Details for: TNRC18P2

Gene ID: 27320

Symbol: TNRC18P2

Ensembl ID: ENSG00000223566

Description: trinucleotide repeat containing 18 pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 66.8600
    Cell Significance Index: 1333.2600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 64.1795
    Cell Significance Index: 1263.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 60.3919
    Cell Significance Index: 1304.7900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 58.5136
    Cell Significance Index: 1221.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 55.6343
    Cell Significance Index: 1100.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 51.6617
    Cell Significance Index: 1096.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 49.9320
    Cell Significance Index: 1002.4500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 42.7917
    Cell Significance Index: 1499.0800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 41.0274
    Cell Significance Index: 1023.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 38.3598
    Cell Significance Index: 663.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 32.5467
    Cell Significance Index: 1065.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 26.6409
    Cell Significance Index: 848.4800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 21.8244
    Cell Significance Index: 444.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 5.8087
    Cell Significance Index: 1165.2200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.8656
    Cell Significance Index: 12.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2763
    Cell Significance Index: 2.8600
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.1239
    Cell Significance Index: 1.4400
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.1107
    Cell Significance Index: 1.3900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0841
    Cell Significance Index: 0.9500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0738
    Cell Significance Index: 0.6500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0478
    Cell Significance Index: 0.6100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0344
    Cell Significance Index: 0.4100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.0326
    Cell Significance Index: 0.3000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0274
    Cell Significance Index: 0.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0272
    Cell Significance Index: 0.7300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0263
    Cell Significance Index: 0.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0252
    Cell Significance Index: 0.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0237
    Cell Significance Index: 0.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0163
    Cell Significance Index: 0.2400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0121
    Cell Significance Index: 0.1600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0114
    Cell Significance Index: 0.1600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0107
    Cell Significance Index: 0.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.4700
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0007
    Cell Significance Index: -0.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0012
    Cell Significance Index: -0.7800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0023
    Cell Significance Index: -0.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0038
    Cell Significance Index: -0.4000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0040
    Cell Significance Index: -0.0500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0076
    Cell Significance Index: -0.2400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0103
    Cell Significance Index: -0.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0105
    Cell Significance Index: -0.1500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0116
    Cell Significance Index: -0.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0125
    Cell Significance Index: -0.1700
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.0145
    Cell Significance Index: -0.1700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0179
    Cell Significance Index: -0.1500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0181
    Cell Significance Index: -0.2600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0188
    Cell Significance Index: -0.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0230
    Cell Significance Index: -0.3500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0248
    Cell Significance Index: -0.3300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0284
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0285
    Cell Significance Index: -0.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0297
    Cell Significance Index: -0.3300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0298
    Cell Significance Index: -0.3500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0301
    Cell Significance Index: -0.4400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0311
    Cell Significance Index: -0.3900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0318
    Cell Significance Index: -0.2500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0320
    Cell Significance Index: -0.4000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0325
    Cell Significance Index: -0.4100
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0345
    Cell Significance Index: -0.4100
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0362
    Cell Significance Index: -0.4400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0397
    Cell Significance Index: -0.3500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0403
    Cell Significance Index: -0.5100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0408
    Cell Significance Index: -0.5600
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0418
    Cell Significance Index: -0.4600
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: -0.0430
    Cell Significance Index: -0.3800
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0491
    Cell Significance Index: -0.5500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0495
    Cell Significance Index: -0.6500
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0512
    Cell Significance Index: -0.4800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0525
    Cell Significance Index: -0.6200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0533
    Cell Significance Index: -0.5900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0535
    Cell Significance Index: -0.6500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0552
    Cell Significance Index: -0.7200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0560
    Cell Significance Index: -0.6700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0561
    Cell Significance Index: -0.5100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0567
    Cell Significance Index: -0.6700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0572
    Cell Significance Index: -0.6500
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0578
    Cell Significance Index: -0.6400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0581
    Cell Significance Index: -0.6700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0591
    Cell Significance Index: -0.6600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0599
    Cell Significance Index: -0.6200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0600
    Cell Significance Index: -0.6500
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0610
    Cell Significance Index: -0.6700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0611
    Cell Significance Index: -0.7200
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0618
    Cell Significance Index: -0.6600
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0624
    Cell Significance Index: -0.6600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0627
    Cell Significance Index: -0.6400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0633
    Cell Significance Index: -0.7600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0633
    Cell Significance Index: -0.6000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0636
    Cell Significance Index: -0.6000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0642
    Cell Significance Index: -0.5900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0644
    Cell Significance Index: -0.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0659
    Cell Significance Index: -1.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNRC18P2 is a trinucleotide repeat containing pseudogene, implying that it does not encode a functional protein. Pseudogenes, by definition, are non-functional copies of genes that have diverged from their functional counterparts through mutations or other mechanisms. The presence of trinucleotide repeats, a type of microsatellite, suggests that TNRC18P2 may have originated from a functional gene that has undergone repetitive expansions, leading to its pseudogenization. The fact that TNRC18P2 is significantly expressed in various cell types, including those involved in immune responses and tissue maintenance, hints at potential regulatory or modulatory functions. **Pathways and Functions:** Despite its unclear functions, TNRC18P2 appears to be involved in several cellular processes. Its expression in retinal cells, for instance, may be related to the regulation of light adaptation and visual processing. In melanocytes, TNRC18P2 could potentially modulate melanin production or pigmentation. The presence of TNRC18P2 in central nervous system macrophages and astrocytes suggests a role in immune regulation and neuroinflammation. Furthermore, its expression in plasma cells and oligodendrocyte precursor cells implies a potential involvement in humoral immunity and myelination, respectively. The pathways mediated by TNRC18P2 are not yet fully elucidated, but several possibilities emerge from its expression patterns: 1. **MicroRNA-mediated regulation:** TNRC18P2 may serve as a target for microRNAs (miRNAs) that regulate gene expression in various cell types, influencing cellular processes such as proliferation, differentiation, and survival. 2. **Non-coding RNA-mediated regulation:** TNRC18P2 could be involved in the regulation of non-coding RNAs, such as long non-coding RNAs (lncRNAs) or circular RNAs (circRNAs), which play crucial roles in gene expression and chromatin regulation. 3. **Epigenetic regulation:** TNRC18P2 may interact with epigenetic regulators, such as histone-modifying enzymes or DNA methyltransferases, to modulate gene expression and chromatin structure. **Clinical Significance:** The clinical significance of TNRC18P2 remains unclear, but its expression in various cell types suggests potential implications in human disease. Some possible areas of investigation include: 1. **Neurodegenerative diseases:** TNRC18P2's expression in retinal cells and central nervous system macrophages may be related to the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease or multiple sclerosis. 2. **Immune-mediated disorders:** The presence of TNRC18P2 in immune cells may contribute to the development of autoimmune diseases, such as multiple sclerosis or rheumatoid arthritis. 3. **Eye diseases:** TNRC18P2's expression in retinal cells may be related to the pathogenesis of eye diseases, such as age-related macular degeneration or retinitis pigmentosa. In conclusion, TNRC18P2 is a mysterious pseudogene with unclear functions and pathways. Its widespread expression across various cell types suggests potential regulatory or modulatory roles, particularly in immune regulation and tissue maintenance. Further investigation is needed to unravel the secrets of this enigmatic gene and its potential implications in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.