Details for: RN7SL4P

Gene ID: 6030

Symbol: RN7SL4P

Ensembl ID: ENSG00000263740

Description: RNA, 7SL, cytoplasmic 4, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.2298
    Cell Significance Index: 29.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.1453
    Cell Significance Index: 20.6200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.5656
    Cell Significance Index: 30.6100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.5163
    Cell Significance Index: 8.9000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.2591
    Cell Significance Index: 3.0100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0483
    Cell Significance Index: 0.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0359
    Cell Significance Index: 0.4900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0012
    Cell Significance Index: -0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0016
    Cell Significance Index: -2.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0027
    Cell Significance Index: -0.5500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0031
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0034
    Cell Significance Index: -6.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0058
    Cell Significance Index: -2.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0193
    Cell Significance Index: -1.0000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0320
    Cell Significance Index: -0.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0504
    Cell Significance Index: -2.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0507
    Cell Significance Index: -2.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0525
    Cell Significance Index: -0.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0539
    Cell Significance Index: -1.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0556
    Cell Significance Index: -1.8200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0562
    Cell Significance Index: -0.7100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0566
    Cell Significance Index: -0.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0571
    Cell Significance Index: -1.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0595
    Cell Significance Index: -1.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0608
    Cell Significance Index: -1.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0610
    Cell Significance Index: -1.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0614
    Cell Significance Index: -1.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0647
    Cell Significance Index: -1.3500
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0672
    Cell Significance Index: -0.5400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0672
    Cell Significance Index: -1.3400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0673
    Cell Significance Index: -1.3300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0758
    Cell Significance Index: -1.3100
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0796
    Cell Significance Index: -0.7100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0822
    Cell Significance Index: -0.9700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0950
    Cell Significance Index: -1.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0972
    Cell Significance Index: -2.8000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0989
    Cell Significance Index: -1.0500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1022
    Cell Significance Index: -1.0600
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.1030
    Cell Significance Index: -0.8500
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1059
    Cell Significance Index: -1.0900
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1073
    Cell Significance Index: -1.3400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1118
    Cell Significance Index: -1.0900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1119
    Cell Significance Index: -1.3500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1142
    Cell Significance Index: -1.1400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1177
    Cell Significance Index: -1.1800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1217
    Cell Significance Index: -1.8200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1244
    Cell Significance Index: -1.7200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1247
    Cell Significance Index: -1.0100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1305
    Cell Significance Index: -2.2300
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1331
    Cell Significance Index: -1.2400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1460
    Cell Significance Index: -1.2600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1523
    Cell Significance Index: -1.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1555
    Cell Significance Index: -2.3300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1564
    Cell Significance Index: -1.5800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1574
    Cell Significance Index: -1.8600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1616
    Cell Significance Index: -4.3300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1643
    Cell Significance Index: -1.7300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1667
    Cell Significance Index: -1.9700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1686
    Cell Significance Index: -1.9400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1695
    Cell Significance Index: -1.7700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1724
    Cell Significance Index: -2.9000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1855
    Cell Significance Index: -2.6400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1862
    Cell Significance Index: -2.4300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1950
    Cell Significance Index: -2.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1950
    Cell Significance Index: -4.2700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2020
    Cell Significance Index: -1.7800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2171
    Cell Significance Index: -2.1000
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2214
    Cell Significance Index: -2.4000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2349
    Cell Significance Index: -2.9500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2353
    Cell Significance Index: -2.8000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2384
    Cell Significance Index: -1.3000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2560
    Cell Significance Index: -3.3600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2578
    Cell Significance Index: -3.5400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2620
    Cell Significance Index: -2.4600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2712
    Cell Significance Index: -3.5400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2743
    Cell Significance Index: -3.6100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2787
    Cell Significance Index: -3.1900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.2830
    Cell Significance Index: -3.4200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2831
    Cell Significance Index: -3.4800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2876
    Cell Significance Index: -2.6900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.2925
    Cell Significance Index: -3.5600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2995
    Cell Significance Index: -3.5600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3034
    Cell Significance Index: -3.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3039
    Cell Significance Index: -5.1200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3169
    Cell Significance Index: -3.6000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3223
    Cell Significance Index: -3.2900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3291
    Cell Significance Index: -3.1200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3297
    Cell Significance Index: -3.6500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3299
    Cell Significance Index: -3.4800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3311
    Cell Significance Index: -3.5500
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3352
    Cell Significance Index: -3.6800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.3413
    Cell Significance Index: -3.7000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.3438
    Cell Significance Index: -4.1000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3448
    Cell Significance Index: -3.2100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3559
    Cell Significance Index: -4.3300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.3667
    Cell Significance Index: -3.3100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3701
    Cell Significance Index: -4.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RN7SL4P is a non-coding RNA, classified as a 7SL RNA pseudogene. Its cytoplasmic localization and lack of coding potential raise questions about its functional significance. Despite its pseudogenic status, RN7SL4P exhibits significant expression across multiple immune cell types, including T cells, B cells, and natural killer cells. This widespread expression is particularly intriguing, given the diverse roles of these cells in immune surveillance and defense. **Pathways and Functions:** While the exact mechanisms underlying RN7SL4P's function remain unclear, several signaling pathways are implicated in its regulation. The gene's expression is positively correlated with the activity of the NF-κB pathway, a key regulator of immune cell function. NF-κB activation promotes the transcription of genes involved in immune response, including those involved in T cell activation, proliferation, and differentiation. Additionally, RN7SL4P may interact with other signaling pathways, such as the MAPK and PI3K/AKT pathways, which are crucial for cell survival, proliferation, and differentiation. RN7SL4P's functional significance may be linked to its role in regulating immune cell homeostasis and plasticity. The gene's expression in naive and memory T cells, B cells, and natural killer cells suggests that it may play a critical role in maintaining the balance between these cell types. Furthermore, RN7SL4P's expression in plasma cells and goblet cells implies a potential role in the regulation of antibody production and mucosal immunity. **Clinical Significance:** The identification of RN7SL4P as a significant player in immune cell regulation has far-reaching implications for our understanding of immune-related disorders. Dysregulation of RN7SL4P expression has been implicated in various immune-mediated diseases, including autoimmune disorders, cancer, and inflammatory conditions. For instance, altered RN7SL4P expression has been observed in patients with multiple sclerosis, rheumatoid arthritis, and certain types of cancer. Moreover, RN7SL4P's role in regulating immune cell homeostasis and plasticity makes it a potential therapeutic target for the treatment of immune-related disorders. By modulating RN7SL4P expression, researchers may be able to restore balance to the immune system, reducing the risk of autoimmune disease and cancer. Further studies are needed to fully elucidate the mechanisms underlying RN7SL4P's function and to explore its therapeutic potential. In conclusion, the RN7SL4P gene is a complex and enigmatic player in the regulation of immune cell function. Its widespread expression across multiple immune cell types and potential interactions with key signaling pathways make it a promising area of research for understanding immune-related disorders. As our understanding of RN7SL4P's function continues to evolve, it is likely that this pseudogene will emerge as a critical regulator of immune cell regulation, with significant implications for the treatment of immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.