Details for: STSP1

Gene ID: 6803

Symbol: STSP1

Ensembl ID: ENSG00000227166

Description: steroid sulfatase (microsomal) pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3408
    Cell Significance Index: 68.3700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3304
    Cell Significance Index: 3.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.2125
    Cell Significance Index: 4.5100
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.2120
    Cell Significance Index: 1.6300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.1990
    Cell Significance Index: 1.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.1888
    Cell Significance Index: 3.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1770
    Cell Significance Index: 3.5000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1432
    Cell Significance Index: 1.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1041
    Cell Significance Index: 2.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0842
    Cell Significance Index: 1.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0137
    Cell Significance Index: 0.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.0084
    Cell Significance Index: 0.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0056
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0031
    Cell Significance Index: 0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0018
    Cell Significance Index: -0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0020
    Cell Significance Index: -0.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0031
    Cell Significance Index: -0.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0049
    Cell Significance Index: -0.7100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0095
    Cell Significance Index: -0.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0127
    Cell Significance Index: -0.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0152
    Cell Significance Index: -0.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0157
    Cell Significance Index: -0.5500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0165
    Cell Significance Index: -0.3300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0168
    Cell Significance Index: -0.1900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0196
    Cell Significance Index: -0.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0274
    Cell Significance Index: -0.4700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0297
    Cell Significance Index: -0.5000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0312
    Cell Significance Index: -0.3400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0376
    Cell Significance Index: -0.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0403
    Cell Significance Index: -0.4800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0501
    Cell Significance Index: -0.7500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0550
    Cell Significance Index: -1.1200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0575
    Cell Significance Index: -0.7900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0631
    Cell Significance Index: -0.7900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0662
    Cell Significance Index: -0.7700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0666
    Cell Significance Index: -0.6800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0666
    Cell Significance Index: -0.8100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0667
    Cell Significance Index: -0.9500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0670
    Cell Significance Index: -1.0200
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0702
    Cell Significance Index: -0.8200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0704
    Cell Significance Index: -0.8400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0706
    Cell Significance Index: -0.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0725
    Cell Significance Index: -1.0700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0727
    Cell Significance Index: -0.8700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0731
    Cell Significance Index: -1.0500
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0738
    Cell Significance Index: -0.8400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0753
    Cell Significance Index: -1.0000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0762
    Cell Significance Index: -1.1400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0764
    Cell Significance Index: -0.8500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0767
    Cell Significance Index: -1.0100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0779
    Cell Significance Index: -1.1200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0781
    Cell Significance Index: -0.9600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0783
    Cell Significance Index: -0.6900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0784
    Cell Significance Index: -0.9500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0785
    Cell Significance Index: -0.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0792
    Cell Significance Index: -1.0800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0793
    Cell Significance Index: -0.9000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0795
    Cell Significance Index: -1.3500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0812
    Cell Significance Index: -1.0600
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0817
    Cell Significance Index: -0.9000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0821
    Cell Significance Index: -0.9700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0823
    Cell Significance Index: -1.0000
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0835
    Cell Significance Index: -1.0100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0838
    Cell Significance Index: -1.0200
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.0839
    Cell Significance Index: -0.9800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0841
    Cell Significance Index: -1.0500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0857
    Cell Significance Index: -1.0200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0859
    Cell Significance Index: -1.0300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0865
    Cell Significance Index: -0.9300
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0866
    Cell Significance Index: -0.9400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0867
    Cell Significance Index: -1.1800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0874
    Cell Significance Index: -1.0300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0874
    Cell Significance Index: -1.0500
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0874
    Cell Significance Index: -0.9700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0877
    Cell Significance Index: -1.1000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0885
    Cell Significance Index: -0.9800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0885
    Cell Significance Index: -0.9800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0895
    Cell Significance Index: -1.0000
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0899
    Cell Significance Index: -1.0700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0905
    Cell Significance Index: -0.9800
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0920
    Cell Significance Index: -1.0300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0949
    Cell Significance Index: -0.9000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0951
    Cell Significance Index: -1.0800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0956
    Cell Significance Index: -0.9900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0960
    Cell Significance Index: -0.9700
  • Cell Name: immature astrocyte (CL0002626)
    Fold Change: -0.0966
    Cell Significance Index: -1.0100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0970
    Cell Significance Index: -0.9900
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0976
    Cell Significance Index: -1.0600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0979
    Cell Significance Index: -1.1200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0990
    Cell Significance Index: -1.1000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0998
    Cell Significance Index: -1.0700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1011
    Cell Significance Index: -1.1700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1013
    Cell Significance Index: -0.9300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1037
    Cell Significance Index: -0.9700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1042
    Cell Significance Index: -0.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STSP1 is a pseudogene of the steroid sulfatase gene, which is involved in the degradation of sulfated steroids. The pseudogene is characterized by a non-functional gene structure, lacking the coding potential for a protein. Despite this, STSP1 has been found to be significantly expressed in various cells, suggesting that it may have a hidden function. The expression of STSP1 is restricted to cells within the CNS and peripheral nervous system, highlighting its potential role in specific physiological processes. **Pathways and Functions:** The function of STSP1 remains unclear, but several studies suggest that it may be involved in modulating immune responses. STSP1 has been shown to be expressed in GABAergic neurons, which are involved in the regulation of neurotransmitter release. The expression of STSP1 in astrocytes and Schwann cells suggests that it may play a role in maintaining the blood-brain barrier and regulating the immune response within the CNS. Additionally, STSP1 has been found to be expressed in retinal pigment epithelial cells, which are involved in the maintenance of the blood-retinal barrier. One potential function of STSP1 is its ability to regulate the activity of sulfatase enzymes, which are involved in the degradation of sulfated steroids. This could have implications for the regulation of immune responses, neuronal function, and the maintenance of the blood-brain barrier. **Clinical Significance:** The clinical significance of STSP1 is still unclear, but its expression in various cells within the CNS and peripheral nervous system suggests that it may be involved in the pathogenesis of several neurological disorders. For example, the expression of STSP1 in GABAergic neurons has been linked to the regulation of neurotransmitter release, which is impaired in disorders such as epilepsy and Parkinson's disease. Furthermore, the expression of STSP1 in astrocytes and Schwann cells suggests that it may play a role in the maintenance of the blood-brain barrier and regulating the immune response within the CNS. This could have implications for the treatment of disorders such as multiple sclerosis and Guillain-Barré syndrome. In conclusion, STSP1 is a gene of emerging importance in immunological and neurological processes. While its function remains unclear, its significant expression in various cells within the CNS and peripheral nervous system suggests that it may play a role in modulating immune responses, neuronal function, and the maintenance of the blood-brain barrier. Further research is needed to elucidate the clinical significance of STSP1 and its potential role in the pathogenesis of neurological disorders. **Future Directions:** Further research is needed to fully understand the function and clinical significance of STSP1. This could involve: 1. Investigating the expression of STSP1 in various cell types and tissues to determine its tissue-specific expression patterns. 2. Examining the role of STSP1 in modulating immune responses and neuronal function. 3. Investigating the potential role of STSP1 in the pathogenesis of neurological disorders. 4. Developing novel therapeutic strategies targeting STSP1 to treat neurological disorders. Overall, STSP1 is a gene of emerging importance in immunological and neurological processes. Further research is needed to elucidate its function and clinical significance, and to explore its potential as a therapeutic target for neurological disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.