ARHGAP10 | ENSG00000071205 | NCBI 79658

Details for: ARHGAP10

Gene ID: 79658

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ARHGAP10

Ensembl ID: ENSG00000071205

Description: Rho GTPase activating protein 10

Cell Significance Landscape

Display Count:

Associated with

Apoptosis
(R-HSA-109581)
Cdc42 gtpase cycle
(R-HSA-9013148)
Programmed cell death
(R-HSA-5357801)
Rac1 gtpase cycle
(R-HSA-9013149)
Regulation of apoptosis
(R-HSA-169911)
Regulation of pak-2p34 activity by ps-gap/rhg10
(R-HSA-211728)
Rhoa gtpase cycle
(R-HSA-8980692)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Cytoskeleton organization
(GO:0007010)
Cytosol
(GO:0005829)
Endosome membrane
(GO:0010008)
Gtpase activator activity
(GO:0005096)
Negative regulation of apoptotic process
(GO:0043066)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of small gtpase mediated signal transduction
(GO:0051056)
Signal transduction
(GO:0007165)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

cardiac muscle cell CL0000746

CSI 34.15

rCSI 49%

PRS 77.69
vascular leptomeningeal cell CL4023051

CSI 29.42

rCSI 51.57%

PRS 81.81
retinal pigment epithelial cell CL0002586

CSI 20.78

rCSI 41.26%

PRS 82.7
alternatively activated macrophage CL0000890

CSI 19.24

rCSI 24.19%

PRS 93.09
adipocyte CL0000136

CSI 18.73

rCSI 24.04%

PRS 77.4
keratocyte CL0002363

CSI 15.91

rCSI 38.25%

PRS 88.11
effector CD8-positive, alpha-beta T cell CL0001050

CSI 15.07

rCSI 11.46%

PRS 95.84
renal interstitial pericyte CL1001318

CSI 14.47

rCSI 39.88%

PRS 82.74
inhibitory interneuron CL0000498

CSI 13.67

rCSI 31.55%

PRS 76.06
retinal rod cell CL0000604

CSI 13.53

rCSI 23.85%

PRS 82.1
ependymal cell CL0000065

CSI 13.18

rCSI 26.75%

PRS 67.18
microcirculation associated smooth muscle cell CL0008035

CSI 12.32

rCSI 35.68%

PRS 85.77
vascular associated smooth muscle cell CL0000359

CSI 12.11

rCSI 39.28%

PRS 84.45
placental villous trophoblast CL2000060

CSI 10.98

rCSI 16.96%

PRS 85.14
epithelial cell of proximal tubule CL0002306

CSI 10.7

rCSI 26.13%

PRS 79.36
mucosal invariant T cell CL0000940

CSI 10.55

rCSI 8.52%

PRS 92.61
contractile cell CL0000183

CSI 10.33

rCSI 30.48%

PRS 85.64
myeloid leukocyte CL0000766

CSI 10.26

rCSI 9.46%

PRS 87.51
skin fibroblast CL0002620

CSI 10.15

rCSI 8.75%

PRS 86.03
mural cell CL0008034

CSI 10.04

rCSI 34.03%

PRS 81.58
parietal epithelial cell CL1000452

CSI 9.61

rCSI 25.69%

PRS 79.71
GABAergic neuron CL0000617

CSI 9.23

rCSI 30.94%

PRS 71.65
bronchus fibroblast of lung CL2000093

CSI 8.58

rCSI 6.97%

PRS 85.92
squamous epithelial cell CL0000076

CSI 8.41

rCSI 19.96%

PRS 85.02
chondrocyte CL0000138

CSI 7.8

rCSI 12.41%

PRS 80.83
myofibroblast cell CL0000186

CSI 7.8

rCSI 10.8%

PRS 82.97
Kupffer cell CL0000091

CSI 7.69

rCSI 17.59%

PRS 87.48
melanocyte CL0000148

CSI 7.37

rCSI 5.46%

PRS 81.63
pericyte CL0000669

CSI 7.33

rCSI 19.52%

PRS 62.81
Schwann cell CL0002573

CSI 7.27

rCSI 20.67%

PRS 82.34
epicardial adipocyte CL1000309

CSI 6.88

rCSI 22.39%

PRS 83.66
pvalb GABAergic cortical interneuron CL4023018

CSI 6.76

rCSI 8.4%

PRS 68.92
perivascular cell CL4033054

CSI 5.84

rCSI 7.98%

PRS 90.19
extravillous trophoblast CL0008036

CSI 5.8

rCSI 7.17%

PRS 84.81
conjunctival epithelial cell CL1000432

CSI 5.7

rCSI 8.7%

PRS 86.28
VIP GABAergic cortical interneuron CL4023016

CSI 5.42

rCSI 6.47%

PRS 71.24
mononuclear phagocyte CL0000113

CSI 5.31

rCSI 11.69%

PRS 89.31
fibroblast of cardiac tissue CL0002548

CSI 5.3

rCSI 25.37%

PRS 86.91
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 5.21

rCSI 12.47%

PRS 74.76
fibroblast of lung CL0002553

CSI 5.15

rCSI 4.79%

PRS 87.45
Hofbauer cell CL3000001

CSI 5.06

rCSI 9.54%

PRS 92.47
regular atrial cardiac myocyte CL0002129

CSI 4.95

rCSI 15.93%

PRS 83.31
kidney interstitial alternatively activated macrophage CL1000695

CSI 4.72

rCSI 12.31%

PRS 87.77
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 4.69

rCSI 6.64%

PRS 83.72
sst GABAergic cortical interneuron CL4023017

CSI 4.64

rCSI 5.98%

PRS 72.28
T follicular helper cell CL0002038

CSI 4.58

rCSI 3.43%

PRS 95.38
hepatic stellate cell CL0000632

CSI 4.52

rCSI 16.94%

PRS 80.6
myeloid cell CL0000763

CSI 4.52

rCSI 18.61%

PRS 91.16
smooth muscle cell CL0000192

CSI 4.37

rCSI 10.42%

PRS 81.41
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 4.36

rCSI 10.6%

PRS 68.9
cerebral cortex endothelial cell CL1001602

CSI 4.32

rCSI 7.48%

PRS 79.84
endocardial cell CL0002350

CSI 4.19

rCSI 20.07%

PRS 82.54
differentiation-committed oligodendrocyte precursor CL4023059

CSI 4.19

rCSI 7.61%

PRS 79.07
peripheral nervous system neuron CL2000032

CSI 4.19

rCSI 5.71%

PRS 79.26
kidney interstitial fibroblast CL1000692

CSI 4.19

rCSI 22.25%

PRS 77.97
Mueller cell CL0000636

CSI 4.19

rCSI 9.55%

PRS 79.18
lung macrophage CL1001603

CSI 4.07

rCSI 9.1%

PRS 91.82
choroid plexus epithelial cell CL0000706

CSI 4.05

rCSI 6.63%

PRS 77.94
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 4.04

rCSI 7.13%

PRS 70.61
subcutaneous adipocyte CL0002521

CSI 4

rCSI 20.47%

PRS 88.79
basal cell CL0000646

CSI 3.92

rCSI 5.24%

PRS 84.14
neural crest cell CL0011012

CSI 3.78

rCSI 2.99%

PRS 77.67
retinal blood vessel endothelial cell CL0002585

CSI 3.76

rCSI 6%

PRS 89.62
lung pericyte CL0009089

CSI 3.75

rCSI 9.89%

PRS 91.32
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 3.71

rCSI 3.38%

PRS 95.13
alveolar type 1 fibroblast cell CL4028004

CSI 3.69

rCSI 4.05%

PRS 88.06
CD1c-positive myeloid dendritic cell CL0002399

CSI 3.66

rCSI 4.42%

PRS 92.28
Bergmann glial cell CL0000644

CSI 3.63

rCSI 4.96%

PRS 78.37
group 3 innate lymphoid cell CL0001071

CSI 3.48

rCSI 2.62%

PRS 90.7
retinal cone cell CL0000573

CSI 3.46

rCSI 5.57%

PRS 77.91
kidney connecting tubule epithelial cell CL1000768

CSI 3.4

rCSI 8.62%

PRS 78.71
amacrine cell CL0000561

CSI 3.33

rCSI 9.64%

PRS 77.2
tissue-resident macrophage CL0000864

CSI 3.33

rCSI 15.57%

PRS 94.28
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.23

rCSI 8.35%

PRS 82.93
cardiac neuron CL0010022

CSI 3.23

rCSI 10.33%

PRS 84.57
intermediate monocyte CL0002393

CSI 3.2

rCSI 4.83%

PRS 90.93
mature T cell CL0002419

CSI 3.06

rCSI 2.38%

PRS 95.73
mesangial cell CL0000650

CSI 3.02

rCSI 12.31%

PRS 92.66
interstitial cell of Cajal CL0002088

CSI 3.02

rCSI 3.84%

PRS 90.58
cardiac endothelial cell CL0010008

CSI 2.84

rCSI 11.44%

PRS 86.93
elicited macrophage CL0000861

CSI 2.82

rCSI 2.59%

PRS 92.15
mesothelial cell CL0000077

CSI 2.8

rCSI 10.94%

PRS 66.94
medium spiny neuron CL1001474

CSI 2.77

rCSI 23.87%

PRS 76.58
mesodermal cell CL0000222

CSI 2.76

rCSI 3.32%

PRS 84.83
corneal epithelial cell CL0000575

CSI 2.74

rCSI 7.84%

PRS 89.87
alveolar macrophage CL0000583

CSI 2.58

rCSI 4.25%

PRS 89.16
glycinergic amacrine cell CL4030028

CSI 2.54

rCSI 6.62%

PRS 80.67
glutamatergic neuron CL0000679

CSI 2.53

rCSI 5.2%

PRS 74.04
tendon cell CL0000388

CSI 2.5

rCSI 6.48%

PRS 90.69
CD14-positive monocyte CL0001054

CSI 2.41

rCSI 3.01%

PRS 93.11
direct pathway medium spiny neuron CL4023026

CSI 2.33

rCSI 55.85%

PRS 68.83
regular ventricular cardiac myocyte CL0002131

CSI 2.33

rCSI 14.56%

PRS 79.43
brain vascular cell CL4023072

CSI 2.31

rCSI 23.86%

PRS 80.46
indirect pathway medium spiny neuron CL4023029

CSI 2.3

rCSI 55.5%

PRS 69.26
effector CD4-positive, alpha-beta T cell CL0001044

CSI 2.28

rCSI 6.53%

PRS 97.54
myoepithelial cell CL0000185

CSI 2.23

rCSI 5.63%

PRS 89.78
alveolar adventitial fibroblast CL4028006

CSI 2.19

rCSI 3.46%

PRS 87.43
skeletal muscle satellite cell CL0000594

CSI 2.17

rCSI 6.34%

PRS 93.73
podocyte CL0000653

CSI 2.16

rCSI 9.6%

PRS 87.04
tracheobronchial smooth muscle cell CL0019019

CSI 2.12

rCSI 3.74%

PRS 90.01

mesenchymal stem cell CL0000134

CSI 0.2

rCSI 2.3%

PRS 89.4%
pancreatic stellate cell CL0002410

CSI 0.5

rCSI 3.1%

PRS 88.7%
bronchiolar smooth muscle cell CL4033017

CSI 0.6

rCSI 8.5%

PRS 92.1%
mesenchymal cell CL0008019

CSI 0.7

rCSI 1.7%

PRS 80.5%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.7

rCSI 2.2%

PRS 74.7%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.8

rCSI 4.5%

PRS 71.6%
smooth muscle cell of the pulmonary artery CL0002591

CSI 0.8

rCSI 6.0%

PRS 86.9%
flat midget bipolar cell CL4033033

CSI 0.9

rCSI 6.1%

PRS 76.9%
colon macrophage CL0009038

CSI 1.1

rCSI 4.9%

PRS 94.7%
sncg GABAergic cortical interneuron CL4023015

CSI 1.2

rCSI 2.0%

PRS 72.5%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 1.2

rCSI 14.4%

PRS 95.8%
small intestine goblet cell CL1000495

CSI 1.3

rCSI 2.8%

PRS 90.0%
glial cell CL0000125

CSI 1.3

rCSI 4.9%

PRS 78.9%
Langerhans cell CL0000453

CSI 1.3

rCSI 2.0%

PRS 94.2%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.4

rCSI 2.3%

PRS 71.1%
central nervous system neuron CL2000029

CSI 1.4

rCSI 10.3%

PRS 76.0%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 1.4

rCSI 5.1%

PRS 69.1%
blood vessel smooth muscle cell CL0019018

CSI 1.4

rCSI 11.6%

PRS 82.3%
mesenchymal stem cell of adipose tissue CL0002570

CSI 1.5

rCSI 8.2%

PRS 87.9%
luminal epithelial cell of mammary gland CL0002326

CSI 1.5

rCSI 2.7%

PRS 93.1%
enteric smooth muscle cell CL0002504

CSI 1.6

rCSI 2.3%

PRS 87.0%
retinal ganglion cell CL0000740

CSI 1.6

rCSI 3.5%

PRS 74.2%
dopaminergic neuron CL0000700

CSI 1.6

rCSI 9.3%

PRS 74.3%
stem cell CL0000034

CSI 1.7

rCSI 1.6%

PRS 81.5%
starburst amacrine cell CL0004232

CSI 1.7

rCSI 13.9%

PRS 73.6%
stromal cell of ovary CL0002132

CSI 1.7

rCSI 4.6%

PRS 90.7%
muscle cell CL0000187

CSI 1.7

rCSI 3.4%

PRS 91.7%
ON parasol ganglion cell CL4033052

CSI 1.7

rCSI 23.7%

PRS 78.4%
L6b glutamatergic cortical neuron CL4023038

CSI 1.7

rCSI 5.2%

PRS 72.5%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 1.7

rCSI 5.7%

PRS 73.6%
lung perichondrial fibroblast CL4033026

CSI 1.8

rCSI 38.4%

PRS 85.0%
lung interstitial macrophage CL4033043

CSI 1.8

rCSI 4.1%

PRS 94.7%
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 1.9

rCSI 4.0%

PRS 74.9%
stromal cell CL0000499

CSI 1.9

rCSI 5.3%

PRS 81.8%
near-projecting glutamatergic cortical neuron CL4023012

CSI 1.9

rCSI 7.2%

PRS 71.4%
dendritic cell, human CL0001056

CSI 2.0

rCSI 3.0%

PRS 92.8%
myeloid dendritic cell CL0000782

CSI 2.0

rCSI 2.9%

PRS 95.4%
adventitial cell CL0002503

CSI 2.0

rCSI 4.8%

PRS 89.2%
pancreatic acinar cell CL0002064

CSI 2.0

rCSI 2.7%

PRS 90.6%
lung secretory cell CL1000272

CSI 2.0

rCSI 5.0%

PRS 87.0%
fast muscle cell CL0000190

CSI 2.1

rCSI 8.0%

PRS 80.5%
tracheobronchial smooth muscle cell CL0019019

CSI 2.1

rCSI 3.7%

PRS 90.0%
podocyte CL0000653

CSI 2.2

rCSI 9.6%

PRS 87.0%
skeletal muscle satellite cell CL0000594

CSI 2.2

rCSI 6.3%

PRS 93.7%
alveolar adventitial fibroblast CL4028006

CSI 2.2

rCSI 3.5%

PRS 87.4%
myoepithelial cell CL0000185

CSI 2.2

rCSI 5.6%

PRS 89.8%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 2.3

rCSI 6.5%

PRS 97.5%
indirect pathway medium spiny neuron CL4023029

CSI 2.3

rCSI 55.5%

PRS 69.3%
brain vascular cell CL4023072

CSI 2.3

rCSI 23.9%

PRS 80.5%
regular ventricular cardiac myocyte CL0002131

CSI 2.3

rCSI 14.6%

PRS 79.4%
direct pathway medium spiny neuron CL4023026

CSI 2.3

rCSI 55.9%

PRS 68.8%
CD14-positive monocyte CL0001054

CSI 2.4

rCSI 3.0%

PRS 93.1%
tendon cell CL0000388

CSI 2.5

rCSI 6.5%

PRS 90.7%
glutamatergic neuron CL0000679

CSI 2.5

rCSI 5.2%

PRS 74.0%
glycinergic amacrine cell CL4030028

CSI 2.5

rCSI 6.6%

PRS 80.7%
alveolar macrophage CL0000583

CSI 2.6

rCSI 4.3%

PRS 89.2%
corneal epithelial cell CL0000575

CSI 2.7

rCSI 7.8%

PRS 89.9%
mesodermal cell CL0000222

CSI 2.8

rCSI 3.3%

PRS 84.8%
medium spiny neuron CL1001474

CSI 2.8

rCSI 23.9%

PRS 76.6%
mesothelial cell CL0000077

CSI 2.8

rCSI 10.9%

PRS 66.9%
elicited macrophage CL0000861

CSI 2.8

rCSI 2.6%

PRS 92.2%
cardiac endothelial cell CL0010008

CSI 2.8

rCSI 11.4%

PRS 86.9%
interstitial cell of Cajal CL0002088

CSI 3.0

rCSI 3.8%

PRS 90.6%
mesangial cell CL0000650

CSI 3.0

rCSI 12.3%

PRS 92.7%
mature T cell CL0002419

CSI 3.1

rCSI 2.4%

PRS 95.7%
intermediate monocyte CL0002393

CSI 3.2

rCSI 4.8%

PRS 90.9%
cardiac neuron CL0010022

CSI 3.2

rCSI 10.3%

PRS 84.6%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.2

rCSI 8.4%

PRS 82.9%
tissue-resident macrophage CL0000864

CSI 3.3

rCSI 15.6%

PRS 94.3%
amacrine cell CL0000561

CSI 3.3

rCSI 9.6%

PRS 77.2%
kidney connecting tubule epithelial cell CL1000768

CSI 3.4

rCSI 8.6%

PRS 78.7%
retinal cone cell CL0000573

CSI 3.5

rCSI 5.6%

PRS 77.9%
group 3 innate lymphoid cell CL0001071

CSI 3.5

rCSI 2.6%

PRS 90.7%
Bergmann glial cell CL0000644

CSI 3.6

rCSI 5.0%

PRS 78.4%
CD1c-positive myeloid dendritic cell CL0002399

CSI 3.7

rCSI 4.4%

PRS 92.3%
alveolar type 1 fibroblast cell CL4028004

CSI 3.7

rCSI 4.1%

PRS 88.1%
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 3.7

rCSI 3.4%

PRS 95.1%
lung pericyte CL0009089

CSI 3.8

rCSI 9.9%

PRS 91.3%
retinal blood vessel endothelial cell CL0002585

CSI 3.8

rCSI 6.0%

PRS 89.6%
neural crest cell CL0011012

CSI 3.8

rCSI 3.0%

PRS 77.7%
basal cell CL0000646

CSI 3.9

rCSI 5.2%

PRS 84.1%
subcutaneous adipocyte CL0002521

CSI 4.0

rCSI 20.5%

PRS 88.8%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 4.0

rCSI 7.1%

PRS 70.6%
choroid plexus epithelial cell CL0000706

CSI 4.1

rCSI 6.6%

PRS 77.9%
lung macrophage CL1001603

CSI 4.1

rCSI 9.1%

PRS 91.8%
Mueller cell CL0000636

CSI 4.2

rCSI 9.6%

PRS 79.2%
kidney interstitial fibroblast CL1000692

CSI 4.2

rCSI 22.3%

PRS 78.0%
peripheral nervous system neuron CL2000032

CSI 4.2

rCSI 5.7%

PRS 79.3%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 4.2

rCSI 7.6%

PRS 79.1%
endocardial cell CL0002350

CSI 4.2

rCSI 20.1%

PRS 82.5%
cerebral cortex endothelial cell CL1001602

CSI 4.3

rCSI 7.5%

PRS 79.8%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 4.4

rCSI 10.6%

PRS 68.9%
smooth muscle cell CL0000192

CSI 4.4

rCSI 10.4%

PRS 81.4%
myeloid cell CL0000763

CSI 4.5

rCSI 18.6%

PRS 91.2%
hepatic stellate cell CL0000632

CSI 4.5

rCSI 16.9%

PRS 80.6%
T follicular helper cell CL0002038

CSI 4.6

rCSI 3.4%

PRS 95.4%
sst GABAergic cortical interneuron CL4023017

CSI 4.6

rCSI 6.0%

PRS 72.3%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 4.7

rCSI 6.6%

PRS 83.7%
kidney interstitial alternatively activated macrophage CL1000695

CSI 4.7

rCSI 12.3%

PRS 87.8%
regular atrial cardiac myocyte CL0002129

CSI 5.0

rCSI 15.9%

PRS 83.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- High
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- Low
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [ARHGAP10](/details-gene/79658) (Rho GTPase Activating Protein 10) is a protein-coding gene located on chromosome 4q31.23. It functions as a GTPase-activating protein (GAP) that negatively regulates members of the Rho family of small GTPases, including RhoA, Cdc42, and Rac1. By promoting the hydrolysis of GTP to GDP, [ARHGAP10](/details-gene/79658) inactivates these molecular switches, thereby playing a crucial role in fundamental cellular processes such as [cytoskeleton organization](/details-go/GO:0007010), [signal transduction](/details-go/GO:0007165), and the [negative regulation of apoptotic process](/details-go/GO:0043066). Its expression profile is widespread, with notable significance across diverse cell types, including muscle, epithelial, and immune cells. **Overall**, it shows the highest significance in [cardiac muscle cells](/details-cell/CL0000746), suggesting a key role in myocardial cell biology. ## Cellular Roles and Expression Landscape The expression pattern of [ARHGAP10](/details-gene/79658) suggests it is a broadly important regulator of cellular structure and signaling rather than a specific lineage marker. Its functional footprint spans multiple tissue types. **Overall**, the gene exhibits its highest significance in [cardiac muscle cells](/details-cell/CL0000746) (CSI: 34.15), indicating a primary role in the regulation of cardiomyocyte cytoarchitecture and function. It is also highly significant in various stromal and structural cells, including [vascular leptomeningeal cells](/details-cell/CL4023051) (CSI: 29.42), [adipocytes](/details-cell/CL0000136) (CSI: 18.73), [keratocytes](/details-cell/CL0002363) (CSI: 15.91), and smooth muscle cells, pointing towards a general role in maintaining tissue integrity and contractility. Furthermore, [ARHGAP10](/details-gene/79658) is significantly expressed in specialized epithelial cells, such as [retinal pigment epithelial cells](/details-cell/CL0002586) and [epithelial cells of the proximal tubule](/details-cell/CL0002306), where dynamic cytoskeletal arrangements are critical for transport and barrier functions. A notable presence in the immune system is suggested by its significance in [alternatively activated macrophages](/details-cell/CL0000890) and [effector CD8-positive, alpha-beta T cells](/details-cell/CL0001050), consistent with the Rho GTPase-dependent cytoskeletal rearrangements required for cell migration, phagocytosis, and immune synapse formation. The gene also shows relevance in the central nervous system, with significant expression in [inhibitory interneurons](/details-cell/CL0000498) and [ependymal cells](/details-cell/CL0000065). ## Pathways and Molecular Function The molecular function of [ARHGAP10](/details-gene/79658) is centered on its [GTPase activator activity](/details-go/GO:0005096) for Rho family proteins. This activity places it as a key node in the [Signaling by Rho GTPases](/details-pathway/R-HSA-194315) super-pathway. Specifically, it participates in the regulation of the [Cdc42 GTPase cycle](/details-pathway/R-HSA-9013148), [Rac1 GTPase cycle](/details-pathway/R-HSA-9013149), and [RhoA GTPase cycle](/details-pathway/R-HSA-8980692). This regulatory role directly impacts downstream processes, most notably [cytoskeleton organization](/details-go/GO:0007010). Research has shown it interacts with other proteins via its SH3 domains to exert its GAP activity ([Link](https://pubmed.ncbi.nlm.nih.gov/11432776/)). Beyond the cytoskeleton, [ARHGAP10](/details-gene/79658) is implicated in [Apoptosis](/details-pathway/R-HSA-109581) and its regulation ([Link](https://pubmed.ncbi.nlm.nih.gov/11432776/)). Its localization to the [cytosol](/details-go/GO:0005829), [plasma membrane](/details-go/GO:0005886), and [endosome membrane](/details-go/GO:0010008) is consistent with its function in transducing extracellular signals to intracellular cytoskeletal and survival pathways. More recent work has also implicated its relatives in mediating the export of transmembrane proteins, a process reliant on vesicle trafficking and cytoskeletal networks ([Link](https://doi.org/10.1083/jcb.201811014)). ## Research Directions The broad yet significant expression of [ARHGAP10](/details-gene/79658) across functionally diverse cells, particularly its prominence in [cardiac muscle cells](/details-cell/CL0000746), provides several avenues for future investigation. **Proposed Hypotheses:** 1. Given its top rank in [cardiac muscle cells](/details-cell/CL0000746) and its function as a negative regulator of RhoA, a known mediator of cardiac hypertrophy, we hypothesize that **[ARHGAP10](/details-gene/79658) acts as a protective brake against pathological cardiac remodeling.** Downregulation or loss of function of [ARHGAP10](/details-gene/79658) in cardiomyocytes under stress may lead to sustained RhoA activation, driving hypertrophic growth and fibrosis. 2. The significant expression of [ARHGAP10](/details-gene/79658) in [alternatively activated macrophages](/details-cell/CL0000890) suggests a role in modulating immune responses. We hypothesize that **[ARHGAP10](/details-gene/79658) is critical for controlling macrophage polarization and migratory capacity.** By regulating Rac1 and Cdc42 activity, it may fine-tune the cytoskeletal dynamics required for M2-like functions such as tissue repair and phagocytosis, potentially limiting pro-inflammatory phenotypes. **Key Experimental Approach:** To test the first hypothesis regarding its role in cardiac pathology, a compelling approach would be to **generate a cardiomyocyte-specific conditional knockout of [ARHGAP10](/details-gene/79658) in a mouse model.** These mice would be subjected to pressure-overload stress via transverse aortic constriction (TAC). The experimental readout would involve: * **In vivo functional analysis:** Serial echocardiography to measure changes in cardiac function, wall thickness, and chamber dimensions compared to wild-type controls. * **Ex vivo tissue analysis:** Histological examination of heart tissue to quantify cardiomyocyte size (hypertrophy) and collagen deposition (fibrosis) using H&E and Masson's trichrome staining. * **Molecular analysis:** Biochemical assays on isolated cardiomyocytes to measure the activation status (GTP-bound levels) of RhoA, Rac1, and Cdc42, and qPCR/Western blot to assess the expression of hypertrophic and fibrotic marker genes (e.g., *Nppa*, *Nppb*, *Col1a1*). **Therapeutic Potential:** Due to its widespread expression, systemic targeting of [ARHGAP10](/details-gene/79658) could lead to significant off-target effects. However, its role as a GAP protein makes its activity potentially druggable with small molecule inhibitors. In disease contexts characterized by excessive cell motility and invasion, such as cancer metastasis or fibrosis, **inhibition of [ARHGAP10](/details-gene/79658) is unlikely to be beneficial, as this would be expected to *increase* Rho GTPase activity.** Conversely, strategies to **enhance or stabilize [ARHGAP10](/details-gene/79658) activity or expression** could represent a novel therapeutic strategy to suppress pathological cellular phenotypes in specific diseases, such as attenuating cardiac hypertrophy or limiting fibrosis. Development of such therapies would require tissue-specific delivery mechanisms to mitigate systemic toxicity.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Rho GTPase-activating protein 10

Genular Protein ID: 3258751333

Symbol: RHG10_HUMAN

Name: Rho GTPase-activating protein 10

UniProtKB Accession Codes:

A1A4S6 A1L0S5 Q2VPC4 Q2VPC5 Q96EV3 Q96S75

Database IDs:

Citations:

PubMed ID: 11432776

Title: PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family.

PubMed ID: 11432776

DOI: 10.1093/oxfordjournals.jbchem.a002958

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 32344433

Title: GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508.

PubMed ID: 32344433

DOI: 10.1083/jcb.201811014

Sequence Information:

Length: 786
Mass: 89375
Checksum: 7D7006CEAC0094BD
Sequence:

MGLQPLEFSD CYLDSPWFRE RIRAHEAELE RTNKFIKELI KDGKNLIAAT KSLSVAQRKF 
AHSLRDFKFE FIGDAVTDDE RCIDASLREF SNFLKNLEEQ REIMALSVTE TLIKPLEKFR 
KEQLGAVKEE KKKFDKETEK NYSLIDKHLN LSAKKKDSHL QEADIQVEQN RQHFYELSLE 
YVCKLQEIQE RKKFEFVEPM LSFFQGMFTF YHQGHELAKD FNHYKMELQI NIQNTRNRFE 
GTRSEVEELM NKIRQNPKDH KRASQFTAEG YLYVQEKRPA PFGSSWVKHY CMYRKAAKKF 
NMIPFEHRSG GKLGDGEVFF LKECTKRHTD SIDRRFCFDI EAADRPGVSL TMQAFSEEER 
KQWLEALGGK EALSHSFNTA IIPRPEGNAQ LDKMGFTIIR KCISAVETRG INDQGLYRVV 
GVSSKVQRLL SMLMDVKTCN EVDLENSADW EVKTITSALK QYLRSLPEPL MTYELHGDFI 
VPAKSGSPES RVNAIHFLVH KLPEKNKEML DILVKHLTNV SNHSKQNLMT VANLGVVFGP 
TLMRPQEETV AALMDLKFQN IVVEILIENH EKIFRTPPDT TFPEPTCLSA SPPNAPPRQS 
KRQGQRTKRP VAVYNLCLEL EDGDNPYPSK EDTPTSSLDS LSSPSPVTTA VPGPPGPDKN 
HLLADGGSFG DWASTIPGQT RSSMVQWLNP QSPTTTSSNS AVTPLSPGSS PFPFSPPATV 
ADKPPESIRS RKARAVYPCE AEHSSELSFE IGAIFEDVQT SREPGWLEGT LNGKRGLIPQ 
NYVKLL