Details for: ZRANB3
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 27.02rCSI 22.56%PRS 85.02
-
CSI 17.43rCSI 42.35%PRS 73.44
-
CSI 15.09rCSI 17.45%PRS 83.62
-
CSI 14.73rCSI 39.09%PRS 90.99
-
CSI 13.14rCSI 47.3%PRS 73.66
-
CSI 12.13rCSI 19.36%PRS 81.89
-
CSI 11.22rCSI 24.79%PRS 78.4
-
CSI 10.95rCSI 17.42%PRS 84.36
-
CSI 10.36rCSI 17.39%PRS 75.67
-
CSI 10.15rCSI 31.73%PRS 77.06
-
CSI 9.96rCSI 18.11%PRS 82.83
-
CSI 9.92rCSI 17.48%PRS 85.31
-
CSI 9.71rCSI 13.23%PRS 59.63
-
CSI 8.15rCSI 31.88%PRS 71.82
-
CSI 8rCSI 14.37%PRS 84.23
-
CSI 7.94rCSI 10.24%PRS 76.85
-
CSI 7.84rCSI 9.06%PRS 82.3
-
CSI 7.59rCSI 17.53%PRS 80.02
-
CSI 7.46rCSI 10.37%PRS 88
-
CSI 7.28rCSI 10.45%PRS 81.36
-
CSI 7.04rCSI 9.04%PRS 81
-
CSI 6.4rCSI 7.64%PRS 75.72
-
CSI 6.31rCSI 10.91%PRS 83.7
-
CSI 6.31rCSI 4.98%PRS 81.84
-
CSI 6.29rCSI 21.53%PRS 76.74
-
CSI 6.23rCSI 17.51%PRS 85.36
-
CSI 6.05rCSI 15.78%PRS 90.76
-
CSI 6.01rCSI 9.81%PRS 59.96
-
CSI 5.94rCSI 9.56%PRS 81.49
-
CSI 5.64rCSI 16.73%PRS 95.03
-
CSI 5.42rCSI 12.36%PRS 82.55
-
CSI 5.35rCSI 12.24%PRS 90.32
-
CSI 5.32rCSI 15.43%PRS 80.73
-
CSI 5.28rCSI 31.06%PRS 76.19
-
CSI 5.11rCSI 9.06%PRS 60.29
-
CSI 5.06rCSI 6.29%PRS 73.53
-
CSI 4.92rCSI 25.21%PRS 91.55
-
CSI 4.87rCSI 9.13%PRS 80.47
-
CSI 4.65rCSI 15.59%PRS 75.73
-
CSI 4.35rCSI 25.06%PRS 86.3
-
CSI 4.34rCSI 9.41%PRS 78.29
-
CSI 4.21rCSI 20.14%PRS 85.54
-
CSI 4.1rCSI 3.82%PRS 90.61
-
CSI 4.05rCSI 12.97%PRS 87.81
-
CSI 4.05rCSI 6.67%PRS 91.39
-
CSI 3.92rCSI 14.69%PRS 84.35
-
CSI 3.85rCSI 7.73%PRS 82.97
-
CSI 3.81rCSI 10.13%PRS 77.42
-
CSI 3.65rCSI 2.7%PRS 85.33
-
CSI 3.64rCSI 10.35%PRS 85.68
-
CSI 3.63rCSI 11.94%PRS 77.6
-
CSI 3.55rCSI 6.28%PRS 75.13
-
CSI 3.55rCSI 5.82%PRS 81.79
-
CSI 3.48rCSI 9.06%PRS 83.63
-
CSI 3.42rCSI 6%PRS 85.49
-
CSI 3.32rCSI 4.7%PRS 86.88
-
CSI 3.28rCSI 12.39%PRS 75.93
-
CSI 3.21rCSI 5.17%PRS 76.77
-
CSI 3.08rCSI 2.15%PRS 92.47
-
CSI 3.07rCSI 4.52%PRS 84.01
-
CSI 3.07rCSI 9.05%PRS 88.72
-
CSI 3.06rCSI 6.87%PRS 76.15
-
CSI 3.02rCSI 7.2%PRS 89.23
-
CSI 3.02rCSI 7.8%PRS 86.16
-
CSI 3.01rCSI 14.4%PRS 90.02
-
CSI 2.94rCSI 11.2%PRS 82.59
-
CSI 2.91rCSI 11.74%PRS 90.01
-
CSI 2.9rCSI 9.08%PRS 78.93
-
CSI 2.84rCSI 16.05%PRS 78.44
-
CSI 2.82rCSI 14%PRS 83.76
-
CSI 2.72rCSI 38.65%PRS 81.65
-
CSI 2.71rCSI 2.96%PRS 90.88
-
CSI 2.68rCSI 7.06%PRS 93.35
-
CSI 2.68rCSI 6.4%PRS 78.61
-
CSI 2.65rCSI 6.7%PRS 92.07
-
CSI 2.62rCSI 53.32%PRS 80.55
-
CSI 2.61rCSI 11.66%PRS 75.06
-
CSI 2.55rCSI 18.71%PRS 80.45
-
CSI 2.49rCSI 2.01%PRS 90.9
-
CSI 2.48rCSI 50.46%PRS 81.31
-
CSI 2.44rCSI 6.19%PRS 82.62
-
CSI 2.44rCSI 5.05%PRS 87.61
-
CSI 2.43rCSI 7.1%PRS 95.22
-
CSI 2.35rCSI 56.21%PRS 73.44
-
CSI 2.32rCSI 55.95%PRS 73.7
-
CSI 2.3rCSI 3.41%PRS 91.31
-
CSI 2.16rCSI 9.5%PRS 78.81
-
CSI 2.13rCSI 5.28%PRS 89.87
-
CSI 2.11rCSI 2.89%PRS 81.6
-
CSI 2.08rCSI 5.07%PRS 82.52
-
CSI 2.07rCSI 12.98%PRS 69.83
-
CSI 2.05rCSI 3.68%PRS 88.24
-
CSI 1.86rCSI 3.82%PRS 77.69
-
CSI 1.8rCSI 4.96%PRS 86.41
-
CSI 1.79rCSI 4.66%PRS 88.7
-
CSI 1.74rCSI 4.47%PRS 85.54
-
CSI 1.67rCSI 3.32%PRS 85.76
-
CSI 1.61rCSI 2.54%PRS 90.21
-
CSI 1.59rCSI 6.98%PRS 84.62
-
CSI 1.58rCSI 4.22%PRS 83.53
-
CSI 0.4rCSI 3.9%PRS 85.4%
-
CSI 0.6rCSI 7.2%PRS 77.5%
-
CSI 0.7rCSI 5.3%PRS 82.5%
-
CSI 0.7rCSI 5.1%PRS 80.1%
-
CSI 0.7rCSI 4.8%PRS 83.5%
-
CSI 0.7rCSI 5.5%PRS 79.4%
-
CSI 0.8rCSI 5.3%PRS 81.5%
-
CSI 0.8rCSI 1.1%PRS 85.6%
-
CSI 0.8rCSI 5.0%PRS 83.0%
-
CSI 0.8rCSI 3.7%PRS 89.9%
-
CSI 1.0rCSI 4.1%PRS 83.5%
-
CSI 1.0rCSI 5.5%PRS 79.9%
-
CSI 1.2rCSI 4.8%PRS 94.4%
-
CSI 1.2rCSI 7.1%PRS 80.7%
-
CSI 1.2rCSI 10.8%PRS 77.6%
-
CSI 1.3rCSI 10.1%PRS 86.2%
-
CSI 1.3rCSI 1.5%PRS 70.1%
-
CSI 1.3rCSI 2.7%PRS 84.2%
-
CSI 1.4rCSI 4.5%PRS 86.1%
-
CSI 1.5rCSI 4.9%PRS 86.8%
-
CSI 1.6rCSI 4.2%PRS 83.5%
-
CSI 1.6rCSI 7.0%PRS 84.6%
-
CSI 1.6rCSI 2.5%PRS 90.2%
-
CSI 1.7rCSI 3.3%PRS 85.8%
-
CSI 1.7rCSI 4.5%PRS 85.5%
-
CSI 1.8rCSI 4.7%PRS 88.7%
-
CSI 1.8rCSI 5.0%PRS 86.4%
-
CSI 1.9rCSI 3.8%PRS 77.7%
-
CSI 2.1rCSI 3.7%PRS 88.2%
-
CSI 2.1rCSI 13.0%PRS 69.8%
-
CSI 2.1rCSI 5.1%PRS 82.5%
-
CSI 2.1rCSI 2.9%PRS 81.6%
-
CSI 2.1rCSI 5.3%PRS 89.9%
-
CSI 2.2rCSI 9.5%PRS 78.8%
-
CSI 2.3rCSI 3.4%PRS 91.3%
-
CSI 2.3rCSI 56.0%PRS 73.7%
-
CSI 2.4rCSI 56.2%PRS 73.4%
-
CSI 2.4rCSI 7.1%PRS 95.2%
-
CSI 2.4rCSI 5.1%PRS 87.6%
-
CSI 2.4rCSI 6.2%PRS 82.6%
-
CSI 2.5rCSI 50.5%PRS 81.3%
-
CSI 2.5rCSI 2.0%PRS 90.9%
-
CSI 2.6rCSI 18.7%PRS 80.5%
-
CSI 2.6rCSI 11.7%PRS 75.1%
-
CSI 2.6rCSI 53.3%PRS 80.6%
-
CSI 2.7rCSI 6.7%PRS 92.1%
-
CSI 2.7rCSI 6.4%PRS 78.6%
-
CSI 2.7rCSI 7.1%PRS 93.4%
-
CSI 2.7rCSI 3.0%PRS 90.9%
-
CSI 2.7rCSI 38.7%PRS 81.7%
-
CSI 2.8rCSI 14.0%PRS 83.8%
-
CSI 2.8rCSI 16.1%PRS 78.4%
-
CSI 2.9rCSI 9.1%PRS 78.9%
-
CSI 2.9rCSI 11.7%PRS 90.0%
-
CSI 2.9rCSI 11.2%PRS 82.6%
-
CSI 3.0rCSI 14.4%PRS 90.0%
-
CSI 3.0rCSI 7.8%PRS 86.2%
-
CSI 3.0rCSI 7.2%PRS 89.2%
-
CSI 3.1rCSI 6.9%PRS 76.2%
-
CSI 3.1rCSI 9.1%PRS 88.7%
-
CSI 3.1rCSI 4.5%PRS 84.0%
-
CSI 3.1rCSI 2.2%PRS 92.5%
-
CSI 3.2rCSI 5.2%PRS 76.8%
-
CSI 3.3rCSI 12.4%PRS 75.9%
-
CSI 3.3rCSI 4.7%PRS 86.9%
-
CSI 3.4rCSI 6.0%PRS 85.5%
-
CSI 3.5rCSI 9.1%PRS 83.6%
-
CSI 3.6rCSI 5.8%PRS 81.8%
-
CSI 3.6rCSI 6.3%PRS 75.1%
-
CSI 3.6rCSI 11.9%PRS 77.6%
-
CSI 3.6rCSI 10.4%PRS 85.7%
-
CSI 3.7rCSI 2.7%PRS 85.3%
-
CSI 3.8rCSI 10.1%PRS 77.4%
-
CSI 3.9rCSI 7.7%PRS 83.0%
-
CSI 3.9rCSI 14.7%PRS 84.4%
-
CSI 4.1rCSI 6.7%PRS 91.4%
-
CSI 4.1rCSI 13.0%PRS 87.8%
-
CSI 4.1rCSI 3.8%PRS 90.6%
-
CSI 4.2rCSI 20.1%PRS 85.5%
-
CSI 4.3rCSI 9.4%PRS 78.3%
-
CSI 4.4rCSI 25.1%PRS 86.3%
-
CSI 4.7rCSI 15.6%PRS 75.7%
-
CSI 4.9rCSI 9.1%PRS 80.5%
-
CSI 4.9rCSI 25.2%PRS 91.6%
-
CSI 5.1rCSI 6.3%PRS 73.5%
-
CSI 5.1rCSI 9.1%PRS 60.3%
-
CSI 5.3rCSI 31.1%PRS 76.2%
-
CSI 5.3rCSI 15.4%PRS 80.7%
-
CSI 5.4rCSI 12.2%PRS 90.3%
-
CSI 5.4rCSI 12.4%PRS 82.6%
-
CSI 5.6rCSI 16.7%PRS 95.0%
-
CSI 5.9rCSI 9.6%PRS 81.5%
-
CSI 6.0rCSI 9.8%PRS 60.0%
-
CSI 6.1rCSI 15.8%PRS 90.8%
-
CSI 6.2rCSI 17.5%PRS 85.4%
-
CSI 6.3rCSI 21.5%PRS 76.7%
-
CSI 6.3rCSI 5.0%PRS 81.8%
-
CSI 6.3rCSI 10.9%PRS 83.7%
-
CSI 6.4rCSI 7.6%PRS 75.7%
-
CSI 7.0rCSI 9.0%PRS 81.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1477818141
Symbol: ZRAB3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21078962
Title: Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif.
PubMed ID: 21078962
PubMed ID: 22759634
Title: ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response.
PubMed ID: 22759634
PubMed ID: 22705370
Title: The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress.
PubMed ID: 22705370
PubMed ID: 22704558
Title: Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
PubMed ID: 22704558
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26884333
Title: Identification of a substrate recognition domain in the replication stress response protein zinc finger Ran-binding domain-containing protein 3 (ZRANB3).
PubMed ID: 26884333
PubMed ID: 25412445
Title: Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway.
PubMed ID: 25412445
PubMed ID: 27445336
Title: Identification of a distinct substrate-binding domain in the bacterial cysteine methyltransferase effectors NleE and OspZ.
PubMed ID: 27445336
Sequence Information:
- Length: 1079
- Mass: 123248
- Checksum: 7B65AB9568B15AAE
- Sequence:
MPRVHNIKKS LTPHISCVTN ESDNLLDFLP DRLRAKLLPF QKDGIIFALK RNGRCMVADE MGLGKTIQAI GITYFYKEEW PLLIVVPSSL RYPWTEEIEK WIPELSPEEI NVIQNKTDVR RMSTSKVTVL GYGLLTADAK TLIDALNNQN FKVVIVDESH YMKSRNATRS RILLPIVQKA RRAILLTGTP ALGRPEELFM QIEALFPQKF GRWTDYAKRY CNAHIRYFGK RPQWDCRGAS NLNELHQLLS DIMIRRLKTE VLTQLPPKVR QRIPFDLPSA AAKELNTSFE EWEKIMRTPN SGAMETVMGL ITRMFKQTAI AKAGAVKDYI KMMLQNDSLK FLVFAHHLSM LQACTEAVIE NKTRYIRIDG SVSSSERIHL VNQFQKDPDT RVAILSIQAA GQGLTFTAAS HVVFAELYWD PGHIKQAEDR AHRIGQCSSV NIHYLIANGT LDTLMWGMLN RKAQVTGSTL NGRKEKIQAE EGDKEKWDFL QFAEAWTPND SSEELRKEAL FTHFEKEKQH DIRSFFVPQP KKRQLMTSCD ESKRFREENT VVSSDPTKTA ARDIIDYESD VEPETKRLKL AASEDHCSPS EETPSQSKQI RTPLVESVQE AKAQLTTPAF PVEGWQCSLC TYINNSELPY CEMCETPQGS AVMQIDSLNH IQDKNEKDDS QKDTSKKVQT ISDCEKQALA QSEPGQLADS KEETPKIEKE DGLTSQPGNE QWKSSDTLPV YDTLMFCASR NTDRIHIYTK DGKQMSCNFI PLDIKLDLWE DLPASFQLKQ YRSLILRFVR EWSSLTAMKQ RIIRKSGQLF CSPILALEEI TKQQTKQNCT KRYITKEDVA VASMDKVKNV GGHVRLITKE SRPRDPFTKK LLEDGACVPF LNPYTVQADL TVKPSTSKGY LQAVDNEGNP LCLRCQQPTC QTKQACKANS WDSRFCSLKC QEEFWIRSNN SYLRAKVFET EHGVCQLCNV NAQELFLRLR DAPKSQRKNL LYATWTSKLP LEQLNEMIRN PGEGHFWQVD HIKPVYGGGG QCSLDNLQTL CTVCHKERTA RQAKERSQVR RQSLASKHGS DITRFLVKK
Genular Protein ID: 362866944
Symbol: F5GYN7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
Sequence Information:
- Length: 625
- Mass: 71515
- Checksum: 3DD36A0B50FF0B91
- Sequence:
MWGMLNRKAQ VTGSTLNGRK EKIQAEEGDK EKWDFLQFAE AWTPNDSSEE LRKEALFTHF EKEKQHDIRS FFVPQPKKRQ LMTSCDESKR FREENTVVSS DPTKTAARDI IDYESDVEPE TKRLKLAASE DHCSPSEETP SQSKQIRTPL VESVQEAKAQ LTTPAFPVEG WQCSLCTYIN NSELPYCEMC ETPQGSAVMQ IDSLNHIQDK NEKDDSQKDT SKKVQTISDC EKQALAQSEP GQLADSKEET PKIEKEDGLT SQPGNEQWKS SDTLPVYDTL MFCASRNTDR IHIYTKDGKQ MSCNFIPLDI KLDLWEDLPA SFQLKQYRSL ILRFVREWSS LTAMKQRIIR KSGQLFCSPI LALEEITKQQ TKQNCTKRYI TKEDVAVASM DKVKNVGGHV RLITKESRPR DPFTKKLLED GACVPFLNPY TVQADLTVKP STSKGYLQAV DNEGNPLCLR CQQPTCQTKQ ACKANSWDSR FCSLKCQEEF WIRSNNSYLR AKVFETEHGV CQLCNVNAQE LFLRLRDAPK SQRKNLLYAT WTSKLPLEQL NEMIRNPGEG HFWQVDHIKP VYGGGGQCSL DNLQTLCTVC HKERTARQAK ERSQVRRQSL ASKHGSDITR FLVKK