Details for: ITGB3BP
Gene ID: 23421
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ITGB3BP
Ensembl ID: ENSG00000142856
Description: integrin subunit beta 3 binding protein
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 10.97rCSI 8.24%PRS 54.96
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CSI 9.38rCSI 22.43%PRS 39.17
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CSI 7.81rCSI 11.56%PRS 56.15
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CSI 7.45rCSI 6.03%PRS 51.67
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CSI 5.39rCSI 8.52%PRS 51.91
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CSI 5rCSI 15.65%PRS 37.73
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CSI 4.96rCSI 6.89%PRS 50.09
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CSI 4.66rCSI 5.57%PRS 33.87
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CSI 4.41rCSI 9.77%PRS 48.31
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CSI 4.34rCSI 5.59%PRS 35.03
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CSI 3.97rCSI 9.08%PRS 50.12
-
CSI 3.88rCSI 2.61%PRS 62.49
-
CSI 3.84rCSI 3.7%PRS 50.99
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CSI 3.84rCSI 4.75%PRS 46.53
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CSI 3.84rCSI 22%PRS 61.37
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CSI 3.58rCSI 2.83%PRS 38.02
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CSI 3.58rCSI 4.55%PRS 56.52
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CSI 3.54rCSI 4.73%PRS 59.3
-
CSI 3.31rCSI 9.46%PRS 64.55
-
CSI 3.28rCSI 2.72%PRS 52.18
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CSI 3.24rCSI 10.36%PRS 47.49
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CSI 3.16rCSI 7.53%PRS 52.2
-
CSI 3.15rCSI 2.73%PRS 55.11
-
CSI 3.13rCSI 20.14%PRS 71.54
-
CSI 3.09rCSI 7.82%PRS 59.12
-
CSI 3.05rCSI 4.9%PRS 36.06
-
CSI 3.01rCSI 4.78%PRS 43.31
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CSI 2.96rCSI 4.39%PRS 52.94
-
CSI 2.95rCSI 2.48%PRS 68.43
-
CSI 2.91rCSI 4.13%PRS 47.27
-
CSI 2.83rCSI 2.78%PRS 66.79
-
CSI 2.71rCSI 2.11%PRS 68.78
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CSI 2.7rCSI 2.44%PRS 47.47
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CSI 2.67rCSI 1.97%PRS 43.74
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CSI 2.51rCSI 1.75%PRS 53.03
-
CSI 2.44rCSI 5.3%PRS 40.1
-
CSI 2.42rCSI 5.52%PRS 43.52
-
CSI 2.41rCSI 5.4%PRS 34.76
-
CSI 2.38rCSI 57.49%PRS 34.36
-
CSI 2.35rCSI 2.93%PRS 32.3
-
CSI 2.31rCSI 2.03%PRS 39.4
-
CSI 2.31rCSI 55.22%PRS 33.42
-
CSI 2.25rCSI 8.44%PRS 43.24
-
CSI 2.24rCSI 4.23%PRS 61.19
-
CSI 2.22rCSI 3.91%PRS 48.33
-
CSI 2.2rCSI 1.73%PRS 57.33
-
CSI 2.18rCSI 5.52%PRS 40.65
-
CSI 2.16rCSI 2.37%PRS 54.41
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CSI 2.16rCSI 7.77%PRS 32.74
-
CSI 2.15rCSI 4.31%PRS 40.19
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CSI 2.1rCSI 1.74%PRS 49.47
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CSI 2.09rCSI 2.39%PRS 72.51
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CSI 2.07rCSI 2.06%PRS 44.59
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CSI 2.02rCSI 3.63%PRS 43.97
-
CSI 2.01rCSI 2.06%PRS 68.84
-
CSI 1.98rCSI 2.83%PRS 53.21
-
CSI 1.97rCSI 1.47%PRS 64.44
-
CSI 1.91rCSI 2.45%PRS 45.12
-
CSI 1.9rCSI 3.29%PRS 41.11
-
CSI 1.88rCSI 1.25%PRS 54.49
-
CSI 1.88rCSI 3.65%PRS 52.93
-
CSI 1.88rCSI 8.24%PRS 47.95
-
CSI 1.87rCSI 3.8%PRS 32.11
-
CSI 1.85rCSI 2.96%PRS 54.72
-
CSI 1.83rCSI 3.21%PRS 42.83
-
CSI 1.82rCSI 4.14%PRS 48.52
-
CSI 1.78rCSI 1.91%PRS 49
-
CSI 1.76rCSI 1.54%PRS 56.08
-
CSI 1.75rCSI 1.69%PRS 41.28
-
CSI 1.75rCSI 3.13%PRS 49.3
-
CSI 1.73rCSI 2.03%PRS 53.86
-
CSI 1.69rCSI 6.59%PRS 71.4
-
CSI 1.68rCSI 3.87%PRS 41.26
-
CSI 1.67rCSI 4.13%PRS 48.62
-
CSI 1.66rCSI 3.11%PRS 39.84
-
CSI 1.66rCSI 1.92%PRS 44.72
-
CSI 1.64rCSI 3.71%PRS 56.06
-
CSI 1.63rCSI 1.37%PRS 55.73
-
CSI 1.57rCSI 2.01%PRS 48.56
-
CSI 1.52rCSI 2.7%PRS 65.78
-
CSI 1.51rCSI 2.17%PRS 41.28
-
CSI 1.51rCSI 1.57%PRS 49.6
-
CSI 1.44rCSI 2.08%PRS 60.67
-
CSI 1.43rCSI 3.63%PRS 45.98
-
CSI 1.41rCSI 3.68%PRS 49.34
-
CSI 1.41rCSI 1.87%PRS 56.08
-
CSI 1.38rCSI 3.05%PRS 38.18
-
CSI 1.37rCSI 1.72%PRS 60.91
-
CSI 1.35rCSI 4.34%PRS 49.61
-
CSI 1.34rCSI 1.83%PRS 45.95
-
CSI 1.33rCSI 2.34%PRS 33.03
-
CSI 1.32rCSI 2.11%PRS 44.22
-
CSI 1.3rCSI 4.07%PRS 35.37
-
CSI 1.29rCSI 6.19%PRS 49.65
-
CSI 1.28rCSI 1.18%PRS 51.67
-
CSI 1.27rCSI 2.08%PRS 40.67
-
CSI 1.26rCSI 1.69%PRS 51.9
-
CSI 1.23rCSI 2.96%PRS 69.35
-
CSI 1.23rCSI 3.17%PRS 46.37
-
CSI 1.21rCSI 3.45%PRS 49.61
-
CSI 0.2rCSI 3.2%PRS 42.4%
-
CSI 0.3rCSI 2.4%PRS 37.9%
-
CSI 0.3rCSI 2.4%PRS 38.1%
-
CSI 0.4rCSI 2.4%PRS 47.4%
-
CSI 0.4rCSI 1.0%PRS 64.0%
-
CSI 0.4rCSI 7.4%PRS 43.7%
-
CSI 0.5rCSI 10.2%PRS 42.3%
-
CSI 0.5rCSI 3.3%PRS 80.4%
-
CSI 0.6rCSI 3.3%PRS 35.4%
-
CSI 0.6rCSI 17.4%PRS 73.4%
-
CSI 0.6rCSI 4.6%PRS 65.4%
-
CSI 0.6rCSI 2.0%PRS 58.3%
-
CSI 0.6rCSI 2.7%PRS 68.2%
-
CSI 0.6rCSI 2.4%PRS 34.8%
-
CSI 0.6rCSI 3.3%PRS 74.2%
-
CSI 0.7rCSI 2.9%PRS 49.8%
-
CSI 0.7rCSI 3.6%PRS 65.0%
-
CSI 0.7rCSI 5.1%PRS 45.2%
-
CSI 0.8rCSI 2.4%PRS 57.6%
-
CSI 0.8rCSI 2.6%PRS 41.0%
-
CSI 0.8rCSI 2.2%PRS 52.9%
-
CSI 0.8rCSI 2.4%PRS 71.8%
-
CSI 0.8rCSI 0.9%PRS 40.7%
-
CSI 0.8rCSI 4.1%PRS 87.0%
-
CSI 0.8rCSI 5.2%PRS 42.9%
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CSI 0.9rCSI 3.4%PRS 42.9%
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CSI 1.0rCSI 1.6%PRS 34.0%
-
CSI 1.0rCSI 2.6%PRS 59.1%
-
CSI 1.0rCSI 0.9%PRS 74.6%
-
CSI 1.0rCSI 2.4%PRS 32.9%
-
CSI 1.0rCSI 1.5%PRS 48.5%
-
CSI 1.0rCSI 2.7%PRS 42.7%
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CSI 1.0rCSI 1.7%PRS 41.0%
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CSI 1.0rCSI 8.4%PRS 44.5%
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CSI 1.1rCSI 1.9%PRS 59.0%
-
CSI 1.1rCSI 3.1%PRS 41.4%
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CSI 1.1rCSI 3.1%PRS 49.3%
-
CSI 1.1rCSI 1.3%PRS 48.7%
-
CSI 1.1rCSI 1.4%PRS 69.5%
-
CSI 1.1rCSI 1.6%PRS 53.1%
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CSI 1.2rCSI 3.1%PRS 59.0%
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CSI 1.2rCSI 2.0%PRS 60.3%
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CSI 1.2rCSI 1.8%PRS 45.4%
-
CSI 1.2rCSI 1.1%PRS 61.0%
-
CSI 1.2rCSI 3.5%PRS 49.6%
-
CSI 1.2rCSI 3.2%PRS 46.4%
-
CSI 1.2rCSI 3.0%PRS 69.4%
-
CSI 1.3rCSI 1.7%PRS 51.9%
-
CSI 1.3rCSI 2.1%PRS 40.7%
-
CSI 1.3rCSI 1.2%PRS 51.7%
-
CSI 1.3rCSI 6.2%PRS 49.7%
-
CSI 1.3rCSI 4.1%PRS 35.4%
-
CSI 1.3rCSI 2.1%PRS 44.2%
-
CSI 1.3rCSI 2.3%PRS 33.0%
-
CSI 1.3rCSI 1.8%PRS 46.0%
-
CSI 1.4rCSI 4.3%PRS 49.6%
-
CSI 1.4rCSI 1.7%PRS 60.9%
-
CSI 1.4rCSI 3.1%PRS 38.2%
-
CSI 1.4rCSI 1.9%PRS 56.1%
-
CSI 1.4rCSI 3.7%PRS 49.3%
-
CSI 1.4rCSI 3.6%PRS 46.0%
-
CSI 1.4rCSI 2.1%PRS 60.7%
-
CSI 1.5rCSI 1.6%PRS 49.6%
-
CSI 1.5rCSI 2.2%PRS 41.3%
-
CSI 1.5rCSI 2.7%PRS 65.8%
-
CSI 1.6rCSI 2.0%PRS 48.6%
-
CSI 1.6rCSI 1.4%PRS 55.7%
-
CSI 1.6rCSI 3.7%PRS 56.1%
-
CSI 1.7rCSI 1.9%PRS 44.7%
-
CSI 1.7rCSI 3.1%PRS 39.8%
-
CSI 1.7rCSI 4.1%PRS 48.6%
-
CSI 1.7rCSI 3.9%PRS 41.3%
-
CSI 1.7rCSI 6.6%PRS 71.4%
-
CSI 1.7rCSI 2.0%PRS 53.9%
-
CSI 1.8rCSI 3.1%PRS 49.3%
-
CSI 1.8rCSI 1.7%PRS 41.3%
-
CSI 1.8rCSI 1.5%PRS 56.1%
-
CSI 1.8rCSI 1.9%PRS 49.0%
-
CSI 1.8rCSI 4.1%PRS 48.5%
-
CSI 1.8rCSI 3.2%PRS 42.8%
-
CSI 1.9rCSI 3.0%PRS 54.7%
-
CSI 1.9rCSI 3.8%PRS 32.1%
-
CSI 1.9rCSI 8.2%PRS 48.0%
-
CSI 1.9rCSI 3.7%PRS 52.9%
-
CSI 1.9rCSI 1.3%PRS 54.5%
-
CSI 1.9rCSI 3.3%PRS 41.1%
-
CSI 1.9rCSI 2.5%PRS 45.1%
-
CSI 2.0rCSI 1.5%PRS 64.4%
-
CSI 2.0rCSI 2.8%PRS 53.2%
-
CSI 2.0rCSI 2.1%PRS 68.8%
-
CSI 2.0rCSI 3.6%PRS 44.0%
-
CSI 2.1rCSI 2.1%PRS 44.6%
-
CSI 2.1rCSI 2.4%PRS 72.5%
-
CSI 2.1rCSI 1.7%PRS 49.5%
-
CSI 2.2rCSI 4.3%PRS 40.2%
-
CSI 2.2rCSI 7.8%PRS 32.7%
-
CSI 2.2rCSI 2.4%PRS 54.4%
-
CSI 2.2rCSI 5.5%PRS 40.7%
-
CSI 2.2rCSI 1.7%PRS 57.3%
-
CSI 2.2rCSI 3.9%PRS 48.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2292231475
Symbol: CENPR_HUMAN
Name: Centromere protein R
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7593198
Title: Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit.
PubMed ID: 7593198
PubMed ID: 10490654
Title: NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors.
PubMed ID: 10490654
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11864709
Title: Novel alternatively spliced form of beta(3)-endonexin.
PubMed ID: 11864709
PubMed ID: 9182673
Title: Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail.
PubMed ID: 9182673
PubMed ID: 10673397
Title: Beta3-endonexin as a novel inhibitor of cyclin A-associated kinase.
PubMed ID: 10673397
PubMed ID: 11713274
Title: Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation.
PubMed ID: 11713274
PubMed ID: 12244126
Title: Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor.
PubMed ID: 12244126
DOI: 10.1242/jcs.00081
PubMed ID: 15082778
Title: The NRIF3 family of transcriptional coregulators induces rapid and profound apoptosis in breast cancer cells.
PubMed ID: 15082778
PubMed ID: 15254226
Title: Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator.
PubMed ID: 15254226
PubMed ID: 16622420
Title: The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.
PubMed ID: 16622420
DOI: 10.1038/ncb1396
PubMed ID: 16622419
Title: The human CENP-A centromeric nucleosome-associated complex.
PubMed ID: 16622419
DOI: 10.1038/ncb1397
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
Sequence Information:
- Length: 177
- Mass: 20194
- Checksum: C0A6FD5A56E98D43
- Sequence:
MPVKRSLKLD GLLEENSFDP SKITRKKSVI TYSPTTGTCQ MSLFASPTSS EEQKHRNGLS NEKRKKLNHP SLTESKESTT KDNDEFMMLL SKVEKLSEEI MEIMQNLSSI QALEGSRELE NLIGISCASH FLKREMQKTK ELMTKVNKQK LFEKSTGLPH KASRHLDSYE FLKAILN