Details for: SPOCK2
Gene ID: 9806
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SPOCK2
Ensembl ID: ENSG00000107742
Description: SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 80.97rCSI 54.55%PRS 51.42
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CSI 50.02rCSI 39.72%PRS 63.45
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CSI 45.11rCSI 34.12%PRS 53.53
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CSI 35.8rCSI 28.93%PRS 52.61
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CSI 32.83rCSI 65.45%PRS 59.53
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CSI 26.38rCSI 44.28%PRS 27.32
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CSI 22.62rCSI 23.05%PRS 54.47
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CSI 21.92rCSI 16.47%PRS 44.88
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CSI 21.7rCSI 21.31%PRS 56.83
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CSI 17.08rCSI 27.27%PRS 45.3
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CSI 16.17rCSI 71.84%PRS 40.38
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CSI 14.82rCSI 17.18%PRS 64.29
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CSI 14.21rCSI 25.64%PRS 68.66
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CSI 13.76rCSI 23.79%PRS 33.12
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CSI 13.28rCSI 18.09%PRS 69.47
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CSI 12.26rCSI 38.34%PRS 30.53
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CSI 12.21rCSI 11.28%PRS 62.01
-
CSI 12.15rCSI 19.38%PRS 36.11
-
CSI 11.76rCSI 8.8%PRS 56.18
-
CSI 11.67rCSI 8.71%PRS 59.96
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CSI 11.08rCSI 7.95%PRS 54.13
-
CSI 10.38rCSI 7.29%PRS 64.63
-
CSI 9.61rCSI 55.41%PRS 44.29
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CSI 9.58rCSI 14.73%PRS 44.54
-
CSI 9.43rCSI 53.27%PRS 29.19
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CSI 9.42rCSI 11.72%PRS 25.91
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CSI 9.22rCSI 18.51%PRS 32.38
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CSI 9.14rCSI 13.97%PRS 50.54
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CSI 9.07rCSI 5.36%PRS 56.05
-
CSI 8.95rCSI 12.66%PRS 50.79
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CSI 8.73rCSI 19.22%PRS 45.54
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CSI 8.72rCSI 10.24%PRS 82.46
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CSI 8.44rCSI 6.42%PRS 52.7
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CSI 8.25rCSI 8.62%PRS 72.12
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CSI 8.25rCSI 6.41%PRS 58.02
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CSI 8.24rCSI 29.83%PRS 60.72
-
CSI 8.18rCSI 10.46%PRS 74.61
-
CSI 7.54rCSI 5.25%PRS 54.2
-
CSI 7.28rCSI 9.38%PRS 28.23
-
CSI 7.19rCSI 12.29%PRS 62.62
-
CSI 7.09rCSI 6.83%PRS 42.27
-
CSI 6.84rCSI 5.99%PRS 51.16
-
CSI 6.73rCSI 5.05%PRS 74.35
-
CSI 6.66rCSI 27.62%PRS 51.57
-
CSI 6.54rCSI 5.24%PRS 63.06
-
CSI 6.46rCSI 7.57%PRS 56.77
-
CSI 6.45rCSI 11.39%PRS 26.35
-
CSI 6.38rCSI 6.27%PRS 69.63
-
CSI 6.31rCSI 4.2%PRS 67.65
-
CSI 5.92rCSI 9.52%PRS 29.32
-
CSI 5.9rCSI 7.04%PRS 27.25
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CSI 5.7rCSI 7.16%PRS 79.8
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CSI 5.61rCSI 12.4%PRS 31.04
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CSI 5.5rCSI 12.69%PRS 34.35
-
CSI 5.46rCSI 6.52%PRS 61.9
-
CSI 5.41rCSI 6.55%PRS 38.55
-
CSI 4.95rCSI 51.21%PRS 38.32
-
CSI 4.89rCSI 4.45%PRS 56.46
-
CSI 4.86rCSI 4.27%PRS 46.5
-
CSI 4.81rCSI 7.07%PRS 38.23
-
CSI 4.7rCSI 6.98%PRS 44.63
-
CSI 4.67rCSI 10.6%PRS 47.43
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CSI 4.54rCSI 3.95%PRS 50.45
-
CSI 4.41rCSI 9.9%PRS 27.97
-
CSI 4.29rCSI 11.1%PRS 38.21
-
CSI 4.18rCSI 2.91%PRS 49.86
-
CSI 4.18rCSI 15.91%PRS 36.05
-
CSI 4.04rCSI 5.53%PRS 38.7
-
CSI 4.04rCSI 31.64%PRS 58.97
-
CSI 4.01rCSI 7.2%PRS 35.6
-
CSI 4rCSI 17.85%PRS 29.14
-
CSI 3.98rCSI 7.19%PRS 64.34
-
CSI 3.91rCSI 45.36%PRS 77.78
-
CSI 3.84rCSI 6%PRS 68.78
-
CSI 3.8rCSI 10.89%PRS 58.78
-
CSI 3.76rCSI 5.33%PRS 38.96
-
CSI 3.59rCSI 6.73%PRS 32.31
-
CSI 3.57rCSI 6.87%PRS 71.59
-
CSI 3.52rCSI 2.62%PRS 54.51
-
CSI 3.41rCSI 5.98%PRS 34.73
-
CSI 3.29rCSI 4.5%PRS 51.83
-
CSI 3.01rCSI 6.19%PRS 36.98
-
CSI 3rCSI 17.66%PRS 28.58
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CSI 2.94rCSI 11.96%PRS 39.8
-
CSI 2.92rCSI 6.02%PRS 48.65
-
CSI 2.91rCSI 3.97%PRS 44.32
-
CSI 2.85rCSI 25.12%PRS 31.17
-
CSI 2.73rCSI 3.75%PRS 62.42
-
CSI 2.71rCSI 19.94%PRS 30.59
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CSI 2.7rCSI 6.98%PRS 73.14
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CSI 2.68rCSI 11.4%PRS 39.89
-
CSI 2.59rCSI 8.1%PRS 28.41
-
CSI 2.52rCSI 3.87%PRS 48.41
-
CSI 2.52rCSI 8.62%PRS 34.32
-
CSI 2.5rCSI 6.68%PRS 35.34
-
CSI 2.42rCSI 10.64%PRS 35.98
-
CSI 2.36rCSI 1.85%PRS 47.9
-
CSI 2.3rCSI 2.59%PRS 57.66
-
CSI 2.29rCSI 8.23%PRS 26.24
-
CSI 2.2rCSI 2.12%PRS 32.95
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CSI 0.3rCSI 8.4%PRS 88.6%
-
CSI 0.3rCSI 5.6%PRS 84.9%
-
CSI 0.5rCSI 1.1%PRS 84.5%
-
CSI 0.5rCSI 2.9%PRS 77.3%
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CSI 0.7rCSI 3.7%PRS 53.9%
-
CSI 0.8rCSI 1.8%PRS 32.0%
-
CSI 0.8rCSI 2.0%PRS 44.8%
-
CSI 0.9rCSI 19.2%PRS 35.2%
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CSI 1.0rCSI 13.7%PRS 35.0%
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CSI 1.1rCSI 21.4%PRS 36.3%
-
CSI 1.1rCSI 2.3%PRS 32.7%
-
CSI 1.1rCSI 9.4%PRS 30.2%
-
CSI 1.1rCSI 3.6%PRS 31.4%
-
CSI 1.1rCSI 1.3%PRS 60.6%
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CSI 1.2rCSI 3.0%PRS 41.6%
-
CSI 1.2rCSI 3.9%PRS 73.8%
-
CSI 1.2rCSI 6.2%PRS 52.4%
-
CSI 1.4rCSI 8.7%PRS 28.3%
-
CSI 1.4rCSI 33.9%PRS 26.7%
-
CSI 1.4rCSI 4.1%PRS 33.9%
-
CSI 1.5rCSI 6.8%PRS 77.9%
-
CSI 1.5rCSI 2.3%PRS 38.6%
-
CSI 1.7rCSI 3.1%PRS 35.8%
-
CSI 1.7rCSI 6.4%PRS 28.2%
-
CSI 1.7rCSI 41.3%PRS 27.6%
-
CSI 1.7rCSI 3.3%PRS 75.7%
-
CSI 1.9rCSI 6.3%PRS 31.1%
-
CSI 2.1rCSI 5.6%PRS 44.4%
-
CSI 2.1rCSI 5.2%PRS 26.5%
-
CSI 2.2rCSI 2.1%PRS 33.0%
-
CSI 2.3rCSI 8.2%PRS 26.2%
-
CSI 2.3rCSI 2.6%PRS 57.7%
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CSI 2.4rCSI 1.9%PRS 47.9%
-
CSI 2.4rCSI 10.6%PRS 36.0%
-
CSI 2.5rCSI 6.7%PRS 35.3%
-
CSI 2.5rCSI 8.6%PRS 34.3%
-
CSI 2.5rCSI 3.9%PRS 48.4%
-
CSI 2.6rCSI 8.1%PRS 28.4%
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CSI 2.7rCSI 11.4%PRS 39.9%
-
CSI 2.7rCSI 7.0%PRS 73.1%
-
CSI 2.7rCSI 19.9%PRS 30.6%
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CSI 2.7rCSI 3.8%PRS 62.4%
-
CSI 2.9rCSI 25.1%PRS 31.2%
-
CSI 2.9rCSI 4.0%PRS 44.3%
-
CSI 2.9rCSI 6.0%PRS 48.7%
-
CSI 2.9rCSI 12.0%PRS 39.8%
-
CSI 3.0rCSI 17.7%PRS 28.6%
-
CSI 3.0rCSI 6.2%PRS 37.0%
-
CSI 3.3rCSI 4.5%PRS 51.8%
-
CSI 3.4rCSI 6.0%PRS 34.7%
-
CSI 3.5rCSI 2.6%PRS 54.5%
-
CSI 3.6rCSI 6.9%PRS 71.6%
-
CSI 3.6rCSI 6.7%PRS 32.3%
-
CSI 3.8rCSI 5.3%PRS 39.0%
-
CSI 3.8rCSI 10.9%PRS 58.8%
-
CSI 3.8rCSI 6.0%PRS 68.8%
-
CSI 3.9rCSI 45.4%PRS 77.8%
-
CSI 4.0rCSI 7.2%PRS 64.3%
-
CSI 4.0rCSI 17.9%PRS 29.1%
-
CSI 4.0rCSI 7.2%PRS 35.6%
-
CSI 4.0rCSI 31.6%PRS 59.0%
-
CSI 4.0rCSI 5.5%PRS 38.7%
-
CSI 4.2rCSI 15.9%PRS 36.1%
-
CSI 4.2rCSI 2.9%PRS 49.9%
-
CSI 4.3rCSI 11.1%PRS 38.2%
-
CSI 4.4rCSI 9.9%PRS 28.0%
-
CSI 4.5rCSI 4.0%PRS 50.5%
-
CSI 4.7rCSI 10.6%PRS 47.4%
-
CSI 4.7rCSI 7.0%PRS 44.6%
-
CSI 4.8rCSI 7.1%PRS 38.2%
-
CSI 4.9rCSI 4.3%PRS 46.5%
-
CSI 4.9rCSI 4.5%PRS 56.5%
-
CSI 5.0rCSI 51.2%PRS 38.3%
-
CSI 5.4rCSI 6.6%PRS 38.6%
-
CSI 5.5rCSI 6.5%PRS 61.9%
-
CSI 5.5rCSI 12.7%PRS 34.4%
-
CSI 5.6rCSI 12.4%PRS 31.0%
-
CSI 5.7rCSI 7.2%PRS 79.8%
-
CSI 5.9rCSI 7.0%PRS 27.3%
-
CSI 5.9rCSI 9.5%PRS 29.3%
-
CSI 6.3rCSI 4.2%PRS 67.7%
-
CSI 6.4rCSI 6.3%PRS 69.6%
-
CSI 6.5rCSI 11.4%PRS 26.4%
-
CSI 6.5rCSI 7.6%PRS 56.8%
-
CSI 6.5rCSI 5.2%PRS 63.1%
-
CSI 6.7rCSI 27.6%PRS 51.6%
-
CSI 6.7rCSI 5.1%PRS 74.4%
-
CSI 6.8rCSI 6.0%PRS 51.2%
-
CSI 7.1rCSI 6.8%PRS 42.3%
-
CSI 7.2rCSI 12.3%PRS 62.6%
-
CSI 7.3rCSI 9.4%PRS 28.2%
-
CSI 7.5rCSI 5.3%PRS 54.2%
-
CSI 8.2rCSI 10.5%PRS 74.6%
-
CSI 8.2rCSI 29.8%PRS 60.7%
-
CSI 8.3rCSI 6.4%PRS 58.0%
-
CSI 8.3rCSI 8.6%PRS 72.1%
-
CSI 8.4rCSI 6.4%PRS 52.7%
-
CSI 8.7rCSI 10.2%PRS 82.5%
-
CSI 8.7rCSI 19.2%PRS 45.5%
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CSI 9.0rCSI 12.7%PRS 50.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1776726250
Symbol: TICN2_HUMAN
Name: Testican-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10386950
Title: Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain.
PubMed ID: 10386950
PubMed ID: 9039502
Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
PubMed ID: 9039502
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15340161
Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.
PubMed ID: 15340161
DOI: 10.1110/ps.04682504
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
Sequence Information:
- Length: 424
- Mass: 46779
- Checksum: B7894E657FC2257F
- Sequence:
MRAPGCGRLV LPLLLLAAAA LAEGDAKGLK EGETPGNFME DEQWLSSISQ YSGKIKHWNR FRDEVEDDYI KSWEDNQQGD EALDTTKDPC QKVKCSRHKV CIAQGYQRAM CISRKKLEHR IKQPTVKLHG NKDSICKPCH MAQLASVCGS DGHTYSSVCK LEQQACLSSK QLAVRCEGPC PCPTEQAATS TADGKPETCT GQDLADLGDR LRDWFQLLHE NSKQNGSASS VAGPASGLDK SLGASCKDSI GWMFSKLDTS ADLFLDQTEL AAINLDKYEV CIRPFFNSCD TYKDGRVSTA EWCFCFWREK PPCLAELERI QIQEAAKKKP GIFIPSCDED GYYRKMQCDQ SSGDCWCVDQ LGLELTGTRT HGSPDCDDIV GFSGDFGSGV GWEDEEEKET EEAGEEAEEE EGEAGEADDG GYIW