Details for: HSPA7

Gene ID: 3311

Symbol: HSPA7

Ensembl ID: ENSG00000225217

Description: heat shock protein family A (Hsp70) member 7 (pseudogene)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.9700
    Cell Significance Index: 32.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.5469
    Cell Significance Index: 115.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.5104
    Cell Significance Index: 378.1000
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.5072
    Cell Significance Index: 3.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3835
    Cell Significance Index: 216.2500
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.2243
    Cell Significance Index: 1.6300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0938
    Cell Significance Index: 1.0800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0781
    Cell Significance Index: 1.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0678
    Cell Significance Index: 42.3400
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.0604
    Cell Significance Index: 0.3800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.0314
    Cell Significance Index: 0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0006
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0004
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0016
    Cell Significance Index: -0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0038
    Cell Significance Index: -5.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0044
    Cell Significance Index: -6.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0061
    Cell Significance Index: -3.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0098
    Cell Significance Index: -4.4300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0170
    Cell Significance Index: -0.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0193
    Cell Significance Index: -3.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0255
    Cell Significance Index: -3.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0292
    Cell Significance Index: -1.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0316
    Cell Significance Index: -1.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0400
    Cell Significance Index: -1.0000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0857
    Cell Significance Index: -1.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0866
    Cell Significance Index: -2.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0888
    Cell Significance Index: -3.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0922
    Cell Significance Index: -3.0200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0966
    Cell Significance Index: -1.6700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0996
    Cell Significance Index: -3.1500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0998
    Cell Significance Index: -1.3700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1097
    Cell Significance Index: -0.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1152
    Cell Significance Index: -3.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1265
    Cell Significance Index: -3.3900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1291
    Cell Significance Index: -2.7900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1315
    Cell Significance Index: -1.1100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1317
    Cell Significance Index: -1.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1390
    Cell Significance Index: -2.9500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1439
    Cell Significance Index: -1.9900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1463
    Cell Significance Index: -1.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1469
    Cell Significance Index: -2.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1473
    Cell Significance Index: -2.0100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1522
    Cell Significance Index: -3.0100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1652
    Cell Significance Index: -1.5800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1679
    Cell Significance Index: -3.3100
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1695
    Cell Significance Index: -1.8400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1725
    Cell Significance Index: -2.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1731
    Cell Significance Index: -4.4100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1790
    Cell Significance Index: -1.7000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1914
    Cell Significance Index: -2.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1914
    Cell Significance Index: -1.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2077
    Cell Significance Index: -4.5000
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2096
    Cell Significance Index: -2.8500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2226
    Cell Significance Index: -3.7800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2361
    Cell Significance Index: -2.4100
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.2536
    Cell Significance Index: -2.3500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2551
    Cell Significance Index: -2.7100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2571
    Cell Significance Index: -2.7300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2611
    Cell Significance Index: -3.1500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2639
    Cell Significance Index: -4.5500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2679
    Cell Significance Index: -2.8500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2735
    Cell Significance Index: -3.2800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2791
    Cell Significance Index: -2.6200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2842
    Cell Significance Index: -3.2700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2935
    Cell Significance Index: -3.8300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2961
    Cell Significance Index: -3.6400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3026
    Cell Significance Index: -3.3500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.3031
    Cell Significance Index: -3.6400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.3041
    Cell Significance Index: -3.7000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.3061
    Cell Significance Index: -3.4500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.3067
    Cell Significance Index: -3.6500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3081
    Cell Significance Index: -3.8700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3118
    Cell Significance Index: -4.0700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3227
    Cell Significance Index: -4.2200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.3228
    Cell Significance Index: -2.9200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.3228
    Cell Significance Index: -3.7500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3258
    Cell Significance Index: -3.8500
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.3263
    Cell Significance Index: -3.4200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.3285
    Cell Significance Index: -3.9700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.3322
    Cell Significance Index: -3.0200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3343
    Cell Significance Index: -4.4000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.3350
    Cell Significance Index: -3.7100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.3362
    Cell Significance Index: -4.2000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.3365
    Cell Significance Index: -3.7600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3383
    Cell Significance Index: -3.1500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3383
    Cell Significance Index: -4.4400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3416
    Cell Significance Index: -3.9100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3421
    Cell Significance Index: -3.3100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3441
    Cell Significance Index: -3.6300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.3456
    Cell Significance Index: -4.0800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.3459
    Cell Significance Index: -3.5100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.3470
    Cell Significance Index: -4.0000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3484
    Cell Significance Index: -3.5600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.3488
    Cell Significance Index: -4.2400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.3514
    Cell Significance Index: -3.8100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.3516
    Cell Significance Index: -3.7700
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.3568
    Cell Significance Index: -4.5700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3644
    Cell Significance Index: -3.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSPA7 is a pseudogene belonging to the Hsp70 family, which is a group of heat shock proteins that play a crucial role in protein folding, refolding, and degradation. Unlike its functional counterparts, HSPA7 lacks a complete coding sequence, suggesting that it may have evolved from a functional Hsp70 gene. Despite this, HSPA7 has been shown to be significantly expressed in various cell types, including pancreatic and conjunctival epithelial cells, as well as innate lymphoid cells. **Pathways and Functions:** HSPA7 has been implicated in multiple cellular pathways, including: 1. **Protein Folding and Refolding:** HSPA7 has been shown to interact with various proteins, including chaperone cofactors, to facilitate protein folding and refolding. This suggests that HSPA7 may play a role in maintaining protein homeostasis and preventing protein misfolding. 2. **Heat Shock Response:** HSPA7 has been shown to be induced in response to heat shock, suggesting that it may play a role in the heat shock response, a cellular mechanism that helps to protect against protein denaturation. 3. **Chaperone Cofactor-Dependent Protein Refolding:** HSPA7 has been shown to interact with chaperone cofactors, such as Hsp70, to facilitate protein refolding. This suggests that HSPA7 may play a role in the regulation of protein refolding. **Clinical Significance:** The clinical significance of HSPA7 is still unclear, but its expression in immune cells suggests that it may play a role in immune regulation. In the context of pancreatic disease, HSPA7 has been shown to be significantly expressed in pancreatic islet cells, suggesting that it may play a role in the regulation of glucose metabolism. Additionally, HSPA7 has been shown to be induced in response to stress, suggesting that it may play a role in the regulation of stress responses. In conclusion, HSPA7, a pseudogene belonging to the Hsp70 family, has been shown to be significantly expressed in multiple cell types, including pancreatic and conjunctival epithelial cells, as well as innate lymphoid cells. Its involvement in protein folding, refolding, and heat shock response suggests that it may play a role in maintaining protein homeostasis and preventing protein misfolding. Further studies are needed to fully elucidate the functions and significance of HSPA7 in the context of immune regulation and disease. **Recommendations:** 1. Further studies are needed to elucidate the functions of HSPA7 in the context of immune regulation. 2. The expression of HSPA7 in various cell types should be further investigated to determine its role in different diseases. 3. The involvement of HSPA7 in protein folding, refolding, and heat shock response should be further investigated to determine its potential therapeutic applications. **Limitations:** This review is based on a limited number of studies, and further research is needed to fully elucidate the functions and significance of HSPA7. Additionally, the pseudogene status of HSPA7 may limit its potential as a therapeutic target. **Future Directions:** Further studies are needed to fully elucidate the functions and significance of HSPA7 in the context of immune regulation. The expression of HSPA7 in various cell types should be further investigated to determine its role in different diseases. The involvement of HSPA7 in protein folding, refolding, and heat shock response should be further investigated to determine its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.