Details for: MAP4K3

Gene ID: 8491

Symbol: MAP4K3

Ensembl ID: ENSG00000011566

Description: mitogen-activated protein kinase kinase kinase kinase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.79
    Marker Score: 84696
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.69
    Marker Score: 9244
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.68
    Marker Score: 4954
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.54
    Marker Score: 3058
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.41
    Marker Score: 60486
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.36
    Marker Score: 4065
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.25
    Marker Score: 7136
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.16
    Marker Score: 106878
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.1
    Marker Score: 2387
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 3.08
    Marker Score: 1622
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.07
    Marker Score: 3821
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.05
    Marker Score: 1775
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.03
    Marker Score: 5826
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.02
    Marker Score: 1677
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.84
    Marker Score: 3272
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.84
    Marker Score: 11877
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.63
    Marker Score: 8808
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.57
    Marker Score: 13504
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.56
    Marker Score: 54676
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.53
    Marker Score: 50361
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.5
    Marker Score: 1460
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.47
    Marker Score: 1859
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.46
    Marker Score: 36827
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.45
    Marker Score: 11349
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.45
    Marker Score: 1700
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.44
    Marker Score: 92674
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.4
    Marker Score: 1435
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.39
    Marker Score: 8502
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.39
    Marker Score: 698
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.38
    Marker Score: 2632
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.37
    Marker Score: 750
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.36
    Marker Score: 18113
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.34
    Marker Score: 12592
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.31
    Marker Score: 5312
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.31
    Marker Score: 9563
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.3
    Marker Score: 17332
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.27
    Marker Score: 83855
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.19
    Marker Score: 696
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.13
    Marker Score: 3584
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.13
    Marker Score: 892
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.12
    Marker Score: 6052
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1
    Marker Score: 8104
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.09
    Marker Score: 8720.5
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.09
    Marker Score: 1131
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.05
    Marker Score: 19304
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.05
    Marker Score: 1955
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.04
    Marker Score: 979
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.02
    Marker Score: 1173
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2
    Marker Score: 122740
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.95
    Marker Score: 4666
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.93
    Marker Score: 1709
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.93
    Marker Score: 1581
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.92
    Marker Score: 1072
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 17915
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.87
    Marker Score: 19259
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.83
    Marker Score: 15727
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.79
    Marker Score: 1926
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.77
    Marker Score: 647
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.76
    Marker Score: 640
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.76
    Marker Score: 7165
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.73
    Marker Score: 2434
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.73
    Marker Score: 968
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.67
    Marker Score: 26858
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.66
    Marker Score: 640
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.61
    Marker Score: 417
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.6
    Marker Score: 2466
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.59
    Marker Score: 3911
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.59
    Marker Score: 1378
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.57
    Marker Score: 5159
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.57
    Marker Score: 400
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.57
    Marker Score: 451
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.56
    Marker Score: 578.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.55
    Marker Score: 5501
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.54
    Marker Score: 1906
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.54
    Marker Score: 765
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.54
    Marker Score: 420
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.52
    Marker Score: 1001
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.47
    Marker Score: 466
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.46
    Marker Score: 958
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.45
    Marker Score: 1647
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.45
    Marker Score: 547
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.43
    Marker Score: 2073
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.4
    Marker Score: 1494.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.38
    Marker Score: 683
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.38
    Marker Score: 1050
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.37
    Marker Score: 1653
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.34
    Marker Score: 691
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.32
    Marker Score: 1871
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.31
    Marker Score: 447
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.3
    Marker Score: 1623
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.27
    Marker Score: 8183
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.27
    Marker Score: 3205
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.27
    Marker Score: 475
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.26
    Marker Score: 2206
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19631
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.25
    Marker Score: 2546
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.22
    Marker Score: 5086
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.21
    Marker Score: 2008
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.18
    Marker Score: 428
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.17
    Marker Score: 370

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Other Information

**Key Characteristics:** MAP4K3 is a member of the MAPK kinase kinase family, which is involved in the regulation of cellular signaling pathways. It contains a characteristic kinase domain and a regulatory domain, allowing for the phosphorylation and activation of downstream targets. MAP4K3 is highly expressed in various tissues, including the heart, skeletal muscle, and lens epithelial cells. Its expression is also observed in immune cells, suggesting a potential role in immune responses. **Pathways and Functions:** MAP4K3 is integral to several key signaling pathways, including: 1. **JNK Cascade:** MAP4K3 activates the c-Jun N-terminal kinase (JNK) cascade, which is involved in stress responses, apoptosis, and cell differentiation. 2. **MAPK Pathway:** MAP4K3 regulates the MAPK pathway, which is crucial for cell proliferation, differentiation, and survival. 3. **Protein Phosphorylation:** MAP4K3 phosphorylates and activates downstream targets, including other kinases and transcription factors. MAP4K3's functions include: * Cell proliferation and differentiation * Apoptosis and stress response * Immune responses * Tissue development and homeostasis **Clinical Significance:** Dysregulation of MAP4K3 has been implicated in various diseases, including: 1. **Cardiovascular Disease:** Abnormal expression of MAP4K3 has been linked to cardiac hypertrophy, fibrosis, and arrhythmias. 2. **Cancer:** Overexpression of MAP4K3 has been observed in various cancers, including breast, lung, and colon cancer, suggesting a potential role in tumorigenesis. 3. **Neurological Disorders:** MAP4K3 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it regulates neuronal survival and apoptosis. 4. **Inflammatory Disorders:** MAP4K3 plays a role in immune responses, and its dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis. In conclusion, MAP4K3 is a critical component of the MAPK signaling pathway, regulating various cellular processes, including cell proliferation, differentiation, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of MAP4K3 in human health and disease. Further research is needed to fully understand the mechanisms of MAP4K3 and its role in disease.

Genular Protein ID: 1550748027

Symbol: M4K3_HUMAN

Name: Mitogen-activated protein kinase kinase kinase kinase 3

UniProtKB Accession Codes:

Q8IVH8 Q6IQ39 Q8IVH7 Q9UDM5 Q9Y6R5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 4 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 60 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 Rhea 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9275185

Title: Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase.

PubMed ID: 9275185

DOI: 10.1073/pnas.94.18.9687

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 894
  • Mass: 101316
  • Checksum: 6EB77BBB34E5B733
  • Sequence:
    • MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ 
EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD IYHVTGPLSE LQIAYVSRET 
LQGLYYLHSK GKMHRDIKGA NILLTDNGHV KLADFGVSAQ ITATIAKRKS FIGTPYWMAP 
EVAAVERKGG YNQLCDLWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKM 
KWSNSFHHFV KMALTKNPKK RPTAEKLLQH PFVTQHLTRS LAIELLDKVN NPDHSTYHDF 
DDDDPEPLVA VPHRIHSTSR NVREEKTRSE ITFGQVKFDP PLRKETEPHH ELPDSDGFLD 
SSEEIYYTAR SNLDLQLEYG QGHQGGYFLG ANKSLLKSVE EELHQRGHVA HLEDDEGDDD 
ESKHSTLKAK IPPPLPPKPK SIFIPQEMHS TEDENQGTIK RCPMSGSPAK PSQVPPRPPP 
PRLPPHKPVA LGNGMSSFQL NGERDGSLCQ QQNEHRGTNL SRKEKKDVPK PISNGLPPTP 
KVHMGACFSK VFNGCPLKIH CASSWINPDT RDQYLIFGAE EGIYTLNLNE LHETSMEQLF 
PRRCTWLYVM NNCLLSISGK ASQLYSHNLP GLFDYARQMQ KLPVAIPAHK LPDRILPRKF 
SVSAKIPETK WCQKCCVVRN PYTGHKYLCG ALQTSIVLLE WVEPMQKFML IKHIDFPIPC 
PLRMFEMLVV PEQEYPLVCV GVSRGRDFNQ VVRFETVNPN STSSWFTESD TPQTNVTHVT 
QLERDTILVC LDCCIKIVNL QGRLKSSRKL SSELTFDFQI ESIVCLQDSV LAFWKHGMQG 
RSFRSNEVTQ EISDSTRIFR LLGSDRVVVL ESRPTDNPTA NSNLYILAGH ENSY

Genular Protein ID: 3660650350

Symbol: B3KMM5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KMM5

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 168
  • Mass: 19048
  • Checksum: 306C43F760F19B79
  • Sequence:
    • MLVVPEQEYP LVCVGVSRGR DFNQVVRFET VNPNSTSSWF TESDTPQTNV THVTQLERDT 
ILVCLDCCIK IVNLQGRLKS SRKLSSELTF DFQIESIVCL QDSVLAFWKH GMQGRSFRSN 
EVTQEISDST RIFRLLGSDR VVVLESRPTD NPTANSNLYI LAGHENSY

Genular Protein ID: 3321205736

Symbol: A8K602_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K602

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 13 DNASU 1 EC 2 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 894
  • Mass: 101344
  • Checksum: 43B27C1030A684DE
  • Sequence:
    • MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ 
EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD IYHVTGPLSE LQIAYVSRET 
LQGLYYLHSK GKMHRDIKGA NILLTDNGHV KLADFGVSAQ ITATIAKRKS FIGTPYWMAP 
EVAAVERKGG YNQLCDLWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKM 
KWSNSFHHFV RMALTKNPKK RPTAEKLLQH PFVTQHLTRS LAIELLDKVN NPDHSTYHDF 
DDDDPEPLVA VPHRIHSTSR NVREEKTRSE ITFGQVKFDP PLRKETEPHH ELPDSDGFLD 
SSEEIYYTAR SNLDLQLEYG QGHQGGYFLG ANKSLLKSVE EELHQRGHVA HLEDDEGDDD 
ESKHSTLKAK IPPPLPPKPK SIFIPQEMHS TEDENQGTIK RCPMSGSPAK PSQVPPRPPP 
PRLPPHKPVA LGNGMSSFQL NGERDGSLCQ QQNEHRGTNL SRKEKKDVPK PISNGLPPTP 
KVHMGACFSK VFNGCPLKIH CASSWINPDT RDQYLIFGAE EGIYTLNLNE LHETSMEQLF 
PRRCTWLYVM NNCLLSISGK ASQLYSHNLP GLFDYARQMQ KLPVAIPAHK LPDRILPRKF 
SVSAKIPETK WCQKCCVVRN PYTGHKYLCG ALQTSIVLLE WVEPMQKFML IKHIDFPIPC 
PLRMFEMLVV PEQEYPLVCV GVSRGRDFNQ VVRFETVNPN STSSWFTESD TPQTNVTHVT 
QLERDTILVC LDCCIKIVNL QGRLKSSRKL SSELTFDFQI ESIVCLQDSV LAFWKHGMQG 
RSFRSNEVTQ EISDSTRIFR LLGSDRVVVL ESRPTDNPTA NSNLYILAGH ENSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.