Details for: NCALD

Gene ID: 83988

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: NCALD

Ensembl ID: ENSG00000104490

Description: neurocalcin delta

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pvalb GABAergic cortical interneuron CL4023018
    CSI 52.81
    rCSI 65.69%
    PRS 62.14
  • sst GABAergic cortical interneuron CL4023017
    CSI 46.39
    rCSI 59.8%
    PRS 65.43
  • VIP GABAergic cortical interneuron CL4023016
    CSI 45.18
    rCSI 53.97%
    PRS 64.38
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 32.68
    rCSI 57.72%
    PRS 63.73
  • sncg GABAergic cortical interneuron CL4023015
    CSI 30.79
    rCSI 49.52%
    PRS 65.78
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 25.5
    rCSI 42.81%
    PRS 64.27
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 23.02
    rCSI 55.05%
    PRS 68.73
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 22.6
    rCSI 54.93%
    PRS 62.23
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 19.93
    rCSI 62.32%
    PRS 68.26
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 19.88
    rCSI 43.12%
    PRS 69.44
  • oligodendrocyte precursor cell CL0002453
    CSI 18.75
    rCSI 41.26%
    PRS 64.13
  • mucosal invariant T cell CL0000940
    CSI 16.75
    rCSI 13.54%
    PRS 89.78
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 15.05
    rCSI 49.45%
    PRS 67.67
  • neural cell CL0002319
    CSI 14.75
    rCSI 55.65%
    PRS 65.22
  • L6b glutamatergic cortical neuron CL4023038
    CSI 13.89
    rCSI 43.4%
    PRS 65.93
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 13.57
    rCSI 51.27%
    PRS 64.84
  • retinal bipolar neuron CL0000748
    CSI 13
    rCSI 24.34%
    PRS 70.41
  • fallopian tube secretory epithelial cell CL4030006
    CSI 12.03
    rCSI 11.58%
    PRS 81.03
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 11.87
    rCSI 9.03%
    PRS 92.88
  • ionocyte CL0005006
    CSI 11.33
    rCSI 12.14%
    PRS 83.04
  • lung secretory cell CL1000272
    CSI 11.04
    rCSI 27.33%
    PRS 81.76
  • ependymal cell CL0000065
    CSI 10.71
    rCSI 21.73%
    PRS 60.6
  • neuron CL0000540
    CSI 10.42
    rCSI 27.75%
    PRS 69.25
  • retinal cone cell CL0000573
    CSI 10.28
    rCSI 16.55%
    PRS 72.17
  • blood vessel endothelial cell CL0000071
    CSI 10
    rCSI 20.76%
    PRS 78.53
  • group 3 innate lymphoid cell CL0001071
    CSI 9.96
    rCSI 7.48%
    PRS 87.08
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 9.87
    rCSI 58.13%
    PRS 64.93
  • glioblast CL0000030
    CSI 9.72
    rCSI 15.5%
    PRS 73.36
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 9.52
    rCSI 7.14%
    PRS 95.3
  • neural crest cell CL0011012
    CSI 9.2
    rCSI 7.27%
    PRS 71.07
  • ON-bipolar cell CL0000749
    CSI 8.57
    rCSI 12.74%
    PRS 81.35
  • bronchus fibroblast of lung CL2000093
    CSI 8.56
    rCSI 6.96%
    PRS 81.05
  • glutamatergic neuron CL0000679
    CSI 8.56
    rCSI 17.59%
    PRS 69.13
  • hepatic stellate cell CL0000632
    CSI 8.04
    rCSI 30.11%
    PRS 74.48
  • astrocyte of the cerebral cortex CL0002605
    CSI 7.79
    rCSI 17.46%
    PRS 65.1
  • adipocyte CL0000136
    CSI 7.61
    rCSI 9.77%
    PRS 72.12
  • ciliated epithelial cell CL0000067
    CSI 7.56
    rCSI 6.65%
    PRS 71.19
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 7.52
    rCSI 9.65%
    PRS 77.81
  • neuroendocrine cell CL0000165
    CSI 7.45
    rCSI 28.83%
    PRS 89.2
  • radial glial cell CL0000681
    CSI 7.02
    rCSI 9.75%
    PRS 80.09
  • myofibroblast cell CL0000186
    CSI 6.74
    rCSI 9.34%
    PRS 78.65
  • pulmonary capillary endothelial cell CL4028001
    CSI 6.64
    rCSI 12.66%
    PRS 90.5
  • pulmonary ionocyte CL0017000
    CSI 6.53
    rCSI 7.95%
    PRS 87.54
  • vascular leptomeningeal cell CL4023051
    CSI 6.51
    rCSI 11.42%
    PRS 76.04
  • inhibitory interneuron CL0000498
    CSI 6.22
    rCSI 14.36%
    PRS 70.03
  • mesenchymal cell CL0008019
    CSI 6.17
    rCSI 15.66%
    PRS 75.34
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 6.15
    rCSI 11.17%
    PRS 73.54
  • Mueller cell CL0000636
    CSI 5.88
    rCSI 13.42%
    PRS 73.38
  • fibroblast of lung CL0002553
    CSI 5.85
    rCSI 5.45%
    PRS 82.47
  • retinal pigment epithelial cell CL0002586
    CSI 5.64
    rCSI 11.2%
    PRS 77.48
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 5.64
    rCSI 6.51%
    PRS 73.96
  • cardiac blood vessel endothelial cell CL0010006
    CSI 5.64
    rCSI 39.89%
    PRS 74.88
  • mesothelial cell CL0000077
    CSI 5.55
    rCSI 21.7%
    PRS 60.39
  • conjunctival epithelial cell CL1000432
    CSI 5.48
    rCSI 8.37%
    PRS 81.77
  • Bergmann glial cell CL0000644
    CSI 5.35
    rCSI 7.32%
    PRS 73.17
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 5.32
    rCSI 4.85%
    PRS 92.05
  • alveolar type 1 fibroblast cell CL4028004
    CSI 5.25
    rCSI 5.75%
    PRS 83.58
  • ciliated cell CL0000064
    CSI 5.18
    rCSI 8.4%
    PRS 76.52
  • kidney interstitial fibroblast CL1000692
    CSI 5.14
    rCSI 27.34%
    PRS 71.84
  • enteroendocrine cell of small intestine CL0009006
    CSI 5.1
    rCSI 11.23%
    PRS 88.4
  • GABAergic neuron CL0000617
    CSI 5.1
    rCSI 17.07%
    PRS 65.81
  • tracheobronchial smooth muscle cell CL0019019
    CSI 5.1
    rCSI 8.99%
    PRS 86.38
  • cardiac muscle cell CL0000746
    CSI 5.06
    rCSI 7.26%
    PRS 71.74
  • melanocyte CL0000148
    CSI 4.99
    rCSI 3.7%
    PRS 75.49
  • central nervous system neuron CL2000029
    CSI 4.94
    rCSI 36.32%
    PRS 69.58
  • cerebral cortex endothelial cell CL1001602
    CSI 4.71
    rCSI 8.14%
    PRS 73.66
  • cerebral cortex neuron CL0010012
    CSI 4.65
    rCSI 18.93%
    PRS 73.82
  • Schwann cell CL0002573
    CSI 4.37
    rCSI 12.43%
    PRS 77.41
  • epithelial cell CL0000066
    CSI 4.34
    rCSI 6.67%
    PRS 70.78
  • enteric smooth muscle cell CL0002504
    CSI 4.29
    rCSI 6.12%
    PRS 82.42
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 4.28
    rCSI 3.07%
    PRS 92.92
  • T follicular helper cell CL0002038
    CSI 4.12
    rCSI 3.09%
    PRS 92.93
  • choroid plexus epithelial cell CL0000706
    CSI 4.07
    rCSI 6.67%
    PRS 71.55
  • interneuron CL0000099
    CSI 4.07
    rCSI 8.16%
    PRS 72.49
  • squamous epithelial cell CL0000076
    CSI 4.06
    rCSI 9.63%
    PRS 81.56
  • type B pancreatic cell CL0000169
    CSI 4.01
    rCSI 8.88%
    PRS 81.09
  • mature T cell CL0002419
    CSI 3.98
    rCSI 3.09%
    PRS 93.56
  • tracheobronchial serous cell CL0019001
    CSI 3.82
    rCSI 16.51%
    PRS 87.92
  • endothelial cell of arteriole CL1000412
    CSI 3.73
    rCSI 20.69%
    PRS 89.84
  • pancreatic A cell CL0000171
    CSI 3.7
    rCSI 3.87%
    PRS 84.68
  • duct epithelial cell CL0000068
    CSI 3.59
    rCSI 5.25%
    PRS 86.38
  • regular atrial cardiac myocyte CL0002129
    CSI 3.54
    rCSI 11.39%
    PRS 78.51
  • peripheral nervous system neuron CL2000032
    CSI 3.44
    rCSI 4.69%
    PRS 73.54
  • epithelial cell of lung CL0000082
    CSI 3.42
    rCSI 2.83%
    PRS 82.56
  • lung neuroendocrine cell CL1000223
    CSI 3.34
    rCSI 4.94%
    PRS 85.32
  • fibroblast of cardiac tissue CL0002548
    CSI 3.33
    rCSI 15.96%
    PRS 81.7
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 3.29
    rCSI 3.92%
    PRS 94.52
  • renal interstitial pericyte CL1001318
    CSI 3.26
    rCSI 8.97%
    PRS 77.01
  • enteroendocrine cell CL0000164
    CSI 3.17
    rCSI 4.32%
    PRS 81.23
  • lung pericyte CL0009089
    CSI 3.16
    rCSI 8.33%
    PRS 87.85
  • rod bipolar cell CL0000751
    CSI 3.11
    rCSI 5.59%
    PRS 75.19
  • GABAergic interneuron CL0011005
    CSI 3.08
    rCSI 48.61%
    PRS 82.89
  • neural progenitor cell CL0011020
    CSI 3.06
    rCSI 13.45%
    PRS 70.3
  • serotonergic neuron CL0000850
    CSI 3.05
    rCSI 13.64%
    PRS 65.9
  • cardiac endothelial cell CL0010008
    CSI 3.02
    rCSI 12.19%
    PRS 81.63
  • myoepithelial cell CL0000185
    CSI 2.95
    rCSI 7.46%
    PRS 86.25
  • amacrine cell CL0000561
    CSI 2.74
    rCSI 7.95%
    PRS 71.5
  • skeletal muscle satellite cell CL0000594
    CSI 2.69
    rCSI 7.87%
    PRS 92.23
  • dopaminergic neuron CL0000700
    CSI 2.58
    rCSI 14.6%
    PRS 68.06
  • contractile cell CL0000183
    CSI 2.58
    rCSI 7.62%
    PRS 80.74
  • mesenchymal stem cell CL0000134
    CSI 0.2
    rCSI 1.9%
    PRS 86.5%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.7
    rCSI 2.5%
    PRS 62.2%
  • cerebral cortex pyramidal neuron CL4023111
    CSI 0.8
    rCSI 5.2%
    PRS 86.0%
  • starburst amacrine cell CL0004232
    CSI 1.0
    rCSI 8.3%
    PRS 69.6%
  • midbrain dopaminergic neuron CL2000097
    CSI 1.0
    rCSI 6.4%
    PRS 77.6%
  • stromal cell of ovary CL0002132
    CSI 1.0
    rCSI 2.8%
    PRS 87.8%
  • regular ventricular cardiac myocyte CL0002131
    CSI 1.1
    rCSI 6.8%
    PRS 73.7%
  • retinal ganglion cell CL0000740
    CSI 1.3
    rCSI 2.9%
    PRS 67.9%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 1.4
    rCSI 2.5%
    PRS 90.6%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 1.4
    rCSI 3.2%
    PRS 75.2%
  • pancreatic PP cell CL0002275
    CSI 1.4
    rCSI 5.7%
    PRS 88.0%
  • forebrain radial glial cell CL0013000
    CSI 1.5
    rCSI 4.8%
    PRS 83.2%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 1.5
    rCSI 4.4%
    PRS 81.1%
  • tissue-resident macrophage CL0000864
    CSI 1.5
    rCSI 7.2%
    PRS 91.7%
  • glial cell CL0000125
    CSI 1.6
    rCSI 6.0%
    PRS 73.1%
  • macroglial cell CL0000126
    CSI 1.6
    rCSI 4.0%
    PRS 78.4%
  • GABAergic amacrine cell CL4030027
    CSI 1.6
    rCSI 5.5%
    PRS 68.0%
  • alveolar adventitial fibroblast CL4028006
    CSI 1.6
    rCSI 2.6%
    PRS 83.1%
  • chondrocyte CL0000138
    CSI 1.7
    rCSI 2.7%
    PRS 75.1%
  • innate lymphoid cell CL0001065
    CSI 1.7
    rCSI 3.6%
    PRS 78.4%
  • blood vessel smooth muscle cell CL0019018
    CSI 1.7
    rCSI 14.1%
    PRS 76.2%
  • mesangial cell CL0000650
    CSI 1.8
    rCSI 7.2%
    PRS 89.6%
  • extravillous trophoblast CL0008036
    CSI 1.8
    rCSI 2.2%
    PRS 79.9%
  • cytotoxic T cell CL0000910
    CSI 1.9
    rCSI 10.6%
    PRS 84.5%
  • epithelial cell of lower respiratory tract CL0002632
    CSI 1.9
    rCSI 1.4%
    PRS 85.3%
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 1.9
    rCSI 1.3%
    PRS 92.9%
  • pancreatic D cell CL0000173
    CSI 1.9
    rCSI 1.8%
    PRS 84.1%
  • BEST4+ enteroycte CL4030026
    CSI 1.9
    rCSI 2.4%
    PRS 82.4%
  • S cone cell CL0003050
    CSI 1.9
    rCSI 8.5%
    PRS 76.4%
  • glycinergic amacrine cell CL4030028
    CSI 2.1
    rCSI 5.4%
    PRS 76.3%
  • adventitial cell CL0002503
    CSI 2.2
    rCSI 5.2%
    PRS 85.4%
  • endothelial cell of vascular tree CL0002139
    CSI 2.2
    rCSI 12.3%
    PRS 78.2%
  • small intestine goblet cell CL1000495
    CSI 2.3
    rCSI 5.0%
    PRS 86.6%
  • multi-ciliated epithelial cell CL0005012
    CSI 2.3
    rCSI 2.3%
    PRS 75.7%
  • acinar cell of salivary gland CL0002623
    CSI 2.3
    rCSI 54.1%
    PRS 91.8%
  • endocardial cell CL0002350
    CSI 2.4
    rCSI 11.3%
    PRS 78.1%
  • lung ciliated cell CL1000271
    CSI 2.4
    rCSI 2.8%
    PRS 74.2%
  • parietal epithelial cell CL1000452
    CSI 2.5
    rCSI 6.7%
    PRS 73.8%
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.5
    rCSI 4.0%
    PRS 85.1%
  • activated type II NK T cell CL0000931
    CSI 2.6
    rCSI 2.9%
    PRS 92.8%
  • mesenchymal stem cell of adipose tissue CL0002570
    CSI 2.6
    rCSI 14.4%
    PRS 84.5%
  • interstitial cell of Cajal CL0002088
    CSI 2.6
    rCSI 3.3%
    PRS 86.5%
  • contractile cell CL0000183
    CSI 2.6
    rCSI 7.6%
    PRS 80.7%
  • dopaminergic neuron CL0000700
    CSI 2.6
    rCSI 14.6%
    PRS 68.1%
  • skeletal muscle satellite cell CL0000594
    CSI 2.7
    rCSI 7.9%
    PRS 92.2%
  • amacrine cell CL0000561
    CSI 2.7
    rCSI 8.0%
    PRS 71.5%
  • myoepithelial cell CL0000185
    CSI 3.0
    rCSI 7.5%
    PRS 86.3%
  • cardiac endothelial cell CL0010008
    CSI 3.0
    rCSI 12.2%
    PRS 81.6%
  • serotonergic neuron CL0000850
    CSI 3.1
    rCSI 13.6%
    PRS 65.9%
  • neural progenitor cell CL0011020
    CSI 3.1
    rCSI 13.5%
    PRS 70.3%
  • GABAergic interneuron CL0011005
    CSI 3.1
    rCSI 48.6%
    PRS 82.9%
  • rod bipolar cell CL0000751
    CSI 3.1
    rCSI 5.6%
    PRS 75.2%
  • lung pericyte CL0009089
    CSI 3.2
    rCSI 8.3%
    PRS 87.9%
  • enteroendocrine cell CL0000164
    CSI 3.2
    rCSI 4.3%
    PRS 81.2%
  • renal interstitial pericyte CL1001318
    CSI 3.3
    rCSI 9.0%
    PRS 77.0%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 3.3
    rCSI 3.9%
    PRS 94.5%
  • fibroblast of cardiac tissue CL0002548
    CSI 3.3
    rCSI 16.0%
    PRS 81.7%
  • lung neuroendocrine cell CL1000223
    CSI 3.3
    rCSI 4.9%
    PRS 85.3%
  • epithelial cell of lung CL0000082
    CSI 3.4
    rCSI 2.8%
    PRS 82.6%
  • peripheral nervous system neuron CL2000032
    CSI 3.4
    rCSI 4.7%
    PRS 73.5%
  • regular atrial cardiac myocyte CL0002129
    CSI 3.5
    rCSI 11.4%
    PRS 78.5%
  • duct epithelial cell CL0000068
    CSI 3.6
    rCSI 5.3%
    PRS 86.4%
  • pancreatic A cell CL0000171
    CSI 3.7
    rCSI 3.9%
    PRS 84.7%
  • endothelial cell of arteriole CL1000412
    CSI 3.7
    rCSI 20.7%
    PRS 89.8%
  • tracheobronchial serous cell CL0019001
    CSI 3.8
    rCSI 16.5%
    PRS 87.9%
  • mature T cell CL0002419
    CSI 4.0
    rCSI 3.1%
    PRS 93.6%
  • type B pancreatic cell CL0000169
    CSI 4.0
    rCSI 8.9%
    PRS 81.1%
  • squamous epithelial cell CL0000076
    CSI 4.1
    rCSI 9.6%
    PRS 81.6%
  • interneuron CL0000099
    CSI 4.1
    rCSI 8.2%
    PRS 72.5%
  • choroid plexus epithelial cell CL0000706
    CSI 4.1
    rCSI 6.7%
    PRS 71.6%
  • T follicular helper cell CL0002038
    CSI 4.1
    rCSI 3.1%
    PRS 92.9%
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI 4.3
    rCSI 3.1%
    PRS 92.9%
  • enteric smooth muscle cell CL0002504
    CSI 4.3
    rCSI 6.1%
    PRS 82.4%
  • epithelial cell CL0000066
    CSI 4.3
    rCSI 6.7%
    PRS 70.8%
  • Schwann cell CL0002573
    CSI 4.4
    rCSI 12.4%
    PRS 77.4%
  • cerebral cortex neuron CL0010012
    CSI 4.7
    rCSI 18.9%
    PRS 73.8%
  • cerebral cortex endothelial cell CL1001602
    CSI 4.7
    rCSI 8.1%
    PRS 73.7%
  • central nervous system neuron CL2000029
    CSI 4.9
    rCSI 36.3%
    PRS 69.6%
  • melanocyte CL0000148
    CSI 5.0
    rCSI 3.7%
    PRS 75.5%
  • cardiac muscle cell CL0000746
    CSI 5.1
    rCSI 7.3%
    PRS 71.7%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 5.1
    rCSI 9.0%
    PRS 86.4%
  • GABAergic neuron CL0000617
    CSI 5.1
    rCSI 17.1%
    PRS 65.8%
  • enteroendocrine cell of small intestine CL0009006
    CSI 5.1
    rCSI 11.2%
    PRS 88.4%
  • kidney interstitial fibroblast CL1000692
    CSI 5.1
    rCSI 27.3%
    PRS 71.8%
  • ciliated cell CL0000064
    CSI 5.2
    rCSI 8.4%
    PRS 76.5%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 5.3
    rCSI 5.8%
    PRS 83.6%
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 5.3
    rCSI 4.9%
    PRS 92.1%
  • Bergmann glial cell CL0000644
    CSI 5.4
    rCSI 7.3%
    PRS 73.2%
  • conjunctival epithelial cell CL1000432
    CSI 5.5
    rCSI 8.4%
    PRS 81.8%
  • mesothelial cell CL0000077
    CSI 5.6
    rCSI 21.7%
    PRS 60.4%
  • cardiac blood vessel endothelial cell CL0010006
    CSI 5.6
    rCSI 39.9%
    PRS 74.9%
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 5.6
    rCSI 6.5%
    PRS 74.0%
  • retinal pigment epithelial cell CL0002586
    CSI 5.6
    rCSI 11.2%
    PRS 77.5%
  • fibroblast of lung CL0002553
    CSI 5.9
    rCSI 5.5%
    PRS 82.5%
  • Mueller cell CL0000636
    CSI 5.9
    rCSI 13.4%
    PRS 73.4%
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 6.2
    rCSI 11.2%
    PRS 73.5%
  • mesenchymal cell CL0008019
    CSI 6.2
    rCSI 15.7%
    PRS 75.3%
  • inhibitory interneuron CL0000498
    CSI 6.2
    rCSI 14.4%
    PRS 70.0%
  • vascular leptomeningeal cell CL4023051
    CSI 6.5
    rCSI 11.4%
    PRS 76.0%
  • pulmonary ionocyte CL0017000
    CSI 6.5
    rCSI 8.0%
    PRS 87.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [NCALD](/details-gene/83988) (neurocalcin delta) is a protein-coding gene located on chromosome 8q22.3 that encodes a member of the neuronal calcium sensor (NCS) family of proteins. As a calcium-binding protein, [NCALD](/details-gene/83988) is primarily involved in [Calcium-mediated signaling](/details-cell/GO:0019722) and the regulation of signal transduction. Expression data indicates that [NCALD](/details-gene/83988) is a highly significant marker for specific neuronal subtypes, particularly various GABAergic cortical interneurons and glutamatergic neurons. Its functional annotations strongly link it to synaptic transmission, vesicle transport, and cytoskeletal dynamics, positioning it as a key modulator of neuronal activity. Initial characterization of the human [NCALD](/details-gene/83988) gene was described in early genomics and cDNA sequencing projects ([Link](https://doi.org/10.1016/s0167-4781(00)00290-6), [Link](https://doi.org/10.1101/gr.gr1547r), [Link](https://doi.org/10.1101/gr.2596504)). ## Cellular Roles and Expression Landscape The expression profile of [NCALD](/details-gene/83988) underscores its specialized role within the central nervous system. **Overall**, the gene shows the highest significance in distinct classes of cortical interneurons, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 52.81), [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 46.39), and [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 45.18). This pattern suggests that [NCALD](/details-gene/83988) is a defining molecular feature of inhibitory circuits in the cortex. In addition to its prominence in GABAergic neurons, [NCALD](/details-gene/83988) is also a significant marker in several excitatory glutamatergic neuron populations, such as [L4 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030063) (CSI: 23.02) and [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 22.60). Its expression extends to glial lineage cells, with notable significance in [oligodendrocyte precursor cell](/details-cell/CL0002453) (CSI: 18.75), hinting at a potential role in glial development or neuron-glia communication. A minor but significant expression is also noted in [mucosal invariant T cell](/details-cell/CL0000940) (CSI: 16.75), which may suggest a less characterized function outside the nervous system. The highly specific expression pattern across these neuronal subtypes points to a crucial role in regulating the sophisticated signaling dynamics of cortical circuits. ## Pathways and Molecular Function The functions of [NCALD](/details-gene/83988) are tightly linked to neuronal signaling and intracellular transport, consistent with its cellular expression profile. As a [Calcium ion binding](/details-cell/GO:0005509) protein, its primary role is to transduce changes in intracellular calcium concentration into downstream cellular responses. Reactome pathway analysis places [NCALD](/details-gene/83988) squarely within the [Neuronal system](/details-cell/R-HSA-112316), specifically in processes related to [Neurotransmitter receptors and postsynaptic signal transmission](/details-cell/R-HSA-112314) and [Transmission across chemical synapses](/details-cell/R-HSA-112315). Its association with pathways like [Activation of ca-permeable kainate receptor](/details-cell/R-HSA-451308) is consistent with its high expression in glutamatergic neurons and suggests a role in modulating excitatory synaptic activity. Functionally, [NCALD](/details-gene/83988) is implicated in [Vesicle-mediated transport](/details-cell/GO:0016192), potentially regulating neurotransmitter release or receptor trafficking through its interaction with components like the clathrin coat. Moreover, its annotated ability to bind to cytoskeletal components such as actin ([Actin binding](/details-cell/GO:0003779)) and tubulin ([Tubulin binding](/details-cell/GO:0015631)) suggests it may act as a calcium-sensitive linker between signaling cascades and the structural machinery that governs synaptic shape and function. ## Research Directions The specific expression pattern and functional annotations of [NCALD](/details-gene/83988) suggest several avenues for future research into its role in neuronal physiology and disease. ### Proposed Hypotheses: 1. **Modulation of Synaptic Release:** Given its role in [Calcium-mediated signaling](/details-cell/GO:0019722) and [Vesicle-mediated transport](/details-cell/GO:0016192), [NCALD](/details-gene/83988) may act as a calcium sensor that directly regulates the probability of neurotransmitter release at presynaptic terminals in both GABAergic and glutamatergic neurons. Its activity could fine-tune the balance of excitation and inhibition in cortical circuits. 2. **Regulation of Synaptic Plasticity via Cytoskeletal Dynamics:** The capacity of [NCALD](/details-gene/83988) to bind both actin and tubulin suggests it could mediate calcium-dependent structural changes at the synapse. We hypothesize that [NCALD](/details-gene/83988) is a key player in synaptic plasticity, linking postsynaptic calcium influx to the cytoskeletal rearrangements necessary for long-term potentiation (LTP) or long-term depression (LTD). ### Experimental Approach: To test the hypothesis that [NCALD](/details-gene/83988) modulates neurotransmitter release, one could utilize CRISPR/Cas9 to knock down or knock out the gene in primary cortical neuron cultures derived from mice. Electrophysiological recordings, such as whole-cell patch-clamp, could then be performed on transfected (knockdown) and non-transfected (control) neurons. By measuring the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSCs) and miniature inhibitory postsynaptic currents (mIPSCs), one could directly assess changes in the quantal properties of synaptic release. Furthermore, measuring paired-pulse ratios would provide insight into alterations in presynaptic release probability. ### Therapeutic Potential: As an intracellular protein central to synaptic transmission and calcium signaling, [NCALD](/details-gene/83988) represents a potential therapeutic target for neurological disorders characterized by synaptic dysfunction or calcium homeostasis disruption, such as epilepsy or certain neurodegenerative conditions. Its high expression in specific neuronal subtypes might allow for targeted interventions. Because it is a cytosolic protein, therapeutic strategies would likely focus on the development of cell-permeable small molecules to either inhibit or activate its function, depending on whether its activity is pathogenic or protective in a specific disease context. Targeting [NCALD](/details-gene/83988) could offer a novel approach to re-balancing aberrant neural circuit activity.

Genular Protein ID: 1212819262

Symbol: NCALD_HUMAN

Name: Neurocalcin-delta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11267673

Title: Molecular cloning, mapping and characterization of the human neurocalcin delta gene (NCALD).

PubMed ID: 11267673

DOI: 10.1016/s0167-4781(00)00290-6

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 193
  • Mass: 22245
  • Checksum: 20DD8B6FF47C4CBF
  • Sequence:
  • MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK IYGNFFPYGD 
    ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISKAE 
    MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV 
    RLLQCDPSSA GQF