Details for: GLIS3
Gene ID: 169792
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: GLIS3
Ensembl ID: ENSG00000107249
Description: GLIS family zinc finger 3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 48.93rCSI 80.13%PRS 58.44
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CSI 41.14rCSI 83.47%PRS 47.68
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CSI 38.18rCSI 52.24%PRS 61.81
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CSI 35.36rCSI 75.35%PRS 43.27
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CSI 34.54rCSI 77.44%PRS 51.28
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CSI 34.35rCSI 48.7%PRS 65.58
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CSI 27.54rCSI 73.6%PRS 60.35
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CSI 25.41rCSI 62.05%PRS 62.43
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CSI 24.2rCSI 29.33%PRS 53.26
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CSI 23.06rCSI 58.48%PRS 58.98
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CSI 20.98rCSI 41.66%PRS 66.07
-
CSI 17.74rCSI 36.81%PRS 66.47
-
CSI 17.65rCSI 38.29%PRS 57.04
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CSI 17.59rCSI 30.42%PRS 59.83
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CSI 17.13rCSI 27.76%PRS 65.2
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CSI 17.04rCSI 26.19%PRS 62.1
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CSI 17.03rCSI 21.95%PRS 51.93
-
CSI 16.37rCSI 78.42%PRS 69.36
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CSI 16.18rCSI 28.96%PRS 68.81
-
CSI 15.81rCSI 18.88%PRS 50.4
-
CSI 14.64rCSI 33.78%PRS 57.65
-
CSI 14.57rCSI 27.51%PRS 79.34
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CSI 13.41rCSI 44.94%PRS 53.98
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CSI 13.38rCSI 22.46%PRS 50.62
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CSI 13.26rCSI 18.36%PRS 68.95
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CSI 12.97rCSI 48.6%PRS 61.42
-
CSI 12.68rCSI 17.33%PRS 75.18
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CSI 11.97rCSI 11.52%PRS 69.23
-
CSI 11.91rCSI 30.62%PRS 67.74
-
CSI 11.43rCSI 25.17%PRS 73.53
-
CSI 11.34rCSI 36.27%PRS 66.62
-
CSI 11.21rCSI 19.8%PRS 49.72
-
CSI 11.01rCSI 30.33%PRS 64.4
-
CSI 10.81rCSI 26.28%PRS 49.01
-
CSI 10.76rCSI 11.15%PRS 75.13
-
CSI 10.6rCSI 14.99%PRS 72.14
-
CSI 9.74rCSI 18.95%PRS 72.69
-
CSI 9.7rCSI 28.78%PRS 79.17
-
CSI 9.39rCSI 49.36%PRS 73.1
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CSI 9.28rCSI 14.81%PRS 61.25
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CSI 9.02rCSI 14.25%PRS 71.67
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CSI 8.98rCSI 11.17%PRS 48.67
-
CSI 8.67rCSI 51.97%PRS 74.39
-
CSI 8.23rCSI 10.57%PRS 60.89
-
CSI 8.16rCSI 43.36%PRS 60.34
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CSI 7.77rCSI 25.75%PRS 73.72
-
CSI 7.71rCSI 6.78%PRS 57.41
-
CSI 7.63rCSI 8.36%PRS 72.78
-
CSI 7.6rCSI 27.37%PRS 48.79
-
CSI 7.6rCSI 9.46%PRS 71.19
-
CSI 7.15rCSI 9.56%PRS 77.8
-
CSI 6.93rCSI 26.15%PRS 53.67
-
CSI 6.68rCSI 17.36%PRS 72.09
-
CSI 6.45rCSI 10.26%PRS 62.08
-
CSI 6.35rCSI 11.13%PRS 61.85
-
CSI 6.33rCSI 14.45%PRS 60.9
-
CSI 6.31rCSI 17.95%PRS 66.76
-
CSI 6.31rCSI 5.23%PRS 69.33
-
CSI 6.22rCSI 19.43%PRS 52.39
-
CSI 5.97rCSI 23.35%PRS 46.54
-
CSI 5.96rCSI 9.59%PRS 52.56
-
CSI 5.88rCSI 12.14%PRS 69.11
-
CSI 5.86rCSI 10.34%PRS 76.84
-
CSI 5.8rCSI 6.05%PRS 69.41
-
CSI 5.68rCSI 28.6%PRS 68.3
-
CSI 5.57rCSI 5.18%PRS 70.18
-
CSI 5.56rCSI 13.25%PRS 69.75
-
CSI 5.53rCSI 14.43%PRS 69.74
-
CSI 5.51rCSI 32.43%PRS 51.73
-
CSI 5.36rCSI 17.43%PRS 68.6
-
CSI 5.29rCSI 5.1%PRS 61.13
-
CSI 5.2rCSI 24.91%PRS 67.22
-
CSI 5.11rCSI 6.98%PRS 70.4
-
CSI 5.08rCSI 5.07%PRS 62.93
-
CSI 4.87rCSI 8.63%PRS 41.04
-
CSI 4.61rCSI 19.6%PRS 62.1
-
CSI 4.48rCSI 14.53%PRS 68.77
-
CSI 4.28rCSI 6.54%PRS 70.07
-
CSI 4.21rCSI 8.35%PRS 80.04
-
CSI 4.21rCSI 16.37%PRS 71.89
-
CSI 4.05rCSI 23.21%PRS 76.84
-
CSI 4.01rCSI 16.16%PRS 68.7
-
CSI 3.98rCSI 15.16%PRS 59.88
-
CSI 3.81rCSI 2.95%PRS 72.54
-
CSI 3.59rCSI 25.66%PRS 68.75
-
CSI 3.36rCSI 6.91%PRS 58.41
-
CSI 3.35rCSI 9.89%PRS 68.43
-
CSI 3.25rCSI 4.75%PRS 74.36
-
CSI 3.23rCSI 5.15%PRS 73.62
-
CSI 3.13rCSI 33.14%PRS 66.73
-
CSI 3.09rCSI 13.75%PRS 82.86
-
CSI 3.08rCSI 6.79%PRS 55.3
-
CSI 3.06rCSI 4.53%PRS 74.56
-
CSI 3.01rCSI 3.73%PRS 66.32
-
CSI 2.99rCSI 6.84%PRS 70.01
-
CSI 2.99rCSI 3.13%PRS 73.02
-
CSI 2.98rCSI 19.07%PRS 77.9
-
CSI 2.95rCSI 10.1%PRS 57.42
-
CSI 2.88rCSI 4.47%PRS 75.9
-
CSI 2.82rCSI 6.78%PRS 75.36
-
CSI 0.2rCSI 2.0%PRS 81.6%
-
CSI 0.3rCSI 2.5%PRS 56.6%
-
CSI 0.4rCSI 8.8%PRS 50.4%
-
CSI 0.4rCSI 5.6%PRS 60.3%
-
CSI 0.4rCSI 10.5%PRS 49.7%
-
CSI 0.5rCSI 2.4%PRS 79.8%
-
CSI 0.5rCSI 3.9%PRS 56.0%
-
CSI 0.5rCSI 10.9%PRS 59.7%
-
CSI 0.7rCSI 13.2%PRS 61.2%
-
CSI 0.7rCSI 1.5%PRS 68.0%
-
CSI 0.8rCSI 1.9%PRS 56.2%
-
CSI 0.8rCSI 1.3%PRS 37.2%
-
CSI 0.8rCSI 4.9%PRS 80.5%
-
CSI 0.9rCSI 5.0%PRS 76.5%
-
CSI 1.0rCSI 4.2%PRS 58.8%
-
CSI 1.0rCSI 4.7%PRS 83.4%
-
CSI 1.1rCSI 7.6%PRS 61.8%
-
CSI 1.1rCSI 4.0%PRS 76.3%
-
CSI 1.1rCSI 3.6%PRS 67.0%
-
CSI 1.2rCSI 3.4%PRS 80.0%
-
CSI 1.3rCSI 3.3%PRS 70.8%
-
CSI 1.4rCSI 5.7%PRS 79.8%
-
CSI 1.4rCSI 1.4%PRS 72.2%
-
CSI 1.5rCSI 4.0%PRS 85.0%
-
CSI 1.5rCSI 8.5%PRS 76.2%
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CSI 1.6rCSI 4.4%PRS 65.6%
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CSI 1.6rCSI 2.0%PRS 73.8%
-
CSI 1.7rCSI 4.6%PRS 75.6%
-
CSI 1.7rCSI 4.1%PRS 76.5%
-
CSI 2.0rCSI 5.2%PRS 77.9%
-
CSI 2.0rCSI 8.1%PRS 80.7%
-
CSI 2.0rCSI 42.5%PRS 40.0%
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CSI 2.0rCSI 15.1%PRS 83.0%
-
CSI 2.0rCSI 3.7%PRS 60.7%
-
CSI 2.1rCSI 4.8%PRS 64.8%
-
CSI 2.2rCSI 2.9%PRS 75.7%
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CSI 2.2rCSI 5.4%PRS 68.2%
-
CSI 2.2rCSI 11.9%PRS 79.4%
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CSI 2.2rCSI 12.6%PRS 54.8%
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CSI 2.3rCSI 5.9%PRS 64.3%
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CSI 2.3rCSI 3.4%PRS 80.6%
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CSI 2.3rCSI 3.6%PRS 68.1%
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CSI 2.3rCSI 10.4%PRS 69.6%
-
CSI 2.5rCSI 12.9%PRS 77.2%
-
CSI 2.6rCSI 3.0%PRS 60.3%
-
CSI 2.6rCSI 22.7%PRS 65.2%
-
CSI 2.7rCSI 5.8%PRS 80.3%
-
CSI 2.7rCSI 21.6%PRS 62.9%
-
CSI 2.7rCSI 3.6%PRS 38.0%
-
CSI 2.7rCSI 6.5%PRS 77.3%
-
CSI 2.8rCSI 6.8%PRS 75.4%
-
CSI 2.9rCSI 4.5%PRS 75.9%
-
CSI 3.0rCSI 10.1%PRS 57.4%
-
CSI 3.0rCSI 19.1%PRS 77.9%
-
CSI 3.0rCSI 3.1%PRS 73.0%
-
CSI 3.0rCSI 6.8%PRS 70.0%
-
CSI 3.0rCSI 3.7%PRS 66.3%
-
CSI 3.1rCSI 4.5%PRS 74.6%
-
CSI 3.1rCSI 6.8%PRS 55.3%
-
CSI 3.1rCSI 13.8%PRS 82.9%
-
CSI 3.1rCSI 33.1%PRS 66.7%
-
CSI 3.2rCSI 5.2%PRS 73.6%
-
CSI 3.3rCSI 4.8%PRS 74.4%
-
CSI 3.4rCSI 9.9%PRS 68.4%
-
CSI 3.4rCSI 6.9%PRS 58.4%
-
CSI 3.6rCSI 25.7%PRS 68.8%
-
CSI 3.8rCSI 3.0%PRS 72.5%
-
CSI 4.0rCSI 15.2%PRS 59.9%
-
CSI 4.0rCSI 16.2%PRS 68.7%
-
CSI 4.1rCSI 23.2%PRS 76.8%
-
CSI 4.2rCSI 16.4%PRS 71.9%
-
CSI 4.2rCSI 8.4%PRS 80.0%
-
CSI 4.3rCSI 6.5%PRS 70.1%
-
CSI 4.5rCSI 14.5%PRS 68.8%
-
CSI 4.6rCSI 19.6%PRS 62.1%
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CSI 4.9rCSI 8.6%PRS 41.0%
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CSI 5.1rCSI 5.1%PRS 62.9%
-
CSI 5.1rCSI 7.0%PRS 70.4%
-
CSI 5.2rCSI 24.9%PRS 67.2%
-
CSI 5.3rCSI 5.1%PRS 61.1%
-
CSI 5.4rCSI 17.4%PRS 68.6%
-
CSI 5.5rCSI 32.4%PRS 51.7%
-
CSI 5.5rCSI 14.4%PRS 69.7%
-
CSI 5.6rCSI 13.3%PRS 69.8%
-
CSI 5.6rCSI 5.2%PRS 70.2%
-
CSI 5.7rCSI 28.6%PRS 68.3%
-
CSI 5.8rCSI 6.1%PRS 69.4%
-
CSI 5.9rCSI 10.3%PRS 76.8%
-
CSI 5.9rCSI 12.1%PRS 69.1%
-
CSI 6.0rCSI 9.6%PRS 52.6%
-
CSI 6.0rCSI 23.4%PRS 46.5%
-
CSI 6.2rCSI 19.4%PRS 52.4%
-
CSI 6.3rCSI 5.2%PRS 69.3%
-
CSI 6.3rCSI 18.0%PRS 66.8%
-
CSI 6.3rCSI 14.5%PRS 60.9%
-
CSI 6.4rCSI 11.1%PRS 61.9%
-
CSI 6.5rCSI 10.3%PRS 62.1%
-
CSI 6.7rCSI 17.4%PRS 72.1%
-
CSI 6.9rCSI 26.2%PRS 53.7%
-
CSI 7.2rCSI 9.6%PRS 77.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1135758929
Symbol: GLIS3_HUMAN
Name: Zinc finger protein GLIS3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16715098
Title: Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.
PubMed ID: 16715098
DOI: 10.1038/ng1802
PubMed ID: 14500813
Title: GLIS3, a novel member of the GLIS subfamily of Kruppel-like zinc finger proteins with repressor and activation functions.
PubMed ID: 14500813
DOI: 10.1093/nar/gkg776
PubMed ID: 21139041
Title: Novel GLIS3 mutations demonstrate an extended multisystem phenotype.
PubMed ID: 21139041
DOI: 10.1530/eje-10-0893
Sequence Information:
- Length: 775
- Mass: 83636
- Checksum: 1C8519AFCDF6C813
- Sequence:
MMVQRLGLIS PPASQVSTAC NQISPSLQRA MNAANLNIPP SDTRSLISRE SLASTTLSLT ESQSASSMKQ EWSQGYRALP SLSNHGSQNG LDLGDLLSLP PGTSMSSNSV SNSLPSYLFG TESSHSPYPS PRHSSTRSHS ARSKKRALSL SPLSDGIGID FNTIIRTSPT SLVAYINGSR ASPANLSPQP EVYGHFLGVR GSCIPQPRPV PGSQKGVLVA PGGLALPAYG EDGALEHERM QQLEHGGLQP GLVNHMVVQH GLPGPDSQSA GLFKTERLEE FPGSTVDLPP APPLPPLPPP PGPPPPYHAH AHLHHPELGP HAQQLALPQA TLDDDGEMDG IGGKHCCRWI DCSALYDQQE ELVRHIEKVH IDQRKGEDFT CFWAGCPRRY KPFNARYKLL IHMRVHSGEK PNKCTFEGCE KAFSRLENLK IHLRSHTGEK PYLCQHPGCQ KAFSNSSDRA KHQRTHLDTK PYACQIPGCT KRYTDPSSLR KHVKAHSSKE QQARKKLRSS TELHPDLLTD CLTVQSLQPA TSPRDAAAEG TVGRSPGPGP DLYSAPIFSS NYSSRSGTAA GAVPPPHPVS HPSPGHNVQG SPHNPSSQLP PLTAVDAGAE RFAPSAPSPH HISPRRVPAP SSILQRTQPP YTQQPSGSHL KSYQPETNSS FQPNGIHVHG FYGQLQKFCP PHYPDSQRIV PPVSSCSVVP SFEDCLVPTS MGQASFDVFH RAFSTHSGIT VYDLPSSSSS LFGESLRSGA EDATFLQIST VDRCPSQLSS VYTEG
Genular Protein ID: 3024891442
Symbol: Q1PHJ8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16715098
Title: Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.
PubMed ID: 16715098
DOI: 10.1038/ng1802
Sequence Information:
- Length: 244
- Mass: 25488
- Checksum: 544C5C19D49E5344
- Sequence:
MNGRSCSMSL HRTSGTPQGP RMVSGHHIPA IRAHSGTPGP SPCGSTSSPT MASLANNLHL KMPSGGGMAP QNNVAESRIH LPALSPRRQM LTNGKPRFQV TQAGGMSGSH TLKPKQQEFG SPFPPNPGKG ALGFGPQCKS IGKGSCNNLV VTSSPMMVQR LGLISPPASQ VSTACNQISP SLQRAMNAAN LNIPPSDTRS LISRESLAST TLSLTESQSA SSMKQEWSQG YRALPSLSNH GSQN