Details for: EMB

Gene ID: 133418

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: EMB

Ensembl ID: ENSG00000170571

Description: embigin

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • retinal cone cell CL0000573
    CSI 24.6
    rCSI 39.59%
    PRS 49.92
  • mature T cell CL0002419
    CSI 16.22
    rCSI 12.61%
    PRS 78.34
  • retinal ganglion cell CL0000740
    CSI 14.58
    rCSI 32.21%
    PRS 46.59
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 10.27
    rCSI 6.92%
    PRS 73.49
  • ciliated epithelial cell CL0000067
    CSI 9.98
    rCSI 8.78%
    PRS 48.13
  • activated type II NK T cell CL0000931
    CSI 9.61
    rCSI 10.82%
    PRS 76.68
  • hematopoietic stem cell CL0000037
    CSI 9.54
    rCSI 6.34%
    PRS 63.42
  • myelocyte CL0002193
    CSI 9.34
    rCSI 61.38%
    PRS 85.76
  • type B pancreatic cell CL0000169
    CSI 9.04
    rCSI 20.01%
    PRS 58.18
  • IgA plasma cell CL0000987
    CSI 7.75
    rCSI 7.94%
    PRS 75.17
  • granulocyte monocyte progenitor cell CL0000557
    CSI 6.99
    rCSI 6.05%
    PRS 65.29
  • club cell CL0000158
    CSI 6.51
    rCSI 9.54%
    PRS 56.55
  • dendritic cell, human CL0001056
    CSI 6.03
    rCSI 9.26%
    PRS 69.33
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 5.8
    rCSI 21.91%
    PRS 43
  • helper T cell CL0000912
    CSI 5.13
    rCSI 7.25%
    PRS 65.84
  • pancreatic D cell CL0000173
    CSI 4.77
    rCSI 4.7%
    PRS 62.91
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 4.48
    rCSI 10.71%
    PRS 47.57
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 4.35
    rCSI 6.78%
    PRS 84.24
  • unswitched memory B cell CL0000970
    CSI 4.34
    rCSI 3.65%
    PRS 77.39
  • naive B cell CL0000788
    CSI 4.28
    rCSI 3.67%
    PRS 68.48
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 4.08
    rCSI 2.86%
    PRS 78.69
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 3.99
    rCSI 4.16%
    PRS 82.72
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 3.92
    rCSI 3.14%
    PRS 80.77
  • neutrophil CL0000775
    CSI 3.91
    rCSI 21.87%
    PRS 67.37
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 3.69
    rCSI 2.65%
    PRS 74.75
  • naive T cell CL0000898
    CSI 3.67
    rCSI 2.56%
    PRS 75.57
  • pro-B cell CL0000826
    CSI 3.65
    rCSI 3.02%
    PRS 62.36
  • ON midget ganglion cell CL4033046
    CSI 3.63
    rCSI 73.87%
    PRS 51.33
  • OFF midget ganglion cell CL4033047
    CSI 3.61
    rCSI 73.57%
    PRS 52.59
  • mononuclear phagocyte CL0000113
    CSI 3.61
    rCSI 7.94%
    PRS 64.6
  • small intestine goblet cell CL1000495
    CSI 3.53
    rCSI 7.74%
    PRS 68.51
  • mature NK T cell CL0000814
    CSI 3.46
    rCSI 4.42%
    PRS 81.79
  • hematopoietic precursor cell CL0008001
    CSI 3.43
    rCSI 3.53%
    PRS 76.88
  • mature alpha-beta T cell CL0000791
    CSI 3.38
    rCSI 12.22%
    PRS 80
  • mucosal invariant T cell CL0000940
    CSI 3.28
    rCSI 2.65%
    PRS 70.96
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 3.22
    rCSI 8.33%
    PRS 85.49
  • T follicular helper cell CL0002038
    CSI 3.19
    rCSI 2.38%
    PRS 75.54
  • myeloid leukocyte CL0000766
    CSI 3.19
    rCSI 2.94%
    PRS 61.82
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 3.18
    rCSI 3.84%
    PRS 69.11
  • alpha-beta T cell CL0000789
    CSI 3.06
    rCSI 3.59%
    PRS 76.82
  • natural T-regulatory cell CL0000903
    CSI 2.91
    rCSI 5.51%
    PRS 88.47
  • CD14-positive monocyte CL0001054
    CSI 2.89
    rCSI 3.59%
    PRS 71.16
  • early lymphoid progenitor CL0000936
    CSI 2.84
    rCSI 2.49%
    PRS 65.79
  • granulocyte CL0000094
    CSI 2.8
    rCSI 4.28%
    PRS 69.81
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.8
    rCSI 2.53%
    PRS 57.1
  • memory B cell CL0000787
    CSI 2.75
    rCSI 2.71%
    PRS 84.04
  • ciliated cell CL0000064
    CSI 2.74
    rCSI 4.44%
    PRS 56.92
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 2.72
    rCSI 2.04%
    PRS 86.5
  • immature B cell CL0000816
    CSI 2.72
    rCSI 2.02%
    PRS 73.68
  • pancreatic A cell CL0000171
    CSI 2.6
    rCSI 2.72%
    PRS 63.93
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 2.58
    rCSI 6.26%
    PRS 40.79
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 2.56
    rCSI 6.91%
    PRS 67.75
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 2.51
    rCSI 2.32%
    PRS 79.88
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 2.5
    rCSI 1.9%
    PRS 73.33
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.5
    rCSI 2.45%
    PRS 76.19
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 2.49
    rCSI 15.07%
    PRS 79.24
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 2.49
    rCSI 3.42%
    PRS 80.12
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.47
    rCSI 1.72%
    PRS 62.99
  • secretory cell CL0000151
    CSI 2.39
    rCSI 2.49%
    PRS 60.58
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 2.31
    rCSI 1.54%
    PRS 80.54
  • epithelial cell of lung CL0000082
    CSI 2.31
    rCSI 1.91%
    PRS 59.31
  • double negative thymocyte CL0002489
    CSI 2.23
    rCSI 1.55%
    PRS 71.34
  • inflammatory macrophage CL0000863
    CSI 2.21
    rCSI 3.77%
    PRS 83.35
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 2.18
    rCSI 8.5%
    PRS 80.37
  • antibody secreting cell CL0000946
    CSI 2.16
    rCSI 9.6%
    PRS 91.46
  • enterocyte CL0000584
    CSI 2.08
    rCSI 3.35%
    PRS 64.24
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.06
    rCSI 5.37%
    PRS 60.15
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 2.05
    rCSI 1.21%
    PRS 77.72
  • lung interstitial macrophage CL4033043
    CSI 2.01
    rCSI 4.52%
    PRS 78.18
  • erythrocyte CL0000232
    CSI 1.99
    rCSI 4.52%
    PRS 64.38
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.99
    rCSI 2.38%
    PRS 41.97
  • CD4-positive helper T cell CL0000492
    CSI 1.99
    rCSI 1.5%
    PRS 74.21
  • precursor B cell CL0000817
    CSI 1.98
    rCSI 1.74%
    PRS 70.12
  • colonocyte CL1000347
    CSI 1.97
    rCSI 2.82%
    PRS 64.34
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.94
    rCSI 7%
    PRS 40.6
  • promyelocyte CL0000836
    CSI 1.92
    rCSI 2.77%
    PRS 69.89
  • group 3 innate lymphoid cell CL0001071
    CSI 1.91
    rCSI 1.43%
    PRS 65.78
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.87
    rCSI 2.23%
    PRS 79.98
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 1.86
    rCSI 2.54%
    PRS 84.73
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 1.85
    rCSI 1.82%
    PRS 81.89
  • multi-ciliated epithelial cell CL0005012
    CSI 1.82
    rCSI 1.82%
    PRS 53.49
  • placental villous trophoblast CL2000060
    CSI 1.8
    rCSI 2.79%
    PRS 58.36
  • class switched memory B cell CL0000972
    CSI 1.8
    rCSI 1.35%
    PRS 77.12
  • common lymphoid progenitor CL0000051
    CSI 1.8
    rCSI 2.4%
    PRS 81.17
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 1.79
    rCSI 1.63%
    PRS 75.11
  • ON parasol ganglion cell CL4033052
    CSI 1.78
    rCSI 25.27%
    PRS 51.55
  • respiratory suprabasal cell CL4033048
    CSI 1.73
    rCSI 2.22%
    PRS 65.03
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.72
    rCSI 2.25%
    PRS 73.95
  • fraction A pre-pro B cell CL0002045
    CSI 1.71
    rCSI 1.96%
    PRS 79.18
  • respiratory hillock cell CL4030023
    CSI 1.71
    rCSI 3.05%
    PRS 73.79
  • common myeloid progenitor CL0000049
    CSI 1.64
    rCSI 1.32%
    PRS 61.64
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 1.63
    rCSI 3.92%
    PRS 78.09
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 1.63
    rCSI 9.6%
    PRS 43.44
  • lung macrophage CL1001603
    CSI 1.56
    rCSI 3.49%
    PRS 68.1
  • intermediate monocyte CL0002393
    CSI 1.54
    rCSI 2.32%
    PRS 64.39
  • medium spiny neuron CL1001474
    CSI 1.53
    rCSI 13.18%
    PRS 47.63
  • respiratory basal cell CL0002633
    CSI 1.48
    rCSI 1.54%
    PRS 65.76
  • alternatively activated macrophage CL0000890
    CSI 1.48
    rCSI 1.86%
    PRS 72.4
  • adipocyte CL0000136
    CSI 1.47
    rCSI 1.88%
    PRS 53.12
  • plasmablast CL0000980
    CSI 1.46
    rCSI 1.15%
    PRS 67.03
  • pre-conventional dendritic cell CL0002010
    CSI 0.2
    rCSI 2.2%
    PRS 86.6%
  • cytotoxic T cell CL0000910
    CSI 0.2
    rCSI 1.3%
    PRS 69.9%
  • central nervous system neuron CL2000029
    CSI 0.3
    rCSI 1.9%
    PRS 47.1%
  • erythroid progenitor cell CL0000038
    CSI 0.3
    rCSI 1.6%
    PRS 69.6%
  • direct pathway medium spiny neuron CL4023026
    CSI 0.4
    rCSI 8.3%
    PRS 41.3%
  • megakaryocyte CL0000556
    CSI 0.4
    rCSI 1.8%
    PRS 72.9%
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.4
    rCSI 10.7%
    PRS 42.2%
  • colon macrophage CL0009038
    CSI 0.5
    rCSI 2.3%
    PRS 79.1%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.5
    rCSI 1.6%
    PRS 43.7%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 0.5
    rCSI 1.2%
    PRS 56.8%
  • transit amplifying cell of small intestine CL0009012
    CSI 0.5
    rCSI 2.4%
    PRS 75.2%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 0.6
    rCSI 2.8%
    PRS 72.9%
  • paneth cell of epithelium of small intestine CL1000343
    CSI 0.6
    rCSI 1.8%
    PRS 71.9%
  • large pre-B-II cell CL0000957
    CSI 0.7
    rCSI 1.9%
    PRS 72.2%
  • dopaminergic neuron CL0000700
    CSI 0.7
    rCSI 4.2%
    PRS 45.4%
  • transitional stage B cell CL0000818
    CSI 0.8
    rCSI 2.6%
    PRS 86.1%
  • myeloid dendritic cell CL0000782
    CSI 0.8
    rCSI 1.2%
    PRS 76.3%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 0.9
    rCSI 1.5%
    PRS 41.2%
  • promonocyte CL0000559
    CSI 0.9
    rCSI 1.5%
    PRS 69.2%
  • tissue-resident macrophage CL0000864
    CSI 0.9
    rCSI 4.2%
    PRS 76.9%
  • lung ciliated cell CL1000271
    CSI 1.0
    rCSI 1.1%
    PRS 50.3%
  • intestinal epithelial cell CL0002563
    CSI 1.0
    rCSI 1.0%
    PRS 58.4%
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 1.0
    rCSI 1.7%
    PRS 78.5%
  • intestine goblet cell CL0019031
    CSI 1.0
    rCSI 0.9%
    PRS 58.4%
  • duct epithelial cell CL0000068
    CSI 1.0
    rCSI 1.5%
    PRS 64.7%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.1
    rCSI 1.3%
    PRS 48.0%
  • T-helper 1 cell CL0000545
    CSI 1.1
    rCSI 1.9%
    PRS 82.5%
  • enterocyte of epithelium of small intestine CL1000334
    CSI 1.1
    rCSI 16.4%
    PRS 78.0%
  • nasal mucosa goblet cell CL0002480
    CSI 1.1
    rCSI 1.3%
    PRS 68.1%
  • elicited macrophage CL0000861
    CSI 1.1
    rCSI 1.0%
    PRS 69.2%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 1.1
    rCSI 3.3%
    PRS 80.1%
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.2
    rCSI 1.5%
    PRS 43.4%
  • small pre-B-II cell CL0000954
    CSI 1.2
    rCSI 1.2%
    PRS 81.9%
  • vascular leptomeningeal cell CL4023051
    CSI 1.2
    rCSI 2.1%
    PRS 52.3%
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 1.3
    rCSI 6.6%
    PRS 81.8%
  • mature B cell CL0000785
    CSI 1.3
    rCSI 1.1%
    PRS 71.1%
  • conjunctival epithelial cell CL1000432
    CSI 1.3
    rCSI 2.0%
    PRS 60.9%
  • regulatory T cell CL0000815
    CSI 1.4
    rCSI 1.6%
    PRS 71.6%
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 1.4
    rCSI 2.7%
    PRS 78.0%
  • mesothelial cell CL0000077
    CSI 1.4
    rCSI 5.4%
    PRS 37.1%
  • innate lymphoid cell CL0001065
    CSI 1.4
    rCSI 2.9%
    PRS 62.3%
  • common dendritic progenitor CL0001029
    CSI 1.4
    rCSI 1.8%
    PRS 70.8%
  • T-helper 17 cell CL0000899
    CSI 1.4
    rCSI 1.2%
    PRS 81.9%
  • memory T cell CL0000813
    CSI 1.5
    rCSI 2.8%
    PRS 86.3%
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.5
    rCSI 1.8%
    PRS 40.3%
  • plasmablast CL0000980
    CSI 1.5
    rCSI 1.2%
    PRS 67.0%
  • adipocyte CL0000136
    CSI 1.5
    rCSI 1.9%
    PRS 53.1%
  • alternatively activated macrophage CL0000890
    CSI 1.5
    rCSI 1.9%
    PRS 72.4%
  • respiratory basal cell CL0002633
    CSI 1.5
    rCSI 1.5%
    PRS 65.8%
  • medium spiny neuron CL1001474
    CSI 1.5
    rCSI 13.2%
    PRS 47.6%
  • intermediate monocyte CL0002393
    CSI 1.5
    rCSI 2.3%
    PRS 64.4%
  • lung macrophage CL1001603
    CSI 1.6
    rCSI 3.5%
    PRS 68.1%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 1.6
    rCSI 9.6%
    PRS 43.4%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 1.6
    rCSI 3.9%
    PRS 78.1%
  • common myeloid progenitor CL0000049
    CSI 1.6
    rCSI 1.3%
    PRS 61.6%
  • respiratory hillock cell CL4030023
    CSI 1.7
    rCSI 3.1%
    PRS 73.8%
  • fraction A pre-pro B cell CL0002045
    CSI 1.7
    rCSI 2.0%
    PRS 79.2%
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.7
    rCSI 2.3%
    PRS 74.0%
  • respiratory suprabasal cell CL4033048
    CSI 1.7
    rCSI 2.2%
    PRS 65.0%
  • ON parasol ganglion cell CL4033052
    CSI 1.8
    rCSI 25.3%
    PRS 51.6%
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 1.8
    rCSI 1.6%
    PRS 75.1%
  • common lymphoid progenitor CL0000051
    CSI 1.8
    rCSI 2.4%
    PRS 81.2%
  • class switched memory B cell CL0000972
    CSI 1.8
    rCSI 1.4%
    PRS 77.1%
  • placental villous trophoblast CL2000060
    CSI 1.8
    rCSI 2.8%
    PRS 58.4%
  • multi-ciliated epithelial cell CL0005012
    CSI 1.8
    rCSI 1.8%
    PRS 53.5%
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 1.9
    rCSI 1.8%
    PRS 81.9%
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 1.9
    rCSI 2.5%
    PRS 84.7%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.9
    rCSI 2.2%
    PRS 80.0%
  • group 3 innate lymphoid cell CL0001071
    CSI 1.9
    rCSI 1.4%
    PRS 65.8%
  • promyelocyte CL0000836
    CSI 1.9
    rCSI 2.8%
    PRS 69.9%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.9
    rCSI 7.0%
    PRS 40.6%
  • colonocyte CL1000347
    CSI 2.0
    rCSI 2.8%
    PRS 64.3%
  • precursor B cell CL0000817
    CSI 2.0
    rCSI 1.7%
    PRS 70.1%
  • CD4-positive helper T cell CL0000492
    CSI 2.0
    rCSI 1.5%
    PRS 74.2%
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.0
    rCSI 2.4%
    PRS 42.0%
  • erythrocyte CL0000232
    CSI 2.0
    rCSI 4.5%
    PRS 64.4%
  • lung interstitial macrophage CL4033043
    CSI 2.0
    rCSI 4.5%
    PRS 78.2%
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 2.1
    rCSI 1.2%
    PRS 77.7%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.1
    rCSI 5.4%
    PRS 60.2%
  • enterocyte CL0000584
    CSI 2.1
    rCSI 3.4%
    PRS 64.2%
  • antibody secreting cell CL0000946
    CSI 2.2
    rCSI 9.6%
    PRS 91.5%
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 2.2
    rCSI 8.5%
    PRS 80.4%
  • inflammatory macrophage CL0000863
    CSI 2.2
    rCSI 3.8%
    PRS 83.4%
  • double negative thymocyte CL0002489
    CSI 2.2
    rCSI 1.6%
    PRS 71.3%
  • epithelial cell of lung CL0000082
    CSI 2.3
    rCSI 1.9%
    PRS 59.3%
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 2.3
    rCSI 1.5%
    PRS 80.5%
  • secretory cell CL0000151
    CSI 2.4
    rCSI 2.5%
    PRS 60.6%
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.5
    rCSI 1.7%
    PRS 63.0%
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 2.5
    rCSI 3.4%
    PRS 80.1%
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 2.5
    rCSI 15.1%
    PRS 79.2%
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.5
    rCSI 2.5%
    PRS 76.2%
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 2.5
    rCSI 1.9%
    PRS 73.3%
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 2.5
    rCSI 2.3%
    PRS 79.9%
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 2.6
    rCSI 6.9%
    PRS 67.8%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 2.6
    rCSI 6.3%
    PRS 40.8%
  • pancreatic A cell CL0000171
    CSI 2.6
    rCSI 2.7%
    PRS 63.9%
  • immature B cell CL0000816
    CSI 2.7
    rCSI 2.0%
    PRS 73.7%
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 2.7
    rCSI 2.0%
    PRS 86.5%
  • ciliated cell CL0000064
    CSI 2.7
    rCSI 4.4%
    PRS 56.9%
  • memory B cell CL0000787
    CSI 2.8
    rCSI 2.7%
    PRS 84.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [EMB](/details-gene/133418), or embigin, is a protein-coding gene located on chromosome 5q11.1 that encodes a transmembrane glycoprotein. Functionally, it is characterized as a cell adhesion molecule and is also involved in the transport of small molecules, particularly monocarboxylates like lactate. Expression data indicates that [EMB](/details-gene/133418) has a broad but significant role across diverse and highly specialized cell types. It shows high significance in the nervous system, particularly in [retinal cone cell](/details-cell/CL0000573) and [retinal ganglion cell](/details-cell/CL0000740), as well as throughout the adaptive immune system, with prominent expression in [mature T cell](/details-cell/CL0002419) populations. This wide-ranging expression profile suggests that [EMB](/details-gene/133418) may mediate fundamental cellular processes common to multiple lineages, such as cell-cell interaction and metabolic transport. ## Cellular Roles and Expression Landscape The expression profile of [EMB](/details-gene/133418) highlights its importance in several distinct physiological systems. **Overall**, the gene shows the highest significance in cells of the retina, immune system, and hematopoietic lineage. - **Nervous System and Sensory Function:** [EMB](/details-gene/133418) is a top marker in both [retinal cone cell](/details-cell/CL0000573) (CSI: 24.60) and [retinal ganglion cell](/details-cell/CL0000740) (CSI: 14.58), suggesting a critical role in the structure or function of the visual system. Its notable expression in [near-projecting glutamatergic cortical neuron](/details-cell/CL4023012) further supports a role in neuronal biology, which is consistent with its annotated function in axon guidance. - **Immune System Regulation:** The gene is highly significant across multiple lymphocyte populations. This includes [mature T cell](/details-cell/CL0002419) (CSI: 16.22), [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 10.27), [activated type II NK T cell](/details-cell/CL0000931) (CSI: 9.61), and [helper T cell](/details-cell/CL0000912) (CSI: 5.13). Its significance extends to [IgA plasma cell](/details-cell/CL0000987) and [dendritic cell, human](/details-cell/CL0001056), indicating a potential role in both adaptive and innate immune cell interactions and functions. - **Hematopoiesis and Epithelial Function:** [EMB](/details-gene/133418) is also a significant marker in progenitor populations, including [hematopoietic stem cell](/details-cell/CL0000037) and [granulocyte monocyte progenitor cell](/details-cell/CL0000557). This suggests a role during the early stages of blood cell development. Furthermore, its expression in secretory and barrier cells like [ciliated epithelial cell](/details-cell/CL0000067), [type B pancreatic cell](/details-cell/CL0000169), and [club cell](/details-cell/CL0000158) indicates its functional relevance outside of the nervous and immune systems. The broad expression across functionally disparate cells suggests that [EMB](/details-gene/133418) is not a specific lineage marker but rather a facilitator of common biological processes, such as adhesion and metabolism, required by many specialized cell types. ## Pathways and Molecular Function Functional annotations for [EMB](/details-gene/133418) align closely with its observed cellular expression pattern. As a cell surface protein, its primary roles involve mediating cell-cell interactions and transporting small molecules across the plasma membrane. - **Cell Adhesion:** The gene is annotated with roles in [homophilic cell adhesion via plasma membrane adhesion molecules](/details-cell/GO:0007156) and [cell-cell adhesion mediator activity](/details-cell/GO:0098632). This function is critical in the nervous system for processes like [axon guidance](/details-cell/GO:0007411) and synapse formation, consistent with its high expression in retinal and cortical neurons. In the immune system, these adhesion properties may be crucial for the formation of the immunological synapse between T cells and antigen-presenting cells. - **Small Molecule Transport:** [EMB](/details-gene/133418) is a key component of pathways related to the [transport of small molecules](/details-cell/R-HSA-382551), including [proton-coupled monocarboxylate transport](/details-cell/R-HSA-433692) and [plasma membrane lactate transport](/details-cell/GO:0035879). Lactate is a vital energy substrate for highly active cells such as neurons and proliferating lymphocytes. This transport function likely supports the high metabolic demands of the T cells, retinal cells, and hematopoietic stem cells where its expression is prominent. These dual functions suggest that [EMB](/details-gene/133418) may physically link cells while simultaneously facilitating the metabolic communication or support between them. ## Research Directions The widespread yet significant expression of [EMB](/details-gene/133418) in metabolically active and highly interactive cells provides several avenues for future investigation. **Testable Hypotheses:** 1. **Immunological Synapse Stability:** Given its role in cell adhesion and high expression in T cells and dendritic cells, it can be hypothesized that [EMB](/details-gene/133418) is a key component of the immunological synapse, where its homophilic binding stabilizes the interaction between T cells and antigen-presenting cells, thereby modulating the strength and duration of T cell activation. 2. **Metabolic Support in the Retina:** Based on its function in lactate transport and its exceptionally high significance in retinal cells, it is hypothesized that [EMB](/details-gene/133418) facilitates the lactate shuttle between glial cells (e.g., Müller cells) and photoreceptors or ganglion cells, which is essential for meeting the high energy demands of neurotransmission and visual processing. **Proposed Experimental Approach:** To test the first hypothesis regarding the role of [EMB](/details-gene/133418) in T cell function, a CRISPR-Cas9-based knockout could be generated in a human T cell line (e.g., Jurkat) or in primary human T cells. These [EMB](/details-gene/133418)-deficient T cells would then be co-cultured with antigen-presenting cells pulsed with a cognate antigen. The effects of [EMB](/details-gene/133418) loss could be assessed by: - **Microscopy:** Using live-cell imaging to quantify the stability and morphology of the immunological synapse formed by knockout versus wild-type T cells. - **Flow Cytometry:** Measuring downstream markers of T cell activation, such as CD69 and CD25 expression, after stimulation. - **ELISA/Luminex:** Quantifying the secretion of key cytokines like IL-2 and IFN-gamma to determine the functional outcome of altered T cell activation. **Therapeutic Potential:** As a cell surface glycoprotein, [EMB](/details-gene/133418) is, in principle, an accessible drug target. However, its broad expression across critical healthy tissues, including the immune system, nervous system, and hematopoietic stem cells, suggests that systemic inhibition would likely lead to significant on-target toxicity. Therefore, its potential as a therapeutic target may be limited to specific contexts, such as cancers that exhibit a unique dependency on or dramatic overexpression of [EMB](/details-gene/133418) for survival or proliferation. In such cases, targeted therapies like antibody-drug conjugates or CAR-T cells directed against [EMB](/details-gene/133418) could be a viable strategy.

Genular Protein ID: 2184581245

Symbol: EMB_HUMAN

Name: Embigin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

Sequence Information:

  • Length: 327
  • Mass: 36881
  • Checksum: E6B933DAF6A3B0D4
  • Sequence:
  • MRALPGLLEA RARTPRLLLL QCLLAAARPS SADGSAPDSP FTSPPLREEI MANNFSLESH 
    NISLTEHSSM PVEKNITLER PSNVNLTCQF TTSGDLNAVN VTWKKDGEQL ENNYLVSATG 
    STLYTQYRFT IINSKQMGSY SCFFREEKEQ RGTFNFKVPE LHGKNKPLIS YVGDSTVLTC 
    KCQNCFPLNW TWYSSNGSVK VPVGVQMNKY VINGTYANET KLKITQLLEE DGESYWCRAL 
    FQLGESEEHI ELVVLSYLVP LKPFLVIVAE VILLVATILL CEKYTQKKKK HSDEGKEFEQ 
    IEQLKSDDSN GIENNVPRHR KNESLGQ