Details for: PARD3B
Gene ID: 117583
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PARD3B
Ensembl ID: ENSG00000116117
Description: par-3 family cell polarity regulator beta
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 36.58rCSI 74.23%PRS 46.34
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CSI 32.16rCSI 52.67%PRS 56.93
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CSI 31.3rCSI 40.2%PRS 59.72
-
CSI 29.2rCSI 36.32%PRS 69.48
-
CSI 26.58rCSI 59.59%PRS 49.77
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CSI 25.08rCSI 34.32%PRS 60.48
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CSI 25rCSI 35.44%PRS 64.25
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CSI 24.87rCSI 66.47%PRS 58.86
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CSI 24.37rCSI 63.01%PRS 62.79
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CSI 21.54rCSI 45.9%PRS 41.09
-
CSI 20.98rCSI 53.23%PRS 57.36
-
CSI 18.79rCSI 25.68%PRS 73.51
-
CSI 18.42rCSI 45.6%PRS 66.57
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CSI 18.23rCSI 43.83%PRS 74.33
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CSI 17.29rCSI 42.23%PRS 60.89
-
CSI 16.59rCSI 12.29%PRS 60.68
-
CSI 16.58rCSI 23.8%PRS 57.36
-
CSI 15.73rCSI 25.09%PRS 59.86
-
CSI 14.51rCSI 31.78%PRS 74.95
-
CSI 14.15rCSI 32.66%PRS 56.22
-
CSI 14.13rCSI 16.32%PRS 60.47
-
CSI 14.07rCSI 38.78%PRS 63.03
-
CSI 13.5rCSI 14.14%PRS 64.42
-
CSI 13.44rCSI 24.15%PRS 60.89
-
CSI 13.19rCSI 26.47%PRS 57.06
-
CSI 13.17rCSI 66.29%PRS 67.11
-
CSI 13.11rCSI 34.17%PRS 68
-
CSI 12.97rCSI 57.65%PRS 67.94
-
CSI 12.87rCSI 33.44%PRS 70.83
-
CSI 12.68rCSI 67.37%PRS 59
-
CSI 12.58rCSI 13.49%PRS 67.93
-
CSI 12.45rCSI 10.74%PRS 71.81
-
CSI 12.35rCSI 17.1%PRS 67.64
-
CSI 12.04rCSI 10.68%PRS 65.52
-
CSI 11.99rCSI 19.43%PRS 63.73
-
CSI 11.72rCSI 11.07%PRS 66.81
-
CSI 11.34rCSI 32.86%PRS 57.32
-
CSI 10.75rCSI 22.31%PRS 64.82
-
CSI 10.64rCSI 8.41%PRS 54.88
-
CSI 10.48rCSI 23.06%PRS 79.03
-
CSI 10.28rCSI 18.02%PRS 60.43
-
CSI 10.15rCSI 14.1%PRS 66.4
-
CSI 10.06rCSI 19.97%PRS 64.73
-
CSI 9.84rCSI 14.04%PRS 69.65
-
CSI 9.64rCSI 32.66%PRS 63.17
-
CSI 9.28rCSI 14.93%PRS 51.16
-
CSI 9.2rCSI 11.86%PRS 50.46
-
CSI 9.16rCSI 20.95%PRS 68.31
-
CSI 8.83rCSI 16.18%PRS 77
-
CSI 8.78rCSI 10.92%PRS 47.21
-
CSI 8.75rCSI 32.79%PRS 59.78
-
CSI 8.69rCSI 13.88%PRS 72.08
-
CSI 8.68rCSI 8.99%PRS 73.54
-
CSI 8.54rCSI 27.31%PRS 65.18
-
CSI 7.9rCSI 13.67%PRS 58.26
-
CSI 7.85rCSI 17.28%PRS 71.92
-
CSI 7.8rCSI 13.75%PRS 75.51
-
CSI 7.67rCSI 18.28%PRS 68.22
-
CSI 7.66rCSI 25.67%PRS 52.54
-
CSI 7.47rCSI 16.5%PRS 53.77
-
CSI 7.35rCSI 52.45%PRS 67.59
-
CSI 7.23rCSI 12.14%PRS 49.18
-
CSI 7.19rCSI 18.49%PRS 66.3
-
CSI 7.16rCSI 11.11%PRS 74.39
-
CSI 6.8rCSI 19.32%PRS 65.49
-
CSI 6.66rCSI 10.16%PRS 64.16
-
CSI 6.66rCSI 19.77%PRS 77.6
-
CSI 6.59rCSI 5.11%PRS 70.81
-
CSI 6.53rCSI 21.25%PRS 67.29
-
CSI 6.41rCSI 27.24%PRS 60.48
-
CSI 6.27rCSI 9.97%PRS 60.53
-
CSI 6.04rCSI 30.95%PRS 72.66
-
CSI 6.03rCSI 24.33%PRS 66.98
-
CSI 5.95rCSI 17.56%PRS 66.67
-
CSI 5.94rCSI 19.13%PRS 65.53
-
CSI 5.62rCSI 11.9%PRS 83.55
-
CSI 5.34rCSI 23.51%PRS 57.35
-
CSI 5.3rCSI 10.3%PRS 70.88
-
CSI 5.23rCSI 13.63%PRS 64.52
-
CSI 5.22rCSI 20.43%PRS 45.13
-
CSI 5.21rCSI 6.22%PRS 48.97
-
CSI 5.09rCSI 8.99%PRS 48.23
-
CSI 5.07rCSI 31.68%PRS 59.44
-
CSI 5.05rCSI 6.87%PRS 78.76
-
CSI 4.88rCSI 5.34%PRS 71.39
-
CSI 4.72rCSI 4.39%PRS 68.48
-
CSI 4.67rCSI 11.15%PRS 69.27
-
CSI 4.52rCSI 6.91%PRS 68.55
-
CSI 4.52rCSI 11.93%PRS 76.33
-
CSI 4.43rCSI 8.79%PRS 79.3
-
CSI 4.42rCSI 7.91%PRS 67.3
-
CSI 4.19rCSI 18.67%PRS 82.09
-
CSI 4.1rCSI 19.64%PRS 65.87
-
CSI 3.94rCSI 5.27%PRS 67.72
-
CSI 3.9rCSI 14.85%PRS 58.3
-
CSI 3.86rCSI 21.83%PRS 53.26
-
CSI 3.86rCSI 5.67%PRS 61.03
-
CSI 3.83rCSI 39.66%PRS 61.93
-
CSI 3.8rCSI 19.98%PRS 72.17
-
CSI 3.74rCSI 8.93%PRS 75.4
-
CSI 0.3rCSI 3.7%PRS 80.4%
-
CSI 0.4rCSI 2.9%PRS 54.5%
-
CSI 0.5rCSI 1.2%PRS 61.6%
-
CSI 0.6rCSI 8.6%PRS 78.3%
-
CSI 0.6rCSI 3.2%PRS 78.3%
-
CSI 0.8rCSI 3.3%PRS 81.2%
-
CSI 0.8rCSI 2.8%PRS 69.7%
-
CSI 0.8rCSI 1.3%PRS 66.4%
-
CSI 0.9rCSI 1.2%PRS 74.0%
-
CSI 0.9rCSI 7.2%PRS 72.8%
-
CSI 0.9rCSI 2.7%PRS 78.1%
-
CSI 1.1rCSI 3.1%PRS 78.9%
-
CSI 1.2rCSI 17.5%PRS 59.0%
-
CSI 1.3rCSI 4.9%PRS 80.6%
-
CSI 1.3rCSI 5.0%PRS 65.9%
-
CSI 1.3rCSI 7.4%PRS 65.8%
-
CSI 1.3rCSI 15.1%PRS 58.6%
-
CSI 1.5rCSI 2.4%PRS 78.1%
-
CSI 1.6rCSI 4.2%PRS 74.1%
-
CSI 1.6rCSI 33.5%PRS 58.2%
-
CSI 1.8rCSI 36.0%PRS 59.8%
-
CSI 1.8rCSI 1.6%PRS 55.7%
-
CSI 1.9rCSI 4.4%PRS 70.5%
-
CSI 1.9rCSI 16.0%PRS 55.1%
-
CSI 2.0rCSI 12.6%PRS 76.7%
-
CSI 2.0rCSI 12.2%PRS 73.3%
-
CSI 2.0rCSI 21.5%PRS 65.5%
-
CSI 2.1rCSI 2.4%PRS 58.6%
-
CSI 2.1rCSI 5.3%PRS 75.1%
-
CSI 2.2rCSI 6.8%PRS 75.2%
-
CSI 2.3rCSI 55.8%PRS 48.3%
-
CSI 2.4rCSI 13.4%PRS 75.4%
-
CSI 2.4rCSI 57.9%PRS 49.0%
-
CSI 2.6rCSI 4.7%PRS 59.3%
-
CSI 2.6rCSI 21.3%PRS 61.4%
-
CSI 2.7rCSI 14.8%PRS 81.6%
-
CSI 2.7rCSI 2.7%PRS 61.3%
-
CSI 2.8rCSI 10.0%PRS 47.3%
-
CSI 2.9rCSI 6.9%PRS 76.2%
-
CSI 2.9rCSI 6.6%PRS 59.4%
-
CSI 2.9rCSI 16.0%PRS 65.9%
-
CSI 3.0rCSI 26.0%PRS 64.1%
-
CSI 3.0rCSI 5.0%PRS 73.3%
-
CSI 3.1rCSI 7.0%PRS 63.4%
-
CSI 3.1rCSI 6.4%PRS 57.1%
-
CSI 3.2rCSI 5.0%PRS 70.2%
-
CSI 3.2rCSI 9.1%PRS 64.2%
-
CSI 3.3rCSI 9.3%PRS 77.7%
-
CSI 3.4rCSI 23.9%PRS 60.4%
-
CSI 3.4rCSI 5.0%PRS 72.6%
-
CSI 3.4rCSI 2.8%PRS 68.2%
-
CSI 3.5rCSI 3.4%PRS 59.2%
-
CSI 3.6rCSI 17.2%PRS 67.8%
-
CSI 3.7rCSI 14.9%PRS 79.2%
-
CSI 3.7rCSI 8.9%PRS 75.4%
-
CSI 3.8rCSI 20.0%PRS 72.2%
-
CSI 3.8rCSI 39.7%PRS 61.9%
-
CSI 3.9rCSI 5.7%PRS 61.0%
-
CSI 3.9rCSI 21.8%PRS 53.3%
-
CSI 3.9rCSI 14.9%PRS 58.3%
-
CSI 3.9rCSI 5.3%PRS 67.7%
-
CSI 4.1rCSI 19.6%PRS 65.9%
-
CSI 4.2rCSI 18.7%PRS 82.1%
-
CSI 4.4rCSI 7.9%PRS 67.3%
-
CSI 4.4rCSI 8.8%PRS 79.3%
-
CSI 4.5rCSI 11.9%PRS 76.3%
-
CSI 4.5rCSI 6.9%PRS 68.6%
-
CSI 4.7rCSI 11.2%PRS 69.3%
-
CSI 4.7rCSI 4.4%PRS 68.5%
-
CSI 4.9rCSI 5.3%PRS 71.4%
-
CSI 5.1rCSI 6.9%PRS 78.8%
-
CSI 5.1rCSI 31.7%PRS 59.4%
-
CSI 5.1rCSI 9.0%PRS 48.2%
-
CSI 5.2rCSI 6.2%PRS 49.0%
-
CSI 5.2rCSI 20.4%PRS 45.1%
-
CSI 5.2rCSI 13.6%PRS 64.5%
-
CSI 5.3rCSI 10.3%PRS 70.9%
-
CSI 5.3rCSI 23.5%PRS 57.4%
-
CSI 5.6rCSI 11.9%PRS 83.6%
-
CSI 5.9rCSI 19.1%PRS 65.5%
-
CSI 6.0rCSI 17.6%PRS 66.7%
-
CSI 6.0rCSI 24.3%PRS 67.0%
-
CSI 6.0rCSI 31.0%PRS 72.7%
-
CSI 6.3rCSI 10.0%PRS 60.5%
-
CSI 6.4rCSI 27.2%PRS 60.5%
-
CSI 6.5rCSI 21.3%PRS 67.3%
-
CSI 6.6rCSI 5.1%PRS 70.8%
-
CSI 6.7rCSI 19.8%PRS 77.6%
-
CSI 6.7rCSI 10.2%PRS 64.2%
-
CSI 6.8rCSI 19.3%PRS 65.5%
-
CSI 7.2rCSI 11.1%PRS 74.4%
-
CSI 7.2rCSI 18.5%PRS 66.3%
-
CSI 7.2rCSI 12.1%PRS 49.2%
-
CSI 7.4rCSI 52.5%PRS 67.6%
-
CSI 7.5rCSI 16.5%PRS 53.8%
-
CSI 7.7rCSI 25.7%PRS 52.5%
-
CSI 7.7rCSI 18.3%PRS 68.2%
-
CSI 7.8rCSI 13.8%PRS 75.5%
-
CSI 7.9rCSI 17.3%PRS 71.9%
-
CSI 7.9rCSI 13.7%PRS 58.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3403743804
Symbol: PAR3L_HUMAN
Name: Partitioning defective 3 homolog B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11586298
Title: A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
PubMed ID: 11586298
DOI: 10.1038/ng1001-166
PubMed ID: 12459187
Title: PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions.
PubMed ID: 12459187
PubMed ID: 12234671
Title: Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties.
PubMed ID: 12234671
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16458856
Title: Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.
PubMed ID: 16458856
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 1205
- Mass: 132494
- Checksum: 26E6704CCDCE8CD8
- Sequence:
MKVTVCFGRT GIVVPCKEGQ LRVGELTQQA LQRYLKTREK GPGYWVKIHH LEYTDGGILD PDDVLADVVE DKDKLIAVFE EQEPLHKIES PSGNPADRQS PDAFETEVAA QLAAFKPIGG EIEVTPSALK LGTPLLVRRS SDPVPGPPAD TQPSASHPGG QSLKLVVPDS TQNLEDREVL NGVQTELLTS PRTKDTLSDM TRTVEISGEG GPLGIHVVPF FSSLSGRILG LFIRGIEDNS RSKREGLFHE NECIVKINNV DLVDKTFAQA QDVFRQAMKS PSVLLHVLPP QNREQYEKSV IGSLNIFGNN DGVLKTKVPP PVHGKSGLKT ANLTGTDSPE TDASASLQQN KSPRVPRLGG KPSSPSLSPL MGFGSNKNAK KIKIDLKKGP EGLGFTVVTR DSSIHGPGPI FVKNILPKGA AIKDGRLQSG DRILEVNGRD VTGRTQEELV AMLRSTKQGE TASLVIARQE GHFLPRELKG EPDCCALSLE TSEQLTFEIP LNDSGSAGLG VSLKGNKSRE TGTDLGIFIK SIIHGGAAFK DGRLRMNDQL IAVNGESLLG KSNHEAMETL RRSMSMEGNI RGMIQLVILR RPERPMEDPA ECGAFSKPCF ENCQNAVTTS RRNDNSILHP LGTCSPQDKQ KGLLLPNDGW AESEVPPSPT PHSALGLGLE DYSHSSGVDS AVYFPDQHIN FRSVTPARQP ESINLKASKS MDLVPDESKV HSLAGQKSES PSKDFGPTLG LKKSSSLESL QTAVAEVRKN DLPFHRPRPH MVRGRGCNES FRAAIDKSYD GPEEIEADGL SDKSSHSGQG ALNCESAPQG NSELEDMENK ARKVKKTKEK EKKKEKGKLK VKEKKRKEEN EDPERKIKKK GFGAMLRFGK KKEDKGGKAE QKGTLKHGGL REEELEKMKE ERERIGAKHQ ELREKQARGL LDYATGAIGS VYDMDDDEMD PNYARVNHFR EPCTSANVFR SPSPPRAGPF GYPRDGHPLS PERDHLEGLY AKVNKPYHPL VPADSGRPTG GSTDRIQKLR KEYYQARREG FPLYEDDEGR ARPSEYDLLW VPGRGPDGNA HNLRFEGMER QYASLPRGGP ADPVDYLPAA PRGLYKEREL PYYPGAHPMH PPKGSYPRPT ELRVADLRYP QHYPPPPAPQ HKGPFRQDVP PSPPQHQRMP AYQETGRPGP RGGSPDQYPY RTQDSRQKNP MTAAV