Details for: EXOC2
Gene ID: 55770
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: EXOC2
Ensembl ID: ENSG00000112685
Description: exocyst complex component 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 29.62rCSI 49.72%PRS 69.78
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CSI 19.54rCSI 47.48%PRS 67.61
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CSI 14.97rCSI 53.85%PRS 67.76
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CSI 14.87rCSI 32.85%PRS 73.08
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CSI 14.05rCSI 10.52%PRS 94.94
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CSI 13.3rCSI 41.56%PRS 71.28
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CSI 10.57rCSI 39.95%PRS 70.13
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CSI 8.36rCSI 33.74%PRS 86.1
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CSI 8.2rCSI 48.27%PRS 70.26
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CSI 7.99rCSI 16.58%PRS 83.01
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CSI 7.91rCSI 24.73%PRS 73.45
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CSI 7.67rCSI 9.85%PRS 76.45
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CSI 7.64rCSI 16.92%PRS 85.44
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CSI 7.36rCSI 5.29%PRS 95.4
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CSI 6.85rCSI 15.64%PRS 78.09
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CSI 6.84rCSI 11.01%PRS 76.87
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CSI 6.32rCSI 10.09%PRS 77.61
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CSI 6.12rCSI 6.24%PRS 92.73
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CSI 6.1rCSI 9.64%PRS 86.76
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CSI 5.9rCSI 4.66%PRS 76.49
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CSI 5.86rCSI 14.5%PRS 86.08
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CSI 5.79rCSI 27.76%PRS 85.9
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CSI 5.51rCSI 40.47%PRS 74.85
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CSI 5.43rCSI 4.02%PRS 80.47
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CSI 5.32rCSI 6.35%PRS 69.92
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CSI 5.18rCSI 6.65%PRS 82
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CSI 5.16rCSI 4.17%PRS 92.22
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CSI 5.11rCSI 4.38%PRS 90.41
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CSI 5.08rCSI 6.32%PRS 67.67
-
CSI 4.82rCSI 13.96%PRS 76.16
-
CSI 4.79rCSI 6.17%PRS 70.93
-
CSI 4.61rCSI 7.41%PRS 71.16
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CSI 4.6rCSI 3.5%PRS 95.45
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CSI 4.41rCSI 7.73%PRS 80.75
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CSI 4.19rCSI 9.68%PRS 74.92
-
CSI 4.17rCSI 12.38%PRS 92.52
-
CSI 4.09rCSI 4.73%PRS 79.11
-
CSI 3.9rCSI 6.39%PRS 76.73
-
CSI 3.86rCSI 6.93%PRS 79.89
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CSI 3.81rCSI 6.6%PRS 78.65
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CSI 3.76rCSI 2.92%PRS 95.41
-
CSI 3.73rCSI 6.99%PRS 75.56
-
CSI 3.71rCSI 13.89%PRS 79.4
-
CSI 3.66rCSI 10.08%PRS 81.81
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CSI 3.66rCSI 8.75%PRS 73.62
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CSI 3.65rCSI 2.16%PRS 96.95
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CSI 3.59rCSI 7.2%PRS 77.76
-
CSI 3.55rCSI 22.16%PRS 78.4
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CSI 3.54rCSI 8.1%PRS 86.57
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CSI 3.52rCSI 7.13%PRS 66.03
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CSI 3.44rCSI 3.97%PRS 78.11
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CSI 3.28rCSI 2.46%PRS 90.21
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CSI 3.27rCSI 46.41%PRS 77.43
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CSI 3.17rCSI 4.91%PRS 88.06
-
CSI 3.1rCSI 5.48%PRS 69.35
-
CSI 3.1rCSI 2.44%PRS 89.28
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CSI 3.08rCSI 2.14%PRS 94.72
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CSI 3.07rCSI 7.99%PRS 79.64
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CSI 3.05rCSI 2.12%PRS 95.96
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CSI 3.02rCSI 17.42%PRS 82.19
-
CSI 2.88rCSI 7.7%PRS 78.68
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CSI 2.84rCSI 4.51%PRS 79.71
-
CSI 2.82rCSI 57.38%PRS 75.87
-
CSI 2.68rCSI 54.66%PRS 76.75
-
CSI 2.68rCSI 4.42%PRS 88.71
-
CSI 2.67rCSI 2.35%PRS 75.93
-
CSI 2.62rCSI 5.87%PRS 70.71
-
CSI 2.6rCSI 2.55%PRS 87.54
-
CSI 2.54rCSI 1.71%PRS 95.54
-
CSI 2.54rCSI 60.83%PRS 67.57
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CSI 2.52rCSI 60.89%PRS 68.02
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CSI 2.48rCSI 6.61%PRS 73.17
-
CSI 2.48rCSI 14%PRS 73.13
-
CSI 2.47rCSI 2.71%PRS 87.3
-
CSI 2.43rCSI 1.87%PRS 88.86
-
CSI 2.39rCSI 3.6%PRS 90.3
-
CSI 2.37rCSI 6.18%PRS 86.85
-
CSI 2.31rCSI 2.15%PRS 86.61
-
CSI 2.3rCSI 2.1%PRS 94.72
-
CSI 2.27rCSI 3.22%PRS 82.84
-
CSI 2.21rCSI 7.09%PRS 83.55
-
CSI 2.16rCSI 5.15%PRS 88.46
-
CSI 2.14rCSI 2.24%PRS 88.34
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CSI 2.08rCSI 5.38%PRS 81.96
-
CSI 2.08rCSI 3.67%PRS 81.19
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CSI 2rCSI 1.84%PRS 91.75
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CSI 2rCSI 6.17%PRS 88.63
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CSI 1.99rCSI 3.04%PRS 85.47
-
CSI 1.97rCSI 5.59%PRS 81.4
-
CSI 1.97rCSI 2.43%PRS 84
-
CSI 1.97rCSI 2.69%PRS 77.3
-
CSI 1.95rCSI 6.68%PRS 72.22
-
CSI 1.93rCSI 2.78%PRS 76.63
-
CSI 1.91rCSI 3.06%PRS 88.87
-
CSI 1.89rCSI 2.78%PRS 79.39
-
CSI 1.87rCSI 4.56%PRS 78.38
-
CSI 1.86rCSI 2.32%PRS 92.72
-
CSI 1.84rCSI 4.04%PRS 89.41
-
CSI 1.79rCSI 4.26%PRS 85.47
-
CSI 1.78rCSI 6.77%PRS 77.64
-
CSI 0.2rCSI 2.2%PRS 81.8%
-
CSI 0.6rCSI 4.5%PRS 76.0%
-
CSI 0.6rCSI 2.8%PRS 86.3%
-
CSI 0.7rCSI 5.1%PRS 75.0%
-
CSI 0.7rCSI 3.4%PRS 91.3%
-
CSI 0.7rCSI 4.6%PRS 79.7%
-
CSI 0.8rCSI 3.6%PRS 70.4%
-
CSI 0.9rCSI 3.4%PRS 80.0%
-
CSI 0.9rCSI 7.2%PRS 81.2%
-
CSI 0.9rCSI 5.3%PRS 76.8%
-
CSI 1.0rCSI 2.4%PRS 87.5%
-
CSI 1.0rCSI 2.8%PRS 81.0%
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CSI 1.1rCSI 3.4%PRS 82.4%
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CSI 1.1rCSI 4.9%PRS 74.3%
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CSI 1.2rCSI 5.5%PRS 76.3%
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CSI 1.2rCSI 2.4%PRS 73.1%
-
CSI 1.2rCSI 12.3%PRS 79.4%
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CSI 1.3rCSI 4.4%PRS 72.5%
-
CSI 1.4rCSI 3.5%PRS 96.5%
-
CSI 1.4rCSI 3.6%PRS 77.5%
-
CSI 1.4rCSI 2.5%PRS 89.4%
-
CSI 1.4rCSI 4.8%PRS 70.5%
-
CSI 1.5rCSI 7.3%PRS 79.9%
-
CSI 1.5rCSI 8.1%PRS 82.0%
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CSI 1.5rCSI 1.8%PRS 91.8%
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CSI 1.6rCSI 2.0%PRS 83.9%
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CSI 1.7rCSI 3.0%PRS 78.0%
-
CSI 1.7rCSI 14.3%PRS 75.4%
-
CSI 1.7rCSI 4.3%PRS 85.4%
-
CSI 1.7rCSI 3.6%PRS 74.0%
-
CSI 1.7rCSI 3.3%PRS 81.7%
-
CSI 1.7rCSI 4.9%PRS 97.3%
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CSI 1.7rCSI 4.5%PRS 90.7%
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CSI 1.8rCSI 11.9%PRS 77.6%
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CSI 1.8rCSI 8.8%PRS 94.8%
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CSI 1.8rCSI 1.4%PRS 85.0%
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CSI 1.8rCSI 11.4%PRS 88.5%
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CSI 1.8rCSI 6.8%PRS 77.6%
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CSI 1.8rCSI 4.3%PRS 85.5%
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CSI 1.8rCSI 4.0%PRS 89.4%
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CSI 1.9rCSI 2.3%PRS 92.7%
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CSI 1.9rCSI 4.6%PRS 78.4%
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CSI 1.9rCSI 2.8%PRS 79.4%
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CSI 1.9rCSI 3.1%PRS 88.9%
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CSI 1.9rCSI 2.8%PRS 76.6%
-
CSI 2.0rCSI 6.7%PRS 72.2%
-
CSI 2.0rCSI 2.7%PRS 77.3%
-
CSI 2.0rCSI 2.4%PRS 84.0%
-
CSI 2.0rCSI 5.6%PRS 81.4%
-
CSI 2.0rCSI 3.0%PRS 85.5%
-
CSI 2.0rCSI 6.2%PRS 88.6%
-
CSI 2.0rCSI 1.8%PRS 91.8%
-
CSI 2.1rCSI 3.7%PRS 81.2%
-
CSI 2.1rCSI 5.4%PRS 82.0%
-
CSI 2.1rCSI 2.2%PRS 88.3%
-
CSI 2.2rCSI 5.2%PRS 88.5%
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CSI 2.2rCSI 7.1%PRS 83.6%
-
CSI 2.3rCSI 3.2%PRS 82.8%
-
CSI 2.3rCSI 2.1%PRS 94.7%
-
CSI 2.3rCSI 2.2%PRS 86.6%
-
CSI 2.4rCSI 6.2%PRS 86.9%
-
CSI 2.4rCSI 3.6%PRS 90.3%
-
CSI 2.4rCSI 1.9%PRS 88.9%
-
CSI 2.5rCSI 2.7%PRS 87.3%
-
CSI 2.5rCSI 14.0%PRS 73.1%
-
CSI 2.5rCSI 6.6%PRS 73.2%
-
CSI 2.5rCSI 60.9%PRS 68.0%
-
CSI 2.5rCSI 60.8%PRS 67.6%
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CSI 2.5rCSI 1.7%PRS 95.5%
-
CSI 2.6rCSI 2.6%PRS 87.5%
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CSI 2.6rCSI 5.9%PRS 70.7%
-
CSI 2.7rCSI 2.4%PRS 75.9%
-
CSI 2.7rCSI 4.4%PRS 88.7%
-
CSI 2.7rCSI 54.7%PRS 76.8%
-
CSI 2.8rCSI 57.4%PRS 75.9%
-
CSI 2.8rCSI 4.5%PRS 79.7%
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CSI 2.9rCSI 7.7%PRS 78.7%
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CSI 3.0rCSI 17.4%PRS 82.2%
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CSI 3.1rCSI 2.1%PRS 96.0%
-
CSI 3.1rCSI 8.0%PRS 79.6%
-
CSI 3.1rCSI 2.1%PRS 94.7%
-
CSI 3.1rCSI 2.4%PRS 89.3%
-
CSI 3.1rCSI 5.5%PRS 69.4%
-
CSI 3.2rCSI 4.9%PRS 88.1%
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CSI 3.3rCSI 46.4%PRS 77.4%
-
CSI 3.3rCSI 2.5%PRS 90.2%
-
CSI 3.4rCSI 4.0%PRS 78.1%
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CSI 3.5rCSI 7.1%PRS 66.0%
-
CSI 3.5rCSI 8.1%PRS 86.6%
-
CSI 3.6rCSI 22.2%PRS 78.4%
-
CSI 3.6rCSI 7.2%PRS 77.8%
-
CSI 3.7rCSI 2.2%PRS 97.0%
-
CSI 3.7rCSI 8.8%PRS 73.6%
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CSI 3.7rCSI 10.1%PRS 81.8%
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CSI 3.7rCSI 13.9%PRS 79.4%
-
CSI 3.7rCSI 7.0%PRS 75.6%
-
CSI 3.8rCSI 2.9%PRS 95.4%
-
CSI 3.8rCSI 6.6%PRS 78.7%
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CSI 3.9rCSI 6.9%PRS 79.9%
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CSI 3.9rCSI 6.4%PRS 76.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 824271845
Symbol: EXOC2_HUMAN
Name: Exocyst complex component 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12459492
Title: DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion.
PubMed ID: 12459492
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16213214
Title: Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission.
PubMed ID: 16213214
PubMed ID: 18756269
Title: Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.
PubMed ID: 18756269
PubMed ID: 19166349
Title: Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding.
PubMed ID: 19166349
DOI: 10.1021/bi802129d
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 32639540
Title: Mutations in the exocyst component EXOC2 cause severe defects in human brain development.
PubMed ID: 32639540
DOI: 10.1084/jem.20192040
Sequence Information:
- Length: 924
- Mass: 104066
- Checksum: 2234E463DE8B076F
- Sequence:
MSRSRQPPLV TGISPNEGIP WTKVTIRGEN LGTGPTDLIG LTICGHNCLL TAEWMSASKI VCRVGQAKND KGDIIVTTKS GGRGTSTVSF KLLKPEKIGI LDQSAVWVDE MNYYDMRTDR NKGIPPLSLR PANPLGIEIE KSKFSQKDLE MLFHGMSADF TSENFSAAWY LIENHSNTSF EQLKMAVTNL KRQANKKSEG SLAYVKGGLS TFFEAQDALS AIHQKLEADG TEKVEGSMTQ KLENVLNRAS NTADTLFQEV LGRKDKADST RNALNVLQRF KFLFNLPLNI ERNIQKGDYD VVINDYEKAK SLFGKTEVQV FKKYYAEVET RIEALRELLL DKLLETPSTL HDQKRYIRYL SDLHASGDPA WQCIGAQHKW ILQLMHSCKE GYVKDLKGNP GLHSPMLDLD NDTRPSVLGH LSQTASLKRG SSFQSGRDDT WRYKTPHRVA FVEKLTKLVL SQLPNFWKLW ISYVNGSLFS ETAEKSGQIE RSKNVRQRQN DFKKMIQEVM HSLVKLTRGA LLPLSIRDGE AKQYGGWEVK CELSGQWLAH AIQTVRLTHE SLTALEIPND LLQTIQDLIL DLRVRCVMAT LQHTAEEIKR LAEKEDWIVD NEGLTSLPCQ FEQCIVCSLQ SLKGVLECKP GEASVFQQPK TQEEVCQLSI NIMQVFIYCL EQLSTKPDAD IDTTHLSVDV SSPDLFGSIH EDFSLTSEQR LLIVLSNCCY LERHTFLNIA EHFEKHNFQG IEKITQVSMA SLKELDQRLF ENYIELKADP IVGSLEPGIY AGYFDWKDCL PPTGVRNYLK EALVNIIAVH AEVFTISKEL VPRVLSKVIE AVSEELSRLM QCVSSFSKNG ALQARLEICA LRDTVAVYLT PESKSSFKQA LEALPQLSSG ADKKLLEELL NKFKSSMHLQ LTCFQAASST MMKT