Details for: HADHAP1

Gene ID: 3031

Symbol: HADHAP1

Ensembl ID: ENSG00000251596

Description: HADHA pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2619
    Cell Significance Index: 2.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2222
    Cell Significance Index: 3.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2198
    Cell Significance Index: 2.2800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.2123
    Cell Significance Index: 2.2400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0894
    Cell Significance Index: 1.2400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0861
    Cell Significance Index: 1.1900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0738
    Cell Significance Index: 0.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0546
    Cell Significance Index: 3.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0008
    Cell Significance Index: 0.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0012
    Cell Significance Index: -0.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0028
    Cell Significance Index: -1.2500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0077
    Cell Significance Index: -1.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0077
    Cell Significance Index: -0.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0115
    Cell Significance Index: -0.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0150
    Cell Significance Index: -0.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0165
    Cell Significance Index: -1.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0175
    Cell Significance Index: -0.3000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0191
    Cell Significance Index: -0.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0208
    Cell Significance Index: -0.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0223
    Cell Significance Index: -0.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0223
    Cell Significance Index: -0.7300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0249
    Cell Significance Index: -0.4300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0272
    Cell Significance Index: -0.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0285
    Cell Significance Index: -0.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0318
    Cell Significance Index: -0.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0322
    Cell Significance Index: -0.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0334
    Cell Significance Index: -0.6700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0345
    Cell Significance Index: -0.4200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0345
    Cell Significance Index: -0.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0354
    Cell Significance Index: -0.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0356
    Cell Significance Index: -1.0500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0363
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0365
    Cell Significance Index: -0.4600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0366
    Cell Significance Index: -0.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0382
    Cell Significance Index: -1.0400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0412
    Cell Significance Index: -0.4600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0416
    Cell Significance Index: -0.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0425
    Cell Significance Index: -0.9300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0446
    Cell Significance Index: -1.1400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0455
    Cell Significance Index: -0.4400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0455
    Cell Significance Index: -0.4800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0470
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0500
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0541
    Cell Significance Index: -0.6700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0563
    Cell Significance Index: -0.5900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0617
    Cell Significance Index: -0.6500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0725
    Cell Significance Index: -0.7900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0731
    Cell Significance Index: -0.8700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0734
    Cell Significance Index: -0.8900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0739
    Cell Significance Index: -0.8500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0754
    Cell Significance Index: -0.7700
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0756
    Cell Significance Index: -0.9300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0792
    Cell Significance Index: -0.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0885
    Cell Significance Index: -1.0600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0894
    Cell Significance Index: -1.1200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0897
    Cell Significance Index: -1.0600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0971
    Cell Significance Index: -0.9200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0972
    Cell Significance Index: -1.1600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0972
    Cell Significance Index: -0.9000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1019
    Cell Significance Index: -1.4000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1045
    Cell Significance Index: -1.1100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1065
    Cell Significance Index: -1.3900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1068
    Cell Significance Index: -1.0900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1070
    Cell Significance Index: -1.3500
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1098
    Cell Significance Index: -1.2500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1125
    Cell Significance Index: -1.2200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1146
    Cell Significance Index: -1.3700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1171
    Cell Significance Index: -1.3600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1184
    Cell Significance Index: -1.4000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1196
    Cell Significance Index: -1.3300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1213
    Cell Significance Index: -1.4800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1225
    Cell Significance Index: -1.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1232
    Cell Significance Index: -1.4100
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.1253
    Cell Significance Index: -1.3600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1267
    Cell Significance Index: -2.1800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1298
    Cell Significance Index: -1.1800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1309
    Cell Significance Index: -1.8800
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1310
    Cell Significance Index: -1.5300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1320
    Cell Significance Index: -1.5000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1322
    Cell Significance Index: -1.6500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1328
    Cell Significance Index: -1.5000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1334
    Cell Significance Index: -2.0300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1346
    Cell Significance Index: -1.4900
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1350
    Cell Significance Index: -1.5000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1352
    Cell Significance Index: -1.4500
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.1365
    Cell Significance Index: -1.6500
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.1368
    Cell Significance Index: -1.2700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1372
    Cell Significance Index: -1.5200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1400
    Cell Significance Index: -1.6500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1423
    Cell Significance Index: -1.7900
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.1424
    Cell Significance Index: -1.3100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1450
    Cell Significance Index: -1.3500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1456
    Cell Significance Index: -1.3800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1458
    Cell Significance Index: -1.5100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1525
    Cell Significance Index: -1.6400
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.1532
    Cell Significance Index: -1.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HADHAP1 is a pseudogene that arises from the non-functional HADHA gene, which is involved in the beta-oxidation of fatty acids. Unlike its functional counterpart, HADHAP1 lacks the necessary coding sequences to produce a functional protein. However, this pseudogene has evolved to acquire novel regulatory elements and expression patterns, allowing it to interact with other genes and influence cellular behavior. One of the most striking features of HADHAP1 is its widespread expression in various cell types, including non-pigmented ciliary epithelial cells, plasma cells, Bergmann glial cells, and ependymal cells. This expression pattern suggests that HADHAP1 plays a role in regulating cellular differentiation, proliferation, and survival. **Pathways and Functions:** The mechanisms by which HADHAP1 regulates cellular behavior are not yet fully understood. However, several key pathways have been implicated in its function: 1. **Immune Regulation:** HADHAP1 has been shown to interact with genes involved in the immune response, including those involved in the production of cytokines and the regulation of T-cell activation. 2. **Cellular Differentiation:** HADHAP1 has been implicated in the regulation of cellular differentiation, particularly in the development of neural cells and immune cells. 3. **Transcriptional Regulation:** HADHAP1 has been shown to act as a transcriptional regulator, influencing the expression of genes involved in various biological processes. **Clinical Significance:** While the clinical significance of HADHAP1 is still unclear, its expression in various cell types and its involvement in immune regulation and cellular differentiation suggest potential implications for human disease. Some potential areas of investigation include: 1. **Immunological Disorders:** HADHAP1's role in immune regulation may make it a target for the treatment of immunological disorders, such as autoimmune diseases and cancer. 2. **Neurological Disorders:** The pseudogene's involvement in cellular differentiation and neural development may make it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** HADHAP1's expression in muscle cells and its potential role in cellular differentiation may make it a target for the treatment of muscle-related cancers, such as sarcomas. In conclusion, the HADHAP1 gene is a fascinating example of a pseudogene that has evolved to acquire novel regulatory elements and expression patterns, allowing it to interact with other genes and influence cellular behavior. Further research is needed to fully understand the mechanisms by which HADHAP1 regulates cellular behavior and its potential clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.