Details for: LRRC28
Gene ID: 123355
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: LRRC28
Ensembl ID: ENSG00000168904
Description: leucine rich repeat containing 28
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 22.63rCSI 54.99%PRS 52.07
-
CSI 13.77rCSI 32.94%PRS 59.14
-
CSI 13.18rCSI 47.42%PRS 51.89
-
CSI 13.02rCSI 49.2%PRS 54.3
-
CSI 12.75rCSI 39.84%PRS 55.61
-
CSI 8.94rCSI 11.12%PRS 51.82
-
CSI 8.2rCSI 48.29%PRS 54.8
-
CSI 7.82rCSI 9.73%PRS 74.05
-
CSI 7.8rCSI 6.85%PRS 77.99
-
CSI 7.79rCSI 13.73%PRS 68.66
-
CSI 7.09rCSI 11.41%PRS 55.6
-
CSI 6.86rCSI 10.48%PRS 76.87
-
CSI 6.41rCSI 7.66%PRS 53.67
-
CSI 5.56rCSI 7.17%PRS 55.13
-
CSI 5.31rCSI 8.91%PRS 53.82
-
CSI 4.96rCSI 11.35%PRS 73.31
-
CSI 4.8rCSI 10.42%PRS 60.07
-
CSI 4.55rCSI 14.96%PRS 58.95
-
CSI 4.5rCSI 7.95%PRS 52.9
-
CSI 4.48rCSI 4.31%PRS 89.34
-
CSI 4.26rCSI 9.4%PRS 58.21
-
CSI 4.21rCSI 9.6%PRS 63.87
-
CSI 4.1rCSI 9.62%PRS 74.46
-
CSI 4.03rCSI 6.5%PRS 73.25
-
CSI 3.88rCSI 6.97%PRS 65.72
-
CSI 3.78rCSI 4.81%PRS 78.16
-
CSI 3.77rCSI 5.6%PRS 73.15
-
CSI 3.76rCSI 5.99%PRS 64.39
-
CSI 3.46rCSI 2.73%PRS 60.03
-
CSI 3.45rCSI 13.48%PRS 49.77
-
CSI 3.42rCSI 10.71%PRS 58.1
-
CSI 3.38rCSI 6.34%PRS 60.43
-
CSI 3.27rCSI 7.54%PRS 60.48
-
CSI 3.22rCSI 2.38%PRS 65.43
-
CSI 3.17rCSI 8.45%PRS 60.59
-
CSI 3.07rCSI 2.69%PRS 80.64
-
CSI 3.07rCSI 2.54%PRS 74.98
-
CSI 3.05rCSI 2.12%PRS 83.98
-
CSI 3rCSI 22.05%PRS 59.23
-
CSI 2.97rCSI 2.68%PRS 70
-
CSI 2.92rCSI 16.85%PRS 70.04
-
CSI 2.9rCSI 5.82%PRS 61.9
-
CSI 2.73rCSI 1.61%PRS 88.57
-
CSI 2.7rCSI 4.13%PRS 73.15
-
CSI 2.66rCSI 3.91%PRS 65.48
-
CSI 2.63rCSI 2.59%PRS 75.28
-
CSI 2.6rCSI 4.26%PRS 61.6
-
CSI 2.59rCSI 6.76%PRS 73.13
-
CSI 2.58rCSI 5.64%PRS 79.12
-
CSI 2.57rCSI 1.98%PRS 74.67
-
CSI 2.56rCSI 8.18%PRS 69.73
-
CSI 2.55rCSI 9.54%PRS 64.53
-
CSI 2.53rCSI 2.64%PRS 70.32
-
CSI 2.51rCSI 60.17%PRS 52.61
-
CSI 2.49rCSI 2.32%PRS 73.35
-
CSI 2.48rCSI 2.01%PRS 74.72
-
CSI 2.48rCSI 6.47%PRS 68.37
-
CSI 2.48rCSI 59.8%PRS 53.23
-
CSI 2.47rCSI 6.03%PRS 65.58
-
CSI 2.46rCSI 2.69%PRS 75.4
-
CSI 2.44rCSI 9.84%PRS 71.77
-
CSI 2.36rCSI 10.83%PRS 79.29
-
CSI 2.35rCSI 6.28%PRS 63.53
-
CSI 2.25rCSI 2.17%PRS 64.68
-
CSI 2.25rCSI 3.06%PRS 63.82
-
CSI 2.24rCSI 2.63%PRS 74.63
-
CSI 2.23rCSI 3.91%PRS 65.27
-
CSI 2.2rCSI 3.81%PRS 63.11
-
CSI 2.16rCSI 4.76%PRS 82.8
-
CSI 2.12rCSI 2.45%PRS 64.86
-
CSI 2.11rCSI 2.71%PRS 63.41
-
CSI 2.08rCSI 3.31%PRS 65.16
-
CSI 2.08rCSI 29.45%PRS 63.27
-
CSI 2.02rCSI 4.99%PRS 71.69
-
CSI 1.98rCSI 4.12%PRS 69.48
-
CSI 1.94rCSI 2.4%PRS 69.83
-
CSI 1.92rCSI 2.92%PRS 69.18
-
CSI 1.9rCSI 7.38%PRS 74.36
-
CSI 1.89rCSI 1.32%PRS 75.73
-
CSI 1.88rCSI 2.28%PRS 55.36
-
CSI 1.83rCSI 3.27%PRS 71.98
-
CSI 1.82rCSI 3.31%PRS 63.59
-
CSI 1.82rCSI 3.61%PRS 68.86
-
CSI 1.82rCSI 2.1%PRS 63.86
-
CSI 1.77rCSI 6.05%PRS 59.87
-
CSI 1.77rCSI 3.96%PRS 54.42
-
CSI 1.76rCSI 8.42%PRS 70
-
CSI 1.71rCSI 4.86%PRS 69.16
-
CSI 1.7rCSI 1.55%PRS 85.6
-
CSI 1.65rCSI 33.62%PRS 62.42
-
CSI 1.65rCSI 6.71%PRS 65.18
-
CSI 1.6rCSI 4.4%PRS 67.41
-
CSI 1.55rCSI 4.05%PRS 73.14
-
CSI 1.51rCSI 3.92%PRS 74.72
-
CSI 1.49rCSI 1.86%PRS 82.86
-
CSI 1.47rCSI 29.88%PRS 63.9
-
CSI 1.38rCSI 2.22%PRS 62.06
-
CSI 1.35rCSI 2.98%PRS 71.46
-
CSI 1.32rCSI 1.89%PRS 61.98
-
CSI 1.31rCSI 3.12%PRS 72.97
-
CSI 0.3rCSI 2.3%PRS 66.2%
-
CSI 0.3rCSI 3.3%PRS 69.9%
-
CSI 0.6rCSI 4.5%PRS 67.8%
-
CSI 0.6rCSI 3.0%PRS 68.3%
-
CSI 0.6rCSI 4.1%PRS 66.8%
-
CSI 0.6rCSI 3.8%PRS 65.7%
-
CSI 0.7rCSI 4.7%PRS 64.7%
-
CSI 0.7rCSI 4.6%PRS 68.4%
-
CSI 0.7rCSI 2.1%PRS 81.8%
-
CSI 0.8rCSI 2.3%PRS 61.6%
-
CSI 0.8rCSI 5.1%PRS 64.0%
-
CSI 0.9rCSI 3.1%PRS 94.2%
-
CSI 0.9rCSI 5.0%PRS 57.9%
-
CSI 0.9rCSI 3.0%PRS 70.1%
-
CSI 1.0rCSI 2.6%PRS 78.7%
-
CSI 1.0rCSI 8.6%PRS 60.8%
-
CSI 1.0rCSI 4.5%PRS 68.2%
-
CSI 1.0rCSI 2.7%PRS 67.6%
-
CSI 1.1rCSI 1.9%PRS 43.2%
-
CSI 1.1rCSI 4.2%PRS 63.0%
-
CSI 1.2rCSI 2.2%PRS 82.2%
-
CSI 1.2rCSI 1.6%PRS 64.7%
-
CSI 1.2rCSI 2.5%PRS 61.0%
-
CSI 1.2rCSI 1.7%PRS 89.4%
-
CSI 1.2rCSI 3.2%PRS 62.4%
-
CSI 1.3rCSI 1.8%PRS 74.5%
-
CSI 1.3rCSI 1.8%PRS 68.9%
-
CSI 1.3rCSI 1.7%PRS 40.3%
-
CSI 1.3rCSI 4.3%PRS 56.8%
-
CSI 1.3rCSI 3.1%PRS 73.0%
-
CSI 1.3rCSI 1.9%PRS 62.0%
-
CSI 1.4rCSI 3.0%PRS 71.5%
-
CSI 1.4rCSI 2.2%PRS 62.1%
-
CSI 1.5rCSI 29.9%PRS 63.9%
-
CSI 1.5rCSI 1.9%PRS 82.9%
-
CSI 1.5rCSI 3.9%PRS 74.7%
-
CSI 1.6rCSI 4.1%PRS 73.1%
-
CSI 1.6rCSI 4.4%PRS 67.4%
-
CSI 1.7rCSI 6.7%PRS 65.2%
-
CSI 1.7rCSI 33.6%PRS 62.4%
-
CSI 1.7rCSI 1.6%PRS 85.6%
-
CSI 1.7rCSI 4.9%PRS 69.2%
-
CSI 1.8rCSI 8.4%PRS 70.0%
-
CSI 1.8rCSI 4.0%PRS 54.4%
-
CSI 1.8rCSI 6.1%PRS 59.9%
-
CSI 1.8rCSI 2.1%PRS 63.9%
-
CSI 1.8rCSI 3.6%PRS 68.9%
-
CSI 1.8rCSI 3.3%PRS 63.6%
-
CSI 1.8rCSI 3.3%PRS 72.0%
-
CSI 1.9rCSI 2.3%PRS 55.4%
-
CSI 1.9rCSI 1.3%PRS 75.7%
-
CSI 1.9rCSI 7.4%PRS 74.4%
-
CSI 1.9rCSI 2.9%PRS 69.2%
-
CSI 1.9rCSI 2.4%PRS 69.8%
-
CSI 2.0rCSI 4.1%PRS 69.5%
-
CSI 2.0rCSI 5.0%PRS 71.7%
-
CSI 2.1rCSI 29.5%PRS 63.3%
-
CSI 2.1rCSI 3.3%PRS 65.2%
-
CSI 2.1rCSI 2.7%PRS 63.4%
-
CSI 2.1rCSI 2.5%PRS 64.9%
-
CSI 2.2rCSI 4.8%PRS 82.8%
-
CSI 2.2rCSI 3.8%PRS 63.1%
-
CSI 2.2rCSI 3.9%PRS 65.3%
-
CSI 2.2rCSI 2.6%PRS 74.6%
-
CSI 2.3rCSI 3.1%PRS 63.8%
-
CSI 2.3rCSI 2.2%PRS 64.7%
-
CSI 2.4rCSI 6.3%PRS 63.5%
-
CSI 2.4rCSI 10.8%PRS 79.3%
-
CSI 2.4rCSI 9.8%PRS 71.8%
-
CSI 2.5rCSI 2.7%PRS 75.4%
-
CSI 2.5rCSI 6.0%PRS 65.6%
-
CSI 2.5rCSI 59.8%PRS 53.2%
-
CSI 2.5rCSI 6.5%PRS 68.4%
-
CSI 2.5rCSI 2.0%PRS 74.7%
-
CSI 2.5rCSI 2.3%PRS 73.4%
-
CSI 2.5rCSI 60.2%PRS 52.6%
-
CSI 2.5rCSI 2.6%PRS 70.3%
-
CSI 2.6rCSI 9.5%PRS 64.5%
-
CSI 2.6rCSI 8.2%PRS 69.7%
-
CSI 2.6rCSI 2.0%PRS 74.7%
-
CSI 2.6rCSI 5.6%PRS 79.1%
-
CSI 2.6rCSI 6.8%PRS 73.1%
-
CSI 2.6rCSI 4.3%PRS 61.6%
-
CSI 2.6rCSI 2.6%PRS 75.3%
-
CSI 2.7rCSI 3.9%PRS 65.5%
-
CSI 2.7rCSI 4.1%PRS 73.2%
-
CSI 2.7rCSI 1.6%PRS 88.6%
-
CSI 2.9rCSI 5.8%PRS 61.9%
-
CSI 2.9rCSI 16.9%PRS 70.0%
-
CSI 3.0rCSI 2.7%PRS 70.0%
-
CSI 3.0rCSI 22.1%PRS 59.2%
-
CSI 3.1rCSI 2.1%PRS 84.0%
-
CSI 3.1rCSI 2.5%PRS 75.0%
-
CSI 3.1rCSI 2.7%PRS 80.6%
-
CSI 3.2rCSI 8.5%PRS 60.6%
-
CSI 3.2rCSI 2.4%PRS 65.4%
-
CSI 3.3rCSI 7.5%PRS 60.5%
-
CSI 3.4rCSI 6.3%PRS 60.4%
-
CSI 3.4rCSI 10.7%PRS 58.1%
-
CSI 3.5rCSI 13.5%PRS 49.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1747824064
Symbol: LRC28_HUMAN
Name: Leucine-rich repeat-containing protein 28
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12975309
Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
PubMed ID: 12975309
DOI: 10.1101/gr.1293003
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 367
- Mass: 41912
- Checksum: C2B00E60BF74ADB0
- Sequence:
MASELCKTIS VARLEKHKNL FLNYRNLHHF PLELLKDEGL QYLERLYMKR NSLTSLPENL AQKLPNLVEL YLHSNNIVVV PEAIGSLVKL QCLDLSDNAL EIVCPEIGRL RALRHLRLAN NQLQFLPPEV GDLKELQTLD ISTNRLLTLP ERLHMCLSLQ YLTVDRNRLW YVPRHLCQLP SLNELSMAGN RLAFLPLDLG RSRELQYVYV DNNIHLKGLP SYLYNKVIGC SGCGAPIQVS EVKLLSFSSG QRTVFLPAEV KAIGTEHDHV LPLQELAMRG LYHTYHSLLK DLNFLSPISL PRSLLELLHC PLGHCHRCSE PMFTIVYPKL FPLRETPMAG LHQWKTTVSF VAYCCSTQCL QTFDLLS
Genular Protein ID: 4096122905
Symbol: B4DHL3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 298
- Mass: 33897
- Checksum: 5C8AD6865BB27C65
- Sequence:
MASELCKTIS VARLEKHKNL FLNYRNLHHF PLELLKDEGL QYLERLYMKR NSLTSLPENL AQKLPNLVEL YLHSNNIVVV PEAIGSLVKL QCLDLSDNAL EIVCPEIGRL RALRHLRLAN NQLQFLPPDL GRSRELQYVY VDNNIHLKGL PSYLYNKVIG CSGCGAPIQV SEVKLLSFSS GQRTVFLPAE VKAIGTEHDH VLPLQELAMR GLYHTYHSLL KDLNFLSPIS LPRSLLELLH CPLGHCHRCS EPMFTIVYPK LFPLRETPMA GLHQWKTTVS FVAYCCSTQC LQTFDLLS
Genular Protein ID: 3138260068
Symbol: Q8NB41_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 213
- Mass: 24193
- Checksum: 6416DEF9565285ED
- Sequence:
MCLSLQYLTV DRNRLWYVPR HLCQLPSLNE LSMAGNRLAF LPLDLGRSRE LQYVYVDNNI HLKGLPSYLY NKVIGCSGCG APIQVSEVKL LSFSSGQRTV FLPAEVKAIG TEHDHVLPLQ ELAMRGLYHT YHSLLKDLNF LSPISLPRSL LELLHCPLGH CHRCSEPMFT IVYPKLFPLR ETPMAGLHQW KTTVSFVAYC CSTQCLQTFD LLS