Details for: TWF1
Gene ID: 5756
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: TWF1
Ensembl ID: ENSG00000151239
Description: twinfilin actin binding protein 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 11.25rCSI 9.89%PRS 46.01
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CSI 9.66rCSI 11.76%PRS 65.67
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CSI 8.47rCSI 20.96%PRS 56.38
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CSI 6.74rCSI 10.18%PRS 61.64
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CSI 6.1rCSI 9.01%PRS 74.28
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CSI 5.48rCSI 5.27%PRS 80.03
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CSI 5.44rCSI 13.79%PRS 47.61
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CSI 4.65rCSI 6.8%PRS 62.16
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CSI 4.19rCSI 6.41%PRS 67.29
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CSI 3.62rCSI 3.17%PRS 67.88
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CSI 3.53rCSI 3.69%PRS 54.48
-
CSI 3.44rCSI 2.41%PRS 60.67
-
CSI 3.36rCSI 2.61%PRS 59.54
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CSI 3.32rCSI 5.09%PRS 66.67
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CSI 3.28rCSI 4.54%PRS 59.78
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CSI 3.26rCSI 16.37%PRS 70.43
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CSI 3.21rCSI 4.38%PRS 30.21
-
CSI 3.19rCSI 2.51%PRS 64.59
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CSI 3.18rCSI 3.79%PRS 40.06
-
CSI 3.11rCSI 2.69%PRS 64.11
-
CSI 3.04rCSI 2.31%PRS 70.8
-
CSI 2.96rCSI 12.98%PRS 73.72
-
CSI 2.93rCSI 2.21%PRS 71.63
-
CSI 2.81rCSI 2.11%PRS 62.98
-
CSI 2.78rCSI 2.14%PRS 58.04
-
CSI 2.76rCSI 2.29%PRS 56.95
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CSI 2.73rCSI 1.9%PRS 68.67
-
CSI 2.72rCSI 2.68%PRS 60.67
-
CSI 2.69rCSI 8.74%PRS 58.94
-
CSI 2.61rCSI 2.52%PRS 58.28
-
CSI 2.57rCSI 3.18%PRS 54.22
-
CSI 2.53rCSI 2.93%PRS 66.15
-
CSI 2.52rCSI 4%PRS 69.23
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CSI 2.45rCSI 4.92%PRS 47.22
-
CSI 2.38rCSI 2.49%PRS 58.2
-
CSI 2.37rCSI 2.43%PRS 73.42
-
CSI 2.37rCSI 3.17%PRS 67.07
-
CSI 2.37rCSI 2.36%PRS 51.38
-
CSI 2.36rCSI 2.28%PRS 48.54
-
CSI 2.36rCSI 4.16%PRS 39.22
-
CSI 2.35rCSI 2.47%PRS 61.46
-
CSI 2.32rCSI 2.96%PRS 64.31
-
CSI 2.3rCSI 3.51%PRS 58.65
-
CSI 2.28rCSI 2.15%PRS 57.69
-
CSI 2.28rCSI 3.03%PRS 64.23
-
CSI 2.25rCSI 4.28%PRS 73.44
-
CSI 2.23rCSI 3.32%PRS 59.69
-
CSI 2.2rCSI 2.05%PRS 58.16
-
CSI 2.19rCSI 2.02%PRS 59.11
-
CSI 2.18rCSI 2.97%PRS 63.74
-
CSI 2.14rCSI 3.46%PRS 54.95
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CSI 2.1rCSI 2.87%PRS 65.78
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CSI 2.1rCSI 3.96%PRS 68.66
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CSI 2.08rCSI 4.04%PRS 60.69
-
CSI 2.07rCSI 1.4%PRS 70.93
-
CSI 2.06rCSI 6.61%PRS 63.54
-
CSI 2.05rCSI 6.05%PRS 61.24
-
CSI 2.04rCSI 1.61%PRS 44.94
-
CSI 2.03rCSI 1.65%PRS 58.59
-
CSI 2.02rCSI 3.64%PRS 51.08
-
CSI 1.99rCSI 3.05%PRS 55.15
-
CSI 1.98rCSI 4.7%PRS 62.23
-
CSI 1.97rCSI 2.31%PRS 74.35
-
CSI 1.95rCSI 1.64%PRS 62.78
-
CSI 1.91rCSI 1.58%PRS 59.71
-
CSI 1.9rCSI 2.02%PRS 69.13
-
CSI 1.88rCSI 2.36%PRS 68.32
-
CSI 1.84rCSI 2.84%PRS 55.98
-
CSI 1.81rCSI 2.46%PRS 50.11
-
CSI 1.79rCSI 2.57%PRS 62.38
-
CSI 1.79rCSI 1.59%PRS 55.99
-
CSI 1.78rCSI 1.86%PRS 56.2
-
CSI 1.77rCSI 2.2%PRS 59.97
-
CSI 1.72rCSI 1.5%PRS 68.49
-
CSI 1.7rCSI 2.45%PRS 69.32
-
CSI 1.7rCSI 2.12%PRS 38.34
-
CSI 1.67rCSI 2.15%PRS 55.44
-
CSI 1.66rCSI 2.43%PRS 54.61
-
CSI 1.66rCSI 1.53%PRS 77.69
-
CSI 1.64rCSI 1.32%PRS 59.27
-
CSI 1.62rCSI 1.66%PRS 71.32
-
CSI 1.61rCSI 1.72%PRS 56.99
-
CSI 1.48rCSI 2.16%PRS 69.62
-
CSI 1.44rCSI 3.65%PRS 52.44
-
CSI 1.42rCSI 1.94%PRS 59.86
-
CSI 1.42rCSI 2.66%PRS 74.36
-
CSI 1.42rCSI 1.64%PRS 48.07
-
CSI 1.38rCSI 1.92%PRS 56.91
-
CSI 1.37rCSI 3%PRS 66.64
-
CSI 1.34rCSI 2.95%PRS 71.28
-
CSI 1.32rCSI 3.77%PRS 71.81
-
CSI 1.31rCSI 2%PRS 62.21
-
CSI 1.3rCSI 4.06%PRS 41.69
-
CSI 1.29rCSI 1.33%PRS 63.63
-
CSI 1.28rCSI 1.95%PRS 71.91
-
CSI 1.27rCSI 2.05%PRS 62.43
-
CSI 1.25rCSI 1.99%PRS 50.92
-
CSI 1.24rCSI 2.02%PRS 29.93
-
CSI 1.21rCSI 1.44%PRS 77.76
-
CSI 1.19rCSI 1.91%PRS 47.7
-
CSI 0.2rCSI 2.3%PRS 74.1%
-
CSI 0.3rCSI 1.9%PRS 67.8%
-
CSI 0.4rCSI 0.5%PRS 46.6%
-
CSI 0.4rCSI 3.2%PRS 75.1%
-
CSI 0.4rCSI 4.3%PRS 77.0%
-
CSI 0.4rCSI 1.9%PRS 71.0%
-
CSI 0.5rCSI 3.0%PRS 67.6%
-
CSI 0.5rCSI 2.0%PRS 71.6%
-
CSI 0.5rCSI 1.2%PRS 54.9%
-
CSI 0.6rCSI 2.0%PRS 67.7%
-
CSI 0.6rCSI 3.2%PRS 70.9%
-
CSI 0.6rCSI 1.8%PRS 59.5%
-
CSI 0.7rCSI 1.6%PRS 65.6%
-
CSI 0.8rCSI 2.7%PRS 71.1%
-
CSI 0.8rCSI 2.2%PRS 70.2%
-
CSI 0.8rCSI 12.5%PRS 76.8%
-
CSI 0.9rCSI 2.0%PRS 67.8%
-
CSI 0.9rCSI 1.8%PRS 70.1%
-
CSI 0.9rCSI 1.3%PRS 64.0%
-
CSI 1.0rCSI 1.3%PRS 41.4%
-
CSI 1.0rCSI 1.6%PRS 54.3%
-
CSI 1.1rCSI 2.4%PRS 56.0%
-
CSI 1.1rCSI 3.2%PRS 72.4%
-
CSI 1.1rCSI 2.0%PRS 33.9%
-
CSI 1.1rCSI 2.6%PRS 71.3%
-
CSI 1.1rCSI 2.5%PRS 72.9%
-
CSI 1.2rCSI 5.0%PRS 71.3%
-
CSI 1.2rCSI 1.4%PRS 60.5%
-
CSI 1.2rCSI 1.9%PRS 47.7%
-
CSI 1.2rCSI 1.4%PRS 77.8%
-
CSI 1.2rCSI 2.0%PRS 29.9%
-
CSI 1.3rCSI 2.0%PRS 50.9%
-
CSI 1.3rCSI 2.1%PRS 62.4%
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CSI 1.3rCSI 2.0%PRS 71.9%
-
CSI 1.3rCSI 1.3%PRS 63.6%
-
CSI 1.3rCSI 4.1%PRS 41.7%
-
CSI 1.3rCSI 2.0%PRS 62.2%
-
CSI 1.3rCSI 3.8%PRS 71.8%
-
CSI 1.3rCSI 3.0%PRS 71.3%
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CSI 1.4rCSI 3.0%PRS 66.6%
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CSI 1.4rCSI 1.9%PRS 56.9%
-
CSI 1.4rCSI 1.6%PRS 48.1%
-
CSI 1.4rCSI 2.7%PRS 74.4%
-
CSI 1.4rCSI 1.9%PRS 59.9%
-
CSI 1.4rCSI 3.7%PRS 52.4%
-
CSI 1.5rCSI 2.2%PRS 69.6%
-
CSI 1.6rCSI 1.7%PRS 57.0%
-
CSI 1.6rCSI 1.7%PRS 71.3%
-
CSI 1.6rCSI 1.3%PRS 59.3%
-
CSI 1.7rCSI 1.5%PRS 77.7%
-
CSI 1.7rCSI 2.4%PRS 54.6%
-
CSI 1.7rCSI 2.2%PRS 55.4%
-
CSI 1.7rCSI 2.1%PRS 38.3%
-
CSI 1.7rCSI 2.5%PRS 69.3%
-
CSI 1.7rCSI 1.5%PRS 68.5%
-
CSI 1.8rCSI 2.2%PRS 60.0%
-
CSI 1.8rCSI 1.9%PRS 56.2%
-
CSI 1.8rCSI 1.6%PRS 56.0%
-
CSI 1.8rCSI 2.6%PRS 62.4%
-
CSI 1.8rCSI 2.5%PRS 50.1%
-
CSI 1.8rCSI 2.8%PRS 56.0%
-
CSI 1.9rCSI 2.4%PRS 68.3%
-
CSI 1.9rCSI 2.0%PRS 69.1%
-
CSI 1.9rCSI 1.6%PRS 59.7%
-
CSI 2.0rCSI 1.6%PRS 62.8%
-
CSI 2.0rCSI 2.3%PRS 74.4%
-
CSI 2.0rCSI 4.7%PRS 62.2%
-
CSI 2.0rCSI 3.1%PRS 55.2%
-
CSI 2.0rCSI 3.6%PRS 51.1%
-
CSI 2.0rCSI 1.7%PRS 58.6%
-
CSI 2.0rCSI 1.6%PRS 44.9%
-
CSI 2.1rCSI 6.1%PRS 61.2%
-
CSI 2.1rCSI 6.6%PRS 63.5%
-
CSI 2.1rCSI 1.4%PRS 70.9%
-
CSI 2.1rCSI 4.0%PRS 60.7%
-
CSI 2.1rCSI 4.0%PRS 68.7%
-
CSI 2.1rCSI 2.9%PRS 65.8%
-
CSI 2.1rCSI 3.5%PRS 55.0%
-
CSI 2.2rCSI 3.0%PRS 63.7%
-
CSI 2.2rCSI 2.0%PRS 59.1%
-
CSI 2.2rCSI 2.1%PRS 58.2%
-
CSI 2.2rCSI 3.3%PRS 59.7%
-
CSI 2.3rCSI 4.3%PRS 73.4%
-
CSI 2.3rCSI 3.0%PRS 64.2%
-
CSI 2.3rCSI 2.2%PRS 57.7%
-
CSI 2.3rCSI 3.5%PRS 58.7%
-
CSI 2.3rCSI 3.0%PRS 64.3%
-
CSI 2.4rCSI 2.5%PRS 61.5%
-
CSI 2.4rCSI 4.2%PRS 39.2%
-
CSI 2.4rCSI 2.3%PRS 48.5%
-
CSI 2.4rCSI 2.4%PRS 51.4%
-
CSI 2.4rCSI 3.2%PRS 67.1%
-
CSI 2.4rCSI 2.4%PRS 73.4%
-
CSI 2.4rCSI 2.5%PRS 58.2%
-
CSI 2.5rCSI 4.9%PRS 47.2%
-
CSI 2.5rCSI 4.0%PRS 69.2%
-
CSI 2.5rCSI 2.9%PRS 66.2%
-
CSI 2.6rCSI 3.2%PRS 54.2%
-
CSI 2.6rCSI 2.5%PRS 58.3%
-
CSI 2.7rCSI 8.7%PRS 58.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 4147383289
Symbol: TWF1_HUMAN
Name: Twinfilin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7507208
Title: Prokaryotic expression cloning of a novel human tyrosine kinase.
PubMed ID: 7507208
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28493397
Title: A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma.
PubMed ID: 28493397
DOI: 10.1002/humu.23246
Sequence Information:
- Length: 350
- Mass: 40283
- Checksum: 5F68A6946E969A80
- Sequence:
MSHQTGIQAS EDVKEIFARA RNGKYRLLKI SIENEQLVIG SYSQPSDSWD KDYDSFVLPL LEDKQPCYIL FRLDSQNAQG YEWIFIAWSP DHSHVRQKML YAATRATLKK EFGGGHIKDE VFGTVKEDVS LHGYKKYLLS QSSPAPLTAA EEELRQIKIN EVQTDVGVDT KHQTLQGVAF PISREAFQAL EKLNNRQLNY VQLEIDIKNE IIILANTTNT ELKDLPKRIP KDSARYHFFL YKHSHEGDYL ESIVFIYSMP GYTCSIRERM LYSSCKSRLL EIVERQLQMD VIRKIEIDNG DELTADFLYE EVHPKQHAHK QSFAKPKGPA GKRGIRRLIR GPAETEATTD