CTTNBP2 | ENSG00000077063 | NCBI 83992

Details for: CTTNBP2

Gene ID: 83992

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CTTNBP2

Ensembl ID: ENSG00000077063

Description: cortactin binding protein 2

Cell Significance Landscape

Display Count:

Associated with

Cell cortex
(GO:0005938)
Dendritic spine
(GO:0043197)
Far/sin/stripak complex
(GO:0090443)
Glutamatergic synapse
(GO:0098978)
Postsynaptic actin cytoskeleton
(GO:0098871)
Protein binding
(GO:0005515)
Regulation of modification of postsynaptic actin cytoskeleton
(GO:1905274)
Regulation of synapse organization
(GO:0050807)
Sh3 domain binding
(GO:0017124)
Synaptic vesicle
(GO:0008021)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

VIP GABAergic cortical interneuron CL4023016

CSI 45.03

rCSI 53.79%

PRS 72.5
sst GABAergic cortical interneuron CL4023017

CSI 43.86

rCSI 56.55%

PRS 73.51
differentiation-committed oligodendrocyte precursor CL4023059

CSI 37.48

rCSI 68.11%

PRS 80.24
lamp5 GABAergic cortical interneuron CL4023011

CSI 32.53

rCSI 54.6%

PRS 72.35
pvalb GABAergic cortical interneuron CL4023018

CSI 31.18

rCSI 38.79%

PRS 70.17
oligodendrocyte precursor cell CL0002453

CSI 30.39

rCSI 66.87%

PRS 70.53
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 21.04

rCSI 51.15%

PRS 70.12
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 20.33

rCSI 63.58%

PRS 75.77
parietal epithelial cell CL1000452

CSI 19.97

rCSI 53.38%

PRS 80.84
L6b glutamatergic cortical neuron CL4023038

CSI 18.1

rCSI 56.58%

PRS 73.74
cerebral cortex endothelial cell CL1001602

CSI 18.08

rCSI 31.27%

PRS 80.88
GABAergic amacrine cell CL4030027

CSI 17.92

rCSI 61.39%

PRS 74.14
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 15.62

rCSI 56.2%

PRS 70.35
near-projecting glutamatergic cortical neuron CL4023012

CSI 15.38

rCSI 58.14%

PRS 72.65
progenitor cell CL0011026

CSI 14.51

rCSI 30.86%

PRS 81.44
retinal cone cell CL0000573

CSI 13.98

rCSI 22.49%

PRS 78.84
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 13.74

rCSI 19.47%

PRS 84.71
neuron CL0000540

CSI 12.14

rCSI 32.33%

PRS 75.08
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 11.51

rCSI 13.29%

PRS 79.95
secretory cell CL0000151

CSI 10.84

rCSI 11.31%

PRS 86.25
retinal ganglion cell CL0000740

CSI 10.4

rCSI 22.97%

PRS 75.34
ciliated epithelial cell CL0000067

CSI 9.39

rCSI 8.26%

PRS 78.07
adipocyte CL0000136

CSI 9.34

rCSI 11.99%

PRS 78.3
oligodendrocyte CL0000128

CSI 9.33

rCSI 27.57%

PRS 77.97
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 9.25

rCSI 54.48%

PRS 72.81
choroid plexus epithelial cell CL0000706

CSI 8.82

rCSI 14.44%

PRS 78.99
Mueller cell CL0000636

CSI 8.57

rCSI 19.55%

PRS 80.14
central nervous system neuron CL2000029

CSI 8.27

rCSI 60.77%

PRS 77.15
vascular leptomeningeal cell CL4023051

CSI 8.1

rCSI 14.2%

PRS 82.78
retinal bipolar neuron CL0000748

CSI 7.94

rCSI 14.87%

PRS 77.69
microglial cell CL0000129

CSI 7.69

rCSI 30.94%

PRS 87.07
granulocyte CL0000094

CSI 7.42

rCSI 11.34%

PRS 92.55
neuroblast (sensu Vertebrata) CL0000031

CSI 7.22

rCSI 9.26%

PRS 83.8
interneuron CL0000099

CSI 7.03

rCSI 14.11%

PRS 80.07
melanocyte CL0000148

CSI 7.02

rCSI 5.2%

PRS 82.67
cerebral cortex GABAergic interneuron CL0010011

CSI 6.93

rCSI 20.44%

PRS 87.94
neural cell CL0002319

CSI 6.87

rCSI 25.94%

PRS 71.34
inhibitory interneuron CL0000498

CSI 6.85

rCSI 15.81%

PRS 77.13
H2 horizontal cell CL0004218

CSI 6.84

rCSI 34%

PRS 81.76
renal alpha-intercalated cell CL0005011

CSI 6.82

rCSI 9.12%

PRS 91.46
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 6.72

rCSI 16.06%

PRS 75.89
retina horizontal cell CL0000745

CSI 6.62

rCSI 10.09%

PRS 84.38
kidney interstitial alternatively activated macrophage CL1000695

CSI 6.59

rCSI 17.19%

PRS 88.58
astrocyte of the cerebral cortex CL0002605

CSI 6.47

rCSI 14.5%

PRS 73.11
Kupffer cell CL0000091

CSI 6.4

rCSI 14.63%

PRS 88.28
ionocyte CL0005006

CSI 6.39

rCSI 6.85%

PRS 89.16
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 6.35

rCSI 11.21%

PRS 71.8
fallopian tube secretory epithelial cell CL4030006

CSI 6.31

rCSI 6.07%

PRS 86.34
myeloid leukocyte CL0000766

CSI 6.28

rCSI 5.79%

PRS 88.44
rod bipolar cell CL0000751

CSI 6.16

rCSI 11.08%

PRS 81.78
epithelial cell of proximal tubule CL0002306

CSI 6.15

rCSI 15.03%

PRS 80.28
sncg GABAergic cortical interneuron CL4023015

CSI 5.66

rCSI 9.11%

PRS 73.5
amacrine cell CL0000561

CSI 5.64

rCSI 16.34%

PRS 78.16
medium spiny neuron CL1001474

CSI 5.43

rCSI 46.78%

PRS 77.83
enteric smooth muscle cell CL0002504

CSI 5.38

rCSI 7.68%

PRS 87.8
alveolar type 1 fibroblast cell CL4028004

CSI 5.28

rCSI 5.78%

PRS 88.99
fibroblast of cardiac tissue CL0002548

CSI 5.26

rCSI 25.19%

PRS 87.89
H1 horizontal cell CL0004217

CSI 5.06

rCSI 20.03%

PRS 81.68
mast cell CL0000097

CSI 4.94

rCSI 10.67%

PRS 87.67
blood vessel endothelial cell CL0000071

CSI 4.86

rCSI 10.08%

PRS 85.09
intestinal tuft cell CL0019032

CSI 4.62

rCSI 7.06%

PRS 89.76
Hofbauer cell CL3000001

CSI 4.59

rCSI 8.67%

PRS 93.03
podocyte CL0000653

CSI 4.5

rCSI 19.98%

PRS 88.05
central nervous system macrophage CL0000878

CSI 4.37

rCSI 14.49%

PRS 90.3
kidney connecting tubule epithelial cell CL1000768

CSI 4.26

rCSI 10.8%

PRS 79.82
mesothelial cell CL0000077

CSI 4.25

rCSI 16.62%

PRS 68.3
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 4.07

rCSI 12.55%

PRS 90.01
glycinergic amacrine cell CL4030028

CSI 4.05

rCSI 10.55%

PRS 81.42
microcirculation associated smooth muscle cell CL0008035

CSI 3.95

rCSI 11.44%

PRS 86.56
neural progenitor cell CL0011020

CSI 3.95

rCSI 17.36%

PRS 76.1
GABAergic interneuron CL0011005

CSI 3.91

rCSI 61.71%

PRS 88.23
GABAergic neuron CL0000617

CSI 3.86

rCSI 12.93%

PRS 72.67
glutamatergic neuron CL0000679

CSI 3.72

rCSI 7.65%

PRS 75.01
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.71

rCSI 9.58%

PRS 83.88
ON parasol ganglion cell CL4033052

CSI 3.6

rCSI 51.09%

PRS 79.34
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 3.6

rCSI 7.81%

PRS 75.75
peripheral nervous system neuron CL2000032

CSI 3.48

rCSI 4.74%

PRS 80.36
ON-bipolar cell CL0000749

CSI 3.42

rCSI 5.09%

PRS 86.67
tissue-resident macrophage CL0000864

CSI 3.41

rCSI 15.96%

PRS 94.63
glial cell CL0000125

CSI 3.2

rCSI 12.19%

PRS 80.01
cardiac muscle cell CL0000746

CSI 3.19

rCSI 4.57%

PRS 78.68
lung neuroendocrine cell CL1000223

CSI 3.06

rCSI 4.53%

PRS 89.67
dopaminergic neuron CL0000700

CSI 2.95

rCSI 16.67%

PRS 75.57
pulmonary ionocyte CL0017000

CSI 2.9

rCSI 3.52%

PRS 91.84
mature microglial cell CL0002629

CSI 2.82

rCSI 11.72%

PRS 86.5
cerebral cortex neuron CL0010012

CSI 2.8

rCSI 11.42%

PRS 79.69
chondrocyte CL0000138

CSI 2.72

rCSI 4.33%

PRS 81.91
OFF midget ganglion cell CL4033047

CSI 2.59

rCSI 52.81%

PRS 78.77
direct pathway medium spiny neuron CL4023026

CSI 2.59

rCSI 62.1%

PRS 69.94
renal interstitial pericyte CL1001318

CSI 2.59

rCSI 7.14%

PRS 83.8
ON midget ganglion cell CL4033046

CSI 2.58

rCSI 52.47%

PRS 77.91
indirect pathway medium spiny neuron CL4023029

CSI 2.57

rCSI 61.89%

PRS 70.39
renal beta-intercalated cell CL0002201

CSI 2.4

rCSI 5.72%

PRS 87.31
Bergmann glial cell CL0000644

CSI 2.29

rCSI 3.13%

PRS 79.33
alveolar adventitial fibroblast CL4028006

CSI 2.24

rCSI 3.53%

PRS 88.3
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 2.16

rCSI 7.09%

PRS 74.75
mesodermal cell CL0000222

CSI 2.01

rCSI 2.41%

PRS 85.92
basophil CL0000767

CSI 1.96

rCSI 4.16%

PRS 94.08
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 1.96

rCSI 2.37%

PRS 67.75
macroglial cell CL0000126

CSI 1.83

rCSI 4.71%

PRS 83.56

diffuse bipolar 2 cell CL4033028

CSI 0.8

rCSI 6.1%

PRS 80.4%
neuroendocrine cell CL0000165

CSI 0.8

rCSI 3.3%

PRS 91.9%
starburst amacrine cell CL0004232

CSI 0.9

rCSI 7.8%

PRS 74.4%
midbrain dopaminergic neuron CL2000097

CSI 1.0

rCSI 6.4%

PRS 82.2%
helper T cell CL0000912

CSI 1.1

rCSI 1.5%

PRS 84.1%
flat midget bipolar cell CL4033033

CSI 1.2

rCSI 8.4%

PRS 77.7%
S cone cell CL0003050

CSI 1.3

rCSI 5.8%

PRS 81.9%
stromal cell CL0000499

CSI 1.4

rCSI 3.9%

PRS 83.0%
kidney collecting duct intercalated cell CL1001432

CSI 1.6

rCSI 11.6%

PRS 84.3%
serotonergic neuron CL0000850

CSI 1.7

rCSI 7.4%

PRS 72.6%
Cajal-Retzius cell CL0000695

CSI 1.7

rCSI 13.1%

PRS 89.7%
diffuse bipolar 6 cell CL4033032

CSI 1.8

rCSI 9.2%

PRS 77.4%
pancreatic ductal cell CL0002079

CSI 1.8

rCSI 3.4%

PRS 89.5%
basal cell of epidermis CL0002187

CSI 1.8

rCSI 3.2%

PRS 57.5%
macroglial cell CL0000126

CSI 1.8

rCSI 4.7%

PRS 83.6%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 2.0

rCSI 2.4%

PRS 67.8%
basophil CL0000767

CSI 2.0

rCSI 4.2%

PRS 94.1%
mesodermal cell CL0000222

CSI 2.0

rCSI 2.4%

PRS 85.9%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 2.2

rCSI 7.1%

PRS 74.8%
alveolar adventitial fibroblast CL4028006

CSI 2.2

rCSI 3.5%

PRS 88.3%
Bergmann glial cell CL0000644

CSI 2.3

rCSI 3.1%

PRS 79.3%
renal beta-intercalated cell CL0002201

CSI 2.4

rCSI 5.7%

PRS 87.3%
indirect pathway medium spiny neuron CL4023029

CSI 2.6

rCSI 61.9%

PRS 70.4%
ON midget ganglion cell CL4033046

CSI 2.6

rCSI 52.5%

PRS 77.9%
renal interstitial pericyte CL1001318

CSI 2.6

rCSI 7.1%

PRS 83.8%
direct pathway medium spiny neuron CL4023026

CSI 2.6

rCSI 62.1%

PRS 69.9%
OFF midget ganglion cell CL4033047

CSI 2.6

rCSI 52.8%

PRS 78.8%
chondrocyte CL0000138

CSI 2.7

rCSI 4.3%

PRS 81.9%
cerebral cortex neuron CL0010012

CSI 2.8

rCSI 11.4%

PRS 79.7%
mature microglial cell CL0002629

CSI 2.8

rCSI 11.7%

PRS 86.5%
pulmonary ionocyte CL0017000

CSI 2.9

rCSI 3.5%

PRS 91.8%
dopaminergic neuron CL0000700

CSI 3.0

rCSI 16.7%

PRS 75.6%
lung neuroendocrine cell CL1000223

CSI 3.1

rCSI 4.5%

PRS 89.7%
cardiac muscle cell CL0000746

CSI 3.2

rCSI 4.6%

PRS 78.7%
glial cell CL0000125

CSI 3.2

rCSI 12.2%

PRS 80.0%
tissue-resident macrophage CL0000864

CSI 3.4

rCSI 16.0%

PRS 94.6%
ON-bipolar cell CL0000749

CSI 3.4

rCSI 5.1%

PRS 86.7%
peripheral nervous system neuron CL2000032

CSI 3.5

rCSI 4.7%

PRS 80.4%
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 3.6

rCSI 7.8%

PRS 75.8%
ON parasol ganglion cell CL4033052

CSI 3.6

rCSI 51.1%

PRS 79.3%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.7

rCSI 9.6%

PRS 83.9%
glutamatergic neuron CL0000679

CSI 3.7

rCSI 7.7%

PRS 75.0%
GABAergic neuron CL0000617

CSI 3.9

rCSI 12.9%

PRS 72.7%
GABAergic interneuron CL0011005

CSI 3.9

rCSI 61.7%

PRS 88.2%
neural progenitor cell CL0011020

CSI 4.0

rCSI 17.4%

PRS 76.1%
microcirculation associated smooth muscle cell CL0008035

CSI 4.0

rCSI 11.4%

PRS 86.6%
glycinergic amacrine cell CL4030028

CSI 4.1

rCSI 10.6%

PRS 81.4%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 4.1

rCSI 12.6%

PRS 90.0%
mesothelial cell CL0000077

CSI 4.3

rCSI 16.6%

PRS 68.3%
kidney connecting tubule epithelial cell CL1000768

CSI 4.3

rCSI 10.8%

PRS 79.8%
central nervous system macrophage CL0000878

CSI 4.4

rCSI 14.5%

PRS 90.3%
podocyte CL0000653

CSI 4.5

rCSI 20.0%

PRS 88.1%
Hofbauer cell CL3000001

CSI 4.6

rCSI 8.7%

PRS 93.0%
intestinal tuft cell CL0019032

CSI 4.6

rCSI 7.1%

PRS 89.8%
blood vessel endothelial cell CL0000071

CSI 4.9

rCSI 10.1%

PRS 85.1%
mast cell CL0000097

CSI 4.9

rCSI 10.7%

PRS 87.7%
H1 horizontal cell CL0004217

CSI 5.1

rCSI 20.0%

PRS 81.7%
fibroblast of cardiac tissue CL0002548

CSI 5.3

rCSI 25.2%

PRS 87.9%
alveolar type 1 fibroblast cell CL4028004

CSI 5.3

rCSI 5.8%

PRS 89.0%
enteric smooth muscle cell CL0002504

CSI 5.4

rCSI 7.7%

PRS 87.8%
medium spiny neuron CL1001474

CSI 5.4

rCSI 46.8%

PRS 77.8%
amacrine cell CL0000561

CSI 5.6

rCSI 16.3%

PRS 78.2%
sncg GABAergic cortical interneuron CL4023015

CSI 5.7

rCSI 9.1%

PRS 73.5%
epithelial cell of proximal tubule CL0002306

CSI 6.2

rCSI 15.0%

PRS 80.3%
rod bipolar cell CL0000751

CSI 6.2

rCSI 11.1%

PRS 81.8%
myeloid leukocyte CL0000766

CSI 6.3

rCSI 5.8%

PRS 88.4%
fallopian tube secretory epithelial cell CL4030006

CSI 6.3

rCSI 6.1%

PRS 86.3%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 6.4

rCSI 11.2%

PRS 71.8%
ionocyte CL0005006

CSI 6.4

rCSI 6.9%

PRS 89.2%
Kupffer cell CL0000091

CSI 6.4

rCSI 14.6%

PRS 88.3%
astrocyte of the cerebral cortex CL0002605

CSI 6.5

rCSI 14.5%

PRS 73.1%
kidney interstitial alternatively activated macrophage CL1000695

CSI 6.6

rCSI 17.2%

PRS 88.6%
retina horizontal cell CL0000745

CSI 6.6

rCSI 10.1%

PRS 84.4%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 6.7

rCSI 16.1%

PRS 75.9%
renal alpha-intercalated cell CL0005011

CSI 6.8

rCSI 9.1%

PRS 91.5%
H2 horizontal cell CL0004218

CSI 6.8

rCSI 34.0%

PRS 81.8%
inhibitory interneuron CL0000498

CSI 6.9

rCSI 15.8%

PRS 77.1%
neural cell CL0002319

CSI 6.9

rCSI 25.9%

PRS 71.3%
cerebral cortex GABAergic interneuron CL0010011

CSI 6.9

rCSI 20.4%

PRS 87.9%
melanocyte CL0000148

CSI 7.0

rCSI 5.2%

PRS 82.7%
interneuron CL0000099

CSI 7.0

rCSI 14.1%

PRS 80.1%
neuroblast (sensu Vertebrata) CL0000031

CSI 7.2

rCSI 9.3%

PRS 83.8%
granulocyte CL0000094

CSI 7.4

rCSI 11.3%

PRS 92.6%
microglial cell CL0000129

CSI 7.7

rCSI 30.9%

PRS 87.1%
retinal bipolar neuron CL0000748

CSI 7.9

rCSI 14.9%

PRS 77.7%
vascular leptomeningeal cell CL4023051

CSI 8.1

rCSI 14.2%

PRS 82.8%
central nervous system neuron CL2000029

CSI 8.3

rCSI 60.8%

PRS 77.2%
Mueller cell CL0000636

CSI 8.6

rCSI 19.6%

PRS 80.1%
choroid plexus epithelial cell CL0000706

CSI 8.8

rCSI 14.4%

PRS 79.0%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 9.3

rCSI 54.5%

PRS 72.8%
oligodendrocyte CL0000128

CSI 9.3

rCSI 27.6%

PRS 78.0%
adipocyte CL0000136

CSI 9.3

rCSI 12.0%

PRS 78.3%
ciliated epithelial cell CL0000067

CSI 9.4

rCSI 8.3%

PRS 78.1%
retinal ganglion cell CL0000740

CSI 10.4

rCSI 23.0%

PRS 75.3%
secretory cell CL0000151

CSI 10.8

rCSI 11.3%

PRS 86.3%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 11.5

rCSI 13.3%

PRS 80.0%
neuron CL0000540

CSI 12.1

rCSI 32.3%

PRS 75.1%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 13.7

rCSI 19.5%

PRS 84.7%
retinal cone cell CL0000573

CSI 14.0

rCSI 22.5%

PRS 78.8%
progenitor cell CL0011026

CSI 14.5

rCSI 30.9%

PRS 81.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [CTTNBP2](/details-gene/83992) (Cortactin Binding Protein 2) is a protein-coding gene located on chromosome 7q31.31, a region that has been identified as a candidate locus for autism [Link](https://doi.org/10.1006/geno.2001.6651). Functionally, [CTTNBP2](/details-gene/83992) is implicated in the structural dynamics of the nervous system. Gene Ontology annotations suggest its involvement in regulating the postsynaptic actin cytoskeleton ([GO:1905274](https://www.ebi.ac.uk/QuickGO/term/GO:1905274)) and synapse organization ([GO:0050807](https://www.ebi.ac.uk/QuickGO/term/GO:0050807)). Consistent with this, its expression is highly significant in a wide range of neuronal subtypes, particularly inhibitory cortical interneurons such as [VIP GABAergic cortical interneuron](/details-cell/CL4023016) and [sst GABAergic cortical interneuron](/details-cell/CL4023017), as well as in glial precursors like the [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059). This expression pattern underscores its likely importance in synaptic function, neuronal circuitry, and central nervous system development. ## Cellular Roles and Expression Landscape The expression profile of [CTTNBP2](/details-gene/83992) strongly indicates a specialized role within the central nervous system. **Overall**, the gene shows the highest significance in various subtypes of inhibitory interneurons within the cerebral cortex, including [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 45.03), [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 43.86), [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 32.53), and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 31.18). Its significance extends to several classes of glutamatergic neurons as well, such as [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) and [L6b glutamatergic cortical neuron](/details-cell/CL4023038), suggesting a broad role in maintaining the architecture and function of cortical circuits. Beyond mature neurons, [CTTNBP2](/details-gene/83992) is also a highly significant marker for glial progenitor cells, specifically [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) (CSI: 37.48) and [oligodendrocyte precursor cell](/details-cell/CL0002453) (CSI: 30.39). This suggests a potential function in glial development, such as the cytoskeletal rearrangements required for migration or the initiation of myelination. The gene's notable expression in these distinct neural and glial lineages points to a fundamental role in dynamic cellular processes within the brain. ## Pathways and Molecular Function The molecular function of [CTTNBP2](/details-gene/83992) is centered on protein-protein interactions and cytoskeletal organization, consistent with its name as a cortactin-binding protein. Its annotated molecular functions include general protein binding ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)) and specific SH3 domain binding ([GO:0017124](https://www.ebi.ac.uk/QuickGO/term/GO:0017124)), a common mechanism for assembling signaling complexes. Biologically, these interactions appear to be directed toward the synapse. [CTTNBP2](/details-gene/83992) is a component of the [dendritic spine](/details-cell/GO0043197) and the [postsynaptic actin cytoskeleton](/details-cell/GO0098871), and it participates in the regulation of this cytoskeleton ([GO:1905274](https://www.ebi.ac.uk/QuickGO/term/GO:1905274)). This role is critical for synaptic plasticity, the process underlying learning and memory. Its localization to the [glutamatergic synapse](/details-cell/GO0098978) directly aligns with its high expression in both GABAergic and glutamatergic neurons, which together form the brain's main excitatory-inhibitory circuits. The protein is also associated with synaptic vesicles ([GO:0008021](https://www.ebi.ac.uk/QuickGO/term/GO:0008021)), suggesting it may also contribute to neurotransmitter release cycles. ## Research Directions The specific expression of [CTTNBP2](/details-gene/83992) in diverse neuronal and glial precursor populations, coupled with its function in cytoskeletal dynamics at the synapse, suggests it may be a critical node in neurodevelopment and circuit maintenance. Its location within an autism-associated genomic region further raises its importance in studying neurodevelopmental disorders. Based on the available data, several testable hypotheses can be proposed: 1. Dysregulation of [CTTNBP2](/details-gene/83992) in cortical interneurons impairs the structural plasticity of dendritic spines, leading to an excitatory/inhibitory imbalance that may contribute to the pathophysiology of neurodevelopmental disorders like autism. 2. [CTTNBP2](/details-gene/83992) is essential for the cytoskeletal reorganization required for the migration and differentiation of [oligodendrocyte precursor cell](/details-cell/CL0002453)s, and its deficiency could lead to defects in myelination. To test the first hypothesis regarding synaptic plasticity, a key experiment would be to use CRISPR-Cas9 to knock down or knock out [CTTNBP2](/details-gene/83992) in primary rodent cortical neuron cultures or in a specific neuronal subtype in a mouse model. Subsequent analysis using high-resolution confocal microscopy could quantify changes in dendritic spine density, morphology, and turnover. Furthermore, electrophysiological recordings (e.g., patch-clamp) could directly measure alterations in miniature excitatory and inhibitory postsynaptic currents (mEPSCs and mIPSCs) to determine the functional impact on synaptic transmission and circuit balance. As a therapeutic target, [CTTNBP2](/details-gene/83992) presents challenges. It is an intracellular scaffolding protein, making it difficult to target with conventional biologics like antibodies. Small molecule modulation of its protein-protein interactions could be a possibility but would require a deep structural understanding. Given its fundamental role in cytoskeletal organization, any therapeutic intervention would need to be highly specific to avoid off-target effects. Therefore, its primary value may lie in being a biomarker or an entry point for understanding pathways that, if dysregulated, could be targeted at more druggable nodes.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cortactin-binding protein 2

Genular Protein ID: 2885792292

Symbol: CTTB2_HUMAN

Name: Cortactin-binding protein 2

UniProtKB Accession Codes:

Q8WZ74 O43389 Q7LG11 Q9C0A5

Database IDs:

Citations:

PubMed ID: 11707066

Title: Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31.

PubMed ID: 11707066

DOI: 10.1006/geno.2001.6651

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11214970

Title: Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11214970

DOI: 10.1093/dnares/7.6.347

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 1663
Mass: 181051
Checksum: 367B933A177D6E3B
Sequence:

MATDGASCEP DLSRAPEDAA GAAAEAAKKE FDVDTLSKSE LRMLLSVMEG ELEARDLVIE 
ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGAGDKEK KPVCTNPLSI LEAVMAHCKK 
MQERMSAQLA AAESRQKKLE MEKLQLQALE QEHKKLAARL EEERGKNKQV VLMLVKECKQ 
LSGKVIEEAQ KLEDVMAKLE EEKKKTNELE EELSAEKRRS TEMEAQMEKQ LSEFDTEREQ 
LRAKLNREEA HTTDLKEEID KMRKMIEQLK RGSDSKPSLS LPRKTKDRRL VSISVGTEGT 
VTRSVACQTD LVTENADHMK KLPLTMPVKP STGSPLVSAN AKGSVCTSAT MARPGIDRQA 
SYGDLIGASV PAFPPPSANK IEENGPSTGS TPDPTSSTPP LPSNAAPPTA QTPGIAPQNS 
QAPPMHSLHS PCANTSLHPG LNPRIQAARF RFQGNANDPD QNGNTTQSPP SRDVSPTSRD 
NLVAKQLARN TVTQALSRFT SPQAGAPSRP GVPPTGDVGT HPPVGRTSLK THGVARVDRG 
NPPPIPPKKP GLSQTPSPPH PQLKVIIDSS RASNTGAKVD NKTVASTPSS LPQGNRVINE 
ENLPKSSSPQ LPPKPSIDLT VAPAGCAVSA LATSQVGAWP AATPGLNQPA CSDSSLVIPT 
TIAFCSSINP VSASSCRPGA SDSLLVTASG WSPSLTPLLM SGGPAPLAGR PTLLQQAAAQ 
GNVTLLSMLL NEEGLDINYS CEDGHSALYS AAKNGHTDCV RLLLSAEAQV NAADKNGFTP 
LCAAAAQGHF ECVELLISYD ANINHAADGG QTPLYLACKN GNKECIKLLL EAGTNRSVKT 
TDGWTPVHAA VDTGNVDSLK LLMYHRIPAH GNSFNEEESE SSVFDLDGGE ESPEGISKPV 
VPADLINHAN REGWTAAHIA ASKGFKNCLE ILCRHGGLEP ERRDKCNRTV HDVATDDCKH 
LLENLNALKI PLRISVGEIE PSNYGSDDLE CENTICALNI RKQTSWDDFS KAVSQALTNH 
FQAISSDGWW SLEDVTCNNT TDSNIGLSAR SIRSITLGNV PWSVGQSFAQ SPWDFMRKNK 
AEHITVLLSG PQEGCLSSVT YASMIPLQMM QNYLRLVEQY HNVIFHGPEG SLQDYIVHQL 
ALCLKHRQMA AGFSCEIVRA EVDAGFSKEQ LLDLFISSAC LIPVKQSPSK KKIIIILENL 
EKSSLSELLR DFLAPLENRS TESPCTFQKG NGLSECYYFH ENCFLMGTIA KACLQGSDLL 
VQQHFRWVQL RWDGEPMQGL LQRFLRRKVV NKFKGQAPSP CDPVCKIVDW ALSVWRQLNS 
CLARLGTPEA LLGPKYFLSC PVVPGHAQVT VKWMSKLWNG VIAPRVQEAI LSRASVKRQP 
GFGQTTAKRH PSQGQQAVVK AALSILLNKA VLHGCPLPRA ELDQHTADFK GGSFPLSIVS 
SYNTCNKKKG ESGAWRKVNT SPRRKSGRFS LPTWNKPDLS TEGMKNKTIS QLNCNRNASL 
SKQKSLENDL SLTLNLDQRL SLGSDDEADL VKELQSMCSS KSESDISKIA DSRDDLRMFD 
SSGNNPVLSA TINNLRMPVS QKEVSPLSSH QTTECSNSKS KTELGVSRVK SFLPVPRSKV 
TQCSQNTKRS SSSSNTRQIE INNNSKEVNW NLHKNEHLEK PNK

Details for: CTTNBP2

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31. PubMed ID: 11707066

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 11214970

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692