Details for: FBXO32
Gene ID: 114907
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: FBXO32
Ensembl ID: ENSG00000156804
Description: F-box protein 32
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 40.29rCSI 76.16%PRS 82.8
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CSI 39.53rCSI 100%PRS 73.59
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CSI 33.87rCSI 48.6%PRS 55.5
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CSI 21.02rCSI 20.23%PRS 65.78
-
CSI 16.72rCSI 39.69%PRS 69.11
-
CSI 15.98rCSI 33.99%PRS 63.96
-
CSI 12.88rCSI 30.01%PRS 76.06
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CSI 12.78rCSI 41.14%PRS 63.73
-
CSI 11.69rCSI 33.83%PRS 76.81
-
CSI 10.29rCSI 40.22%PRS 66.24
-
CSI 9.81rCSI 21.67%PRS 51.96
-
CSI 9.6rCSI 10.05%PRS 62.59
-
CSI 9.49rCSI 9.15%PRS 57.13
-
CSI 9.13rCSI 29.29%PRS 70.58
-
CSI 9.01rCSI 21.89%PRS 45.79
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CSI 8.5rCSI 13.66%PRS 49.32
-
CSI 8.4rCSI 10.78%PRS 70.58
-
CSI 8.14rCSI 22.35%PRS 77.65
-
CSI 7.97rCSI 9.91%PRS 45.47
-
CSI 7.95rCSI 22.37%PRS 62.39
-
CSI 7.58rCSI 5.27%PRS 77.46
-
CSI 7.54rCSI 5.59%PRS 58.79
-
CSI 7.22rCSI 6.41%PRS 63.86
-
CSI 7.22rCSI 20.89%PRS 67.05
-
CSI 7.07rCSI 23.22%PRS 52.82
-
CSI 6.96rCSI 15.61%PRS 48.04
-
CSI 6.89rCSI 91.83%PRS 74.61
-
CSI 6.61rCSI 5.37%PRS 66.45
-
CSI 6.56rCSI 19.01%PRS 55.52
-
CSI 6.48rCSI 4.65%PRS 80.1
-
CSI 6.34rCSI 6.62%PRS 66.19
-
CSI 6.3rCSI 5.22%PRS 65.62
-
CSI 6.1rCSI 13.44%PRS 69.99
-
CSI 5.74rCSI 7.85%PRS 71.89
-
CSI 5.37rCSI 18.85%PRS 77.76
-
CSI 5.31rCSI 3.97%PRS 80.92
-
CSI 5.25rCSI 5.62%PRS 66.09
-
CSI 5.13rCSI 11.72%PRS 57.67
-
CSI 4.95rCSI 5.13%PRS 71.79
-
CSI 4.94rCSI 3.83%PRS 68.77
-
CSI 4.9rCSI 3.81%PRS 83.09
-
CSI 4.76rCSI 7.27%PRS 66.75
-
CSI 4.52rCSI 67.8%PRS 80.71
-
CSI 4.43rCSI 7.05%PRS 58.64
-
CSI 4.38rCSI 16.4%PRS 57.87
-
CSI 4.38rCSI 6.42%PRS 77.42
-
CSI 4.32rCSI 3.29%PRS 79.33
-
CSI 4.12rCSI 3.89%PRS 65.23
-
CSI 4.05rCSI 2.82%PRS 81.32
-
CSI 4rCSI 3.93%PRS 81.67
-
CSI 3.99rCSI 13.68%PRS 54.36
-
CSI 3.99rCSI 6.54%PRS 55.06
-
CSI 3.98rCSI 11.81%PRS 75.79
-
CSI 3.91rCSI 6.86%PRS 58.25
-
CSI 3.83rCSI 2.58%PRS 79.57
-
CSI 3.82rCSI 3.2%PRS 69.93
-
CSI 3.82rCSI 9.11%PRS 67.85
-
CSI 3.52rCSI 7.23%PRS 82.34
-
CSI 3.5rCSI 3.23%PRS 84.65
-
CSI 3.48rCSI 4.04%PRS 72.96
-
CSI 3.34rCSI 7.98%PRS 53.08
-
CSI 3.32rCSI 1.96%PRS 83.21
-
CSI 3.27rCSI 9.31%PRS 63.69
-
CSI 3.23rCSI 9.27%PRS 85.29
-
CSI 3.2rCSI 13.05%PRS 59.66
-
CSI 3.15rCSI 4.37%PRS 66.2
-
CSI 3.09rCSI 14.81%PRS 64.04
-
CSI 3.08rCSI 12.95%PRS 76.99
-
CSI 2.98rCSI 18.6%PRS 57.7
-
CSI 2.93rCSI 9.5%PRS 65.71
-
CSI 2.77rCSI 6.07%PRS 73.45
-
CSI 2.75rCSI 4.38%PRS 58.33
-
CSI 2.7rCSI 2.76%PRS 78.93
-
CSI 2.68rCSI 5.3%PRS 80.58
-
CSI 2.61rCSI 12.48%PRS 65.93
-
CSI 2.6rCSI 5.73%PRS 77.73
-
CSI 2.54rCSI 51.71%PRS 56.47
-
CSI 2.5rCSI 3.66%PRS 71.03
-
CSI 2.46rCSI 2.88%PRS 81.96
-
CSI 2.38rCSI 2.84%PRS 47.15
-
CSI 2.33rCSI 4.12%PRS 46.47
-
CSI 2.31rCSI 3.16%PRS 67.21
-
CSI 2.27rCSI 5.61%PRS 64.61
-
CSI 2.23rCSI 45.46%PRS 57.95
-
CSI 2.23rCSI 3.2%PRS 68.83
-
CSI 2.22rCSI 1.68%PRS 79.74
-
CSI 2.2rCSI 1.75%PRS 86.24
-
CSI 2.2rCSI 3.14%PRS 68.06
-
CSI 2.16rCSI 2.63%PRS 73.54
-
CSI 2.14rCSI 3.16%PRS 71.37
-
CSI 2.1rCSI 50.19%PRS 46.45
-
CSI 2.09rCSI 3.18%PRS 62.53
-
CSI 2.08rCSI 2.69%PRS 48.64
-
CSI 2rCSI 2.4%PRS 64.25
-
CSI 1.93rCSI 3.45%PRS 78.67
-
CSI 1.93rCSI 3.33%PRS 56.29
-
CSI 1.9rCSI 5.13%PRS 72.69
-
CSI 1.9rCSI 2.2%PRS 56.58
-
CSI 1.83rCSI 6.93%PRS 47.98
-
CSI 1.83rCSI 4.37%PRS 66.47
-
CSI 0.1rCSI 0.7%PRS 74.4%
-
CSI 0.1rCSI 1.0%PRS 53.1%
-
CSI 0.2rCSI 4.4%PRS 83.8%
-
CSI 0.3rCSI 2.6%PRS 80.5%
-
CSI 0.3rCSI 4.7%PRS 84.6%
-
CSI 0.3rCSI 1.9%PRS 48.5%
-
CSI 0.5rCSI 3.8%PRS 59.4%
-
CSI 0.6rCSI 1.4%PRS 60.0%
-
CSI 0.6rCSI 4.2%PRS 80.5%
-
CSI 0.6rCSI 1.4%PRS 74.0%
-
CSI 0.6rCSI 14.6%PRS 94.3%
-
CSI 0.6rCSI 3.4%PRS 74.4%
-
CSI 0.6rCSI 1.8%PRS 76.2%
-
CSI 0.7rCSI 5.1%PRS 71.3%
-
CSI 0.7rCSI 3.1%PRS 80.5%
-
CSI 0.7rCSI 3.8%PRS 77.0%
-
CSI 0.7rCSI 1.0%PRS 69.8%
-
CSI 0.8rCSI 3.1%PRS 80.0%
-
CSI 0.8rCSI 11.3%PRS 56.8%
-
CSI 0.9rCSI 3.1%PRS 45.6%
-
CSI 0.9rCSI 2.0%PRS 77.9%
-
CSI 0.9rCSI 21.4%PRS 83.2%
-
CSI 1.0rCSI 2.6%PRS 62.8%
-
CSI 1.0rCSI 3.9%PRS 56.6%
-
CSI 1.1rCSI 1.8%PRS 47.4%
-
CSI 1.1rCSI 3.0%PRS 61.2%
-
CSI 1.1rCSI 2.4%PRS 53.7%
-
CSI 1.1rCSI 4.0%PRS 73.6%
-
CSI 1.2rCSI 2.8%PRS 72.9%
-
CSI 1.2rCSI 3.6%PRS 78.0%
-
CSI 1.3rCSI 1.6%PRS 81.3%
-
CSI 1.3rCSI 1.6%PRS 51.4%
-
CSI 1.3rCSI 2.1%PRS 76.6%
-
CSI 1.4rCSI 3.6%PRS 82.8%
-
CSI 1.4rCSI 4.0%PRS 64.4%
-
CSI 1.4rCSI 2.1%PRS 70.3%
-
CSI 1.4rCSI 4.5%PRS 63.1%
-
CSI 1.4rCSI 4.5%PRS 49.0%
-
CSI 1.5rCSI 6.9%PRS 81.1%
-
CSI 1.5rCSI 2.9%PRS 63.1%
-
CSI 1.5rCSI 2.0%PRS 72.4%
-
CSI 1.5rCSI 2.3%PRS 68.6%
-
CSI 1.5rCSI 2.3%PRS 64.6%
-
CSI 1.6rCSI 9.0%PRS 74.0%
-
CSI 1.6rCSI 2.8%PRS 62.7%
-
CSI 1.6rCSI 3.0%PRS 86.2%
-
CSI 1.7rCSI 7.2%PRS 77.6%
-
CSI 1.7rCSI 2.2%PRS 66.2%
-
CSI 1.7rCSI 3.0%PRS 74.1%
-
CSI 1.7rCSI 2.1%PRS 62.9%
-
CSI 1.7rCSI 2.1%PRS 84.6%
-
CSI 1.7rCSI 42.0%PRS 47.2%
-
CSI 1.8rCSI 3.5%PRS 82.4%
-
CSI 1.8rCSI 7.8%PRS 55.9%
-
CSI 1.8rCSI 1.7%PRS 68.9%
-
CSI 1.8rCSI 11.7%PRS 81.9%
-
CSI 1.8rCSI 3.3%PRS 80.0%
-
CSI 1.8rCSI 4.4%PRS 66.5%
-
CSI 1.8rCSI 6.9%PRS 48.0%
-
CSI 1.9rCSI 2.2%PRS 56.6%
-
CSI 1.9rCSI 5.1%PRS 72.7%
-
CSI 1.9rCSI 3.3%PRS 56.3%
-
CSI 1.9rCSI 3.5%PRS 78.7%
-
CSI 2.0rCSI 2.4%PRS 64.3%
-
CSI 2.1rCSI 2.7%PRS 48.6%
-
CSI 2.1rCSI 3.2%PRS 62.5%
-
CSI 2.1rCSI 50.2%PRS 46.5%
-
CSI 2.1rCSI 3.2%PRS 71.4%
-
CSI 2.2rCSI 2.6%PRS 73.5%
-
CSI 2.2rCSI 3.1%PRS 68.1%
-
CSI 2.2rCSI 1.8%PRS 86.2%
-
CSI 2.2rCSI 1.7%PRS 79.7%
-
CSI 2.2rCSI 3.2%PRS 68.8%
-
CSI 2.2rCSI 45.5%PRS 58.0%
-
CSI 2.3rCSI 5.6%PRS 64.6%
-
CSI 2.3rCSI 3.2%PRS 67.2%
-
CSI 2.3rCSI 4.1%PRS 46.5%
-
CSI 2.4rCSI 2.8%PRS 47.2%
-
CSI 2.5rCSI 2.9%PRS 82.0%
-
CSI 2.5rCSI 3.7%PRS 71.0%
-
CSI 2.5rCSI 51.7%PRS 56.5%
-
CSI 2.6rCSI 5.7%PRS 77.7%
-
CSI 2.6rCSI 12.5%PRS 65.9%
-
CSI 2.7rCSI 5.3%PRS 80.6%
-
CSI 2.7rCSI 2.8%PRS 78.9%
-
CSI 2.8rCSI 4.4%PRS 58.3%
-
CSI 2.8rCSI 6.1%PRS 73.5%
-
CSI 2.9rCSI 9.5%PRS 65.7%
-
CSI 3.0rCSI 18.6%PRS 57.7%
-
CSI 3.1rCSI 13.0%PRS 77.0%
-
CSI 3.1rCSI 14.8%PRS 64.0%
-
CSI 3.2rCSI 4.4%PRS 66.2%
-
CSI 3.2rCSI 13.1%PRS 59.7%
-
CSI 3.2rCSI 9.3%PRS 85.3%
-
CSI 3.3rCSI 9.3%PRS 63.7%
-
CSI 3.3rCSI 2.0%PRS 83.2%
-
CSI 3.3rCSI 8.0%PRS 53.1%
-
CSI 3.5rCSI 4.0%PRS 73.0%
-
CSI 3.5rCSI 3.2%PRS 84.7%
-
CSI 3.5rCSI 7.2%PRS 82.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1511862398
Symbol: FBX32_HUMAN
Name: F-box only protein 32
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11679633
Title: Identification of ubiquitin ligases required for skeletal muscle atrophy.
PubMed ID: 11679633
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15531760
Title: Degradation of MyoD mediated by the SCF (MAFbx) ubiquitin ligase.
PubMed ID: 15531760
PubMed ID: 22249105
Title: Identification of essential sequences for cellular localization in the muscle-specific ubiquitin E3 ligase MAFbx/Atrogin 1.
PubMed ID: 22249105
PubMed ID: 26768247
Title: A substitution mutation in cardiac ubiquitin ligase, FBXO32, is associated with an autosomal recessive form of dilated cardiomyopathy.
PubMed ID: 26768247
PubMed ID: 26753747
Title: FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy.
PubMed ID: 26753747
Sequence Information:
- Length: 355
- Mass: 41637
- Checksum: A0258E5DBEF5CC0E
- Sequence:
MPFLGQDWRS PGQNWVKTAD GWKRFLDEKS GSFVSDLSSY CNKEVYNKEN LFNSLNYDVA AKKRKKDMLN SKTKTQYFHQ EKWIYVHKGS TKERHGYCTL GEAFNRLDFS TAILDSRRFN YVVRLLELIA KSQLTSLSGI AQKNFMNILE KVVLKVLEDQ QNIRLIRELL QTLYTSLCTL VQRVGKSVLV GNINMWVYRM ETILHWQQQL NNIQITRPAF KGLTFTDLPL CLQLNIMQRL SDGRDLVSLG QAAPDLHVLS EDRLLWKKLC QYHFSERQIR KRLILSDKGQ LDWKKMYFKL VRCYPRKEQY GDTLQLCKHC HILSWKGTDH PCTANNPESC SVSLSPQDFI NLFKF
Genular Protein ID: 3207761088
Symbol: Q0VAQ6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 210
- Mass: 24705
- Checksum: F3E5E97AA9EA74D1
- Sequence:
MNILEKVVLK VLEDQQNIRL IRELLQTLYT SLCTLVQRVG KSVLVGNINM WVYRMETILH WQQQLNNIQI TRPAFKGLTF TDLPLCLQLN IMQRLSDGRD LVSLGQAAPD LHVLSEDRLL WKKLCQYHFS ERQIRKRLIL SDKGQLDWKK MYFKLVRCYP RKEQYGDTLQ LCKHCHILSW KGTDHPCTAN NPESCSVSLS PQDFINLFKF
Genular Protein ID: 3255955600
Symbol: I6L984_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 210
- Mass: 24758
- Checksum: 07A0E97AA9EA6FCB
- Sequence:
MNILEKVVLK VLEDQQNIRL IRELLQTLYT SLCTLVQRVG KSVLVGNINM WVYRMETILH WQQQLNNIQI TRPAFKGLTF TDLPLCLQLN IMQRLSDGRD LVSLGQAAPD LHVLSEDRLL WKKLCQYHFS ERQIRKRLIL SDKGQLDWKK MYFKLVRCYP RKEQYGDTLQ LRKHCHILSW KGTDHPCTAN NPESCSVSLS PQDFINLFKF
Genular Protein ID: 949171018
Symbol: Q498Y9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 298
- Mass: 34957
- Checksum: A7FC7E3A5E0EC191
- Sequence:
DVAAKKRKKD MLNSKTKTQY FHQEKWIYVH KGSTKERHGY CTLGEAFNRL DFSTAILDSR RFNYVVRLLE LIAKSQLTSL SGIAQKNFMN ILEKVVLKVL EDQQNIRLIR ELLQTLYTSL CTLVQRVGKS VLVGNINMWV YRMETILHWQ QQLNNIQITR PAFKGLTFTD LPLCLQLNIM QRLSDGRDLV SLGQAAPDLH VLSEDRLLWK KLCQYHFSER QIRKRLILSD KGQLDWKKMY FKLVRCYPRK EQYGDTLQLC KHCHILSWKG TDHPCTANNP ESCSVSLSPQ DFINLFKF