Details for: NIBAN1

Gene ID: 116496

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: NIBAN1

Ensembl ID: ENSG00000135842

Description: niban apoptosis regulator 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cardiac muscle cell CL0000746
    CSI 50.18
    rCSI 72%
    PRS 46.19
  • microcirculation associated smooth muscle cell CL0008035
    CSI 17.3
    rCSI 50.08%
    PRS 57.83
  • lung secretory cell CL1000272
    CSI 16.72
    rCSI 41.38%
    PRS 54.31
  • regular atrial cardiac myocyte CL0002129
    CSI 14.85
    rCSI 47.81%
    PRS 54.47
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 13.47
    rCSI 9.07%
    PRS 68.81
  • IgG plasma cell CL0000985
    CSI 10.66
    rCSI 12.77%
    PRS 73.91
  • enteroglial cell CL4040002
    CSI 10.03
    rCSI 52.7%
    PRS 62.04
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 9.21
    rCSI 28.81%
    PRS 42.47
  • intermediate monocyte CL0002393
    CSI 9.2
    rCSI 13.89%
    PRS 59.53
  • group 3 innate lymphoid cell CL0001071
    CSI 8.62
    rCSI 6.48%
    PRS 61.06
  • myoepithelial cell CL0000185
    CSI 8.19
    rCSI 20.72%
    PRS 64.52
  • brush cell of tracheobronchial tree CL0002075
    CSI 8.08
    rCSI 23.97%
    PRS 66.26
  • regular ventricular cardiac myocyte CL0002131
    CSI 7.39
    rCSI 46.13%
    PRS 47.95
  • respiratory suprabasal cell CL4033048
    CSI 6.98
    rCSI 8.95%
    PRS 61.01
  • vascular associated smooth muscle cell CL0000359
    CSI 6.76
    rCSI 21.91%
    PRS 57.54
  • interstitial cell of Cajal CL0002088
    CSI 6.7
    rCSI 8.53%
    PRS 62.47
  • lung resident memory CD8-positive, alpha-beta T cell CL4033039
    CSI 6.14
    rCSI 15.88%
    PRS 83.34
  • stem cell CL0000034
    CSI 5.95
    rCSI 5.74%
    PRS 46.67
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 5.6
    rCSI 4.02%
    PRS 70.22
  • alternatively activated macrophage CL0000890
    CSI 5.42
    rCSI 6.81%
    PRS 68.67
  • fallopian tube secretory epithelial cell CL4030006
    CSI 5.39
    rCSI 5.19%
    PRS 56.45
  • smooth muscle cell CL0000192
    CSI 5.14
    rCSI 12.26%
    PRS 63.35
  • secretory cell CL0000151
    CSI 5.12
    rCSI 5.34%
    PRS 56.47
  • conjunctival epithelial cell CL1000432
    CSI 5.09
    rCSI 7.78%
    PRS 56.64
  • perivascular cell CL4033054
    CSI 4.88
    rCSI 6.67%
    PRS 61.73
  • tracheal goblet cell CL1000329
    CSI 4.75
    rCSI 10.36%
    PRS 71.9
  • alpha-beta T cell CL0000789
    CSI 4.58
    rCSI 5.37%
    PRS 72.65
  • central nervous system macrophage CL0000878
    CSI 4.4
    rCSI 14.58%
    PRS 59.12
  • contractile cell CL0000183
    CSI 4.22
    rCSI 12.46%
    PRS 54.3
  • adipocyte CL0000136
    CSI 4.21
    rCSI 5.41%
    PRS 49.38
  • mucosal invariant T cell CL0000940
    CSI 4.21
    rCSI 3.4%
    PRS 66.26
  • renal interstitial pericyte CL1001318
    CSI 4.17
    rCSI 11.48%
    PRS 51.83
  • acinar cell CL0000622
    CSI 4.12
    rCSI 6.05%
    PRS 67.69
  • bronchial goblet cell CL1000312
    CSI 4.08
    rCSI 16.3%
    PRS 73.84
  • promonocyte CL0000559
    CSI 4.05
    rCSI 6.94%
    PRS 65.43
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 3.97
    rCSI 3.67%
    PRS 76.08
  • helper T cell CL0000912
    CSI 3.84
    rCSI 5.44%
    PRS 62.44
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 3.77
    rCSI 2.23%
    PRS 73.14
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 3.65
    rCSI 4.36%
    PRS 76.26
  • neutrophil CL0000775
    CSI 3.56
    rCSI 19.91%
    PRS 64.3
  • lung macrophage CL1001603
    CSI 3.51
    rCSI 7.84%
    PRS 63.65
  • ciliated cell CL0000064
    CSI 3.45
    rCSI 5.59%
    PRS 53.37
  • CD14-positive monocyte CL0001054
    CSI 3.44
    rCSI 4.28%
    PRS 66.76
  • exhausted T cell CL0011025
    CSI 3.31
    rCSI 56%
    PRS 80.61
  • mature T cell CL0002419
    CSI 3.26
    rCSI 2.53%
    PRS 74.06
  • inflammatory macrophage CL0000863
    CSI 3.21
    rCSI 5.49%
    PRS 80.57
  • melanocyte CL0000148
    CSI 3.13
    rCSI 2.32%
    PRS 48.79
  • bronchiolar smooth muscle cell CL4033017
    CSI 3.06
    rCSI 45.99%
    PRS 75.17
  • Schwann cell CL0002573
    CSI 2.98
    rCSI 8.47%
    PRS 54.26
  • myeloid dendritic cell CL0000782
    CSI 2.95
    rCSI 4.27%
    PRS 72.13
  • activated type II NK T cell CL0000931
    CSI 2.88
    rCSI 3.24%
    PRS 72.75
  • myeloid leukocyte CL0000766
    CSI 2.85
    rCSI 2.63%
    PRS 57.21
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 2.85
    rCSI 3.73%
    PRS 69.58
  • squamous epithelial cell CL0000076
    CSI 2.74
    rCSI 6.51%
    PRS 60.67
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.74
    rCSI 2.13%
    PRS 57.51
  • colon macrophage CL0009038
    CSI 2.67
    rCSI 12.34%
    PRS 75.75
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.65
    rCSI 3.42%
    PRS 39.68
  • innate lymphoid cell CL0001065
    CSI 2.63
    rCSI 5.44%
    PRS 58.99
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.63
    rCSI 2.59%
    PRS 72.11
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 2.59
    rCSI 2.71%
    PRS 80.36
  • parietal epithelial cell CL1000452
    CSI 2.59
    rCSI 6.92%
    PRS 47.6
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.55
    rCSI 1.78%
    PRS 58.91
  • acinar cell of salivary gland CL0002623
    CSI 2.53
    rCSI 58.98%
    PRS 77.05
  • chondrocyte CL0000138
    CSI 2.49
    rCSI 3.96%
    PRS 48.53
  • Hofbauer cell CL3000001
    CSI 2.42
    rCSI 4.57%
    PRS 66.63
  • blood vessel endothelial cell CL0000071
    CSI 2.41
    rCSI 5%
    PRS 53.36
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 2.27
    rCSI 2.23%
    PRS 79.31
  • hepatic stellate cell CL0000632
    CSI 2.19
    rCSI 8.19%
    PRS 48.29
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.18
    rCSI 5.67%
    PRS 55.45
  • lung interstitial macrophage CL4033043
    CSI 2.17
    rCSI 4.88%
    PRS 74.28
  • duct epithelial cell CL0000068
    CSI 2.16
    rCSI 3.17%
    PRS 60.16
  • glandular epithelial cell CL0000150
    CSI 2.16
    rCSI 5.67%
    PRS 76.07
  • epithelial cell of lung CL0000082
    CSI 2.12
    rCSI 1.76%
    PRS 55.12
  • luminal cell of prostate epithelium CL0002340
    CSI 2.11
    rCSI 11.34%
    PRS 69.58
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 2.1
    rCSI 1.91%
    PRS 70.58
  • IgA plasma cell CL0000987
    CSI 2.09
    rCSI 2.14%
    PRS 72.07
  • ionocyte CL0005006
    CSI 2.07
    rCSI 2.22%
    PRS 54.98
  • granulocyte monocyte progenitor cell CL0000557
    CSI 2.07
    rCSI 1.79%
    PRS 60.9
  • germinal center B cell CL0000844
    CSI 2.05
    rCSI 6.11%
    PRS 75.39
  • mucus secreting cell CL0000319
    CSI 2.05
    rCSI 3.25%
    PRS 67.26
  • tissue-resident macrophage CL0000864
    CSI 2.04
    rCSI 9.57%
    PRS 72.61
  • club cell CL0000158
    CSI 2.04
    rCSI 2.98%
    PRS 53.14
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 2
    rCSI 3.79%
    PRS 75.82
  • basal cell CL0000646
    CSI 2
    rCSI 2.67%
    PRS 56.78
  • basal cell of prostate epithelium CL0002341
    CSI 1.98
    rCSI 5.73%
    PRS 70.27
  • nasal mucosa goblet cell CL0002480
    CSI 1.96
    rCSI 2.27%
    PRS 64.63
  • L6b glutamatergic cortical neuron CL4023038
    CSI 1.92
    rCSI 6.02%
    PRS 40.02
  • CD4-positive helper T cell CL0000492
    CSI 1.91
    rCSI 1.44%
    PRS 69.75
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.91
    rCSI 7.21%
    PRS 39.37
  • myeloid dendritic cell, human CL0001057
    CSI 1.84
    rCSI 10.34%
    PRS 81.69
  • tracheobronchial smooth muscle cell CL0019019
    CSI 1.77
    rCSI 3.12%
    PRS 64.46
  • cardiac endothelial cell CL0010008
    CSI 1.73
    rCSI 6.97%
    PRS 54.58
  • lung ciliated cell CL1000271
    CSI 1.73
    rCSI 2%
    PRS 46.13
  • mononuclear phagocyte CL0000113
    CSI 1.72
    rCSI 3.78%
    PRS 60.11
  • natural T-regulatory cell CL0000903
    CSI 1.71
    rCSI 3.24%
    PRS 86.27
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 1.7
    rCSI 4.88%
    PRS 75.65
  • cardiac neuron CL0010022
    CSI 1.68
    rCSI 5.38%
    PRS 53.19
  • keratocyte CL0002363
    CSI 1.66
    rCSI 4%
    PRS 64.1
  • keratinocyte CL0000312
    CSI 1.66
    rCSI 1.39%
    PRS 60.91
  • enteric smooth muscle cell CL0002504
    CSI 1.66
    rCSI 2.36%
    PRS 58.61
  • mesenchymal stem cell CL0000134
    CSI 0.2
    rCSI 2.0%
    PRS 69.8%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 0.3
    rCSI 1.3%
    PRS 68.7%
  • cytotoxic T cell CL0000910
    CSI 0.3
    rCSI 1.9%
    PRS 66.5%
  • non-myelinating Schwann cell CL0002376
    CSI 0.5
    rCSI 11.0%
    PRS 58.0%
  • pancreatic stellate cell CL0002410
    CSI 0.5
    rCSI 2.9%
    PRS 65.9%
  • tracheobronchial serous cell CL0019001
    CSI 0.5
    rCSI 2.2%
    PRS 70.0%
  • cardiac blood vessel endothelial cell CL0010006
    CSI 0.6
    rCSI 4.4%
    PRS 47.7%
  • basal cell of epithelium of trachea CL1000348
    CSI 0.7
    rCSI 4.6%
    PRS 73.0%
  • peptic cell CL0000155
    CSI 0.7
    rCSI 6.7%
    PRS 77.6%
  • basal cell of epidermis CL0002187
    CSI 0.7
    rCSI 1.3%
    PRS 32.9%
  • smooth muscle cell of prostate CL1000487
    CSI 0.8
    rCSI 4.5%
    PRS 74.4%
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 0.8
    rCSI 5.9%
    PRS 66.1%
  • multi-ciliated epithelial cell CL0005012
    CSI 0.8
    rCSI 0.8%
    PRS 49.7%
  • respiratory goblet cell CL0002370
    CSI 0.9
    rCSI 9.3%
    PRS 72.7%
  • elicited macrophage CL0000861
    CSI 0.9
    rCSI 0.8%
    PRS 64.6%
  • blood vessel smooth muscle cell CL0019018
    CSI 1.0
    rCSI 7.9%
    PRS 49.2%
  • Langerhans cell CL0000453
    CSI 1.0
    rCSI 1.6%
    PRS 72.5%
  • serous secreting cell CL0000313
    CSI 1.1
    rCSI 5.4%
    PRS 83.5%
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 1.1
    rCSI 1.0%
    PRS 52.9%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.1
    rCSI 0.8%
    PRS 56.0%
  • respiratory basal cell CL0002633
    CSI 1.1
    rCSI 1.1%
    PRS 61.6%
  • lung pericyte CL0009089
    CSI 1.1
    rCSI 3.0%
    PRS 64.8%
  • memory T cell CL0000813
    CSI 1.1
    rCSI 2.2%
    PRS 83.2%
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 1.2
    rCSI 1.7%
    PRS 76.2%
  • mammary gland epithelial cell CL0002327
    CSI 1.2
    rCSI 4.2%
    PRS 69.8%
  • fibroblast of cardiac tissue CL0002548
    CSI 1.2
    rCSI 5.9%
    PRS 55.6%
  • muscle cell CL0000187
    CSI 1.3
    rCSI 2.6%
    PRS 75.6%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 1.3
    rCSI 2.3%
    PRS 72.2%
  • BEST4+ enteroycte CL4030026
    CSI 1.3
    rCSI 1.6%
    PRS 58.2%
  • promyelocyte CL0000836
    CSI 1.3
    rCSI 1.9%
    PRS 65.9%
  • cerebral cortex endothelial cell CL1001602
    CSI 1.3
    rCSI 2.3%
    PRS 46.3%
  • T-helper 17 cell CL0000899
    CSI 1.4
    rCSI 1.1%
    PRS 78.1%
  • dendritic cell, human CL0001056
    CSI 1.4
    rCSI 2.1%
    PRS 64.7%
  • T-helper 1 cell CL0000545
    CSI 1.4
    rCSI 2.5%
    PRS 79.6%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.4
    rCSI 1.7%
    PRS 64.6%
  • basophil CL0000767
    CSI 1.4
    rCSI 3.0%
    PRS 74.8%
  • pancreatic acinar cell CL0002064
    CSI 1.4
    rCSI 1.9%
    PRS 62.0%
  • corneal epithelial cell CL0000575
    CSI 1.5
    rCSI 4.1%
    PRS 70.2%
  • tendon cell CL0000388
    CSI 1.5
    rCSI 4.0%
    PRS 73.9%
  • granulocyte CL0000094
    CSI 1.5
    rCSI 2.3%
    PRS 65.4%
  • adventitial cell CL0002503
    CSI 1.6
    rCSI 3.7%
    PRS 65.0%
  • alveolar macrophage CL0000583
    CSI 1.6
    rCSI 2.6%
    PRS 61.4%
  • endocardial cell CL0002350
    CSI 1.6
    rCSI 7.6%
    PRS 55.0%
  • common myeloid progenitor CL0000049
    CSI 1.6
    rCSI 1.3%
    PRS 57.3%
  • enteric smooth muscle cell CL0002504
    CSI 1.7
    rCSI 2.4%
    PRS 58.6%
  • keratinocyte CL0000312
    CSI 1.7
    rCSI 1.4%
    PRS 60.9%
  • keratocyte CL0002363
    CSI 1.7
    rCSI 4.0%
    PRS 64.1%
  • cardiac neuron CL0010022
    CSI 1.7
    rCSI 5.4%
    PRS 53.2%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 1.7
    rCSI 4.9%
    PRS 75.7%
  • natural T-regulatory cell CL0000903
    CSI 1.7
    rCSI 3.2%
    PRS 86.3%
  • mononuclear phagocyte CL0000113
    CSI 1.7
    rCSI 3.8%
    PRS 60.1%
  • lung ciliated cell CL1000271
    CSI 1.7
    rCSI 2.0%
    PRS 46.1%
  • cardiac endothelial cell CL0010008
    CSI 1.7
    rCSI 7.0%
    PRS 54.6%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 1.8
    rCSI 3.1%
    PRS 64.5%
  • myeloid dendritic cell, human CL0001057
    CSI 1.8
    rCSI 10.3%
    PRS 81.7%
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.9
    rCSI 7.2%
    PRS 39.4%
  • CD4-positive helper T cell CL0000492
    CSI 1.9
    rCSI 1.4%
    PRS 69.8%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 1.9
    rCSI 6.0%
    PRS 40.0%
  • nasal mucosa goblet cell CL0002480
    CSI 2.0
    rCSI 2.3%
    PRS 64.6%
  • basal cell of prostate epithelium CL0002341
    CSI 2.0
    rCSI 5.7%
    PRS 70.3%
  • basal cell CL0000646
    CSI 2.0
    rCSI 2.7%
    PRS 56.8%
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 2.0
    rCSI 3.8%
    PRS 75.8%
  • club cell CL0000158
    CSI 2.0
    rCSI 3.0%
    PRS 53.1%
  • tissue-resident macrophage CL0000864
    CSI 2.0
    rCSI 9.6%
    PRS 72.6%
  • mucus secreting cell CL0000319
    CSI 2.1
    rCSI 3.3%
    PRS 67.3%
  • germinal center B cell CL0000844
    CSI 2.1
    rCSI 6.1%
    PRS 75.4%
  • granulocyte monocyte progenitor cell CL0000557
    CSI 2.1
    rCSI 1.8%
    PRS 60.9%
  • ionocyte CL0005006
    CSI 2.1
    rCSI 2.2%
    PRS 55.0%
  • IgA plasma cell CL0000987
    CSI 2.1
    rCSI 2.1%
    PRS 72.1%
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 2.1
    rCSI 1.9%
    PRS 70.6%
  • luminal cell of prostate epithelium CL0002340
    CSI 2.1
    rCSI 11.3%
    PRS 69.6%
  • epithelial cell of lung CL0000082
    CSI 2.1
    rCSI 1.8%
    PRS 55.1%
  • glandular epithelial cell CL0000150
    CSI 2.2
    rCSI 5.7%
    PRS 76.1%
  • duct epithelial cell CL0000068
    CSI 2.2
    rCSI 3.2%
    PRS 60.2%
  • lung interstitial macrophage CL4033043
    CSI 2.2
    rCSI 4.9%
    PRS 74.3%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.2
    rCSI 5.7%
    PRS 55.5%
  • hepatic stellate cell CL0000632
    CSI 2.2
    rCSI 8.2%
    PRS 48.3%
  • activated CD8-positive, alpha-beta T cell CL0000906
    CSI 2.3
    rCSI 2.2%
    PRS 79.3%
  • blood vessel endothelial cell CL0000071
    CSI 2.4
    rCSI 5.0%
    PRS 53.4%
  • Hofbauer cell CL3000001
    CSI 2.4
    rCSI 4.6%
    PRS 66.6%
  • chondrocyte CL0000138
    CSI 2.5
    rCSI 4.0%
    PRS 48.5%
  • acinar cell of salivary gland CL0002623
    CSI 2.5
    rCSI 59.0%
    PRS 77.1%
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.6
    rCSI 1.8%
    PRS 58.9%
  • parietal epithelial cell CL1000452
    CSI 2.6
    rCSI 6.9%
    PRS 47.6%
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 2.6
    rCSI 2.7%
    PRS 80.4%
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 2.6
    rCSI 2.6%
    PRS 72.1%
  • innate lymphoid cell CL0001065
    CSI 2.6
    rCSI 5.4%
    PRS 59.0%
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.7
    rCSI 3.4%
    PRS 39.7%
  • colon macrophage CL0009038
    CSI 2.7
    rCSI 12.3%
    PRS 75.8%
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.7
    rCSI 2.1%
    PRS 57.5%
  • squamous epithelial cell CL0000076
    CSI 2.7
    rCSI 6.5%
    PRS 60.7%
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 2.9
    rCSI 3.7%
    PRS 69.6%
  • myeloid leukocyte CL0000766
    CSI 2.9
    rCSI 2.6%
    PRS 57.2%
  • activated type II NK T cell CL0000931
    CSI 2.9
    rCSI 3.2%
    PRS 72.8%
  • myeloid dendritic cell CL0000782
    CSI 3.0
    rCSI 4.3%
    PRS 72.1%
  • Schwann cell CL0002573
    CSI 3.0
    rCSI 8.5%
    PRS 54.3%
  • bronchiolar smooth muscle cell CL4033017
    CSI 3.1
    rCSI 46.0%
    PRS 75.2%
  • melanocyte CL0000148
    CSI 3.1
    rCSI 2.3%
    PRS 48.8%
  • inflammatory macrophage CL0000863
    CSI 3.2
    rCSI 5.5%
    PRS 80.6%
  • mature T cell CL0002419
    CSI 3.3
    rCSI 2.5%
    PRS 74.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [NIBAN1](/details-gene/116496), or niban apoptosis regulator 1, encodes a protein primarily known as cell growth-inhibiting gene 39. Functional annotations suggest it plays a key regulatory role within the cell, particularly in modulating protein phosphorylation, responding to endoplasmic reticulum stress, and positively regulating translation. Expression data reveal that [NIBAN1](/details-gene/116496) has an exceptionally high significance in [cardiac muscle cells](/details-cell/CL0000746), with notable expression in other muscle lineages, secretory cells, and various immune cell subsets. While its physiological role appears tied to cellular homeostasis and stress responses, several studies have also implicated its upregulation in pathological contexts, including renal and thyroid cancers ([Link](https://doi.org/10.1111/j.1349-7006.2000.tb01027.x), [Link](https://doi.org/10.1016/j.humpath.2006.06.022)). ## Cellular Roles and Expression Landscape The **Overall** expression profile of [NIBAN1](/details-gene/116496) is dominated by its profound significance in [cardiac muscle cell](/details-cell/CL0000746) (CSI: 50.18), indicating a primary role in cardiac biology. This is further supported by its consistent presence in other muscle-related cell types, including [microcirculation associated smooth muscle cell](/details-cell/CL0008035), [regular atrial cardiac myocyte](/details-cell/CL0002129), [regular ventricular cardiac myocyte](/details-cell/CL0002131), and [vascular associated smooth muscle cell](/details-cell/CL0000359), suggesting a conserved function in contractile tissues. Beyond muscle, [NIBAN1](/details-gene/116496) shows a broad but specific expression pattern. It is significant in several secretory and epithelial cell types, such as [lung secretory cell](/details-cell/CL1000272), [myoepithelial cell](/details-cell/CL0000185), and [brush cell of tracheobronchial tree](/details-cell/CL0002075). Furthermore, the gene displays relevance within the immune system, with notable CSI values in both adaptive immune cells like [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) and [IgG plasma cell](/details-cell/CL0000985), and innate immune cells, including [intermediate monocyte](/details-cell/CL0002393) and [group 3 innate lymphoid cell](/details-cell/CL0001071). This diverse expression landscape points towards a fundamental role in managing protein synthesis and stress responses across multiple distinct cell lineages. ## Pathways and Molecular Function The functional profile of [NIBAN1](/details-gene/116496) is centered on its role as a regulator of core cellular processes. Gene Ontology annotations highlight its involvement in both the [negative regulation of protein phosphorylation](/details-cell/GO0001933) and [positive regulation of protein phosphorylation](/details-cell/GO0001934), identifying it as a key modulator of intracellular signaling cascades. This is consistent with multiple large-scale phosphoproteomic studies that have identified the NIBAN1 protein ([Link](https://doi.org/10.1073/pnas.0805139105), [Link](https://doi.org/10.1126/scisignal.2000475)). Its function in the [response to endoplasmic reticulum stress](/details-cell/GO0034976) and [positive regulation of translation](/details-cell/GO0045727) is particularly relevant to its high expression in metabolically active cells like cardiac myocytes and plasma cells, which require robust protein synthesis and quality control mechanisms. As a [protein binding](/details-cell/GO0005515) molecule, its regulatory effects are likely achieved through interactions with other proteins within these pathways. Cellular component analysis places the NIBAN1 protein in the [cytoplasm](/details-cell/GO0005737), [cytosol](/details-cell/GO0005829), and associated with the [membrane](/details-cell/GO0016020). Its presence in [extracellular exosomes](/details-cell/GO0070062) suggests a potential, but as yet uncharacterized, role in intercellular communication. ## Research Directions While the **Overall** data point to a fundamental role for [NIBAN1](/details-gene/116496) in muscle physiology, published literature indicates its expression is dysregulated in certain malignancies ([Link](https://doi.org/10.1111/j.1349-7006.2000.tb01027.x)). This suggests its function may be highly context-dependent, shifting from a homeostatic regulator in healthy tissue to a potential driver of pathology in disease states. Based on the available data, several testable hypotheses can be proposed: 1. Given its high significance in [cardiac muscle cells](/details-cell/CL0000746) and its established role in the [response to endoplasmic reticulum stress](/details-cell/GO0034976), [NIBAN1](/details-gene/116496) may function as a critical node in the cardiac unfolded protein response (UPR), protecting cardiomyocytes from proteotoxic stress during conditions such as ischemia or pressure overload. 2. Based on its reported upregulation in cancers and its function in regulating phosphorylation and translation, [NIBAN1](/details-gene/116496) may contribute to tumorigenesis by dysregulating signaling pathways that control cell growth and survival, possibly as an adaptive mechanism to the high ER stress characteristic of transformed cells. A key experiment to investigate the first hypothesis would be: * To test the role of [NIBAN1](/details-gene/116496) in cardiac stress responses, one could generate a cardiomyocyte-specific knockout mouse model (e.g., using the Cre-Lox system with a *Myh6*-Cre driver). These conditional knockout mice and their wild-type littermates could be subjected to a model of cardiac stress, such as transverse aortic constriction (TAC). The functional impact on cardiac performance could be assessed non-invasively via echocardiography, while molecular analysis of heart tissue lysates by Western blot and RT-qPCR would quantify key markers of the UPR pathway (e.g., PERK phosphorylation, XBP1 splicing) to determine if [NIBAN1](/details-gene/116496) is essential for a proper stress response. Therapeutically, the upregulation of [NIBAN1](/details-gene/116496) in certain cancers suggests it could be a target for **inhibition**. As an intracellular protein likely functioning via protein-protein interactions, a strategy involving small molecule inhibitors designed to disrupt these interactions could be viable. However, its high significance in critical tissues like the heart raises a substantial safety concern for systemic therapies. Therefore, its potential as a therapeutic target may be limited to cancers where a specific vulnerability or therapeutic window exists, or it may require the development of highly targeted drug delivery systems.

Genular Protein ID: 1883634849

Symbol: NIBA1_HUMAN

Name: Cell growth-inhibiting gene 39 protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11011112

Title: A novel gene 'Niban' upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach.

PubMed ID: 11011112

DOI: 10.1111/j.1349-7006.2000.tb01027.x

PubMed ID: 11318611

Title: Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.

PubMed ID: 11318611

DOI: 10.1006/geno.2001.6500

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16949643

Title: A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis.

PubMed ID: 16949643

DOI: 10.1016/j.humpath.2006.06.022

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

Sequence Information:

  • Length: 928
  • Mass: 103135
  • Checksum: 93717F41336488FE
  • Sequence:
  • MGGSASSQLD EGKCAYIRGK TEAAIKNFSP YYSRQYSVAF CNHVRTEVEQ QRDLTSQFLK 
    TKPPLAPGTI LYEAELSQFS EDIKKWKERY VVVKNDYAVE SYENKEAYQR GAAPKCRILP 
    AGGKVLTSED EYNLLSDRHF PDPLASSEKE NTQPFVVLPK EFPVYLWQPF FRHGYFCFHE 
    AADQKRFSAL LSDCVRHLNH DYMKQMTFEA QAFLEAVQFF RQEKGHYGSW EMITGDEIQI 
    LSNLVMEELL PTLQTDLLPK MKGKKNDRKR TWLGLLEEAY TLVQHQVSEG LSALKEECRA 
    LTKGLEGTIR SDMDQIVNSK NYLIGKIKAM VAQPAEKSCL ESVQPFLASI LEELMGPVSS 
    GFSEVRVLFE KEVNEVSQNF QTTKDSVQLK EHLDRLMNLP LHSVKMEPCY TKVNLLHERL 
    QDLKSRFRFP HIDLVVQRTQ NYMQELMENA VFTFEQLLSP HLQGEASKTA VAIEKVKLRV 
    LKQYDYDSST IRKKIFQEAL VQITLPTVQK ALASTCKPEL QKYEQFIFAD HTNMIHVENV 
    YEEILHQILL DETLKVIKEA AILKKHNLFE DNMALPSESV SSLTDLKPPT GSNQASPARR 
    ASAILPGVLG SETLSNEVFQ ESEEEKQPEV PSSLAKGESL SLPGPSPPPD GTEQVIISRV 
    DDPVVNPVAT EDTAGLPGTC SSELEFGGTL EDEEPAQEEP EPITASGSLK ALRKLLTASV 
    EVPVDSAPVM EEDTNGESHV PQENEEEEEK EPSQAAAIHP DNCEESEVSE REAQPPCPEA 
    HGEELGGFPE VGSPASPPAS GGLTEEPLGP MEGELPGEAC TLTAHEGRGG KCTEEGDASQ 
    QEGCTLGSDP ICLSESQVSE EQEEMGGQSS AAQATASVNA EEIKVARIHE CQWVVEDAPN 
    PDVLLSHKDD VKEGEGGQES FPELPSEE