EXOC2 | ENSG00000112685 | NCBI 55770

Details for: EXOC2

Gene ID: 55770

Symbol: EXOC2

Ensembl ID: ENSG00000112685

Description: exocyst complex component 2

Associated with

Cargo trafficking to the periciliary membrane
(R-HSA-5620920)
Cilium assembly
(R-HSA-5617833)
Insulin processing
(R-HSA-264876)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Peptide hormone metabolism
(R-HSA-2980736)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Vesicle-mediated transport
(R-HSA-5653656)
Vxpx cargo-targeting to cilium
(R-HSA-5620916)
Cytosol
(GO:0005829)
Exocyst
(GO:0000145)
Exocytosis
(GO:0006887)
Flemming body
(GO:0090543)
Golgi to plasma membrane transport
(GO:0006893)
Membrane
(GO:0016020)
Membrane fission
(GO:0090148)
Mitotic cytokinesis
(GO:0000281)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein transport
(GO:0015031)
Regulation of entry of bacterium into host cell
(GO:2000535)
Small gtpase binding
(GO:0031267)
Vesicle docking involved in exocytosis
(GO:0006904)
Vesicle tethering involved in exocytosis
(GO:0090522)

Other Information

Proteins

Exocyst complex component 2

Genular Protein ID: 824271845

Symbol: EXOC2_HUMAN

Name: Exocyst complex component 2

UniProtKB Accession Codes:

Q96KP1 B2RBE6 Q5JPC8 Q96AN6 Q9NUZ8 Q9UJM7

Database IDs:

Citations:

PubMed ID: 12459492

Title: DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion.

PubMed ID: 12459492

DOI: 10.1016/s0014-5793(02)03677-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16213214

Title: Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission.

PubMed ID: 16213214

DOI: 10.1016/j.cell.2005.07.027

PubMed ID: 18756269

Title: Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.

PubMed ID: 18756269

DOI: 10.1038/emboj.2008.166

PubMed ID: 19166349

Title: Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding.

PubMed ID: 19166349

DOI: 10.1021/bi802129d

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 32639540

Title: Mutations in the exocyst component EXOC2 cause severe defects in human brain development.

PubMed ID: 32639540

DOI: 10.1084/jem.20192040

Sequence Information:

Length: 924
Mass: 104066
Checksum: 2234E463DE8B076F
Sequence:

MSRSRQPPLV TGISPNEGIP WTKVTIRGEN LGTGPTDLIG LTICGHNCLL TAEWMSASKI 
VCRVGQAKND KGDIIVTTKS GGRGTSTVSF KLLKPEKIGI LDQSAVWVDE MNYYDMRTDR 
NKGIPPLSLR PANPLGIEIE KSKFSQKDLE MLFHGMSADF TSENFSAAWY LIENHSNTSF 
EQLKMAVTNL KRQANKKSEG SLAYVKGGLS TFFEAQDALS AIHQKLEADG TEKVEGSMTQ 
KLENVLNRAS NTADTLFQEV LGRKDKADST RNALNVLQRF KFLFNLPLNI ERNIQKGDYD 
VVINDYEKAK SLFGKTEVQV FKKYYAEVET RIEALRELLL DKLLETPSTL HDQKRYIRYL 
SDLHASGDPA WQCIGAQHKW ILQLMHSCKE GYVKDLKGNP GLHSPMLDLD NDTRPSVLGH 
LSQTASLKRG SSFQSGRDDT WRYKTPHRVA FVEKLTKLVL SQLPNFWKLW ISYVNGSLFS 
ETAEKSGQIE RSKNVRQRQN DFKKMIQEVM HSLVKLTRGA LLPLSIRDGE AKQYGGWEVK 
CELSGQWLAH AIQTVRLTHE SLTALEIPND LLQTIQDLIL DLRVRCVMAT LQHTAEEIKR 
LAEKEDWIVD NEGLTSLPCQ FEQCIVCSLQ SLKGVLECKP GEASVFQQPK TQEEVCQLSI 
NIMQVFIYCL EQLSTKPDAD IDTTHLSVDV SSPDLFGSIH EDFSLTSEQR LLIVLSNCCY 
LERHTFLNIA EHFEKHNFQG IEKITQVSMA SLKELDQRLF ENYIELKADP IVGSLEPGIY 
AGYFDWKDCL PPTGVRNYLK EALVNIIAVH AEVFTISKEL VPRVLSKVIE AVSEELSRLM 
QCVSSFSKNG ALQARLEICA LRDTVAVYLT PESKSSFKQA LEALPQLSSG ADKKLLEELL 
NKFKSSMHLQ LTCFQAASST MMKT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EXOC2

Associated with

Other Information

DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion. PubMed ID: 12459492

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission. PubMed ID: 16213214

Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. PubMed ID: 18756269

Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding. PubMed ID: 19166349

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Mutations in the exocyst component EXOC2 cause severe defects in human brain development. PubMed ID: 32639540