Details for: COA5
Gene ID: 493753
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: COA5
Ensembl ID: ENSG00000183513
Description: cytochrome c oxidase assembly factor 5
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 10.17rCSI 15.63%PRS 81.53
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CSI 8.91rCSI 13.44%PRS 77.49
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CSI 7.01rCSI 5.44%PRS 75.61
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CSI 6.71rCSI 21.75%PRS 71.15
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CSI 6.21rCSI 14.1%PRS 74.23
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CSI 5.27rCSI 8.14%PRS 71.31
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CSI 4.97rCSI 6.76%PRS 82.01
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CSI 4.8rCSI 3.65%PRS 85.09
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CSI 4.03rCSI 5.94%PRS 84.97
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CSI 3.77rCSI 4.38%PRS 77.99
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CSI 3.76rCSI 9.05%PRS 87.16
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CSI 3.73rCSI 2.59%PRS 83.71
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CSI 3.32rCSI 14.77%PRS 72.52
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CSI 3.19rCSI 4.07%PRS 77.92
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CSI 3.17rCSI 2.67%PRS 87.02
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CSI 3.16rCSI 2.55%PRS 74.34
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CSI 3.14rCSI 3.08%PRS 86.84
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CSI 2.98rCSI 3.07%PRS 86.09
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CSI 2.96rCSI 7.52%PRS 65.82
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CSI 2.89rCSI 2.39%PRS 72.58
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CSI 2.88rCSI 5.15%PRS 71.59
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CSI 2.7rCSI 4.85%PRS 65.39
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CSI 2.67rCSI 2.1%PRS 78.77
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CSI 2.67rCSI 1.86%PRS 86.76
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CSI 2.58rCSI 3.31%PRS 68.79
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CSI 2.57rCSI 2.03%PRS 59.65
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CSI 2.51rCSI 3.43%PRS 77.71
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CSI 2.45rCSI 2.94%PRS 70.32
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CSI 2.44rCSI 2.1%PRS 75.25
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CSI 2.43rCSI 12.47%PRS 91.57
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CSI 2.41rCSI 2.71%PRS 86.89
-
CSI 2.36rCSI 3.27%PRS 71.12
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CSI 2.35rCSI 2.26%PRS 71.84
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CSI 2.33rCSI 2.05%PRS 77.79
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CSI 2.33rCSI 3.46%PRS 72.83
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CSI 2.31rCSI 2.47%PRS 72.89
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CSI 2.29rCSI 3.36%PRS 67.2
-
CSI 2.27rCSI 1.84%PRS 72.25
-
CSI 2.24rCSI 2.35%PRS 75.6
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CSI 2.19rCSI 2.82%PRS 54.77
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CSI 2.18rCSI 2.02%PRS 88.66
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CSI 2.18rCSI 2.28%PRS 69.34
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CSI 2.16rCSI 2.87%PRS 78.52
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CSI 2.13rCSI 4.78%PRS 54.02
-
CSI 2.13rCSI 2.79%PRS 84.37
-
CSI 2.13rCSI 2.17%PRS 83.34
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CSI 2.12rCSI 2.22%PRS 72.08
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CSI 2.06rCSI 3.15%PRS 76.51
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CSI 2.04rCSI 1.69%PRS 74.71
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CSI 2.03rCSI 1.8%PRS 70.19
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CSI 2.02rCSI 2.77%PRS 89.38
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CSI 1.97rCSI 1.81%PRS 81.12
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CSI 1.96rCSI 2.34%PRS 53.26
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CSI 1.95rCSI 2.37%PRS 79.21
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CSI 1.95rCSI 2.29%PRS 74.37
-
CSI 1.93rCSI 1.49%PRS 74.33
-
CSI 1.91rCSI 1.84%PRS 64.29
-
CSI 1.86rCSI 2.68%PRS 81.06
-
CSI 1.84rCSI 2.93%PRS 82.19
-
CSI 1.84rCSI 2.69%PRS 77.23
-
CSI 1.84rCSI 1.22%PRS 75.16
-
CSI 1.83rCSI 10.49%PRS 79.6
-
CSI 1.82rCSI 2.11%PRS 64.48
-
CSI 1.82rCSI 1.6%PRS 60.53
-
CSI 1.77rCSI 5.22%PRS 74.19
-
CSI 1.7rCSI 3%PRS 68.31
-
CSI 1.69rCSI 2.3%PRS 63.52
-
CSI 1.67rCSI 2.71%PRS 67.94
-
CSI 1.58rCSI 1.65%PRS 69.98
-
CSI 1.57rCSI 1.56%PRS 65.91
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CSI 1.53rCSI 4.34%PRS 68.79
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CSI 1.5rCSI 1.87%PRS 51.44
-
CSI 1.47rCSI 2.01%PRS 73.08
-
CSI 1.47rCSI 1.27%PRS 82.7
-
CSI 1.43rCSI 6.31%PRS 61.17
-
CSI 1.42rCSI 1.97%PRS 70.87
-
CSI 1.41rCSI 2.42%PRS 80
-
CSI 1.4rCSI 0.98%PRS 75.38
-
CSI 1.39rCSI 3.09%PRS 80.15
-
CSI 1.37rCSI 1.88%PRS 76.22
-
CSI 1.36rCSI 2.17%PRS 63.98
-
CSI 1.34rCSI 3.28%PRS 65.15
-
CSI 1.34rCSI 2.36%PRS 52.5
-
CSI 1.34rCSI 2.25%PRS 53.41
-
CSI 1.33rCSI 1.67%PRS 82.1
-
CSI 1.31rCSI 1.1%PRS 75.73
-
CSI 1.28rCSI 1.11%PRS 77
-
CSI 1.26rCSI 2.45%PRS 75.55
-
CSI 1.24rCSI 1.44%PRS 63.46
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CSI 1.2rCSI 1.91%PRS 64.77
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CSI 1.17rCSI 1.79%PRS 68.78
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CSI 1.15rCSI 1.86%PRS 61.68
-
CSI 1.14rCSI 1.43%PRS 82.96
-
CSI 1.13rCSI 1.65%PRS 83.07
-
CSI 1.11rCSI 1%PRS 69.68
-
CSI 1.01rCSI 1.54%PRS 85.69
-
CSI 1rCSI 5.02%PRS 84.66
-
CSI 0.99rCSI 3.34%PRS 72.78
-
CSI 0.98rCSI 2.33%PRS 79.58
-
CSI 0.97rCSI 3.11%PRS 75.75
-
CSI 0.4rCSI 1.3%PRS 57.7%
-
CSI 0.5rCSI 5.0%PRS 80.7%
-
CSI 0.6rCSI 1.6%PRS 72.7%
-
CSI 0.7rCSI 3.8%PRS 81.1%
-
CSI 0.7rCSI 1.7%PRS 51.7%
-
CSI 0.7rCSI 3.2%PRS 80.8%
-
CSI 0.7rCSI 4.6%PRS 92.2%
-
CSI 0.8rCSI 3.5%PRS 84.4%
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CSI 0.8rCSI 1.9%PRS 67.1%
-
CSI 0.9rCSI 2.7%PRS 55.2%
-
CSI 0.9rCSI 1.9%PRS 71.1%
-
CSI 0.9rCSI 2.0%PRS 81.9%
-
CSI 1.0rCSI 3.5%PRS 89.1%
-
CSI 1.0rCSI 3.1%PRS 75.8%
-
CSI 1.0rCSI 2.3%PRS 79.6%
-
CSI 1.0rCSI 3.3%PRS 72.8%
-
CSI 1.0rCSI 5.0%PRS 84.7%
-
CSI 1.0rCSI 1.5%PRS 85.7%
-
CSI 1.1rCSI 1.0%PRS 69.7%
-
CSI 1.1rCSI 1.7%PRS 83.1%
-
CSI 1.1rCSI 1.4%PRS 83.0%
-
CSI 1.2rCSI 1.9%PRS 61.7%
-
CSI 1.2rCSI 1.8%PRS 68.8%
-
CSI 1.2rCSI 1.9%PRS 64.8%
-
CSI 1.2rCSI 1.4%PRS 63.5%
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CSI 1.3rCSI 2.5%PRS 75.6%
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CSI 1.3rCSI 1.1%PRS 77.0%
-
CSI 1.3rCSI 1.1%PRS 75.7%
-
CSI 1.3rCSI 1.7%PRS 82.1%
-
CSI 1.3rCSI 2.3%PRS 53.4%
-
CSI 1.3rCSI 2.4%PRS 52.5%
-
CSI 1.3rCSI 3.3%PRS 65.2%
-
CSI 1.4rCSI 2.2%PRS 64.0%
-
CSI 1.4rCSI 1.9%PRS 76.2%
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CSI 1.4rCSI 3.1%PRS 80.2%
-
CSI 1.4rCSI 1.0%PRS 75.4%
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CSI 1.4rCSI 2.4%PRS 80.0%
-
CSI 1.4rCSI 2.0%PRS 70.9%
-
CSI 1.4rCSI 6.3%PRS 61.2%
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CSI 1.5rCSI 1.3%PRS 82.7%
-
CSI 1.5rCSI 2.0%PRS 73.1%
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CSI 1.5rCSI 1.9%PRS 51.4%
-
CSI 1.5rCSI 4.3%PRS 68.8%
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CSI 1.6rCSI 1.6%PRS 65.9%
-
CSI 1.6rCSI 1.7%PRS 70.0%
-
CSI 1.7rCSI 2.7%PRS 67.9%
-
CSI 1.7rCSI 2.3%PRS 63.5%
-
CSI 1.7rCSI 3.0%PRS 68.3%
-
CSI 1.8rCSI 5.2%PRS 74.2%
-
CSI 1.8rCSI 1.6%PRS 60.5%
-
CSI 1.8rCSI 2.1%PRS 64.5%
-
CSI 1.8rCSI 10.5%PRS 79.6%
-
CSI 1.8rCSI 1.2%PRS 75.2%
-
CSI 1.8rCSI 2.7%PRS 77.2%
-
CSI 1.8rCSI 2.9%PRS 82.2%
-
CSI 1.9rCSI 2.7%PRS 81.1%
-
CSI 1.9rCSI 1.8%PRS 64.3%
-
CSI 1.9rCSI 1.5%PRS 74.3%
-
CSI 2.0rCSI 2.3%PRS 74.4%
-
CSI 2.0rCSI 2.4%PRS 79.2%
-
CSI 2.0rCSI 2.3%PRS 53.3%
-
CSI 2.0rCSI 1.8%PRS 81.1%
-
CSI 2.0rCSI 2.8%PRS 89.4%
-
CSI 2.0rCSI 1.8%PRS 70.2%
-
CSI 2.0rCSI 1.7%PRS 74.7%
-
CSI 2.1rCSI 3.2%PRS 76.5%
-
CSI 2.1rCSI 2.2%PRS 72.1%
-
CSI 2.1rCSI 2.2%PRS 83.3%
-
CSI 2.1rCSI 2.8%PRS 84.4%
-
CSI 2.1rCSI 4.8%PRS 54.0%
-
CSI 2.2rCSI 2.9%PRS 78.5%
-
CSI 2.2rCSI 2.3%PRS 69.3%
-
CSI 2.2rCSI 2.0%PRS 88.7%
-
CSI 2.2rCSI 2.8%PRS 54.8%
-
CSI 2.2rCSI 2.4%PRS 75.6%
-
CSI 2.3rCSI 1.8%PRS 72.3%
-
CSI 2.3rCSI 3.4%PRS 67.2%
-
CSI 2.3rCSI 2.5%PRS 72.9%
-
CSI 2.3rCSI 3.5%PRS 72.8%
-
CSI 2.3rCSI 2.1%PRS 77.8%
-
CSI 2.4rCSI 2.3%PRS 71.8%
-
CSI 2.4rCSI 3.3%PRS 71.1%
-
CSI 2.4rCSI 2.7%PRS 86.9%
-
CSI 2.4rCSI 12.5%PRS 91.6%
-
CSI 2.4rCSI 2.1%PRS 75.3%
-
CSI 2.5rCSI 2.9%PRS 70.3%
-
CSI 2.5rCSI 3.4%PRS 77.7%
-
CSI 2.6rCSI 2.0%PRS 59.7%
-
CSI 2.6rCSI 3.3%PRS 68.8%
-
CSI 2.7rCSI 1.9%PRS 86.8%
-
CSI 2.7rCSI 2.1%PRS 78.8%
-
CSI 2.7rCSI 4.9%PRS 65.4%
-
CSI 2.9rCSI 5.2%PRS 71.6%
-
CSI 2.9rCSI 2.4%PRS 72.6%
-
CSI 3.0rCSI 7.5%PRS 65.8%
-
CSI 3.0rCSI 3.1%PRS 86.1%
-
CSI 3.1rCSI 3.1%PRS 86.8%
-
CSI 3.2rCSI 2.6%PRS 74.3%
-
CSI 3.2rCSI 2.7%PRS 87.0%
-
CSI 3.2rCSI 4.1%PRS 77.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 3554246145
Symbol: COA5_HUMAN
Name: Cytochrome c oxidase assembly factor 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21457908
Title: A mutation in C2orf64 causes impaired cytochrome c oxidase assembly and mitochondrial cardiomyopathy.
PubMed ID: 21457908
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
Sequence Information:
- Length: 74
- Mass: 8376
- Checksum: CE4D3FF94332B2A9
- Sequence:
MPKYYEDKPQ GGACAGLKED LGACLLQSDC VVQEGKSPRQ CLKEGYCNSL KYAFFECKRS VLDNRARFRG RKGY