Details for: DZIP3

Gene ID: 9666

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DZIP3

Ensembl ID: ENSG00000198919

Description: DAZ interacting zinc finger protein 3

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • lung ciliated cell CL1000271
    CSI 35.3
    rCSI 40.82%
    PRS 72.74
  • retinal cone cell CL0000573
    CSI 30.93
    rCSI 49.78%
    PRS 70.55
  • ependymal cell CL0000065
    CSI 22.66
    rCSI 45.99%
    PRS 58.97
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 22.54
    rCSI 54.78%
    PRS 60.51
  • ciliated epithelial cell CL0000067
    CSI 21.72
    rCSI 19.1%
    PRS 69.67
  • ciliated cell CL0000064
    CSI 19.5
    rCSI 31.59%
    PRS 75.24
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 18.13
    rCSI 30.42%
    PRS 62.48
  • L6b glutamatergic cortical neuron CL4023038
    CSI 16.09
    rCSI 50.29%
    PRS 64.19
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 15.58
    rCSI 35.53%
    PRS 74.09
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 13.52
    rCSI 48.66%
    PRS 60.42
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 13.37
    rCSI 16.63%
    PRS 60.43
  • retinal ganglion cell CL0000740
    CSI 11.27
    rCSI 24.91%
    PRS 66.18
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 10.62
    rCSI 40.12%
    PRS 62.98
  • S cone cell CL0003050
    CSI 10.14
    rCSI 44.56%
    PRS 75.4
  • alpha-beta T cell CL0000789
    CSI 10.06
    rCSI 11.78%
    PRS 92.51
  • squamous epithelial cell CL0000076
    CSI 9.51
    rCSI 22.57%
    PRS 80.54
  • GABAergic amacrine cell CL4030027
    CSI 9.51
    rCSI 32.57%
    PRS 66.64
  • mucosal invariant T cell CL0000940
    CSI 9.4
    rCSI 7.6%
    PRS 88.57
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 8.64
    rCSI 27.02%
    PRS 66.49
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 8.16
    rCSI 48.07%
    PRS 63.23
  • Schwann cell CL0002573
    CSI 8.05
    rCSI 22.89%
    PRS 76.1
  • central nervous system neuron CL2000029
    CSI 7.82
    rCSI 57.48%
    PRS 67.86
  • dopaminergic neuron CL0000700
    CSI 7.74
    rCSI 43.76%
    PRS 66.52
  • cardiac neuron CL0010022
    CSI 7.73
    rCSI 24.73%
    PRS 77.69
  • sst GABAergic cortical interneuron CL4023017
    CSI 7.72
    rCSI 9.95%
    PRS 63.63
  • lung neuroendocrine cell CL1000223
    CSI 7.59
    rCSI 11.22%
    PRS 84.22
  • neuron CL0000540
    CSI 7.43
    rCSI 19.78%
    PRS 68.05
  • immature B cell CL0000816
    CSI 6.62
    rCSI 4.92%
    PRS 90.24
  • ionocyte CL0005006
    CSI 6.41
    rCSI 6.87%
    PRS 81.71
  • sncg GABAergic cortical interneuron CL4023015
    CSI 6.11
    rCSI 9.82%
    PRS 64.06
  • interneuron CL0000099
    CSI 6.04
    rCSI 12.13%
    PRS 70.64
  • VIP GABAergic cortical interneuron CL4023016
    CSI 5.99
    rCSI 7.15%
    PRS 62.6
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 5.93
    rCSI 8.41%
    PRS 77.04
  • vascular leptomeningeal cell CL4023051
    CSI 5.92
    rCSI 10.38%
    PRS 74.32
  • radial glial cell CL0000681
    CSI 5.76
    rCSI 8%
    PRS 78.86
  • melanocyte CL0000148
    CSI 5.65
    rCSI 4.18%
    PRS 73.99
  • pulmonary ionocyte CL0017000
    CSI 5.56
    rCSI 6.77%
    PRS 86.63
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 5.55
    rCSI 3.74%
    PRS 91.94
  • glial cell CL0000125
    CSI 5.46
    rCSI 20.78%
    PRS 71.32
  • multi-ciliated epithelial cell CL0005012
    CSI 5.35
    rCSI 5.34%
    PRS 74.19
  • Mueller cell CL0000636
    CSI 4.93
    rCSI 11.25%
    PRS 71.88
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 4.9
    rCSI 8.66%
    PRS 61.84
  • glioblast CL0000030
    CSI 4.85
    rCSI 7.73%
    PRS 71.94
  • fibroblast of cardiac tissue CL0002548
    CSI 4.76
    rCSI 22.81%
    PRS 80.19
  • adipocyte CL0000136
    CSI 4.6
    rCSI 5.9%
    PRS 70.53
  • mature T cell CL0002419
    CSI 4.59
    rCSI 3.57%
    PRS 92.82
  • interstitial cell of Cajal CL0002088
    CSI 4.55
    rCSI 5.8%
    PRS 85.2
  • enteroendocrine cell CL0000164
    CSI 4.53
    rCSI 6.19%
    PRS 80.11
  • pancreatic PP cell CL0002275
    CSI 4.46
    rCSI 17.76%
    PRS 87.33
  • pancreatic A cell CL0000171
    CSI 4.31
    rCSI 4.52%
    PRS 83.57
  • chondrocyte CL0000138
    CSI 4.24
    rCSI 6.74%
    PRS 73.47
  • epithelial cell of proximal tubule CL0002306
    CSI 4.19
    rCSI 10.23%
    PRS 72.73
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 4.13
    rCSI 5.3%
    PRS 76.46
  • choroid plexus epithelial cell CL0000706
    CSI 4.13
    rCSI 6.76%
    PRS 69.94
  • ON-bipolar cell CL0000749
    CSI 4.11
    rCSI 6.1%
    PRS 80.34
  • retinal bipolar neuron CL0000748
    CSI 4.11
    rCSI 7.69%
    PRS 68.84
  • cerebral cortex endothelial cell CL1001602
    CSI 4.1
    rCSI 7.09%
    PRS 72.03
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 4
    rCSI 8.68%
    PRS 68.08
  • rod bipolar cell CL0000751
    CSI 3.9
    rCSI 7.01%
    PRS 73.79
  • alveolar type 1 fibroblast cell CL4028004
    CSI 3.87
    rCSI 4.24%
    PRS 82.18
  • inhibitory interneuron CL0000498
    CSI 3.76
    rCSI 8.67%
    PRS 68.36
  • neural crest cell CL0011012
    CSI 3.68
    rCSI 2.91%
    PRS 69.26
  • fibroblast of lung CL0002553
    CSI 3.65
    rCSI 3.39%
    PRS 81.11
  • regular ventricular cardiac myocyte CL0002131
    CSI 3.63
    rCSI 22.67%
    PRS 72.09
  • peripheral nervous system neuron CL2000032
    CSI 3.59
    rCSI 4.89%
    PRS 72.05
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 3.5
    rCSI 10.32%
    PRS 81.21
  • early lymphoid progenitor CL0000936
    CSI 3.47
    rCSI 3.05%
    PRS 85.02
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 3.46
    rCSI 8.27%
    PRS 67.31
  • cerebellar granule cell CL0001031
    CSI 3.29
    rCSI 4.83%
    PRS 73.34
  • GABAergic neuron CL0000617
    CSI 3.24
    rCSI 10.84%
    PRS 64.23
  • cerebral cortex neuron CL0010012
    CSI 3.23
    rCSI 13.16%
    PRS 72.42
  • ON parasol ganglion cell CL4033052
    CSI 3.19
    rCSI 45.34%
    PRS 71.42
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 3.15
    rCSI 3.63%
    PRS 72.49
  • retinal rod cell CL0000604
    CSI 3.14
    rCSI 5.54%
    PRS 75.91
  • stem cell CL0000034
    CSI 3.1
    rCSI 2.98%
    PRS 73.7
  • renal alpha-intercalated cell CL0005011
    CSI 3.02
    rCSI 4.03%
    PRS 86.4
  • renal interstitial pericyte CL1001318
    CSI 2.91
    rCSI 8.02%
    PRS 75.5
  • glutamatergic neuron CL0000679
    CSI 2.81
    rCSI 5.77%
    PRS 67.77
  • Bergmann glial cell CL0000644
    CSI 2.77
    rCSI 3.8%
    PRS 71.84
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 2.69
    rCSI 4.6%
    PRS 92.15
  • BEST4+ enteroycte CL4030026
    CSI 2.65
    rCSI 3.3%
    PRS 81.19
  • parietal epithelial cell CL1000452
    CSI 2.62
    rCSI 7.01%
    PRS 72.12
  • hepatic stellate cell CL0000632
    CSI 2.62
    rCSI 9.82%
    PRS 72.89
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.61
    rCSI 5.86%
    PRS 63.33
  • pancreatic D cell CL0000173
    CSI 2.61
    rCSI 2.56%
    PRS 83.01
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.58
    rCSI 4.69%
    PRS 71.89
  • ON midget ganglion cell CL4033046
    CSI 2.55
    rCSI 51.84%
    PRS 70.27
  • OFF midget ganglion cell CL4033047
    CSI 2.52
    rCSI 51.22%
    PRS 71.41
  • direct pathway medium spiny neuron CL4023026
    CSI 2.51
    rCSI 60.08%
    PRS 60.82
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.48
    rCSI 59.88%
    PRS 61.39
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 2.44
    rCSI 6.3%
    PRS 75.8
  • extravillous trophoblast CL0008036
    CSI 2.37
    rCSI 2.94%
    PRS 78.26
  • cardiac muscle cell CL0000746
    CSI 2.37
    rCSI 3.41%
    PRS 70.23
  • renal principal cell CL0005009
    CSI 2.35
    rCSI 6.12%
    PRS 81.02
  • amacrine cell CL0000561
    CSI 2.29
    rCSI 6.64%
    PRS 69.91
  • blood vessel smooth muscle cell CL0019018
    CSI 2.2
    rCSI 17.88%
    PRS 74.65
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 2.18
    rCSI 1.99%
    PRS 91.22
  • mesodermal cell CL0000222
    CSI 2.18
    rCSI 2.61%
    PRS 78.22
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.1
    rCSI 1.89%
    PRS 78.52
  • retinal pigment epithelial cell CL0002586
    CSI 2.05
    rCSI 4.08%
    PRS 76.07
  • GABAergic interneuron CL0011005
    CSI 0.4
    rCSI 5.7%
    PRS 81.3%
  • diffuse bipolar 3b cell CL4033030
    CSI 0.5
    rCSI 3.0%
    PRS 75.1%
  • diffuse bipolar 2 cell CL4033028
    CSI 0.5
    rCSI 4.1%
    PRS 74.5%
  • H2 horizontal cell CL0004218
    CSI 0.6
    rCSI 3.0%
    PRS 75.1%
  • diffuse bipolar 3a cell CL4033029
    CSI 0.6
    rCSI 4.1%
    PRS 73.1%
  • erythroblast CL0000765
    CSI 0.7
    rCSI 1.8%
    PRS 85.8%
  • enteroendocrine cell of colon CL0009042
    CSI 0.7
    rCSI 3.4%
    PRS 88.2%
  • invaginating midget bipolar cell CL4033034
    CSI 0.9
    rCSI 5.3%
    PRS 72.0%
  • deuterosomal cell CL4033044
    CSI 0.9
    rCSI 3.1%
    PRS 77.8%
  • regular atrial cardiac myocyte CL0002129
    CSI 1.0
    rCSI 3.2%
    PRS 77.0%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.1
    rCSI 11.1%
    PRS 76.7%
  • forebrain radial glial cell CL0013000
    CSI 1.2
    rCSI 3.8%
    PRS 82.2%
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 1.2
    rCSI 3.9%
    PRS 66.5%
  • intraepithelial lymphocyte CL0002496
    CSI 1.2
    rCSI 3.3%
    PRS 95.2%
  • enteroendocrine cell of small intestine CL0009006
    CSI 1.2
    rCSI 2.7%
    PRS 87.7%
  • type B pancreatic cell CL0000169
    CSI 1.3
    rCSI 2.8%
    PRS 79.9%
  • H1 horizontal cell CL0004217
    CSI 1.3
    rCSI 5.2%
    PRS 75.7%
  • type L enteroendocrine cell CL0002279
    CSI 1.4
    rCSI 2.6%
    PRS 87.1%
  • cerebellar neuron CL1001611
    CSI 1.4
    rCSI 12.2%
    PRS 68.5%
  • placental villous trophoblast CL2000060
    CSI 1.4
    rCSI 2.2%
    PRS 79.5%
  • glycinergic amacrine cell CL4030028
    CSI 1.5
    rCSI 3.8%
    PRS 75.1%
  • memory T cell CL0000813
    CSI 1.5
    rCSI 2.9%
    PRS 95.5%
  • macroglial cell CL0000126
    CSI 1.5
    rCSI 3.9%
    PRS 77.0%
  • retina horizontal cell CL0000745
    CSI 1.5
    rCSI 2.3%
    PRS 77.2%
  • OFF-bipolar cell CL0000750
    CSI 1.5
    rCSI 2.1%
    PRS 82.3%
  • neural progenitor cell CL0011020
    CSI 1.5
    rCSI 6.8%
    PRS 68.9%
  • medium spiny neuron CL1001474
    CSI 1.6
    rCSI 13.8%
    PRS 68.7%
  • nasal mucosa goblet cell CL0002480
    CSI 1.7
    rCSI 1.9%
    PRS 84.1%
  • alveolar adventitial fibroblast CL4028006
    CSI 1.8
    rCSI 2.9%
    PRS 81.8%
  • erythrocyte CL0000232
    CSI 1.9
    rCSI 4.3%
    PRS 80.8%
  • serotonergic neuron CL0000850
    CSI 1.9
    rCSI 8.5%
    PRS 64.6%
  • lung secretory cell CL1000272
    CSI 1.9
    rCSI 4.8%
    PRS 80.2%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.9
    rCSI 4.9%
    PRS 70.9%
  • retinal pigment epithelial cell CL0002586
    CSI 2.1
    rCSI 4.1%
    PRS 76.1%
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.1
    rCSI 1.9%
    PRS 78.5%
  • mesodermal cell CL0000222
    CSI 2.2
    rCSI 2.6%
    PRS 78.2%
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 2.2
    rCSI 2.0%
    PRS 91.2%
  • blood vessel smooth muscle cell CL0019018
    CSI 2.2
    rCSI 17.9%
    PRS 74.7%
  • amacrine cell CL0000561
    CSI 2.3
    rCSI 6.6%
    PRS 69.9%
  • renal principal cell CL0005009
    CSI 2.4
    rCSI 6.1%
    PRS 81.0%
  • cardiac muscle cell CL0000746
    CSI 2.4
    rCSI 3.4%
    PRS 70.2%
  • extravillous trophoblast CL0008036
    CSI 2.4
    rCSI 2.9%
    PRS 78.3%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 2.4
    rCSI 6.3%
    PRS 75.8%
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.5
    rCSI 59.9%
    PRS 61.4%
  • direct pathway medium spiny neuron CL4023026
    CSI 2.5
    rCSI 60.1%
    PRS 60.8%
  • OFF midget ganglion cell CL4033047
    CSI 2.5
    rCSI 51.2%
    PRS 71.4%
  • ON midget ganglion cell CL4033046
    CSI 2.6
    rCSI 51.8%
    PRS 70.3%
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.6
    rCSI 4.7%
    PRS 71.9%
  • pancreatic D cell CL0000173
    CSI 2.6
    rCSI 2.6%
    PRS 83.0%
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.6
    rCSI 5.9%
    PRS 63.3%
  • hepatic stellate cell CL0000632
    CSI 2.6
    rCSI 9.8%
    PRS 72.9%
  • parietal epithelial cell CL1000452
    CSI 2.6
    rCSI 7.0%
    PRS 72.1%
  • BEST4+ enteroycte CL4030026
    CSI 2.7
    rCSI 3.3%
    PRS 81.2%
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 2.7
    rCSI 4.6%
    PRS 92.2%
  • Bergmann glial cell CL0000644
    CSI 2.8
    rCSI 3.8%
    PRS 71.8%
  • glutamatergic neuron CL0000679
    CSI 2.8
    rCSI 5.8%
    PRS 67.8%
  • renal interstitial pericyte CL1001318
    CSI 2.9
    rCSI 8.0%
    PRS 75.5%
  • renal alpha-intercalated cell CL0005011
    CSI 3.0
    rCSI 4.0%
    PRS 86.4%
  • stem cell CL0000034
    CSI 3.1
    rCSI 3.0%
    PRS 73.7%
  • retinal rod cell CL0000604
    CSI 3.1
    rCSI 5.5%
    PRS 75.9%
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 3.2
    rCSI 3.6%
    PRS 72.5%
  • ON parasol ganglion cell CL4033052
    CSI 3.2
    rCSI 45.3%
    PRS 71.4%
  • cerebral cortex neuron CL0010012
    CSI 3.2
    rCSI 13.2%
    PRS 72.4%
  • GABAergic neuron CL0000617
    CSI 3.2
    rCSI 10.8%
    PRS 64.2%
  • cerebellar granule cell CL0001031
    CSI 3.3
    rCSI 4.8%
    PRS 73.3%
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 3.5
    rCSI 8.3%
    PRS 67.3%
  • early lymphoid progenitor CL0000936
    CSI 3.5
    rCSI 3.1%
    PRS 85.0%
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 3.5
    rCSI 10.3%
    PRS 81.2%
  • peripheral nervous system neuron CL2000032
    CSI 3.6
    rCSI 4.9%
    PRS 72.1%
  • regular ventricular cardiac myocyte CL0002131
    CSI 3.6
    rCSI 22.7%
    PRS 72.1%
  • fibroblast of lung CL0002553
    CSI 3.7
    rCSI 3.4%
    PRS 81.1%
  • neural crest cell CL0011012
    CSI 3.7
    rCSI 2.9%
    PRS 69.3%
  • inhibitory interneuron CL0000498
    CSI 3.8
    rCSI 8.7%
    PRS 68.4%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 3.9
    rCSI 4.2%
    PRS 82.2%
  • rod bipolar cell CL0000751
    CSI 3.9
    rCSI 7.0%
    PRS 73.8%
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 4.0
    rCSI 8.7%
    PRS 68.1%
  • cerebral cortex endothelial cell CL1001602
    CSI 4.1
    rCSI 7.1%
    PRS 72.0%
  • retinal bipolar neuron CL0000748
    CSI 4.1
    rCSI 7.7%
    PRS 68.8%
  • ON-bipolar cell CL0000749
    CSI 4.1
    rCSI 6.1%
    PRS 80.3%
  • choroid plexus epithelial cell CL0000706
    CSI 4.1
    rCSI 6.8%
    PRS 69.9%
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 4.1
    rCSI 5.3%
    PRS 76.5%
  • epithelial cell of proximal tubule CL0002306
    CSI 4.2
    rCSI 10.2%
    PRS 72.7%
  • chondrocyte CL0000138
    CSI 4.2
    rCSI 6.7%
    PRS 73.5%
  • pancreatic A cell CL0000171
    CSI 4.3
    rCSI 4.5%
    PRS 83.6%
  • pancreatic PP cell CL0002275
    CSI 4.5
    rCSI 17.8%
    PRS 87.3%
  • enteroendocrine cell CL0000164
    CSI 4.5
    rCSI 6.2%
    PRS 80.1%
  • interstitial cell of Cajal CL0002088
    CSI 4.6
    rCSI 5.8%
    PRS 85.2%
  • mature T cell CL0002419
    CSI 4.6
    rCSI 3.6%
    PRS 92.8%
  • adipocyte CL0000136
    CSI 4.6
    rCSI 5.9%
    PRS 70.5%
  • fibroblast of cardiac tissue CL0002548
    CSI 4.8
    rCSI 22.8%
    PRS 80.2%
  • glioblast CL0000030
    CSI 4.9
    rCSI 7.7%
    PRS 71.9%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 4.9
    rCSI 8.7%
    PRS 61.8%
  • Mueller cell CL0000636
    CSI 4.9
    rCSI 11.3%
    PRS 71.9%
  • multi-ciliated epithelial cell CL0005012
    CSI 5.4
    rCSI 5.3%
    PRS 74.2%
  • glial cell CL0000125
    CSI 5.5
    rCSI 20.8%
    PRS 71.3%
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 5.6
    rCSI 3.7%
    PRS 91.9%
  • pulmonary ionocyte CL0017000
    CSI 5.6
    rCSI 6.8%
    PRS 86.6%
  • melanocyte CL0000148
    CSI 5.7
    rCSI 4.2%
    PRS 74.0%
  • radial glial cell CL0000681
    CSI 5.8
    rCSI 8.0%
    PRS 78.9%
  • vascular leptomeningeal cell CL4023051
    CSI 5.9
    rCSI 10.4%
    PRS 74.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [DZIP3](/details-gene/9666) (DAZ interacting zinc finger protein 3) is a protein-coding gene located on chromosome 3q13.13 that encodes an E3 ubiquitin-protein ligase. Functionally, it is involved in protein polyubiquitination, a key cellular process for protein degradation and signaling. The gene product also exhibits RNA and protein binding capabilities ([Link](https://doi.org/10.1242/jcs.00261)). Expression analysis shows that **Overall**, [DZIP3](/details-gene/9666) has a high cellular significance in specialized, terminally differentiated cells, particularly in various types of ciliated cells, retinal cells, and a diverse range of glutamatergic and GABAergic neurons. Its involvement in immune system pathways, coupled with its expression in [alpha-beta T cells](/details-cell/CL0000789), suggests a multifaceted role that spans structural cell maintenance, neuronal function, and immune regulation. ## Cellular Roles and Expression Landscape The expression profile of [DZIP3](/details-gene/9666) highlights its importance in several distinct cellular contexts. **Overall**, the gene shows the highest significance in cells characterized by cilia, including [lung ciliated cell](/details-cell/CL1000271) (CSI: 35.30), [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 21.72), and [ciliated columnar cell of tracheobronchial tree](/details-cell/CL0002145) (CSI: 15.58). This strong and consistent signal suggests a fundamental role for [DZIP3](/details-gene/9666) in the maintenance or function of ciliary structures. A second major functional niche for [DZIP3](/details-gene/9666) appears to be the nervous system, with high significance scores across a variety of neuronal subtypes. These include [retinal cone cell](/details-cell/CL0000573) (CSI: 30.93) and both excitatory and inhibitory neurons such as [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 22.54) and [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 18.13). Its presence in [ependymal cells](/details-cell/CL0000065) (CSI: 22.66), which are ciliated glial cells lining the cerebral ventricles, bridges its roles in both nervous and ciliated tissues. Finally, the data indicate a relevant, albeit lower-scoring, role in the adaptive immune system, as evidenced by its expression in [alpha-beta T cells](/details-cell/CL0000789) (CSI: 10.06). This is consistent with its functional annotation linking it to antigen processing and presentation. The broad expression pattern across these specialized cell types suggests that [DZIP3](/details-gene/9666)-mediated ubiquitination is a key regulatory mechanism in diverse biological settings. ## Pathways and Molecular Function [DZIP3](/details-gene/9666) functions as an E3 ubiquitin ligase, which is strongly supported by its molecular function annotations, including [ubiquitin protein ligase activity](/details-gene/GO:0061630) and [ubiquitin-protein transferase activity](/details-gene/GO:0004842). This enzymatic activity leads to the covalent attachment of ubiquitin chains to substrate proteins, a process defined as [protein polyubiquitination](/details-gene/GO:0000209). Its role in the immune system is clearly delineated by its association with several Reactome pathways. [DZIP3](/details-gene/9666) is implicated in the [Adaptive immune system](/details-gene/R-HSA-1280218) and, more specifically, in [Antigen processing: ubiquitination & proteasome degradation](/details-gene/R-HSA-983168) and [Class i mhc mediated antigen processing & presentation](/details-gene/R-HSA-983169). This suggests that [DZIP3](/details-gene/9666) may be involved in tagging intracellular proteins for proteasomal degradation, a critical step for generating peptides that are presented on MHC class I molecules to cytotoxic T cells. This function aligns with its expression in immune cells like [alpha-beta T cells](/details-cell/CL0000789). In addition to its enzymatic role, [DZIP3](/details-gene/9666) is annotated with [Rna binding](/details-gene/GO:0003723) and [protein binding](/details-gene/GO:0005515) capabilities, consistent with early characterizations ([Link](https://doi.org/10.1242/jcs.00261)). This suggests it may function as a scaffold protein or target specific substrates through its RNA-binding domain, potentially linking protein degradation pathways with post-transcriptional gene regulation. ## Research Directions The widespread significance of [DZIP3](/details-gene/9666) in specialized cell types opens several avenues for future investigation. The data prompt several testable hypotheses regarding its specific biological roles. **Proposed Hypotheses:** 1. Given its prominent expression in multiple ciliated cell types ([lung ciliated cell](/details-cell/CL1000271), [ependymal cell](/details-cell/CL0000065)), [DZIP3](/details-gene/9666) likely regulates the homeostasis of cilia by ubiquitinating key structural or motor proteins, and its dysfunction could be a contributing factor in ciliopathies. 2. The high significance of [DZIP3](/details-gene/9666) in a diverse set of cortical neurons ([L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040), [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011)) and its dual RNA-binding and E3 ligase functions suggest it may post-translationally regulate RNA-binding proteins, thereby controlling local mRNA translation or stability at synapses. 3. Based on its involvement in the [Class i mhc mediated antigen processing & presentation](/details-gene/R-HSA-983169) pathway, [DZIP3](/details-gene/9666) may modulate immune surveillance by controlling the ubiquitination and subsequent presentation of specific viral or tumor antigens. **Key Experimental Approach:** To test the first hypothesis regarding its role in ciliary biology, a compelling experiment would involve a targeted knockout of [DZIP3](/details-gene/9666) in human bronchial epithelial cells differentiated at an air-liquid interface, which forms a robustly ciliated epithelium. The experimental workflow would include: * **Genetic Perturbation:** Use CRISPR-Cas9 to generate [DZIP3](/details-gene/9666) knockout cell lines. * **Phenotypic Analysis:** Assess ciliary structure using immunofluorescence microscopy for markers like acetylated tubulin and IFT proteins. Ciliary function could be measured by analyzing ciliary beat frequency with high-speed video microscopy. * **Mechanistic Insight:** Employ quantitative proteomics and ubiquitin-remnant profiling (K-ε-GG) to identify the direct ubiquitination substrates of [DZIP3](/details-gene/9666) in ciliated versus non-ciliated conditions. **Therapeutic Potential:** As an E3 ubiquitin ligase, [DZIP3](/details-gene/9666) is a member of a druggable class of enzymes. However, its high significance in essential cell types like neurons and respiratory epithelial cells suggests that systemic inhibition could lead to substantial toxicity. Therefore, its potential as a therapeutic target is likely context-dependent. If [DZIP3](/details-gene/9666) is found to be overexpressed or hyperactivated in a specific malignancy where it ubiquitinates and degrades a tumor suppressor, then developing a highly specific inhibitor or a proteolysis-targeting chimera (PROTAC) to degrade [DZIP3](/details-gene/9666) could be a viable therapeutic strategy. Inhibition, rather than activation, would be the primary therapeutic approach.

Genular Protein ID: 2419591172

Symbol: DZIP3_HUMAN

Name: E3 ubiquitin-protein ligase DZIP3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12538761

Title: hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase.

PubMed ID: 12538761

DOI: 10.1242/jcs.00261

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12511597

Title: Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.

PubMed ID: 12511597

DOI: 10.1073/pnas.0234478100

Sequence Information:

  • Length: 1208
  • Mass: 138604
  • Checksum: 76945A63AF85207E
  • Sequence:
  • MDSLPDEFFV RHPAVEDQRK EETENKLEKS SGQLNKQEND IPTDLVPVNL LLEVKKLLNA 
    INTLPKGVVP HIKKFLQEDF SFQTMQREVA ANSQNGEEIV PALTLRFLIT QLEAALRNIQ 
    AGNYTAHQIN IGYYLTLLFL YGVALTERGK KEDYTEAENK FLVMKMMIQE NEICENFMSL 
    VYFGRGLLRC AQKRYNGGLL EFHKSLQEIG DKNDHWFDID PTEDEDLPTT FKDLLNNFIK 
    TTESNIMKQT ICSYLDCERS CEADILKNTS YKGFFQLMCS KSCCVYFHKI CWKKFKNLKY 
    PGENDQSFSG KKCLKEGCTG DMVRMLQCDV PGIVKILFEV VRKDEYITIE NLGASYRKLI 
    SLKITDTDIR PKISLKFNTK DEMPIFKLDY NYFYHLLHII IISGTDIVRQ IFDEAMPPPL 
    LKKELLIHKN VLESYYNHLW TNHPLGGSWH LLYPPNKELP QSKQFDLCLL LALIKHLNVF 
    PAPKKGWNME PPSSDISKSA DILRLCKYRD ILLSEILMNG LTESQFNSIW KKVSDILLRL 
    GMMQEDIDKV KENPIENISL DYHQLSVYLG IPVPEIIQRM LSCYQQGIAL QSITGSQRIE 
    IEELQNEEEE LSPPLMEYNI NVKSHPEIQF AEINKDGTSI PSESSTESLK DLQEVKSKQR 
    KKKKTKNKKN KDSKEDQVPY VVEKEEQLRK EQANPHSVSR LIKDDASDVQ EDSAMEDKFY 
    SLDELHILDM IEQGSAGKVT TDYGETEKER LARQRQLYKL HYQCEDFKRQ LRTVTFRWQE 
    NQMQIKKKDK IIASLNQQVA FGINKVSKLQ RQIHAKDNEI KNLKEQLSMK RSQWEMEKHN 
    LESTMKTYVS KLNAETSRAL TAEVYFLQCR RDFGLLHLEQ TEKECLNQLA RVTHMAASNL 
    ESLQLKAAVD SWNAIVADVR NKIAFLRTQY NEQINKVKQG FALSTLPPVQ LPPPPPSPEI 
    LMQQFLGRPL VKESFFRPIL TVPQMPAVCP GVVSATGQPR APLMTGIAWA LPAPVGDAVP 
    PSAGLRSDPS IMNWERITDR LKTAFPQQTR KELTDFLRKL KDAYGKSLSE LTFDEIVCKI 
    SQFIDPKKSQ SQGKSVSNVN CVSPSHSPSQ PDAAQPPKPA WRPLTSQGPA TWEGASNPDE 
    EEEEEEPCVI CHENLSPENL SVLPCAHKFH AQCIRPWLMQ QGTCPTCRLH VLLPEEFPGH 
    PSRQLPKI