PPARA | ENSG00000186951 | NCBI 5465

Details for: PPARA

Gene ID: 5465

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: PPARA

Ensembl ID: ENSG00000186951

Description: peroxisome proliferator activated receptor alpha

Cell Significance Landscape

Display Count:

Associated with

Activation of gene expression by srebf (srebp)
(R-HSA-2426168)
Adipogenesis
(R-HSA-9843745)
Bmal1:clock,npas2 activates circadian gene expression
(R-HSA-1368108)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Circadian clock
(R-HSA-400253)
Cytoprotection by hmox1
(R-HSA-9707564)
Developmental biology
(R-HSA-1266738)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Heme signaling
(R-HSA-9707616)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Metabolism of steroids
(R-HSA-8957322)
Mitochondrial biogenesis
(R-HSA-1592230)
Nuclear receptor transcription pathway
(R-HSA-383280)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Post-translational protein modification
(R-HSA-597592)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Rna polymerase ii transcription
(R-HSA-73857)
Rora activates gene expression
(R-HSA-1368082)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of intracellular receptors
(R-HSA-4090294)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation of brown and beige adipocyte differentiation
(R-HSA-9843743)
Transcriptional regulation of brown and beige adipocyte differentiation by ebf2
(R-HSA-9844594)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Behavioral response to nicotine
(GO:0035095)
Cell differentiation
(GO:0030154)
Cellular response to fructose stimulus
(GO:0071332)
Cellular response to starvation
(GO:0009267)
Chromatin
(GO:0000785)
Circadian regulation of gene expression
(GO:0032922)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Enamel mineralization
(GO:0070166)
Epidermis development
(GO:0008544)
Fatty acid metabolic process
(GO:0006631)
Gluconeogenesis
(GO:0006094)
Heart development
(GO:0007507)
Hormone-mediated signaling pathway
(GO:0009755)
Intracellular receptor signaling pathway
(GO:0030522)
Lipid binding
(GO:0008289)
Lipoprotein metabolic process
(GO:0042157)
Mdm2/mdm4 family protein binding
(GO:0097371)
Mitogen-activated protein kinase kinase kinase binding
(GO:0031435)
Negative regulation of appetite
(GO:0032099)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of cell growth involved in cardiac muscle cell development
(GO:0061052)
Negative regulation of cholesterol storage
(GO:0010887)
Negative regulation of cytokine production involved in inflammatory response
(GO:1900016)
Negative regulation of glycolytic process
(GO:0045820)
Negative regulation of hepatocyte apoptotic process
(GO:1903944)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of leukocyte cell-cell adhesion
(GO:1903038)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Negative regulation of mirna transcription
(GO:1902894)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Negative regulation of reactive oxygen species biosynthetic process
(GO:1903427)
Negative regulation of sequestering of triglyceride
(GO:0010891)
Negative regulation of signaling receptor activity
(GO:2000272)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nfat protein binding
(GO:0051525)
Nitric oxide metabolic process
(GO:0046209)
Nuclear receptor activity
(GO:0004879)
Nuclear steroid receptor activity
(GO:0003707)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatase binding
(GO:0019902)
Positive regulation of atp biosynthetic process
(GO:2001171)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fatty acid beta-oxidation
(GO:0032000)
Positive regulation of fatty acid metabolic process
(GO:0045923)
Positive regulation of fatty acid oxidation
(GO:0046321)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of lipid biosynthetic process
(GO:0046889)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transformation of host cell by virus
(GO:1904189)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of cellular ketone metabolic process
(GO:0010565)
Regulation of circadian rhythm
(GO:0042752)
Regulation of fatty acid metabolic process
(GO:0019217)
Regulation of fatty acid transport
(GO:2000191)
Response to ethanol
(GO:0045471)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Response to nutrient
(GO:0007584)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Steroid hormone receptor signaling pathway
(GO:0043401)
Transcription coactivator binding
(GO:0001223)
Ubiquitin conjugating enzyme binding
(GO:0031624)
Wound healing
(GO:0042060)
Zinc ion binding
(GO:0008270)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 14.11

rCSI 20%

PRS 46.68
epithelial cell of proximal tubule CL0002306

CSI 10.76

rCSI 26.28%

PRS 45.08
ionocyte CL0005006

CSI 10.27

rCSI 11.01%

PRS 48.38
centrilobular region hepatocyte CL0019029

CSI 8.73

rCSI 22.78%

PRS 56.95
cardiac muscle cell CL0000746

CSI 6.93

rCSI 9.94%

PRS 40.69
goblet cell CL0000160

CSI 5.59

rCSI 5.28%

PRS 50.7
retinal rod cell CL0000604

CSI 5.58

rCSI 9.83%

PRS 47.72
IgA plasma cell CL0000987

CSI 5.55

rCSI 5.68%

PRS 67.55
alveolar adventitial fibroblast CL4028006

CSI 5.4

rCSI 8.54%

PRS 51.39
sst GABAergic cortical interneuron CL4023017

CSI 4.88

rCSI 6.29%

PRS 34.53
S cone cell CL0003050

CSI 4.34

rCSI 19.08%

PRS 47.08
periportal region hepatocyte CL0019026

CSI 3.86

rCSI 15.01%

PRS 57.69
erythroblast CL0000765

CSI 3.54

rCSI 9.38%

PRS 63.34
hepatocyte CL0000182

CSI 3.52

rCSI 6.31%

PRS 48.66
epicardial adipocyte CL1000309

CSI 3.39

rCSI 11.04%

PRS 51.53
Mueller cell CL0000636

CSI 3.33

rCSI 7.61%

PRS 42.99
neural crest cell CL0011012

CSI 3.25

rCSI 2.57%

PRS 37.51
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 3.19

rCSI 14.66%

PRS 66
cardiac neuron CL0010022

CSI 3.19

rCSI 10.21%

PRS 46.74
Bergmann glial cell CL0000644

CSI 3.17

rCSI 4.34%

PRS 45.37
pvalb GABAergic cortical interneuron CL4023018

CSI 3.15

rCSI 3.92%

PRS 31.84
hepatic stellate cell CL0000632

CSI 3.14

rCSI 11.75%

PRS 42.69
intestinal crypt stem cell of small intestine CL0009017

CSI 3.08

rCSI 8.3%

PRS 58.57
fibroblast of cardiac tissue CL0002548

CSI 3.05

rCSI 14.62%

PRS 48.96
midzonal region hepatocyte CL0019028

CSI 3.04

rCSI 7.13%

PRS 57.45
sncg GABAergic cortical interneuron CL4023015

CSI 2.89

rCSI 4.64%

PRS 35.6
enterocyte of epithelium of small intestine CL1000334

CSI 2.87

rCSI 44.44%

PRS 73.17
subcutaneous adipocyte CL0002521

CSI 2.84

rCSI 14.55%

PRS 53.53
melanocyte CL0000148

CSI 2.83

rCSI 2.09%

PRS 43.17
cerebral cortex endothelial cell CL1001602

CSI 2.81

rCSI 4.87%

PRS 40.59
retinal bipolar neuron CL0000748

CSI 2.79

rCSI 5.22%

PRS 39.3
acinar cell CL0000622

CSI 2.75

rCSI 4.03%

PRS 61.59
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.7

rCSI 7.04%

PRS 49.1
perivascular cell CL4033054

CSI 2.63

rCSI 3.6%

PRS 55.42
mucus secreting cell CL0000319

CSI 2.6

rCSI 4.13%

PRS 61.03
fibroblast of lung CL0002553

CSI 2.57

rCSI 2.39%

PRS 49.86
interneuron CL0000099

CSI 2.55

rCSI 5.12%

PRS 39.68
secretory cell CL0000151

CSI 2.45

rCSI 2.56%

PRS 50.66
renal interstitial pericyte CL1001318

CSI 2.43

rCSI 6.7%

PRS 46.2
stem cell CL0000034

CSI 2.37

rCSI 2.28%

PRS 40.75
adipocyte CL0000136

CSI 2.34

rCSI 3.01%

PRS 44.65
renal alpha-intercalated cell CL0005011

CSI 2.33

rCSI 3.11%

PRS 58.76
intestinal epithelial cell CL0002563

CSI 2.29

rCSI 2.39%

PRS 49.09
lung secretory cell CL1000272

CSI 2.28

rCSI 5.63%

PRS 48.02
epithelial cell of lower respiratory tract CL0002632

CSI 2.25

rCSI 1.75%

PRS 50.82
mature astrocyte CL0002627

CSI 2.21

rCSI 9.4%

PRS 45.38
Kupffer cell CL0000091

CSI 2.19

rCSI 5%

PRS 49.51
alveolar type 1 fibroblast cell CL4028004

CSI 2.12

rCSI 2.32%

PRS 53.9
paneth cell of epithelium of small intestine CL1000343

CSI 2.08

rCSI 5.83%

PRS 63.98
endocardial cell CL0002350

CSI 2.06

rCSI 9.86%

PRS 50.21
contractile cell CL0000183

CSI 2.05

rCSI 6.06%

PRS 48.09
ependymal cell CL0000065

CSI 2.04

rCSI 4.14%

PRS 31.61
central nervous system neuron CL2000029

CSI 2.04

rCSI 14.99%

PRS 37.57
enterocyte CL0000584

CSI 2.04

rCSI 3.28%

PRS 57.42
vascular leptomeningeal cell CL4023051

CSI 2.02

rCSI 3.55%

PRS 42.23
chondrocyte CL0000138

CSI 1.98

rCSI 3.15%

PRS 42.76
retinal pigment epithelial cell CL0002586

CSI 1.95

rCSI 3.88%

PRS 48.65
colon epithelial cell CL0011108

CSI 1.94

rCSI 2.03%

PRS 47.05
transit amplifying cell of colon CL0009011

CSI 1.9

rCSI 2.23%

PRS 53.27
blood vessel endothelial cell CL0000071

CSI 1.84

rCSI 3.82%

PRS 47.7
colonocyte CL1000347

CSI 1.8

rCSI 2.59%

PRS 56.38
intestine goblet cell CL0019031

CSI 1.8

rCSI 1.6%

PRS 48.69
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.77

rCSI 2.96%

PRS 33.48
BEST4+ enteroycte CL4030026

CSI 1.76

rCSI 2.19%

PRS 52.6
squamous epithelial cell CL0000076

CSI 1.72

rCSI 4.07%

PRS 55.45
common dendritic progenitor CL0001029

CSI 1.69

rCSI 2.12%

PRS 60.24
extravillous trophoblast CL0008036

CSI 1.68

rCSI 2.08%

PRS 45.96
respiratory suprabasal cell CL4033048

CSI 1.63

rCSI 2.08%

PRS 54.96
renal principal cell CL0005009

CSI 1.62

rCSI 4.22%

PRS 54.57
conjunctival epithelial cell CL1000432

CSI 1.6

rCSI 2.44%

PRS 50.84
VIP GABAergic cortical interneuron CL4023016

CSI 1.57

rCSI 1.88%

PRS 33.39
cardiac endothelial cell CL0010008

CSI 1.54

rCSI 6.21%

PRS 48.53
pancreatic acinar cell CL0002064

CSI 1.51

rCSI 2.01%

PRS 55.45
small intestine goblet cell CL1000495

CSI 1.49

rCSI 3.26%

PRS 59.55
Schwann cell CL0002573

CSI 1.45

rCSI 4.13%

PRS 49.05
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 1.45

rCSI 4.53%

PRS 37.21
astrocyte of the cerebral cortex CL0002605

CSI 1.43

rCSI 3.21%

PRS 34.3
alveolar macrophage CL0000583

CSI 1.42

rCSI 2.33%

PRS 55.67
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.41

rCSI 2.49%

PRS 32.57
choroid plexus epithelial cell CL0000706

CSI 1.41

rCSI 2.3%

PRS 40.16
regular atrial cardiac myocyte CL0002129

CSI 1.4

rCSI 4.49%

PRS 48.95
renal beta-intercalated cell CL0002201

CSI 1.39

rCSI 3.31%

PRS 51.61
retinal cone cell CL0000573

CSI 1.38

rCSI 2.23%

PRS 40.44
Hofbauer cell CL3000001

CSI 1.35

rCSI 2.54%

PRS 60.57
enteroendocrine cell of small intestine CL0009006

CSI 1.35

rCSI 2.96%

PRS 64.52
CD14-low, CD16-positive monocyte CL0002396

CSI 1.32

rCSI 1.01%

PRS 49.39
colon goblet cell CL0009039

CSI 1.31

rCSI 3.1%

PRS 61.37
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.28

rCSI 13.59%

PRS 49.94
transit amplifying cell CL0009010

CSI 1.22

rCSI 1.86%

PRS 65.94
intestinal tuft cell CL0019032

CSI 1.21

rCSI 1.85%

PRS 54.79
lung ciliated cell CL1000271

CSI 1.17

rCSI 1.35%

PRS 40.17
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.12

rCSI 2.91%

PRS 45.79
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.09

rCSI 3.36%

PRS 60.92
kidney connecting tubule epithelial cell CL1000768

CSI 1.09

rCSI 2.75%

PRS 40.09
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 1.06

rCSI 9.16%

PRS 49.43
transit amplifying cell of small intestine CL0009012

CSI 1

rCSI 4.37%

PRS 67.75
macroglial cell CL0000126

CSI 0.98

rCSI 2.53%

PRS 51.53
retinal ganglion cell CL0000740

CSI 0.94

rCSI 2.07%

PRS 37.66
type B pancreatic cell CL0000169

CSI 0.92

rCSI 2.04%

PRS 47.72
parietal epithelial cell CL1000452

CSI 0.91

rCSI 2.43%

PRS 42.18

paneth cell of colon CL0009009

CSI 0.4

rCSI 3.5%

PRS 73.1%
pancreatic ductal cell CL0002079

CSI 0.4

rCSI 0.8%

PRS 52.4%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.4

rCSI 1.5%

PRS 32.3%
podocyte CL0000653

CSI 0.5

rCSI 2.0%

PRS 49.1%
regular ventricular cardiac myocyte CL0002131

CSI 0.5

rCSI 3.2%

PRS 42.3%
intestinal crypt stem cell of colon CL0009043

CSI 0.6

rCSI 4.7%

PRS 69.1%
glial cell CL0000125

CSI 0.7

rCSI 2.8%

PRS 42.4%
luminal cell of prostate epithelium CL0002340

CSI 0.7

rCSI 3.9%

PRS 65.0%
type EC enteroendocrine cell CL0000577

CSI 0.8

rCSI 2.7%

PRS 62.0%
type L enteroendocrine cell CL0002279

CSI 0.9

rCSI 1.7%

PRS 68.9%
parietal epithelial cell CL1000452

CSI 0.9

rCSI 2.4%

PRS 42.2%
type B pancreatic cell CL0000169

CSI 0.9

rCSI 2.0%

PRS 47.7%
retinal ganglion cell CL0000740

CSI 0.9

rCSI 2.1%

PRS 37.7%
macroglial cell CL0000126

CSI 1.0

rCSI 2.5%

PRS 51.5%
transit amplifying cell of small intestine CL0009012

CSI 1.0

rCSI 4.4%

PRS 67.8%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 1.1

rCSI 9.2%

PRS 49.4%
kidney connecting tubule epithelial cell CL1000768

CSI 1.1

rCSI 2.8%

PRS 40.1%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 1.1

rCSI 3.4%

PRS 60.9%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.1

rCSI 2.9%

PRS 45.8%
lung ciliated cell CL1000271

CSI 1.2

rCSI 1.4%

PRS 40.2%
intestinal tuft cell CL0019032

CSI 1.2

rCSI 1.9%

PRS 54.8%
transit amplifying cell CL0009010

CSI 1.2

rCSI 1.9%

PRS 65.9%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.3

rCSI 13.6%

PRS 49.9%
colon goblet cell CL0009039

CSI 1.3

rCSI 3.1%

PRS 61.4%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.3

rCSI 1.0%

PRS 49.4%
enteroendocrine cell of small intestine CL0009006

CSI 1.4

rCSI 3.0%

PRS 64.5%
Hofbauer cell CL3000001

CSI 1.4

rCSI 2.5%

PRS 60.6%
retinal cone cell CL0000573

CSI 1.4

rCSI 2.2%

PRS 40.4%
renal beta-intercalated cell CL0002201

CSI 1.4

rCSI 3.3%

PRS 51.6%
regular atrial cardiac myocyte CL0002129

CSI 1.4

rCSI 4.5%

PRS 49.0%
choroid plexus epithelial cell CL0000706

CSI 1.4

rCSI 2.3%

PRS 40.2%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.4

rCSI 2.5%

PRS 32.6%
alveolar macrophage CL0000583

CSI 1.4

rCSI 2.3%

PRS 55.7%
astrocyte of the cerebral cortex CL0002605

CSI 1.4

rCSI 3.2%

PRS 34.3%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 1.5

rCSI 4.5%

PRS 37.2%
Schwann cell CL0002573

CSI 1.5

rCSI 4.1%

PRS 49.1%
small intestine goblet cell CL1000495

CSI 1.5

rCSI 3.3%

PRS 59.6%
pancreatic acinar cell CL0002064

CSI 1.5

rCSI 2.0%

PRS 55.5%
cardiac endothelial cell CL0010008

CSI 1.5

rCSI 6.2%

PRS 48.5%
VIP GABAergic cortical interneuron CL4023016

CSI 1.6

rCSI 1.9%

PRS 33.4%
conjunctival epithelial cell CL1000432

CSI 1.6

rCSI 2.4%

PRS 50.8%
renal principal cell CL0005009

CSI 1.6

rCSI 4.2%

PRS 54.6%
respiratory suprabasal cell CL4033048

CSI 1.6

rCSI 2.1%

PRS 55.0%
extravillous trophoblast CL0008036

CSI 1.7

rCSI 2.1%

PRS 46.0%
common dendritic progenitor CL0001029

CSI 1.7

rCSI 2.1%

PRS 60.2%
squamous epithelial cell CL0000076

CSI 1.7

rCSI 4.1%

PRS 55.5%
BEST4+ enteroycte CL4030026

CSI 1.8

rCSI 2.2%

PRS 52.6%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.8

rCSI 3.0%

PRS 33.5%
intestine goblet cell CL0019031

CSI 1.8

rCSI 1.6%

PRS 48.7%
colonocyte CL1000347

CSI 1.8

rCSI 2.6%

PRS 56.4%
blood vessel endothelial cell CL0000071

CSI 1.8

rCSI 3.8%

PRS 47.7%
transit amplifying cell of colon CL0009011

CSI 1.9

rCSI 2.2%

PRS 53.3%
colon epithelial cell CL0011108

CSI 1.9

rCSI 2.0%

PRS 47.1%
retinal pigment epithelial cell CL0002586

CSI 2.0

rCSI 3.9%

PRS 48.7%
chondrocyte CL0000138

CSI 2.0

rCSI 3.2%

PRS 42.8%
vascular leptomeningeal cell CL4023051

CSI 2.0

rCSI 3.6%

PRS 42.2%
enterocyte CL0000584

CSI 2.0

rCSI 3.3%

PRS 57.4%
central nervous system neuron CL2000029

CSI 2.0

rCSI 15.0%

PRS 37.6%
ependymal cell CL0000065

CSI 2.0

rCSI 4.1%

PRS 31.6%
contractile cell CL0000183

CSI 2.1

rCSI 6.1%

PRS 48.1%
endocardial cell CL0002350

CSI 2.1

rCSI 9.9%

PRS 50.2%
paneth cell of epithelium of small intestine CL1000343

CSI 2.1

rCSI 5.8%

PRS 64.0%
alveolar type 1 fibroblast cell CL4028004

CSI 2.1

rCSI 2.3%

PRS 53.9%
Kupffer cell CL0000091

CSI 2.2

rCSI 5.0%

PRS 49.5%
mature astrocyte CL0002627

CSI 2.2

rCSI 9.4%

PRS 45.4%
epithelial cell of lower respiratory tract CL0002632

CSI 2.3

rCSI 1.8%

PRS 50.8%
lung secretory cell CL1000272

CSI 2.3

rCSI 5.6%

PRS 48.0%
intestinal epithelial cell CL0002563

CSI 2.3

rCSI 2.4%

PRS 49.1%
renal alpha-intercalated cell CL0005011

CSI 2.3

rCSI 3.1%

PRS 58.8%
adipocyte CL0000136

CSI 2.3

rCSI 3.0%

PRS 44.7%
stem cell CL0000034

CSI 2.4

rCSI 2.3%

PRS 40.8%
renal interstitial pericyte CL1001318

CSI 2.4

rCSI 6.7%

PRS 46.2%
secretory cell CL0000151

CSI 2.5

rCSI 2.6%

PRS 50.7%
interneuron CL0000099

CSI 2.6

rCSI 5.1%

PRS 39.7%
fibroblast of lung CL0002553

CSI 2.6

rCSI 2.4%

PRS 49.9%
mucus secreting cell CL0000319

CSI 2.6

rCSI 4.1%

PRS 61.0%
perivascular cell CL4033054

CSI 2.6

rCSI 3.6%

PRS 55.4%
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.7

rCSI 7.0%

PRS 49.1%
acinar cell CL0000622

CSI 2.8

rCSI 4.0%

PRS 61.6%
retinal bipolar neuron CL0000748

CSI 2.8

rCSI 5.2%

PRS 39.3%
cerebral cortex endothelial cell CL1001602

CSI 2.8

rCSI 4.9%

PRS 40.6%
melanocyte CL0000148

CSI 2.8

rCSI 2.1%

PRS 43.2%
subcutaneous adipocyte CL0002521

CSI 2.8

rCSI 14.6%

PRS 53.5%
enterocyte of epithelium of small intestine CL1000334

CSI 2.9

rCSI 44.4%

PRS 73.2%
sncg GABAergic cortical interneuron CL4023015

CSI 2.9

rCSI 4.6%

PRS 35.6%
midzonal region hepatocyte CL0019028

CSI 3.0

rCSI 7.1%

PRS 57.5%
fibroblast of cardiac tissue CL0002548

CSI 3.1

rCSI 14.6%

PRS 49.0%
intestinal crypt stem cell of small intestine CL0009017

CSI 3.1

rCSI 8.3%

PRS 58.6%
hepatic stellate cell CL0000632

CSI 3.1

rCSI 11.8%

PRS 42.7%
pvalb GABAergic cortical interneuron CL4023018

CSI 3.2

rCSI 3.9%

PRS 31.8%
Bergmann glial cell CL0000644

CSI 3.2

rCSI 4.3%

PRS 45.4%
cardiac neuron CL0010022

CSI 3.2

rCSI 10.2%

PRS 46.7%
endothelial cell of periportal hepatic sinusoid CL0019021

CSI 3.2

rCSI 14.7%

PRS 66.0%
neural crest cell CL0011012

CSI 3.3

rCSI 2.6%

PRS 37.5%
Mueller cell CL0000636

CSI 3.3

rCSI 7.6%

PRS 43.0%
epicardial adipocyte CL1000309

CSI 3.4

rCSI 11.0%

PRS 51.5%
hepatocyte CL0000182

CSI 3.5

rCSI 6.3%

PRS 48.7%
erythroblast CL0000765

CSI 3.5

rCSI 9.4%

PRS 63.3%
periportal region hepatocyte CL0019026

CSI 3.9

rCSI 15.0%

PRS 57.7%
S cone cell CL0003050

CSI 4.3

rCSI 19.1%

PRS 47.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Peroxisome proliferator-activated receptor alpha, encoded by the [PPARA](/details-gene/5465) gene, is a ligand-activated nuclear receptor that functions as a key transcription factor. It plays a central role in the regulation of lipid metabolism, particularly fatty acid catabolism, and is integral to energy homeostasis and the inflammatory response. As a member of the steroid hormone receptor superfamily, [PPARA](/details-gene/5465) heterodimerizes with the retinoid X receptor (RXR) to control the expression of a wide array of target genes [Link](https://doi.org/10.1074/jbc.270.30.18117). Its expression is most significant in tissues with high rates of fatty acid oxidation, including the kidney, liver, and heart, underscoring its role as a master regulator of metabolic pathways in these vital organs. ## Cellular Roles and Expression Landscape The expression profile of [PPARA](/details-gene/5465) firmly establishes its importance in metabolically active cell types. **Overall**, its significance is highest in epithelial cells of the kidney, particularly [kidney loop of Henle thin descending limb epithelial cell](/details-cell/CL1001111) (CSI: 14.11) and [epithelial cell of proximal tubule](/details-cell/CL0002306) (CSI: 10.76). This is consistent with the kidney's high energy demand and its role in fatty acid metabolism for fuel. Similarly, high significance is observed in liver cells, including [centrilobular region hepatocyte](/details-cell/CL0019029) (CSI: 8.73) and [periportal region hepatocyte](/details-cell/CL0019026) (CSI: 3.86). Within [hepatocyte](/details-cell/CL0000182)s, [PPARA](/details-gene/5465) is a critical sensor of lipid levels, driving the transcriptional programs for fatty acid beta-oxidation, ketogenesis, and triglyceride turnover. The receptor's high CSI in [cardiac muscle cell](/details-cell/CL0000746) (CSI: 6.93) is also noteworthy, as the heart relies heavily on fatty acid oxidation for its continuous energy supply. The expression pattern collectively highlights [PPARA](/details-gene/5465) as a fundamental regulator in cells and tissues that are central to systemic lipid homeostasis and energy expenditure. ## Pathways and Molecular Function Functionally, [PPARA](/details-gene/5465) operates as a DNA-binding transcription factor with pronounced nuclear receptor activity ([GO:0004879](https://www.ebi.ac.uk/QuickGO/term/GO:0004879)) and lipid binding capabilities ([GO:0008289](https://www.ebi.ac.uk/QuickGO/term/GO:0008289)). Its activation leads to profound changes in gene expression, primarily through its involvement in the [Nuclear receptor transcription pathway](https://reactome.org/content/detail/R-HSA-383280). The biological processes governed by [PPARA](/details-gene/5465) are extensive but converge on metabolic control. It is a cornerstone of the [Fatty acid metabolic process](https://www.ebi.ac.uk/QuickGO/term/GO:0006631), driving the [Positive regulation of fatty acid beta-oxidation](https://www.ebi.ac.uk/QuickGO/term/GO:0032000) and linking directly to the Reactome pathway [Regulation of lipid metabolism by pparalpha](https://reactome.org/content/detail/R-HSA-400206). Beyond lipid handling, [PPARA](/details-gene/5465) is implicated in [Gluconeogenesis](https://www.ebi.ac.uk/QuickGO/term/GO:0006094), managing glucose production during fasting states. It also exerts significant anti-inflammatory effects, as evidenced by its role in the [Negative regulation of inflammatory response](https://www.ebi.ac.uk/QuickGO/term/GO:0050728) and [Negative regulation of cytokine production involved in inflammatory response](https://www.ebi.ac.uk/QuickGO/term/GO:1900016). This dual function positions [PPARA](/details-gene/5465) at the critical intersection of metabolism and inflammation, a nexus frequently dysregulated in metabolic diseases. ## Research Directions The central role of [PPARA](/details-gene/5465) in lipid metabolism and inflammation makes it a key subject for research into metabolic disorders such as non-alcoholic fatty liver disease (NAFLD), diabetic cardiomyopathy, and dyslipidemia. Based on its established functions, several testable hypotheses can be proposed: 1. **Hypothesis 1:** Given its high expression in [hepatocyte](/details-cell/CL0000182)s and its role in promoting fatty acid oxidation, we hypothesize that cell-type-specific downregulation or functional impairment of [PPARA](/details-gene/5465) in hepatocytes is a primary driver of hepatic steatosis in NAFLD. This impairment would disrupt the clearance of fatty acids, leading to their pathological accumulation as triglycerides. 2. **Hypothesis 2:** Based on its significance in [cardiac muscle cell](/details-cell/CL0000746)s, we hypothesize that reduced [PPARA](/details-gene/5465) activity in cardiomyocytes under hyperglycemic conditions contributes to the pathogenesis of diabetic cardiomyopathy by forcing a metabolic shift from efficient fatty acid oxidation to less efficient glucose utilization, resulting in energy deficit and lipotoxicity. A specific experiment could be designed to test the first hypothesis: * **Experimental Approach:** To determine the hepatocyte-specific role of [PPARA](/details-gene/5465) in NAFLD, a conditional knockout mouse model could be generated using the Cre-loxP system with an Albumin-Cre driver to delete `Ppara` specifically in [hepatocyte](/details-cell/CL0000182)s. These knockout mice and their wild-type littermates would be challenged with a high-fat, high-fructose diet to induce NAFLD. The progression of liver disease would be monitored through histological analysis (H&E and Oil Red O staining), measurement of plasma transaminases and lipid profiles, and comprehensive multi-omics analysis (RNA-seq, proteomics, and lipidomics) of liver tissue to confirm the disruption of fatty acid oxidation pathways and characterize the resulting metabolic reprogramming. **Therapeutic Potential:** [PPARA](/details-gene/5465) is a well-validated therapeutic target, with fibrate drugs acting as agonists. The primary therapeutic strategy is **activation**, aimed at increasing fatty acid catabolism and reducing circulating triglycerides. Its demonstrated anti-inflammatory properties further enhance its appeal for treating metabolic syndrome components. Future therapeutic development could focus on creating more potent and selective [PPARA](/details-gene/5465) agonists or developing molecules that specifically target its activity in the liver or heart to maximize efficacy while minimizing potential off-target effects.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Peroxisome proliferator-activated receptor alpha

Genular Protein ID: 2147633462

Symbol: PPARA_HUMAN

Name: Peroxisome proliferator-activated receptor alpha

UniProtKB Accession Codes:

Q07869 B0G0X3 Q16241 Q6I9S0 Q92486 Q92689 Q9Y3N1

Database IDs:

Citations:

PubMed ID: 7684926

Title: cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor.

PubMed ID: 7684926

DOI: 10.1021/bi00072a015

PubMed ID: 7981125

Title: Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators.

PubMed ID: 7981125

DOI: 10.1016/0960-0760(94)90089-2

PubMed ID: 8993548

Title: Peroxisome proliferator-activated receptors: structures and function.

PubMed ID: 8993548

DOI: 10.1111/j.1749-6632.1996.tb18620.x

PubMed ID: 18619963

Title: DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system.

PubMed ID: 18619963

DOI: 10.1016/j.febslet.2008.07.003

PubMed ID: 19263263

Title: Optimization of an enzyme-linked immunosorbent assay to screen ligand of Peroxisome proliferator-activated receptor alpha.

PubMed ID: 19263263

DOI: 10.1080/08923970902785246

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 7629123

Title: Peroxisome proliferator-activated receptor mediates cross-talk with thyroid hormone receptor by competition for retinoid X receptor. Possible role of a leucine zipper-like heptad repeat.

PubMed ID: 7629123

DOI: 10.1074/jbc.270.30.18117

PubMed ID: 9238002

Title: RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2.

PubMed ID: 9238002

DOI: 10.1073/pnas.94.16.8479

PubMed ID: 9556573

Title: Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4.

PubMed ID: 9556573

DOI: 10.1074/jbc.273.18.10948

PubMed ID: 10195690

Title: Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR.

PubMed ID: 10195690

DOI: 10.1016/s0303-7207(98)00217-2

PubMed ID: 10681503

Title: Cloning and characterization of RAP250, a nuclear receptor coactivator.

PubMed ID: 10681503

DOI: 10.1074/jbc.275.8.5308

PubMed ID: 11915042

Title: Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity.

PubMed ID: 11915042

DOI: 10.1053/jhep.2002.32470

PubMed ID: 12955147

Title: Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha.

PubMed ID: 12955147

DOI: 10.1038/nature01921

PubMed ID: 21047783

Title: Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}.

PubMed ID: 21047783

DOI: 10.1074/jbc.m110.177816

PubMed ID: 24043310

Title: SIRT4 represses peroxisome proliferator-activated receptor alpha activity to suppress hepatic fat oxidation.

PubMed ID: 24043310

DOI: 10.1128/mcb.00087-13

PubMed ID: 28167758

Title: MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases.

PubMed ID: 28167758

DOI: 10.1073/pnas.1621425114

PubMed ID: 11698662

Title: Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.

PubMed ID: 11698662

DOI: 10.1073/pnas.241410198

PubMed ID: 11587644

Title: Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family.

PubMed ID: 11587644

DOI: 10.1016/s0969-2126(01)00634-7

PubMed ID: 11845213

Title: Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.

PubMed ID: 11845213

DOI: 10.1038/415813a

PubMed ID: 17157019

Title: Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists.

PubMed ID: 17157019

DOI: 10.1016/j.bmcl.2006.11.050

PubMed ID: 17243659

Title: Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.

PubMed ID: 17243659

DOI: 10.1021/jm058056x

PubMed ID: 19622862

Title: Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures.

PubMed ID: 19622862

DOI: 10.1107/s0907444909015935

PubMed ID: 19349176

Title: Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes.

PubMed ID: 19349176

DOI: 10.1016/j.bmcl.2009.03.036

PubMed ID: 19116277

Title: Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent.

PubMed ID: 19116277

DOI: 10.1073/pnas.0811325106

Sequence Information:

Length: 468
Mass: 52225
Checksum: 850846FD51ADA883
Sequence:

MVDTESPLCP LSPLEAGDLE SPLSEEFLQE MGNIQEISQS IGEDSSGSFG FTEYQYLGSC 
PGSDGSVITD TLSPASSPSS VTYPVVPGSV DESPSGALNI ECRICGDKAS GYHYGVHACE 
GCKGFFRRTI RLKLVYDKCD RSCKIQKKNR NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE 
KAKLKAEILT CEHDIEDSET ADLKSLAKRI YEAYLKNFNM NKVKARVILS GKASNNPPFV 
IHDMETLCMA EKTLVAKLVA NGIQNKEAEV RIFHCCQCTS VETVTELTEF AKAIPGFANL 
DLNDQVTLLK YGVYEAIFAM LSSVMNKDGM LVAYGNGFIT REFLKSLRKP FCDIMEPKFD 
FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNVGHIEKM QEGIVHVLRL HLQSNHPDDI 
FLFPKLLQKM ADLRQLVTEH AQLVQIIKKT ESDAALHPLL QEIYRDMY

Details for: PPARA

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. PubMed ID: 7684926

Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. PubMed ID: 7981125

Peroxisome proliferator-activated receptors: structures and function. PubMed ID: 8993548

DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system. PubMed ID: 18619963

Optimization of an enzyme-linked immunosorbent assay to screen ligand of Peroxisome proliferator-activated receptor alpha. PubMed ID: 19263263

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 22. PubMed ID: 10591208

Peroxisome proliferator-activated receptor mediates cross-talk with thyroid hormone receptor by competition for retinoid X receptor. Possible role of a leucine zipper-like heptad repeat. PubMed ID: 7629123

RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. PubMed ID: 9238002

Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4. PubMed ID: 9556573

Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR. PubMed ID: 10195690

Cloning and characterization of RAP250, a nuclear receptor coactivator. PubMed ID: 10681503

Interaction of hepatitis C virus core protein with retinoid X receptor alpha modulates its transcriptional activity. PubMed ID: 11915042

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. PubMed ID: 12955147

Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}. PubMed ID: 21047783

SIRT4 represses peroxisome proliferator-activated receptor alpha activity to suppress hepatic fat oxidation. PubMed ID: 24043310

MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases. PubMed ID: 28167758

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. PubMed ID: 11698662

Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family. PubMed ID: 11587644

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. PubMed ID: 11845213

Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists. PubMed ID: 17157019

Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. PubMed ID: 17243659

Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures. PubMed ID: 19622862

Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes. PubMed ID: 19349176

Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent. PubMed ID: 19116277