Details for: ZNHIT3
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 15.55rCSI 27.42%PRS 81.95
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CSI 6.81rCSI 6.25%PRS 84.11
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CSI 6.59rCSI 11.84%PRS 68.79
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CSI 6.26rCSI 4.82%PRS 77.88
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CSI 6.21rCSI 6.09%PRS 89.41
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CSI 6rCSI 9.17%PRS 85.24
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CSI 5.51rCSI 15.81%PRS 92.34
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CSI 4.97rCSI 5.11%PRS 88.41
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CSI 4.91rCSI 2.9%PRS 90.96
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CSI 4.85rCSI 4.02%PRS 76.19
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CSI 4.68rCSI 8.26%PRS 56.19
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CSI 4.6rCSI 3.5%PRS 88.08
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CSI 4.35rCSI 5.94%PRS 80.5
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CSI 4.12rCSI 2.96%PRS 88.47
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CSI 3.83rCSI 3.04%PRS 92.75
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CSI 3.72rCSI 2.98%PRS 90.43
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CSI 3.5rCSI 4.67%PRS 74.62
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CSI 3.36rCSI 2.82%PRS 89.03
-
CSI 3.27rCSI 3.68%PRS 89.26
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CSI 3.23rCSI 7.14%PRS 61.05
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CSI 3.22rCSI 6.47%PRS 65.18
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CSI 3.04rCSI 2.4%PRS 63.45
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CSI 3.04rCSI 4.51%PRS 76.11
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CSI 2.92rCSI 3.05%PRS 72.82
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CSI 2.89rCSI 3%PRS 80.42
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CSI 2.86rCSI 2.82%PRS 78.49
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CSI 2.85rCSI 3.79%PRS 81.54
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CSI 2.79rCSI 2.58%PRS 90.58
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CSI 2.78rCSI 2.07%PRS 88.67
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CSI 2.75rCSI 4.45%PRS 70.99
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CSI 2.74rCSI 3.34%PRS 82.56
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CSI 2.73rCSI 2.4%PRS 80.9
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CSI 2.67rCSI 2.57%PRS 74.95
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CSI 2.6rCSI 2.01%PRS 79.14
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CSI 2.59rCSI 4.04%PRS 93.27
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CSI 2.59rCSI 1.92%PRS 87.13
-
CSI 2.53rCSI 1.68%PRS 78.51
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CSI 2.52rCSI 1.89%PRS 88.53
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CSI 2.4rCSI 12.3%PRS 92.28
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CSI 2.35rCSI 3.74%PRS 84.94
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CSI 2.34rCSI 2.89%PRS 73.29
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CSI 2.33rCSI 2.93%PRS 84.94
-
CSI 2.32rCSI 1.83%PRS 81.63
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CSI 2.31rCSI 1.91%PRS 78.13
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CSI 2.29rCSI 2.74%PRS 90.94
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CSI 2.29rCSI 2.95%PRS 58.23
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CSI 2.29rCSI 1.73%PRS 88.02
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CSI 2.25rCSI 2.03%PRS 73.47
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CSI 2.25rCSI 5.41%PRS 89.49
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CSI 2.24rCSI 3.45%PRS 66.32
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CSI 2.23rCSI 3.21%PRS 82.62
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CSI 2.21rCSI 2.53%PRS 87.74
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CSI 2.21rCSI 2.95%PRS 91.09
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CSI 2.2rCSI 2.99%PRS 93.26
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CSI 2.18rCSI 3.03%PRS 74.25
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CSI 2.17rCSI 1.63%PRS 81.64
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CSI 2.14rCSI 3.14%PRS 85.66
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CSI 2.13rCSI 3.08%PRS 83.73
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CSI 2.11rCSI 3.23%PRS 75.97
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CSI 2.09rCSI 3.19%PRS 72.3
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CSI 2.08rCSI 2.61%PRS 85.79
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CSI 2.07rCSI 2%PRS 68.16
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CSI 2.07rCSI 5.24%PRS 81.39
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CSI 2.07rCSI 1.73%PRS 78.94
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CSI 2.05rCSI 1.78%PRS 85.4
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CSI 2.05rCSI 3.16%PRS 74.72
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CSI 2.04rCSI 2.16%PRS 81.86
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CSI 2.02rCSI 2.16%PRS 76.51
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CSI 2.01rCSI 1.77%PRS 64.17
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CSI 1.99rCSI 3%PRS 81.16
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CSI 1.96rCSI 2%PRS 86.13
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CSI 1.87rCSI 3.8%PRS 53.72
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CSI 1.85rCSI 2.14%PRS 67.71
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CSI 1.84rCSI 2.29%PRS 54.92
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CSI 1.84rCSI 2.21%PRS 73.68
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CSI 1.83rCSI 4.14%PRS 77.12
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CSI 1.81rCSI 2.32%PRS 71.95
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CSI 1.8rCSI 2.88%PRS 79.49
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CSI 1.76rCSI 1.76%PRS 69.29
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CSI 1.75rCSI 5.67%PRS 74.03
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CSI 1.74rCSI 2.65%PRS 79.75
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CSI 1.7rCSI 1.6%PRS 74.66
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CSI 1.69rCSI 1.5%PRS 73.51
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CSI 1.67rCSI 2.38%PRS 77.02
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CSI 1.63rCSI 7.08%PRS 82.87
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CSI 1.6rCSI 2.2%PRS 91.7
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CSI 1.55rCSI 2.37%PRS 83.81
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CSI 1.46rCSI 3%PRS 87.17
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CSI 1.43rCSI 2.71%PRS 95.14
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CSI 1.43rCSI 1.95%PRS 76.03
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CSI 1.42rCSI 5.15%PRS 91.37
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CSI 1.42rCSI 2.26%PRS 67.26
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CSI 1.4rCSI 1.14%PRS 75.45
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CSI 1.35rCSI 2.3%PRS 82.69
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CSI 1.34rCSI 2.96%PRS 74.66
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CSI 1.32rCSI 1.94%PRS 70.3
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CSI 1.3rCSI 3.7%PRS 82.64
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CSI 1.29rCSI 2.03%PRS 77.47
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CSI 1.21rCSI 1.47%PRS 83.81
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CSI 1.15rCSI 2.24%PRS 78.92
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CSI 0.2rCSI 1.3%PRS 81.1%
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CSI 0.5rCSI 7.7%PRS 85.9%
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CSI 0.7rCSI 3.3%PRS 87.5%
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CSI 0.7rCSI 3.1%PRS 76.0%
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CSI 0.7rCSI 2.0%PRS 75.8%
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CSI 0.8rCSI 4.6%PRS 81.1%
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CSI 0.8rCSI 2.6%PRS 61.2%
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CSI 0.8rCSI 4.3%PRS 91.5%
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CSI 0.9rCSI 3.2%PRS 84.8%
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CSI 0.9rCSI 2.7%PRS 87.1%
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CSI 0.9rCSI 5.0%PRS 83.4%
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CSI 0.9rCSI 2.1%PRS 83.3%
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CSI 1.0rCSI 3.1%PRS 58.7%
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CSI 1.0rCSI 1.7%PRS 65.3%
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CSI 1.1rCSI 1.5%PRS 76.2%
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CSI 1.1rCSI 34.0%PRS 88.3%
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CSI 1.2rCSI 2.2%PRS 78.9%
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CSI 1.2rCSI 1.5%PRS 83.8%
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CSI 1.3rCSI 2.0%PRS 77.5%
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CSI 1.3rCSI 3.7%PRS 82.6%
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CSI 1.3rCSI 1.9%PRS 70.3%
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CSI 1.3rCSI 3.0%PRS 74.7%
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CSI 1.4rCSI 2.3%PRS 82.7%
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CSI 1.4rCSI 1.1%PRS 75.5%
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CSI 1.4rCSI 2.3%PRS 67.3%
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CSI 1.4rCSI 5.2%PRS 91.4%
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CSI 1.4rCSI 2.0%PRS 76.0%
-
CSI 1.4rCSI 2.7%PRS 95.1%
-
CSI 1.5rCSI 3.0%PRS 87.2%
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CSI 1.6rCSI 2.4%PRS 83.8%
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CSI 1.6rCSI 2.2%PRS 91.7%
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CSI 1.6rCSI 7.1%PRS 82.9%
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CSI 1.7rCSI 2.4%PRS 77.0%
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CSI 1.7rCSI 1.5%PRS 73.5%
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CSI 1.7rCSI 1.6%PRS 74.7%
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CSI 1.7rCSI 2.7%PRS 79.8%
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CSI 1.8rCSI 5.7%PRS 74.0%
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CSI 1.8rCSI 1.8%PRS 69.3%
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CSI 1.8rCSI 2.9%PRS 79.5%
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CSI 1.8rCSI 2.3%PRS 72.0%
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CSI 1.8rCSI 4.1%PRS 77.1%
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CSI 1.8rCSI 2.2%PRS 73.7%
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CSI 1.8rCSI 2.3%PRS 54.9%
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CSI 1.9rCSI 2.1%PRS 67.7%
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CSI 1.9rCSI 3.8%PRS 53.7%
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CSI 2.0rCSI 2.0%PRS 86.1%
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CSI 2.0rCSI 3.0%PRS 81.2%
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CSI 2.0rCSI 1.8%PRS 64.2%
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CSI 2.0rCSI 2.2%PRS 76.5%
-
CSI 2.0rCSI 2.2%PRS 81.9%
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CSI 2.1rCSI 3.2%PRS 74.7%
-
CSI 2.1rCSI 1.8%PRS 85.4%
-
CSI 2.1rCSI 1.7%PRS 78.9%
-
CSI 2.1rCSI 5.2%PRS 81.4%
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CSI 2.1rCSI 2.0%PRS 68.2%
-
CSI 2.1rCSI 2.6%PRS 85.8%
-
CSI 2.1rCSI 3.2%PRS 72.3%
-
CSI 2.1rCSI 3.2%PRS 76.0%
-
CSI 2.1rCSI 3.1%PRS 83.7%
-
CSI 2.1rCSI 3.1%PRS 85.7%
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CSI 2.2rCSI 1.6%PRS 81.6%
-
CSI 2.2rCSI 3.0%PRS 74.3%
-
CSI 2.2rCSI 3.0%PRS 93.3%
-
CSI 2.2rCSI 3.0%PRS 91.1%
-
CSI 2.2rCSI 2.5%PRS 87.7%
-
CSI 2.2rCSI 3.2%PRS 82.6%
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CSI 2.2rCSI 3.5%PRS 66.3%
-
CSI 2.3rCSI 5.4%PRS 89.5%
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CSI 2.3rCSI 2.0%PRS 73.5%
-
CSI 2.3rCSI 1.7%PRS 88.0%
-
CSI 2.3rCSI 3.0%PRS 58.2%
-
CSI 2.3rCSI 2.7%PRS 90.9%
-
CSI 2.3rCSI 1.9%PRS 78.1%
-
CSI 2.3rCSI 1.8%PRS 81.6%
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CSI 2.3rCSI 2.9%PRS 84.9%
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CSI 2.3rCSI 2.9%PRS 73.3%
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CSI 2.4rCSI 3.7%PRS 84.9%
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CSI 2.4rCSI 12.3%PRS 92.3%
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CSI 2.5rCSI 1.9%PRS 88.5%
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CSI 2.5rCSI 1.7%PRS 78.5%
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CSI 2.6rCSI 1.9%PRS 87.1%
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CSI 2.6rCSI 4.0%PRS 93.3%
-
CSI 2.6rCSI 2.0%PRS 79.1%
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CSI 2.7rCSI 2.6%PRS 75.0%
-
CSI 2.7rCSI 2.4%PRS 80.9%
-
CSI 2.7rCSI 3.3%PRS 82.6%
-
CSI 2.8rCSI 4.5%PRS 71.0%
-
CSI 2.8rCSI 2.1%PRS 88.7%
-
CSI 2.8rCSI 2.6%PRS 90.6%
-
CSI 2.9rCSI 3.8%PRS 81.5%
-
CSI 2.9rCSI 2.8%PRS 78.5%
-
CSI 2.9rCSI 3.0%PRS 80.4%
-
CSI 2.9rCSI 3.1%PRS 72.8%
-
CSI 3.0rCSI 4.5%PRS 76.1%
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CSI 3.0rCSI 2.4%PRS 63.5%
-
CSI 3.2rCSI 6.5%PRS 65.2%
-
CSI 3.2rCSI 7.1%PRS 61.1%
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CSI 3.3rCSI 3.7%PRS 89.3%
-
CSI 3.4rCSI 2.8%PRS 89.0%
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CSI 3.5rCSI 4.7%PRS 74.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2749279934
Symbol: ZNHI3_HUMAN
Name: Zinc finger HIT domain-containing protein 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11916906
Title: Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha.
PubMed ID: 11916906
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7776974
Title: Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.
PubMed ID: 7776974
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 28335020
Title: ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss.
PubMed ID: 28335020
DOI: 10.1093/brain/awx040
PubMed ID: 28561026
Title: R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.
PubMed ID: 28561026
DOI: 10.1038/ncomms15615
Sequence Information:
- Length: 155
- Mass: 17607
- Checksum: A115FD0AA9321AB0
- Sequence:
MASLKCSTVV CVICLEKPKY RCPACRVPYC SVVCFRKHKE QCNPETRPVE KKIRSALPTK TVKPVENKDD DDSIADFLNS DEEEDRVSLQ NLKNLGESAT LRSLLLNPHL RQLMVNLDQG EDKAKLMRAY MQEPLFVEFA DCCLGIVEPS QNEES