Details for: RNU12 2P

Gene ID: 26823

Symbol: RNU12 2P

Ensembl ID: ENSG00000201659

Description: RNA, U12 small nuclear 2, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.4075
    Cell Significance Index: 3.5900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.1164
    Cell Significance Index: 1.3500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0454
    Cell Significance Index: 0.6300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0396
    Cell Significance Index: 0.5100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0264
    Cell Significance Index: 0.2600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0184
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0078
    Cell Significance Index: 1.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0065
    Cell Significance Index: 0.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0004
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0003
    Cell Significance Index: -0.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0008
    Cell Significance Index: -1.2500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -0.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0025
    Cell Significance Index: -1.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0025
    Cell Significance Index: -0.5000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0056
    Cell Significance Index: -0.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0073
    Cell Significance Index: -0.3800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0116
    Cell Significance Index: -1.2100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0166
    Cell Significance Index: -0.2000
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0275
    Cell Significance Index: -0.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0281
    Cell Significance Index: -0.8100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0296
    Cell Significance Index: -0.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0297
    Cell Significance Index: -0.6300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0300
    Cell Significance Index: -0.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0319
    Cell Significance Index: -0.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0324
    Cell Significance Index: -0.6400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0325
    Cell Significance Index: -0.6400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0326
    Cell Significance Index: -0.3400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0333
    Cell Significance Index: -0.3400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0338
    Cell Significance Index: -0.3200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0350
    Cell Significance Index: -0.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0360
    Cell Significance Index: -0.9800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0370
    Cell Significance Index: -0.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0370
    Cell Significance Index: -0.6400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0371
    Cell Significance Index: -0.6400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0382
    Cell Significance Index: -0.4400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0443
    Cell Significance Index: -1.4000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0444
    Cell Significance Index: -0.5900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0457
    Cell Significance Index: -1.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0495
    Cell Significance Index: -1.2600
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0495
    Cell Significance Index: -0.5400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0496
    Cell Significance Index: -0.6200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0510
    Cell Significance Index: -0.5700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0521
    Cell Significance Index: -0.5400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0524
    Cell Significance Index: -0.6300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0536
    Cell Significance Index: -0.5600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0542
    Cell Significance Index: -0.5500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0546
    Cell Significance Index: -0.6200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0561
    Cell Significance Index: -0.6800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0567
    Cell Significance Index: -0.6800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0580
    Cell Significance Index: -0.5400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0580
    Cell Significance Index: -0.6900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0591
    Cell Significance Index: -0.5600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0617
    Cell Significance Index: -0.5100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0643
    Cell Significance Index: -0.5800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0645
    Cell Significance Index: -0.4000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0648
    Cell Significance Index: -0.6000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0680
    Cell Significance Index: -0.7900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0705
    Cell Significance Index: -0.7800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0711
    Cell Significance Index: -0.8400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0718
    Cell Significance Index: -1.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0748
    Cell Significance Index: -1.0200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0761
    Cell Significance Index: -0.8600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0776
    Cell Significance Index: -0.9300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0785
    Cell Significance Index: -1.0300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0786
    Cell Significance Index: -0.9900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0789
    Cell Significance Index: -1.0300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0837
    Cell Significance Index: -0.8900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0841
    Cell Significance Index: -1.0500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0851
    Cell Significance Index: -1.1100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0855
    Cell Significance Index: -0.8000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0861
    Cell Significance Index: -1.0800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0874
    Cell Significance Index: -1.3300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0880
    Cell Significance Index: -1.0700
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0893
    Cell Significance Index: -1.0800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0897
    Cell Significance Index: -1.1800
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0908
    Cell Significance Index: -1.0800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0912
    Cell Significance Index: -1.1100
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0932
    Cell Significance Index: -1.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0934
    Cell Significance Index: -1.3300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0939
    Cell Significance Index: -1.1100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0949
    Cell Significance Index: -1.2800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0959
    Cell Significance Index: -1.1300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0961
    Cell Significance Index: -1.0300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0962
    Cell Significance Index: -1.0700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0964
    Cell Significance Index: -1.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0967
    Cell Significance Index: -1.0200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0968
    Cell Significance Index: -1.0800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0970
    Cell Significance Index: -1.1100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0975
    Cell Significance Index: -1.2300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0978
    Cell Significance Index: -0.9000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0979
    Cell Significance Index: -0.8900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0980
    Cell Significance Index: -0.9200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0986
    Cell Significance Index: -1.1200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0989
    Cell Significance Index: -1.4200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0996
    Cell Significance Index: -1.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RNU12 2P gene is a pseudogene, meaning it lacks a coding potential and does not produce a functional protein. Despite this, it exhibits significant expression in various cell types, including: * T cells * Non-pigmented ciliary epithelial cells * Plasma cells * Pigmented ciliary epithelial cells * Melanocytes * Bergmann glial cells * OFF retinal ganglion cells * B cells * Mature NK T cells * Goblet cells This widespread expression suggests that RNU12 2P may play a role in regulating gene expression, cellular differentiation, or immune responses. **Pathways and Functions:** While the exact mechanisms of RNU12 2P are not fully understood, several pathways and functions can be inferred based on its expression profile: 1. **RNA processing and splicing**: RNU12 2P may influence RNA processing and splicing events, particularly in the context of immune cell development and function. 2. **Gene regulation**: As a pseudogene, RNU12 2P may act as a regulatory element, modulating the expression of nearby genes or influencing chromatin structure. 3. **Immune cell development and function**: RNU12 2P expression in immune cells, such as T cells and B cells, suggests a role in immune cell development, differentiation, or function. 4. **Tissue development and maintenance**: The expression of RNU12 2P in non-pigmented ciliary epithelial cells and Bergmann glial cells implies a role in tissue development and maintenance, particularly in the context of the eye and nervous system. **Clinical Significance:** The clinical significance of RNU12 2P is an area of active research, with potential implications for: 1. **Immune-related disorders**: Aberrant expression of RNU12 2P in immune cells may contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis or multiple sclerosis. 2. **Cancer**: RNU12 2P expression in certain cancer types, such as melanoma or glioblastoma, may be associated with tumor progression or metastasis. 3. **Neurological disorders**: The expression of RNU12 2P in neural cells, including retinal ganglion cells, may be relevant to the development of neurodegenerative diseases, such as glaucoma or Alzheimer's disease. 4. **Gene therapy and RNA-based therapies**: Understanding the mechanisms of RNU12 2P may inform the development of RNA-based therapies or gene therapies targeting immune cells or neural cells. In conclusion, the RNU12 2P gene is a complex and enigmatic pseudogene with far-reaching implications for our understanding of immune regulation, tissue development, and disease pathogenesis. Further research is needed to elucidate its functional significance and potential clinical applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.