Details for: OR7E25P

Gene ID: 26647

Symbol: OR7E25P

Ensembl ID: ENSG00000187847

Description: olfactory receptor family 7 subfamily E member 25 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.2597
    Cell Significance Index: 2.7400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2427
    Cell Significance Index: 2.4800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.2362
    Cell Significance Index: 2.7200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1315
    Cell Significance Index: 1.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0909
    Cell Significance Index: 1.2400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0584
    Cell Significance Index: 0.8100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0507
    Cell Significance Index: 0.6600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0297
    Cell Significance Index: 0.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0193
    Cell Significance Index: 0.4100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0146
    Cell Significance Index: 0.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0138
    Cell Significance Index: 2.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0127
    Cell Significance Index: 0.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0095
    Cell Significance Index: 0.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0031
    Cell Significance Index: 0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0003
    Cell Significance Index: -0.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0010
    Cell Significance Index: -0.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0011
    Cell Significance Index: -0.5100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0033
    Cell Significance Index: -0.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0034
    Cell Significance Index: -0.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0050
    Cell Significance Index: -0.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0077
    Cell Significance Index: -0.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0079
    Cell Significance Index: -0.2600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0091
    Cell Significance Index: -0.1900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0101
    Cell Significance Index: -0.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0114
    Cell Significance Index: -0.4000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0119
    Cell Significance Index: -0.2400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0120
    Cell Significance Index: -0.2400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0140
    Cell Significance Index: -0.1400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0168
    Cell Significance Index: -0.2900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0170
    Cell Significance Index: -0.1900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0179
    Cell Significance Index: -0.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0181
    Cell Significance Index: -0.3100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0193
    Cell Significance Index: -0.1700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0209
    Cell Significance Index: -0.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0210
    Cell Significance Index: -0.2500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0237
    Cell Significance Index: -0.2800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0246
    Cell Significance Index: -0.2900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0254
    Cell Significance Index: -0.3000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0257
    Cell Significance Index: -0.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0269
    Cell Significance Index: -0.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0278
    Cell Significance Index: -0.4100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0284
    Cell Significance Index: -0.2500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0292
    Cell Significance Index: -0.4200
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0310
    Cell Significance Index: -0.3200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0320
    Cell Significance Index: -0.4000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0322
    Cell Significance Index: -0.3800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0340
    Cell Significance Index: -0.4000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0353
    Cell Significance Index: -0.3600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0396
    Cell Significance Index: -0.3800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0431
    Cell Significance Index: -0.5700
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.0445
    Cell Significance Index: -0.3600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0450
    Cell Significance Index: -0.6400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0452
    Cell Significance Index: -0.5000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0454
    Cell Significance Index: -0.5400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0462
    Cell Significance Index: -0.4300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0464
    Cell Significance Index: -0.6100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0470
    Cell Significance Index: -0.4400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0470
    Cell Significance Index: -0.5200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0472
    Cell Significance Index: -0.5800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0484
    Cell Significance Index: -0.4000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0487
    Cell Significance Index: -0.5900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0528
    Cell Significance Index: -0.6000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0535
    Cell Significance Index: -0.6700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0538
    Cell Significance Index: -0.5100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0544
    Cell Significance Index: -0.7100
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0549
    Cell Significance Index: -0.6100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0553
    Cell Significance Index: -0.6000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0560
    Cell Significance Index: -0.5800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0561
    Cell Significance Index: -0.7000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0582
    Cell Significance Index: -0.7300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0583
    Cell Significance Index: -0.5100
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0588
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0588
    Cell Significance Index: -0.3700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0588
    Cell Significance Index: -0.5400
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0590
    Cell Significance Index: -0.6300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0591
    Cell Significance Index: -0.7100
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0595
    Cell Significance Index: -0.6300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0598
    Cell Significance Index: -0.9100
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0608
    Cell Significance Index: -0.6600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0609
    Cell Significance Index: -0.7300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0611
    Cell Significance Index: -0.7200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0618
    Cell Significance Index: -0.6100
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0625
    Cell Significance Index: -0.7300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0634
    Cell Significance Index: -0.7100
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.0635
    Cell Significance Index: -0.6300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0638
    Cell Significance Index: -0.5800
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0639
    Cell Significance Index: -0.7400
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0645
    Cell Significance Index: -0.7700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0653
    Cell Significance Index: -0.7000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0655
    Cell Significance Index: -0.7500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0661
    Cell Significance Index: -0.7200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0682
    Cell Significance Index: -0.6400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0697
    Cell Significance Index: -0.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene**: OR7E25P is a non-functional, non-coding pseudogene, which implies that it does not produce a functional protein. However, its expression in various cell types suggests that it may play a role in regulating gene expression or influencing cellular behavior. 2. **Widespread expression**: OR7E25P is significantly expressed in cells of the central nervous system, immune cells, and epithelial tissues, including melanocytes, astrocytes, oligodendrocytes, and fibroblasts. 3. **Cell-type specificity**: The expression of OR7E25P is highly cell-type specific, with some cells expressing it at high levels, while others exhibit low or undetectable expression. 4. **Evolutionary conservation**: OR7E25P exhibits high sequence similarity to functional olfactory receptors, suggesting that it may have evolved from a functional ancestor. **Pathways and Functions:** 1. **Immune regulation**: OR7E25P may play a role in regulating immune responses, particularly in the context of innate immunity. Its expression in innate lymphoid cells and macrophages suggests that it could influence the activation and function of these cells. 2. **Cell differentiation**: OR7E25P may contribute to the differentiation of cells, particularly in the context of the central nervous system. Its expression in oligodendrocytes and astrocytes suggests that it could influence the development and maintenance of these cell types. 3. **Signaling pathways**: OR7E25P may interact with various signaling pathways, including those involved in immune regulation, cell differentiation, and cellular survival. Its expression in cells of the central nervous system and immune cells suggests that it could influence the activity of these pathways. 4. **Epithelial function**: OR7E25P may also play a role in the function of epithelial tissues, particularly in the context of melanocytes and pigmented ciliary epithelial cells. **Clinical Significance:** 1. **Immune-mediated disorders**: OR7E25P may contribute to the development of autoimmune diseases, such as multiple sclerosis, by influencing the activity of immune cells and regulating immune responses. 2. **Neurological disorders**: The expression of OR7E25P in cells of the central nervous system suggests that it may be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: OR7E25P may also play a role in cancer development and progression, particularly in the context of epithelial tissues. 4. **Gene therapy**: The identification of OR7E25P as a potential therapeutic target for immune-mediated disorders and neurological disorders highlights the potential for gene therapy in treating these conditions. In conclusion, the OR7E25P gene, a pseudogene within the olfactory receptor family 7 subfamily, exhibits a unique pattern of expression across various cell types, suggesting its potential involvement in immune regulation, cell differentiation, and epithelial function. Further research is necessary to fully elucidate the functional implications of OR7E25P and its clinical significance in the context of immune-mediated disorders and neurological diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.