Details for: QKI

Gene ID: 9444

Symbol: QKI

Ensembl ID: ENSG00000112531

Description: QKI, KH domain containing RNA binding

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 5.74
    Marker Score: 3,779
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 5.54
    Marker Score: 6,902
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 5.03
    Marker Score: 1,817
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.98
    Marker Score: 111,349
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 4.84
    Marker Score: 11,581
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.4
    Marker Score: 11,006
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.8
    Marker Score: 3,119
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.77
    Marker Score: 1,872
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.54
    Marker Score: 16,355
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.44
    Marker Score: 2,620
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.3
    Marker Score: 1,207
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.25
    Marker Score: 69,279
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.21
    Marker Score: 11,401
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.2
    Marker Score: 3,412
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.12
    Marker Score: 4,195
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.12
    Marker Score: 16,343
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 3.05
    Marker Score: 3,515
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.95
    Marker Score: 1,638
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.81
    Marker Score: 55,914
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.8
    Marker Score: 1,669
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.78
    Marker Score: 20,955
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.77
    Marker Score: 41,486
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.75
    Marker Score: 2,375
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.75
    Marker Score: 21,049
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.74
    Marker Score: 2,373
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.73
    Marker Score: 1,542
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.69
    Marker Score: 47,691
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.66
    Marker Score: 1,489
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.66
    Marker Score: 3,221
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.61
    Marker Score: 14,041
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.61
    Marker Score: 88,832
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.6
    Marker Score: 1,458
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.59
    Marker Score: 4,975
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.58
    Marker Score: 98,118
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.57
    Marker Score: 5,640
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.54
    Marker Score: 10,587
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.52
    Marker Score: 801
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.52
    Marker Score: 1,326
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.51
    Marker Score: 1,468
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.49
    Marker Score: 10,303
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.47
    Marker Score: 3,589
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.46
    Marker Score: 7,006
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.44
    Marker Score: 1,606
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.41
    Marker Score: 2,986
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.39
    Marker Score: 10,023
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.38
    Marker Score: 1,177
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.38
    Marker Score: 87,630
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.36
    Marker Score: 1,816
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.35
    Marker Score: 686
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.32
    Marker Score: 2,627
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.31
    Marker Score: 37,122
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.31
    Marker Score: 2,492
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.29
    Marker Score: 8,871
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.29
    Marker Score: 3,843
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.27
    Marker Score: 2,745
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.27
    Marker Score: 2,432
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.27
    Marker Score: 838
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.25
    Marker Score: 4,093
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.24
    Marker Score: 1,306
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.18
    Marker Score: 2,079
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.16
    Marker Score: 2,159
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.14
    Marker Score: 2,255
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.12
    Marker Score: 1,474
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.11
    Marker Score: 3,682
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.09
    Marker Score: 6,997
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.05
    Marker Score: 2,350
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.03
    Marker Score: 26,958
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.01
    Marker Score: 1,786
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.99
    Marker Score: 967
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.98
    Marker Score: 719
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.97
    Marker Score: 2,372
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.97
    Marker Score: 1,994
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.93
    Marker Score: 1,293
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.9
    Marker Score: 5,098
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.89
    Marker Score: 435
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.89
    Marker Score: 706
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.88
    Marker Score: 104,972
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.84
    Marker Score: 752
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.82
    Marker Score: 986
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.8
    Marker Score: 18,627
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8
    Marker Score: 20,317
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.8
    Marker Score: 466
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.78
    Marker Score: 1,968
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.77
    Marker Score: 1,335
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.76
    Marker Score: 1,934
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.75
    Marker Score: 5,724
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.75
    Marker Score: 503
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.74
    Marker Score: 1,559
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.74
    Marker Score: 2,033
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.73
    Marker Score: 988
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.73
    Marker Score: 1,862
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.72
    Marker Score: 7,014
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.72
    Marker Score: 2,433
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.71
    Marker Score: 583
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.7
    Marker Score: 43,654
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.7
    Marker Score: 10,087
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.7
    Marker Score: 820
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.7
    Marker Score: 2,194
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.68
    Marker Score: 583
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.68
    Marker Score: 703

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** QKI is a RNA-binding protein with a KH (Kimura) domain, a RNA-binding motif, and a SH3 (Src Homology 3) domain. These domains enable it to interact with specific RNA sequences and proteins, facilitating its regulatory functions. QKI is a negative regulator of translation, mRNA splicing, and 3'-UTR-mediated mRNA stabilization. It also exhibits positive regulatory effects on gene expression, particularly in the context of oligodendrocyte differentiation and myelination. **Pathways and Functions** QKI is involved in various signaling pathways, including: 1. **Cytoplasmic stress granule formation**: QKI regulates the assembly and disassembly of cytoplasmic stress granules, which are essential for mRNA localization and translation. 2. **Gene expression regulation**: QKI modulates gene expression by controlling mRNA translation, splicing, and 3'-UTR-mediated stabilization. 3. **Immune cell differentiation**: QKI is involved in the differentiation of immune cells, such as microglia, macrophages, and oligodendrocytes. 4. **Neurotransmission**: QKI regulates neurotransmitter release and synaptic plasticity, particularly in the context of inhibitory interneurons. 5. **Cell cycle regulation**: QKI influences cell cycle progression by regulating the expression of cell cycle-related genes. **Clinical Significance** Dysregulation of QKI has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: QKI mutations or dysregulation have been associated with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: QKI is overexpressed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential as a prognostic biomarker or therapeutic target. 3. **Inflammatory diseases**: QKI is involved in the regulation of inflammatory responses, and its dysregulation has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Cardiovascular diseases**: QKI is involved in the regulation of cardiovascular functions, and its dysregulation has been implicated in heart failure and atherosclerosis. In conclusion, QKI is a crucial regulator of post-transcriptional gene expression, and its dysregulation has significant implications for various diseases. Further research is needed to fully elucidate the mechanisms of QKI's regulatory functions and its role in disease pathogenesis.

Genular Protein ID: 4247507332

Symbol: QKI_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96PU8 Q2I375 Q5MJQ1 Q969L9 Q96EJ3 Q96KA3 Q96PU6 Q96PU7 Q9P0X6 Q9P0X7 Q9P0X8 Q9P0X9 Q9P0Y0 Q9P0Y1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 39 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11856480

Title: Expression of Hqk encoding a KH RNA binding protein is altered in human glioma.

PubMed ID: 11856480

DOI: 10.1111/j.1349-7006.2002.tb01255.x

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12529443

Title: Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.

PubMed ID: 12529443

DOI: 10.1091/mbc.e02-08-0484

PubMed ID: 16342280

Title: Human QKI, a new candidate gene for schizophrenia involved in myelination.

PubMed ID: 16342280

DOI: 10.1002/ajmg.b.30243

PubMed ID: 16641098

Title: Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia.

PubMed ID: 16641098

DOI: 10.1073/pnas.0601213103

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22398723

Title: The RNA-binding protein QKI5 is a direct target of C/EBPalpha and delays macrophage differentiation.

PubMed ID: 22398723

DOI: 10.1091/mbc.e11-05-0412

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23455924

Title: A Y2H-seq approach defines the human protein methyltransferase interactome.

PubMed ID: 23455924

DOI: 10.1038/nmeth.2397

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25768908

Title: The RNA binding protein quaking regulates formation of circRNAs.

PubMed ID: 25768908

DOI: 10.1016/j.cell.2015.02.014

PubMed ID: 27029405

Title: Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression.

PubMed ID: 27029405

DOI: 10.1038/ncomms10846

PubMed ID: 31331967

Title: The RNA-binding protein QKI controls alternative splicing in vascular cells, producing an effective model for therapy.

PubMed ID: 31331967

DOI: 10.1242/jcs.230276

PubMed ID: 31792053

Title: The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3' adenylation and selective stabilization of microRNA-122.

PubMed ID: 31792053

DOI: 10.1074/jbc.ra119.011617

PubMed ID: 32732889

Title: Targeting QKI-7 in vivo restores endothelial cell function in diabetes.

PubMed ID: 32732889

DOI: 10.1038/s41467-020-17468-y

PubMed ID: 31829086

Title: The RNA binding protein Quaking represses host interferon response by downregulating MAVS.

PubMed ID: 31829086

DOI: 10.1080/15476286.2019.1703069

PubMed ID: 34428287

Title: The RNA binding protein Quaking represses splicing of the Fibronectin EDA exon and downregulates the interferon response.

PubMed ID: 34428287

DOI: 10.1093/nar/gkab732

PubMed ID: 37379838

Title: QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism.

PubMed ID: 37379838

DOI: 10.1016/j.cell.2023.05.047

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23630077

Title: Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites.

PubMed ID: 23630077

DOI: 10.1101/gad.216531.113

Sequence Information:

  • Length: 341
  • Mass: 37671
  • Checksum: 43E7F3A426A494C4
  • Sequence:
    • MVGEMETKEK PKPTPDYLMQ LMNDKKLMSS LPNFCGIFNH LERLLDEEIS RVRKDMYNDT 
LNGSTEKRSA ELPDAVGPIV QLQEKLYVPV KEYPDFNFVG RILGPRGLTA KQLEAETGCK 
IMVRGKGSMR DKKKEEQNRG KPNWEHLNED LHVLITVEDA QNRAEIKLKR AVEEVKKLLV 
PAAEGEDSLK KMQLMELAIL NGTYRDANIK SPALAFSLAA TAQAAPRIIT GPAPVLPPAA 
LRTPTPAGPT IMPLIRQIQT AVMPNGTPHP TAAIVPPGPE AGLIYTPYEY PYTLAPATSI 
LEYPIEPSGV LGAVATKVRR HDMRVHPYQR IVTADRAATG N

Genular Protein ID: 3839108971

Symbol: Q8WY44_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8WY44

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 IntAct 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PharmGKB 1 RefSeq 4 SAM 1

Citations:

PubMed ID: 12511597

Title: Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.

PubMed ID: 12511597

DOI: 10.1073/pnas.0234478100

Sequence Information:

  • Length: 193
  • Mass: 20673
  • Checksum: 631052977044AF13
  • Sequence:
    • TSPERPPEPA AQAAAALSGL DQPSERRPRL LLVRRQQPAP RARTRPAETR LPPARRPREG 
RAEPGGRERR RLGARRARAE SACGGRASAR CRPPRGSARE PEREPARSGT PGPERPAAGA 
RPRPSLLSGG GGGGGGRSEL RSLEYGRGNG NEGEAEAHPR LPDAADERQE AHEQPAQLLR 
DLQPPRAAAG RRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.