSB4 Q5JRG6 Q86TB7 Q86YH4 Q96P80

Database IDs:

Citations:

PubMed ID: 12890864

Title: Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9.

PubMed ID: 12890864

DOI: 10.1073/pnas.1333958100

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9736772

Title: Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.

PubMed ID: 9736772

DOI: 10.1093/hmg/7.11.1703

PubMed ID: 12646134

Title: Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.

PubMed ID: 12646134

DOI: 10.1016/s0960-9822(03)00132-5

PubMed ID: 15831468

Title: The phosphatidylinositol 3-phosphate phosphatase myotubularin-related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1.

PubMed ID: 15831468

DOI: 10.1128/mcb.25.9.3630-3638.2005

PubMed ID: 16787938

Title: Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions.

PubMed ID: 16787938

DOI: 10.1242/jcs.03040

PubMed ID: 16847315

Title: Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells.

PubMed ID: 16847315

DOI: 10.1128/mcb.00352-06

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19038970

Title: MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis.

PubMed ID: 19038970

DOI: 10.1074/jbc.m804292200

PubMed ID: 23145062

Title: Human ALKBH4 interacts with proteins associated with transcription.

PubMed ID: 23145062

DOI: 10.1371/journal.pone.0049045

PubMed ID: 22647598

Title: Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8.

PubMed ID: 22647598

DOI: 10.1073/pnas.1207021109

PubMed ID: 23188820

Title: Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways.

PubMed ID: 23188820

DOI: 10.1074/jbc.m112.395087

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24591580

Title: Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.

PubMed ID: 24591580

DOI: 10.1073/pnas.1311029111

Sequence Information:

Length: 621
Mass: 71968
Checksum: 1F34608F99DCEA39
Sequence:

MEHIRTTKVE QVKLLDRFST SNKSLTGTLY LTATHLLFID SHQKETWILH HHIASVEKLA 
LTTSGCPLVI QCKNFRTVHF IVPRERDCHD IYNSLLQLSK QAKYEDLYAF SYNPKQNDSE 
RLQGWQLIDL AEEYKRMGVP NSHWQLSDAN RDYKICETYP RELYVPRIAS KPIIVGSSKF 
RSKGRFPVLS YYHQDKEAAI CRCSQPLSGF SARCLEDEHL LQAISKANPV NRYMYVMDTR 
PKLNAMANRA AGKGYENEDN YSNIRFQFVG IENIHVMRSS LQKLLEVNGT KGLSVNDFYS 
GLESSGWLRH IKAVMDAAIF LAKAITVENA SVLVHCSDGW DRTSQVCSLG SLLLDSYYRT 
IKGFMVLIEK DWISFGHKFS ERCGQLDGDP KEVSPVFTQF LECVWHLTEQ FPQAFEFSEA 
FLLQIHEHIH SCQFGNFLGN CQKEREELKL KEKTYSLWPF LLEDQKKYLN PLYSSESHRF 
TVLEPNTVSF NFKFWRNMYH QFDRTLHPRQ SVFNIIMNMN EQNKQLEKDI KDLESKIKQR 
KNKQTDGILT KELLHSVHPE SPNLKTSLCF KEQTLLPVND ALRTIEGSSP ADNRYSEYAE 
EFSKSEPAVV SLEYGVARMT C

Details for: MTMR6

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. PubMed ID: 12890864

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and analysis of human chromosome 13. PubMed ID: 15057823

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. PubMed ID: 9736772

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases. PubMed ID: 12646134

The phosphatidylinositol 3-phosphate phosphatase myotubularin-related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1. PubMed ID: 15831468

Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. PubMed ID: 16787938

Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. PubMed ID: 16847315

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis. PubMed ID: 19038970

Human ALKBH4 interacts with proteins associated with transcription. PubMed ID: 23145062

Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8. PubMed ID: 22647598

Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways. PubMed ID: 23188820

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis. PubMed ID: 24591580