Gene HSPA7 - ENSG00000225217 | NCBI Gene ID: 3311

Details for: HSPA7

Gene ID: 3311

Symbol: HSPA7

Ensembl ID: ENSG00000225217

Description: heat shock protein family A (Hsp70) member 7 (pseudogene)

Associated with

Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Biological_process
(GO:0008150)
Blood microparticle
(GO:0072562)
Chaperone cofactor-dependent protein refolding
(GO:0051085)
Cop9 signalosome
(GO:0008180)
Cytoplasm
(GO:0005737)
Extracellular exosome
(GO:0070062)
Heat shock protein binding
(GO:0031072)
Molecular_function
(GO:0003674)
Nucleus
(GO:0005634)
Protein folding chaperone
(GO:0044183)
Protein refolding
(GO:0042026)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.82
Marker Score: 799
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.44
Marker Score: 435
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.41
Marker Score: 180
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.25
Marker Score: 87
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.22
Marker Score: 233
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.13
Marker Score: 141
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.11
Marker Score: 44
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1
Marker Score: 206
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.1
Marker Score: 52
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.08
Marker Score: 29
Cell Name: malignant cell (CL0001064)
Fold Change: 0.07
Marker Score: 981
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.07
Marker Score: 108
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.06
Marker Score: 76
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.06
Marker Score: 23
Cell Name: peptic cell (CL0000155)
Fold Change: 0.05
Marker Score: 22
Cell Name: fibroblast (CL0000057)
Fold Change: 0.05
Marker Score: 47
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.04
Marker Score: 22
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.04
Marker Score: 39
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.04
Marker Score: 28.5
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.04
Marker Score: 13
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.04
Marker Score: 67
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.04
Marker Score: 9
Cell Name: stromal cell (CL0000499)
Fold Change: 0.03
Marker Score: 40
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.03
Marker Score: 18
Cell Name: keratocyte (CL0002363)
Fold Change: 0.03
Marker Score: 7
Cell Name: leukocyte (CL0000738)
Fold Change: 0.03
Marker Score: 17
Cell Name: neutrophil (CL0000775)
Fold Change: 0.03
Marker Score: 18
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.03
Marker Score: 18
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.03
Marker Score: 68
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.03
Marker Score: 14
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.03
Marker Score: 22
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.03
Marker Score: 14
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.03
Marker Score: 18.5
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.03
Marker Score: 39
Cell Name: B cell (CL0000236)
Fold Change: 0.03
Marker Score: 25
Cell Name: glial cell (CL0000125)
Fold Change: 0.03
Marker Score: 28.5
Cell Name: memory B cell (CL0000787)
Fold Change: 0.03
Marker Score: 19
Cell Name: macrophage (CL0000235)
Fold Change: 0.02
Marker Score: 27.5
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.02
Marker Score: 11
Cell Name: plasma cell (CL0000786)
Fold Change: 0.02
Marker Score: 25
Cell Name: monocyte (CL0000576)
Fold Change: 0.02
Marker Score: 29
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.02
Marker Score: 9
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.02
Marker Score: 9
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.02
Marker Score: 7
Cell Name: epithelial cell of lacrimal sac (CL1000436)
Fold Change: 0.02
Marker Score: 9
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.02
Marker Score: 7
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.02
Marker Score: 32
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.02
Marker Score: 9
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.02
Marker Score: 30
Cell Name: club cell (CL0000158)
Fold Change: 0.02
Marker Score: 21
Cell Name: T cell (CL0000084)
Fold Change: 0.02
Marker Score: 30
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.02
Marker Score: 6
Cell Name: goblet cell (CL0000160)
Fold Change: 0.02
Marker Score: 115
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.02
Marker Score: 8
Cell Name: type D enteroendocrine cell (CL0000502)
Fold Change: 0.02
Marker Score: 5
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.02
Marker Score: 9
Cell Name: granulocyte (CL0000094)
Fold Change: 0.02
Marker Score: 7
Cell Name: pericyte (CL0000669)
Fold Change: 0.02
Marker Score: 9
Cell Name: basal cell (CL0000646)
Fold Change: 0.01
Marker Score: 19
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.01
Marker Score: 12
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.01
Marker Score: 8
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.01
Marker Score: 8
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.01
Marker Score: 6
Cell Name: chondrocyte (CL0000138)
Fold Change: 0.01
Marker Score: 6
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.01
Marker Score: 11
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.01
Marker Score: 8
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.01
Marker Score: 5
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.01
Marker Score: 7
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.01
Marker Score: 11
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.01
Marker Score: 17
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.01
Marker Score: 12
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.01
Marker Score: 18
Cell Name: acinar cell (CL0000622)
Fold Change: 0.01
Marker Score: 7
Cell Name: microglial cell (CL0000129)
Fold Change: 0.01
Marker Score: 18
Cell Name: naive B cell (CL0000788)
Fold Change: 0.01
Marker Score: 8.5
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.01
Marker Score: 8
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.01
Marker Score: 38
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.01
Marker Score: 9
Cell Name: type I NK T cell (CL0000921)
Fold Change: 0.01
Marker Score: 7
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.01
Marker Score: 8
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.01
Marker Score: 60
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.01
Marker Score: 8
Cell Name: mature T cell (CL0002419)
Fold Change: 0.01
Marker Score: 73
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.01
Marker Score: 19
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.01
Marker Score: 7
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.01
Marker Score: 8
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.01
Marker Score: 7
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.01
Marker Score: 7
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0
Marker Score: 6
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0
Marker Score: 8
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0
Marker Score: 10
Cell Name: enterocyte (CL0000584)
Fold Change: 0
Marker Score: 21
Cell Name: stem cell (CL0000034)
Fold Change: 0
Marker Score: 10
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0
Marker Score: 7
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0
Marker Score: 7
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0
Marker Score: 9
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0
Marker Score: 8
Cell Name: Unknown (CL0000003)
Fold Change: 0
Marker Score: 9
Cell Name: secretory cell (CL0000151)
Fold Change: 0
Marker Score: 5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0
Marker Score: 14

Hover over a box to see details here...

Other Information

Description

**Key characteristics** * HSPA7 is a large gene with a complex structure. * It contains multiple exons and intronic regions. * It is a pseudogene, meaning it is not expressed in mature cells. * It is highly expressed in cells under stress conditions, such as heat shock. **Pathways and functions** * HSPA7 is a key chaperone protein that assists in the folding and refolding of proteins. * It is involved in the Atp-dependent protein folding chaperone pathway, which is responsible for folding and refolding proteins that are produced by the endoplasmic reticulum. * It also plays a role in the biological process, blood microparticle, and chaperone cofactor-dependent protein refolding pathways. * HSPA7 is also involved in the Cop9 signalosome pathway, a pathway that is involved in protein folding and degradation. * It is a key regulator of protein folding and is essential for the proper functioning of cells. **Clinical significance** * HSPA7 mutations can lead to the accumulation of misfolded proteins, which can result in cell damage and disease. * Mutations in HSPA7 have been linked to a number of human diseases, including heat shock, liver disease, and cancer. * Targeting HSPA7 has been explored as a therapeutic strategy for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.