Details for: PDLIM2
Gene ID: 64236
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PDLIM2
Ensembl ID: ENSG00000120913
Description: PDZ and LIM domain 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 27.3rCSI 28.53%PRS 68.82
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CSI 20.16rCSI 17.38%PRS 74.45
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CSI 15.98rCSI 46.26%PRS 71.63
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CSI 15.92rCSI 45.86%PRS 81.37
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CSI 13.75rCSI 21.25%PRS 69.96
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CSI 13.45rCSI 26.66%PRS 80.89
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CSI 12.69rCSI 17.34%PRS 76.68
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CSI 11.81rCSI 52.48%PRS 71.47
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CSI 11.69rCSI 10.88%PRS 71.97
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CSI 11.66rCSI 9.67%PRS 71.27
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CSI 10.58rCSI 23.28%PRS 75.37
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CSI 10.26rCSI 8.34%PRS 71.27
-
CSI 9.62rCSI 22.83%PRS 73.35
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CSI 8.68rCSI 50.52%PRS 77.74
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CSI 8.05rCSI 7%PRS 81.54
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CSI 7.94rCSI 11.98%PRS 76.34
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CSI 7.8rCSI 17.27%PRS 69.81
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CSI 7.27rCSI 14%PRS 91.97
-
CSI 7.12rCSI 20.42%PRS 89.02
-
CSI 6.61rCSI 6.02%PRS 84.49
-
CSI 6.51rCSI 8.53%PRS 83.51
-
CSI 5.82rCSI 6.19%PRS 78.62
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CSI 5.81rCSI 5.6%PRS 70.7
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CSI 5.8rCSI 4.41%PRS 83.91
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CSI 5.48rCSI 14.47%PRS 79.52
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CSI 5.35rCSI 3.56%PRS 86.79
-
CSI 5.1rCSI 5.01%PRS 85.7
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CSI 5.06rCSI 6.89%PRS 91.26
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CSI 4.91rCSI 2.9%PRS 87.25
-
CSI 4.72rCSI 9.8%PRS 68.14
-
CSI 4.67rCSI 3.7%PRS 90.01
-
CSI 4.57rCSI 3.18%PRS 82.61
-
CSI 4.5rCSI 3.6%PRS 88.04
-
CSI 4.34rCSI 6.95%PRS 86.96
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CSI 4.26rCSI 5.31%PRS 81.58
-
CSI 4.07rCSI 9.7%PRS 71.11
-
CSI 4.03rCSI 3.34%PRS 73.54
-
CSI 3.96rCSI 22.83%PRS 68.85
-
CSI 3.8rCSI 15.99%PRS 79.88
-
CSI 3.77rCSI 5.23%PRS 70.34
-
CSI 3.65rCSI 5.89%PRS 72.36
-
CSI 3.6rCSI 3.16%PRS 79.62
-
CSI 3.26rCSI 3.57%PRS 74.24
-
CSI 3.24rCSI 2.26%PRS 85.6
-
CSI 3.15rCSI 2.39%PRS 84.31
-
CSI 3.12rCSI 5.64%PRS 80.69
-
CSI 3.11rCSI 3.64%PRS 85.96
-
CSI 3.11rCSI 2.33%PRS 77.03
-
CSI 3.05rCSI 2.54%PRS 76.51
-
CSI 3.03rCSI 15.2%PRS 83.56
-
CSI 2.98rCSI 2.88%PRS 62.89
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CSI 2.94rCSI 3.3%PRS 86.03
-
CSI 2.87rCSI 4.58%PRS 75.29
-
CSI 2.84rCSI 2.21%PRS 87.08
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CSI 2.84rCSI 4.51%PRS 81.23
-
CSI 2.84rCSI 2.04%PRS 84.52
-
CSI 2.76rCSI 2.14%PRS 74.47
-
CSI 2.71rCSI 8.77%PRS 70.31
-
CSI 2.65rCSI 3.38%PRS 76.97
-
CSI 2.6rCSI 4.15%PRS 62.82
-
CSI 2.6rCSI 1.95%PRS 85.1
-
CSI 2.6rCSI 4.96%PRS 83.45
-
CSI 2.6rCSI 2.25%PRS 75.85
-
CSI 2.58rCSI 2.33%PRS 68.43
-
CSI 2.49rCSI 2.21%PRS 68.99
-
CSI 2.43rCSI 5.43%PRS 79.17
-
CSI 2.41rCSI 19.63%PRS 64.62
-
CSI 2.4rCSI 1.62%PRS 84.27
-
CSI 2.4rCSI 3.27%PRS 62.46
-
CSI 2.4rCSI 4.54%PRS 93.52
-
CSI 2.36rCSI 2.73%PRS 62.16
-
CSI 2.35rCSI 2.95%PRS 82.22
-
CSI 2.31rCSI 1.53%PRS 74.03
-
CSI 2.3rCSI 2.88%PRS 81.03
-
CSI 2.29rCSI 3.58%PRS 90.62
-
CSI 2.24rCSI 1.88%PRS 74.6
-
CSI 2.23rCSI 2.19%PRS 87.89
-
CSI 2.21rCSI 1.64%PRS 83.59
-
CSI 2.2rCSI 3.02%PRS 88.56
-
CSI 2.18rCSI 1.76%PRS 73.09
-
CSI 2.16rCSI 3.84%PRS 82.55
-
CSI 2.08rCSI 1.92%PRS 72.95
-
CSI 2.04rCSI 1.57%PRS 73.09
-
CSI 2.01rCSI 3.07%PRS 84.96
-
CSI 1.99rCSI 4.75%PRS 77.65
-
CSI 1.99rCSI 2.65%PRS 88.59
-
CSI 1.97rCSI 2.53%PRS 75.4
-
CSI 1.95rCSI 1.98%PRS 82.42
-
CSI 1.93rCSI 2.24%PRS 77.13
-
CSI 1.93rCSI 2.02%PRS 68.14
-
CSI 1.93rCSI 2.47%PRS 67.61
-
CSI 1.91rCSI 3.31%PRS 61.6
-
CSI 1.85rCSI 2.92%PRS 73.17
-
CSI 1.83rCSI 2.62%PRS 73.25
-
CSI 1.82rCSI 2.67%PRS 65.99
-
CSI 1.82rCSI 7.87%PRS 81.28
-
CSI 1.82rCSI 1.44%PRS 58.42
-
CSI 1.82rCSI 2.53%PRS 69.55
-
CSI 1.82rCSI 1.43%PRS 77.67
-
CSI 1.79rCSI 2.14%PRS 88.12
-
CSI 0.2rCSI 0.9%PRS 78.1%
-
CSI 0.3rCSI 4.8%PRS 86.2%
-
CSI 0.3rCSI 4.3%PRS 83.6%
-
CSI 0.4rCSI 6.7%PRS 79.4%
-
CSI 0.7rCSI 1.7%PRS 76.8%
-
CSI 0.7rCSI 2.3%PRS 74.6%
-
CSI 0.8rCSI 3.6%PRS 83.0%
-
CSI 0.9rCSI 9.1%PRS 82.0%
-
CSI 0.9rCSI 6.4%PRS 81.2%
-
CSI 1.0rCSI 3.2%PRS 90.8%
-
CSI 1.0rCSI 1.2%PRS 72.8%
-
CSI 1.1rCSI 2.8%PRS 64.8%
-
CSI 1.1rCSI 1.8%PRS 80.5%
-
CSI 1.2rCSI 3.2%PRS 80.9%
-
CSI 1.2rCSI 3.0%PRS 70.0%
-
CSI 1.4rCSI 1.7%PRS 68.2%
-
CSI 1.4rCSI 1.7%PRS 69.3%
-
CSI 1.4rCSI 4.1%PRS 66.8%
-
CSI 1.5rCSI 1.8%PRS 54.4%
-
CSI 1.5rCSI 2.5%PRS 78.9%
-
CSI 1.5rCSI 1.8%PRS 80.1%
-
CSI 1.5rCSI 3.7%PRS 64.2%
-
CSI 1.5rCSI 2.7%PRS 78.1%
-
CSI 1.6rCSI 1.1%PRS 74.2%
-
CSI 1.6rCSI 2.7%PRS 86.2%
-
CSI 1.6rCSI 4.3%PRS 82.0%
-
CSI 1.7rCSI 2.5%PRS 76.1%
-
CSI 1.7rCSI 3.6%PRS 85.3%
-
CSI 1.8rCSI 19.1%PRS 80.2%
-
CSI 1.8rCSI 2.1%PRS 88.1%
-
CSI 1.8rCSI 1.4%PRS 77.7%
-
CSI 1.8rCSI 2.5%PRS 69.6%
-
CSI 1.8rCSI 1.4%PRS 58.4%
-
CSI 1.8rCSI 7.9%PRS 81.3%
-
CSI 1.8rCSI 2.7%PRS 66.0%
-
CSI 1.8rCSI 2.6%PRS 73.3%
-
CSI 1.9rCSI 2.9%PRS 73.2%
-
CSI 1.9rCSI 3.3%PRS 61.6%
-
CSI 1.9rCSI 2.5%PRS 67.6%
-
CSI 1.9rCSI 2.0%PRS 68.1%
-
CSI 1.9rCSI 2.2%PRS 77.1%
-
CSI 2.0rCSI 2.0%PRS 82.4%
-
CSI 2.0rCSI 2.5%PRS 75.4%
-
CSI 2.0rCSI 2.7%PRS 88.6%
-
CSI 2.0rCSI 4.8%PRS 77.7%
-
CSI 2.0rCSI 3.1%PRS 85.0%
-
CSI 2.0rCSI 1.6%PRS 73.1%
-
CSI 2.1rCSI 1.9%PRS 73.0%
-
CSI 2.2rCSI 3.8%PRS 82.6%
-
CSI 2.2rCSI 1.8%PRS 73.1%
-
CSI 2.2rCSI 3.0%PRS 88.6%
-
CSI 2.2rCSI 1.6%PRS 83.6%
-
CSI 2.2rCSI 2.2%PRS 87.9%
-
CSI 2.2rCSI 1.9%PRS 74.6%
-
CSI 2.3rCSI 3.6%PRS 90.6%
-
CSI 2.3rCSI 2.9%PRS 81.0%
-
CSI 2.3rCSI 1.5%PRS 74.0%
-
CSI 2.4rCSI 3.0%PRS 82.2%
-
CSI 2.4rCSI 2.7%PRS 62.2%
-
CSI 2.4rCSI 4.5%PRS 93.5%
-
CSI 2.4rCSI 3.3%PRS 62.5%
-
CSI 2.4rCSI 1.6%PRS 84.3%
-
CSI 2.4rCSI 19.6%PRS 64.6%
-
CSI 2.4rCSI 5.4%PRS 79.2%
-
CSI 2.5rCSI 2.2%PRS 69.0%
-
CSI 2.6rCSI 2.3%PRS 68.4%
-
CSI 2.6rCSI 2.3%PRS 75.9%
-
CSI 2.6rCSI 5.0%PRS 83.5%
-
CSI 2.6rCSI 2.0%PRS 85.1%
-
CSI 2.6rCSI 4.2%PRS 62.8%
-
CSI 2.7rCSI 3.4%PRS 77.0%
-
CSI 2.7rCSI 8.8%PRS 70.3%
-
CSI 2.8rCSI 2.1%PRS 74.5%
-
CSI 2.8rCSI 2.0%PRS 84.5%
-
CSI 2.8rCSI 4.5%PRS 81.2%
-
CSI 2.8rCSI 2.2%PRS 87.1%
-
CSI 2.9rCSI 4.6%PRS 75.3%
-
CSI 2.9rCSI 3.3%PRS 86.0%
-
CSI 3.0rCSI 2.9%PRS 62.9%
-
CSI 3.0rCSI 15.2%PRS 83.6%
-
CSI 3.1rCSI 2.5%PRS 76.5%
-
CSI 3.1rCSI 2.3%PRS 77.0%
-
CSI 3.1rCSI 3.6%PRS 86.0%
-
CSI 3.1rCSI 5.6%PRS 80.7%
-
CSI 3.2rCSI 2.4%PRS 84.3%
-
CSI 3.2rCSI 2.3%PRS 85.6%
-
CSI 3.3rCSI 3.6%PRS 74.2%
-
CSI 3.6rCSI 3.2%PRS 79.6%
-
CSI 3.7rCSI 5.9%PRS 72.4%
-
CSI 3.8rCSI 5.2%PRS 70.3%
-
CSI 3.8rCSI 16.0%PRS 79.9%
-
CSI 4.0rCSI 22.8%PRS 68.9%
-
CSI 4.0rCSI 3.3%PRS 73.5%
-
CSI 4.1rCSI 9.7%PRS 71.1%
-
CSI 4.3rCSI 5.3%PRS 81.6%
-
CSI 4.3rCSI 7.0%PRS 87.0%
-
CSI 4.5rCSI 3.6%PRS 88.0%
-
CSI 4.6rCSI 3.2%PRS 82.6%
-
CSI 4.7rCSI 3.7%PRS 90.0%
-
CSI 4.7rCSI 9.8%PRS 68.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 2925858767
Symbol: PDLI2_HUMAN
Name: PDZ and LIM domain protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15498874
Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.
PubMed ID: 15498874
PubMed ID: 11214971
Title: Characterization of long cDNA clones from human adult spleen.
PubMed ID: 11214971
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15659642
Title: Mystique is a new IGF-I regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage independent growth.
PubMed ID: 15659642
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 352
- Mass: 37459
- Checksum: E36EC66C61C5E9DB
- Sequence:
MALTVDVAGP APWGFRITGG RDFHTPIMVT KVAERGKAKD ADLRPGDIIV AINGESAEGM LHAEAQSKIR QSPSPLRLQL DRSQATSPGQ TNGDSSLEVL ATRFQGSVRT YTESQSSLRS SYSSPTSLSP RAGSPFSPPP SSSSLTGEAA ISRSFQSLAC SPGLPAADRL SYSGRPGSRQ AGLGRAGDSA VLVLPPSPGP RSSRPSMDSE GGSLLLDEDS EVFKMLQENR EGRAAPRQSS SFRLLQEALE AEERGGTPAF LPSSLSPQSS LPASRALATP PKLHTCEKCS TSIANQAVRI QEGRYRHPGC YTCADCGLNL KMRGHFWVGD ELYCEKHARQ RYSAPATLSS RA