Details for: EIF2B3
Gene ID: 8891
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: EIF2B3
Ensembl ID: ENSG00000070785
Description: eukaryotic translation initiation factor 2B subunit gamma
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 10.03rCSI 15.84%PRS 61.84
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CSI 8.25rCSI 13.1%PRS 70.9
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CSI 6.17rCSI 27.57%PRS 43.87
-
CSI 5.89rCSI 19.74%PRS 45.29
-
CSI 5.25rCSI 13.92%PRS 71.48
-
CSI 4.95rCSI 7.96%PRS 49.49
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CSI 4.85rCSI 8.55%PRS 56.93
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CSI 4.81rCSI 9.88%PRS 50.58
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CSI 4.57rCSI 9.49%PRS 57.01
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CSI 4.34rCSI 9.92%PRS 59.62
-
CSI 4.31rCSI 11.14%PRS 54.78
-
CSI 4.11rCSI 6.89%PRS 41.75
-
CSI 3.96rCSI 34.12%PRS 47.37
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CSI 3.89rCSI 5.71%PRS 53.73
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CSI 3.72rCSI 9.05%PRS 40.41
-
CSI 3.71rCSI 14.98%PRS 58.72
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CSI 3.32rCSI 1.96%PRS 77.08
-
CSI 3.14rCSI 18.08%PRS 58.71
-
CSI 3.13rCSI 3.99%PRS 66.35
-
CSI 3.08rCSI 3.83%PRS 39.83
-
CSI 3.01rCSI 2.72%PRS 56.6
-
CSI 2.95rCSI 2.19%PRS 52.43
-
CSI 2.9rCSI 4.66%PRS 43.86
-
CSI 2.89rCSI 4.48%PRS 67.49
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CSI 2.81rCSI 4.96%PRS 40.78
-
CSI 2.64rCSI 3.4%PRS 42.98
-
CSI 2.64rCSI 2.13%PRS 70.61
-
CSI 2.57rCSI 3.09%PRS 57.81
-
CSI 2.53rCSI 5.78%PRS 51.74
-
CSI 2.48rCSI 1.73%PRS 62.45
-
CSI 2.42rCSI 4.87%PRS 48.97
-
CSI 2.41rCSI 2%PRS 61.72
-
CSI 2.36rCSI 4.07%PRS 49.94
-
CSI 2.35rCSI 2.16%PRS 68.57
-
CSI 2.34rCSI 4.38%PRS 48.39
-
CSI 2.33rCSI 1.55%PRS 79.92
-
CSI 2.3rCSI 2.14%PRS 60.23
-
CSI 2.3rCSI 3.67%PRS 52.6
-
CSI 2.29rCSI 8.57%PRS 51.99
-
CSI 2.28rCSI 1.8%PRS 66.4
-
CSI 2.25rCSI 2.9%PRS 52.78
-
CSI 2.25rCSI 1.78%PRS 46.67
-
CSI 2.14rCSI 3.41%PRS 63.76
-
CSI 2.13rCSI 3.49%PRS 49.14
-
CSI 2.12rCSI 2.09%PRS 62.43
-
CSI 2.12rCSI 3.49%PRS 65.19
-
CSI 2.1rCSI 3.11%PRS 65.1
-
CSI 2.1rCSI 12.38%PRS 43.08
-
CSI 2.08rCSI 2.18%PRS 63.41
-
CSI 2.04rCSI 2.79%PRS 53.68
-
CSI 2.01rCSI 4.64%PRS 49.14
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CSI 2.01rCSI 2.98%PRS 61.57
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CSI 1.99rCSI 47.58%PRS 40.93
-
CSI 1.97rCSI 2.16%PRS 63.66
-
CSI 1.89rCSI 1.74%PRS 61.22
-
CSI 1.89rCSI 2.67%PRS 56.04
-
CSI 1.89rCSI 2.42%PRS 57.1
-
CSI 1.88rCSI 6.78%PRS 40.18
-
CSI 1.88rCSI 6.02%PRS 57.45
-
CSI 1.88rCSI 2.61%PRS 58.58
-
CSI 1.86rCSI 44.84%PRS 41.9
-
CSI 1.86rCSI 8.88%PRS 58.77
-
CSI 1.83rCSI 2.18%PRS 41.58
-
CSI 1.81rCSI 2.77%PRS 60.41
-
CSI 1.78rCSI 3.12%PRS 51.87
-
CSI 1.78rCSI 2.83%PRS 52.13
-
CSI 1.77rCSI 3.59%PRS 39.45
-
CSI 1.76rCSI 5.2%PRS 62.97
-
CSI 1.75rCSI 6.67%PRS 50.81
-
CSI 1.74rCSI 1.41%PRS 61.05
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CSI 1.74rCSI 2.01%PRS 53.1
-
CSI 1.7rCSI 1.5%PRS 47.63
-
CSI 1.62rCSI 4.15%PRS 59.62
-
CSI 1.6rCSI 2.34%PRS 64.14
-
CSI 1.59rCSI 3.28%PRS 61.9
-
CSI 1.57rCSI 3.75%PRS 68.63
-
CSI 1.56rCSI 3.86%PRS 58.18
-
CSI 1.51rCSI 1%PRS 62.96
-
CSI 1.5rCSI 3.9%PRS 63.44
-
CSI 1.48rCSI 4.08%PRS 55.64
-
CSI 1.47rCSI 3.59%PRS 53.58
-
CSI 1.46rCSI 3.5%PRS 47.28
-
CSI 1.46rCSI 3.81%PRS 59.63
-
CSI 1.45rCSI 2.6%PRS 52.95
-
CSI 1.44rCSI 3.64%PRS 49.28
-
CSI 1.41rCSI 3.78%PRS 51.01
-
CSI 1.39rCSI 2%PRS 49.73
-
CSI 1.39rCSI 3.31%PRS 60.98
-
CSI 1.39rCSI 1.07%PRS 61.39
-
CSI 1.35rCSI 4.39%PRS 60.52
-
CSI 1.32rCSI 2.62%PRS 57.66
-
CSI 1.29rCSI 1.61%PRS 70.66
-
CSI 1.27rCSI 10.31%PRS 53.11
-
CSI 1.26rCSI 3.95%PRS 43.35
-
CSI 1.21rCSI 3.15%PRS 57.57
-
CSI 1.18rCSI 6.74%PRS 69.1
-
CSI 1.17rCSI 5.61%PRS 60.04
-
CSI 1.16rCSI 1.41%PRS 68.52
-
CSI 1.12rCSI 3.51%PRS 45.94
-
CSI 1.09rCSI 2.41%PRS 46.18
-
CSI 0.2rCSI 4.6%PRS 79.2%
-
CSI 0.3rCSI 5.4%PRS 64.8%
-
CSI 0.4rCSI 2.6%PRS 51.8%
-
CSI 0.4rCSI 3.9%PRS 46.5%
-
CSI 0.6rCSI 4.4%PRS 46.8%
-
CSI 0.6rCSI 3.5%PRS 45.0%
-
CSI 0.6rCSI 2.8%PRS 59.1%
-
CSI 0.7rCSI 2.0%PRS 61.2%
-
CSI 0.7rCSI 2.7%PRS 42.6%
-
CSI 0.8rCSI 4.2%PRS 72.6%
-
CSI 0.8rCSI 0.9%PRS 49.8%
-
CSI 0.8rCSI 5.3%PRS 77.8%
-
CSI 0.9rCSI 2.0%PRS 57.8%
-
CSI 0.9rCSI 4.1%PRS 50.5%
-
CSI 1.0rCSI 2.8%PRS 49.6%
-
CSI 1.0rCSI 3.1%PRS 58.4%
-
CSI 1.0rCSI 1.5%PRS 63.8%
-
CSI 1.0rCSI 1.5%PRS 56.1%
-
CSI 1.0rCSI 4.7%PRS 76.6%
-
CSI 1.0rCSI 2.3%PRS 42.5%
-
CSI 1.0rCSI 0.8%PRS 60.1%
-
CSI 1.1rCSI 1.8%PRS 30.9%
-
CSI 1.1rCSI 2.4%PRS 46.2%
-
CSI 1.1rCSI 3.5%PRS 45.9%
-
CSI 1.2rCSI 1.4%PRS 68.5%
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CSI 1.2rCSI 5.6%PRS 60.0%
-
CSI 1.2rCSI 6.7%PRS 69.1%
-
CSI 1.2rCSI 3.2%PRS 57.6%
-
CSI 1.3rCSI 4.0%PRS 43.4%
-
CSI 1.3rCSI 10.3%PRS 53.1%
-
CSI 1.3rCSI 1.6%PRS 70.7%
-
CSI 1.3rCSI 2.6%PRS 57.7%
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CSI 1.4rCSI 4.4%PRS 60.5%
-
CSI 1.4rCSI 1.1%PRS 61.4%
-
CSI 1.4rCSI 3.3%PRS 61.0%
-
CSI 1.4rCSI 2.0%PRS 49.7%
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CSI 1.4rCSI 3.8%PRS 51.0%
-
CSI 1.4rCSI 3.6%PRS 49.3%
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CSI 1.5rCSI 2.6%PRS 53.0%
-
CSI 1.5rCSI 3.8%PRS 59.6%
-
CSI 1.5rCSI 3.5%PRS 47.3%
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CSI 1.5rCSI 3.6%PRS 53.6%
-
CSI 1.5rCSI 4.1%PRS 55.6%
-
CSI 1.5rCSI 3.9%PRS 63.4%
-
CSI 1.5rCSI 1.0%PRS 63.0%
-
CSI 1.6rCSI 3.9%PRS 58.2%
-
CSI 1.6rCSI 3.8%PRS 68.6%
-
CSI 1.6rCSI 3.3%PRS 61.9%
-
CSI 1.6rCSI 2.3%PRS 64.1%
-
CSI 1.6rCSI 4.2%PRS 59.6%
-
CSI 1.7rCSI 1.5%PRS 47.6%
-
CSI 1.7rCSI 2.0%PRS 53.1%
-
CSI 1.7rCSI 1.4%PRS 61.1%
-
CSI 1.8rCSI 6.7%PRS 50.8%
-
CSI 1.8rCSI 5.2%PRS 63.0%
-
CSI 1.8rCSI 3.6%PRS 39.5%
-
CSI 1.8rCSI 2.8%PRS 52.1%
-
CSI 1.8rCSI 3.1%PRS 51.9%
-
CSI 1.8rCSI 2.8%PRS 60.4%
-
CSI 1.8rCSI 2.2%PRS 41.6%
-
CSI 1.9rCSI 8.9%PRS 58.8%
-
CSI 1.9rCSI 44.8%PRS 41.9%
-
CSI 1.9rCSI 2.6%PRS 58.6%
-
CSI 1.9rCSI 6.0%PRS 57.5%
-
CSI 1.9rCSI 6.8%PRS 40.2%
-
CSI 1.9rCSI 2.4%PRS 57.1%
-
CSI 1.9rCSI 2.7%PRS 56.0%
-
CSI 1.9rCSI 1.7%PRS 61.2%
-
CSI 2.0rCSI 2.2%PRS 63.7%
-
CSI 2.0rCSI 47.6%PRS 40.9%
-
CSI 2.0rCSI 3.0%PRS 61.6%
-
CSI 2.0rCSI 4.6%PRS 49.1%
-
CSI 2.0rCSI 2.8%PRS 53.7%
-
CSI 2.1rCSI 2.2%PRS 63.4%
-
CSI 2.1rCSI 12.4%PRS 43.1%
-
CSI 2.1rCSI 3.1%PRS 65.1%
-
CSI 2.1rCSI 3.5%PRS 65.2%
-
CSI 2.1rCSI 2.1%PRS 62.4%
-
CSI 2.1rCSI 3.5%PRS 49.1%
-
CSI 2.1rCSI 3.4%PRS 63.8%
-
CSI 2.3rCSI 1.8%PRS 46.7%
-
CSI 2.3rCSI 2.9%PRS 52.8%
-
CSI 2.3rCSI 1.8%PRS 66.4%
-
CSI 2.3rCSI 8.6%PRS 52.0%
-
CSI 2.3rCSI 3.7%PRS 52.6%
-
CSI 2.3rCSI 2.1%PRS 60.2%
-
CSI 2.3rCSI 1.6%PRS 79.9%
-
CSI 2.3rCSI 4.4%PRS 48.4%
-
CSI 2.4rCSI 2.2%PRS 68.6%
-
CSI 2.4rCSI 4.1%PRS 49.9%
-
CSI 2.4rCSI 2.0%PRS 61.7%
-
CSI 2.4rCSI 4.9%PRS 49.0%
-
CSI 2.5rCSI 1.7%PRS 62.5%
-
CSI 2.5rCSI 5.8%PRS 51.7%
-
CSI 2.6rCSI 3.1%PRS 57.8%
-
CSI 2.6rCSI 2.1%PRS 70.6%
-
CSI 2.6rCSI 3.4%PRS 43.0%
-
CSI 2.8rCSI 5.0%PRS 40.8%
-
CSI 2.9rCSI 4.5%PRS 67.5%
-
CSI 2.9rCSI 4.7%PRS 43.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3504908248
Symbol: EI2BG_HUMAN
Name: Translation initiation factor eIF2B subunit gamma
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10900014
Title: Identification of eIF2B gamma and eIF2 gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach.
PubMed ID: 10900014
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25858979
Title: Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
PubMed ID: 25858979
PubMed ID: 27023709
Title: Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.
PubMed ID: 27023709
PubMed ID: 31048492
Title: Structural basis for eIF2B inhibition in integrated stress response.
PubMed ID: 31048492
PubMed ID: 11835386
Title: Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter.
PubMed ID: 11835386
DOI: 10.1002/ana.10112
PubMed ID: 19158808
Title: Identification of novel EIF2B mutations in Chinese patients with vanishing white matter disease.
PubMed ID: 19158808
DOI: 10.1038/jhg.2008.10
PubMed ID: 21484434
Title: Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5.
PubMed ID: 21484434
Sequence Information:
- Length: 452
- Mass: 50240
- Checksum: 6F73137F59E52773
- Sequence:
MEFQAVVMAV GGGSRMTDLT SSIPKPLLPV GNKPLIWYPL NLLERVGFEE VIVVTTRDVQ KALCAEFKMK MKPDIVCIPD DADMGTADSL RYIYPKLKTD VLVLSCDLIT DVALHEVVDL FRAYDASLAM LMRKGQDSIE PVPGQKGKKK AVEQRDFIGV DSTGKRLLFM ANEADLDEEL VIKGSILQKH PRIRFHTGLV DAHLYCLKKY IVDFLMENGS ITSIRSELIP YLVRKQFSSA SSQQGQEEKE EDLKKKELKS LDIYSFIKEA NTLNLAPYDA CWNACRGDRW EDLSRSQVRC YVHIMKEGLC SRVSTLGLYM EANRQVPKLL SALCPEEPPV HSSAQIVSKH LVGVDSLIGP ETQIGEKSSI KRSVIGSSCL IKDRVTITNC LLMNSVTVEE GSNIQGSVIC NNAVIEKGAD IKDCLIGSGQ RIEAKAKRVN EVIVGNDQLM EI
Genular Protein ID: 3258226662
Symbol: Q9HA31_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 283
- Mass: 31511
- Checksum: 64906C44D0CB982B
- Sequence:
MANEADLDEE LVIKGSILQK HPRIRFHTGL VDAHLYCLKK YIVDFLMENG SITSIRSELI PYLVRKQFSS ASSQQGQEEK EEDLKKKELK SLDIYSFIKE ANTLNLAPYD ACWNACRGDR WEDLSRSQVR CYVHIMKEGL CSRVSTLGLY MEANRQVPKL LSALCPEEPP VHSSAQIVSK HLVGVDSLIG PETQIGEKSS IKRSVIGSSC LIKDRVTITN CLLMNSVTVE EGSNIQGSVI CNNAVIEKGA DIKDCLIGSG QRIEAKAKRV NEVIVGNDQL MEI