TMEM161B DT | ENSG00000247828 | NCBI 100505894

Details for: TMEM161B DT

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

pvalb GABAergic cortical interneuron CL4023018

CSI 53.36

rCSI 66.38%

PRS 64.81
VIP GABAergic cortical interneuron CL4023016

CSI 51.47

rCSI 61.48%

PRS 66.93
sst GABAergic cortical interneuron CL4023017

CSI 46.51

rCSI 59.96%

PRS 68.08
Bergmann glial cell CL0000644

CSI 39.76

rCSI 54.41%

PRS 75.15
sncg GABAergic cortical interneuron CL4023015

CSI 37.96

rCSI 61.05%

PRS 68.32
lamp5 GABAergic cortical interneuron CL4023011

CSI 37.28

rCSI 62.58%

PRS 66.84
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 36.1

rCSI 63.76%

PRS 66.41
astrocyte of the cerebral cortex CL0002605

CSI 31.99

rCSI 71.72%

PRS 67.79
glioblast CL0000030

CSI 31.84

rCSI 50.79%

PRS 75.46
cerebellar granule cell CL0001031

CSI 29.79

rCSI 43.79%

PRS 77.12
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 29.12

rCSI 63.17%

PRS 71.43
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 28.37

rCSI 67.85%

PRS 70.94
neuron CL0000540

CSI 26.76

rCSI 71.25%

PRS 71.17
glycinergic amacrine cell CL4030028

CSI 26.36

rCSI 68.67%

PRS 77.94
differentiation-committed oligodendrocyte precursor CL4023059

CSI 26.07

rCSI 47.37%

PRS 75.74
cardiac muscle cell CL0000746

CSI 24.75

rCSI 35.52%

PRS 74.14
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 24.39

rCSI 59.27%

PRS 64.8
radial glial cell CL0000681

CSI 23.7

rCSI 32.93%

PRS 82.14
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 23.64

rCSI 16.61%

PRS 93.93
retinal ganglion cell CL0000740

CSI 22.42

rCSI 49.52%

PRS 70.36
interneuron CL0000099

CSI 20.27

rCSI 40.7%

PRS 75.01
oligodendrocyte precursor cell CL0002453

CSI 20.27

rCSI 44.6%

PRS 66.06
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 19.95

rCSI 62.39%

PRS 70.72
L6b glutamatergic cortical neuron CL4023038

CSI 19.88

rCSI 62.13%

PRS 68.43
inhibitory interneuron CL0000498

CSI 18.66

rCSI 43.08%

PRS 72.27
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 18.55

rCSI 60.96%

PRS 69.99
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 18.11

rCSI 10.7%

PRS 96.02
GABAergic amacrine cell CL4030027

CSI 17.64

rCSI 60.43%

PRS 69.89
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 16.32

rCSI 58.72%

PRS 64.82
near-projecting glutamatergic cortical neuron CL4023012

CSI 15.88

rCSI 60.01%

PRS 67.39
forebrain radial glial cell CL0013000

CSI 15.85

rCSI 50.87%

PRS 84.62
glutamatergic neuron CL0000679

CSI 13.89

rCSI 28.55%

PRS 71.01
stromal cell CL0000499

CSI 13.89

rCSI 39.07%

PRS 78.99
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 13.23

rCSI 15.27%

PRS 76.06
neural crest cell CL0011012

CSI 12.57

rCSI 9.93%

PRS 73.81
retinal rod cell CL0000604

CSI 12.56

rCSI 22.14%

PRS 79.03
amacrine cell CL0000561

CSI 12.51

rCSI 36.26%

PRS 73.64
cerebral cortex endothelial cell CL1001602

CSI 12.31

rCSI 21.29%

PRS 75.99
retinal bipolar neuron CL0000748

CSI 11.69

rCSI 21.89%

PRS 72.86
podocyte CL0000653

CSI 11.22

rCSI 49.86%

PRS 84.4
neuroblast (sensu Vertebrata) CL0000031

CSI 11.04

rCSI 14.17%

PRS 80
invaginating midget bipolar cell CL4033034

CSI 11.01

rCSI 65.01%

PRS 75.19
choroid plexus epithelial cell CL0000706

CSI 10.84

rCSI 17.75%

PRS 74.08
colon epithelial cell CL0011108

CSI 10.47

rCSI 10.97%

PRS 81.14
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 10.44

rCSI 61.49%

PRS 67.43
macroglial cell CL0000126

CSI 10.04

rCSI 25.81%

PRS 80.01
adipocyte CL0000136

CSI 9.76

rCSI 12.53%

PRS 74.28
epithelial cell of proximal tubule CL0002306

CSI 9.74

rCSI 23.8%

PRS 76.23
BEST4+ enteroycte CL4030026

CSI 9.7

rCSI 12.07%

PRS 84.38
rod bipolar cell CL0000751

CSI 9.45

rCSI 16.98%

PRS 77.45
melanocyte CL0000148

CSI 9.32

rCSI 6.91%

PRS 77.94
vascular leptomeningeal cell CL4023051

CSI 9.08

rCSI 15.92%

PRS 78.12
kidney interstitial alternatively activated macrophage CL1000695

CSI 9.07

rCSI 23.65%

PRS 84.69
regular atrial cardiac myocyte CL0002129

CSI 8.37

rCSI 26.95%

PRS 80.59
renal alpha-intercalated cell CL0005011

CSI 8.28

rCSI 11.08%

PRS 88.78
naive B cell CL0000788

CSI 8.19

rCSI 7.03%

PRS 88.95
kidney connecting tubule epithelial cell CL1000768

CSI 7.93

rCSI 20.12%

PRS 74.95
secretory cell CL0000151

CSI 7.66

rCSI 7.99%

PRS 83
Mueller cell CL0000636

CSI 7.6

rCSI 17.34%

PRS 75.7
myoepithelial cell CL0000185

CSI 7.48

rCSI 18.92%

PRS 87.7
alpha-beta T cell CL0000789

CSI 7.39

rCSI 8.66%

PRS 94.44
blood vessel endothelial cell CL0000071

CSI 7.34

rCSI 15.23%

PRS 80.81
diffuse bipolar 3b cell CL4033030

CSI 7.22

rCSI 47.89%

PRS 78.21
pro-B cell CL0000826

CSI 7.21

rCSI 5.97%

PRS 85.88
alveolar type 1 fibroblast cell CL4028004

CSI 7.18

rCSI 7.87%

PRS 85.41
cerebral cortex GABAergic interneuron CL0010011

CSI 7.1

rCSI 20.95%

PRS 84.29
ON-bipolar cell CL0000749

CSI 6.9

rCSI 10.26%

PRS 83.19
Schwann cell CL0002573

CSI 6.61

rCSI 18.8%

PRS 79.46
pulmonary ionocyte CL0017000

CSI 6.5

rCSI 7.92%

PRS 89.22
ciliated epithelial cell CL0000067

CSI 6.4

rCSI 5.63%

PRS 73.52
mature T cell CL0002419

CSI 6.3

rCSI 4.9%

PRS 94.6
enteric smooth muscle cell CL0002504

CSI 6.16

rCSI 8.78%

PRS 84.33
lung pericyte CL0009089

CSI 5.98

rCSI 15.78%

PRS 89.24
mature astrocyte CL0002627

CSI 5.96

rCSI 25.31%

PRS 76.13
retinal cone cell CL0000573

CSI 5.76

rCSI 9.27%

PRS 74.43
hepatic stellate cell CL0000632

CSI 5.47

rCSI 20.49%

PRS 76.75
megakaryocyte-erythroid progenitor cell CL0000050

CSI 5.39

rCSI 4.87%

PRS 82.23
lung neuroendocrine cell CL1000223

CSI 5.35

rCSI 7.92%

PRS 86.66
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 5.32

rCSI 7.54%

PRS 80.79
Kupffer cell CL0000091

CSI 4.94

rCSI 11.29%

PRS 84.55
cardiac neuron CL0010022

CSI 4.86

rCSI 15.54%

PRS 81.46
cerebral cortex pyramidal neuron CL4023111

CSI 4.8

rCSI 29.55%

PRS 87.29
renal interstitial pericyte CL1001318

CSI 4.77

rCSI 13.16%

PRS 79.27
peripheral nervous system neuron CL2000032

CSI 4.77

rCSI 6.5%

PRS 75.75
alveolar adventitial fibroblast CL4028006

CSI 4.73

rCSI 7.47%

PRS 84.96
GABAergic neuron CL0000617

CSI 4.69

rCSI 15.72%

PRS 68
transit amplifying cell of colon CL0009011

CSI 4.68

rCSI 5.5%

PRS 85.12
pulmonary alveolar type 1 cell CL0002062

CSI 4.67

rCSI 26.92%

PRS 80.07
bronchus fibroblast of lung CL2000093

CSI 4.67

rCSI 3.79%

PRS 83.14
plasmacytoid dendritic cell, human CL0001058

CSI 4.67

rCSI 3.26%

PRS 87.01
tuft cell of colon CL0009041

CSI 4.64

rCSI 10.81%

PRS 88.03
fibroblast of cardiac tissue CL0002548

CSI 4.62

rCSI 22.13%

PRS 83.75
diffuse bipolar 4 cell CL4033031

CSI 4.51

rCSI 51.64%

PRS 72.31
cardiac endothelial cell CL0010008

CSI 4.5

rCSI 18.15%

PRS 83.88
retina horizontal cell CL0000745

CSI 4.46

rCSI 6.8%

PRS 80.57
diffuse bipolar 3a cell CL4033029

CSI 4.38

rCSI 29.81%

PRS 75.89
mesothelial cell CL0000077

CSI 4.35

rCSI 17%

PRS 63.28
ON parasol ganglion cell CL4033052

CSI 4.28

rCSI 60.8%

PRS 75.18
epithelial cell of lower respiratory tract CL0002632

CSI 4.28

rCSI 3.32%

PRS 87.08
contractile cell CL0000183

CSI 4.2

rCSI 12.41%

PRS 82.85

pancreatic ductal cell CL0002079

CSI 0.8

rCSI 1.6%

PRS 86.6%
enterocyte of epithelium of small intestine CL1000334

CSI 0.9

rCSI 14.4%

PRS 89.7%
Cajal-Retzius cell CL0000695

CSI 1.1

rCSI 8.2%

PRS 87.2%
enteroglial cell CL4040002

CSI 1.1

rCSI 5.9%

PRS 84.8%
placental villous trophoblast CL2000060

CSI 1.2

rCSI 1.8%

PRS 82.6%
type B pancreatic cell CL0000169

CSI 1.2

rCSI 2.7%

PRS 83.3%
starburst amacrine cell CL0004232

CSI 1.3

rCSI 10.6%

PRS 71.5%
eye photoreceptor cell CL0000287

CSI 1.3

rCSI 14.4%

PRS 89.9%
neural progenitor cell CL0011020

CSI 1.4

rCSI 6.1%

PRS 72.2%
transit amplifying cell of small intestine CL0009012

CSI 1.4

rCSI 6.1%

PRS 89.9%
paneth cell of epithelium of small intestine CL1000343

CSI 1.5

rCSI 4.1%

PRS 89.1%
diffuse bipolar 1 cell CL4033027

CSI 1.5

rCSI 11.0%

PRS 73.6%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 1.5

rCSI 2.1%

PRS 96.3%
enterocyte of epithelium of large intestine CL0002071

CSI 1.6

rCSI 8.3%

PRS 87.8%
H2 horizontal cell CL0004218

CSI 1.7

rCSI 8.4%

PRS 78.1%
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 1.8

rCSI 15.2%

PRS 78.2%
enteroendocrine cell of small intestine CL0009006

CSI 1.8

rCSI 4.0%

PRS 89.7%
lung ciliated cell CL1000271

CSI 1.8

rCSI 2.1%

PRS 76.7%
intestinal epithelial cell CL0002563

CSI 1.9

rCSI 1.9%

PRS 81.3%
kidney distal convoluted tubule epithelial cell CL1000849

CSI 1.9

rCSI 20.0%

PRS 79.9%
extravillous trophoblast CL0008036

CSI 1.9

rCSI 2.4%

PRS 82.0%
pancreatic A cell CL0000171

CSI 2.0

rCSI 2.1%

PRS 86.7%
conjunctival epithelial cell CL1000432

CSI 2.0

rCSI 3.1%

PRS 83.7%
common dendritic progenitor CL0001029

CSI 2.1

rCSI 2.6%

PRS 90.8%
duct epithelial cell CL0000068

CSI 2.1

rCSI 3.1%

PRS 88.1%
ionocyte CL0005006

CSI 2.2

rCSI 2.4%

PRS 85.4%
OFF-bipolar cell CL0000750

CSI 2.2

rCSI 3.1%

PRS 84.7%
regular ventricular cardiac myocyte CL0002131

CSI 2.2

rCSI 14.0%

PRS 76.1%
progenitor cell CL0011026

CSI 2.3

rCSI 4.8%

PRS 77.6%
pancreatic acinar cell CL0002064

CSI 2.3

rCSI 3.1%

PRS 88.4%
lymphoid lineage restricted progenitor cell CL0000838

CSI 2.4

rCSI 9.2%

PRS 95.3%
small intestine goblet cell CL1000495

CSI 2.5

rCSI 5.4%

PRS 88.0%
lung secretory cell CL1000272

CSI 2.5

rCSI 6.2%

PRS 83.9%
hepatocyte CL0000182

CSI 2.5

rCSI 4.5%

PRS 82.8%
indirect pathway medium spiny neuron CL4023029

CSI 2.6

rCSI 63.2%

PRS 65.3%
colon goblet cell CL0009039

CSI 2.6

rCSI 6.2%

PRS 87.6%
CD14-low, CD16-positive monocyte CL0002396

CSI 2.6

rCSI 2.0%

PRS 86.8%
direct pathway medium spiny neuron CL4023026

CSI 2.7

rCSI 63.4%

PRS 64.8%
pancreatic D cell CL0000173

CSI 2.7

rCSI 2.6%

PRS 85.8%
interstitial cell of Cajal CL0002088

CSI 2.7

rCSI 3.5%

PRS 88.3%
renal principal cell CL0005009

CSI 2.7

rCSI 7.1%

PRS 83.6%
respiratory suprabasal cell CL4033048

CSI 2.8

rCSI 3.6%

PRS 86.4%
midbrain dopaminergic neuron CL2000097

CSI 2.8

rCSI 18.1%

PRS 78.9%
retinal pigment epithelial cell CL0002586

CSI 2.9

rCSI 5.8%

PRS 79.6%
blood vessel smooth muscle cell CL0019018

CSI 2.9

rCSI 23.8%

PRS 78.7%
microcirculation associated smooth muscle cell CL0008035

CSI 3.0

rCSI 8.6%

PRS 82.9%
OFF midget ganglion cell CL4033047

CSI 3.0

rCSI 61.0%

PRS 74.8%
ON midget ganglion cell CL4033046

CSI 3.0

rCSI 61.8%

PRS 73.8%
common myeloid progenitor CL0000049

CSI 3.1

rCSI 2.5%

PRS 85.7%
mesodermal cell CL0000222

CSI 3.2

rCSI 3.9%

PRS 81.8%
chondrocyte CL0000138

CSI 3.3

rCSI 5.2%

PRS 77.2%
S cone cell CL0003050

CSI 3.4

rCSI 14.8%

PRS 78.3%
OFFx cell CL4033036

CSI 3.4

rCSI 15.9%

PRS 74.8%
intestinal crypt stem cell of small intestine CL0009017

CSI 3.4

rCSI 9.2%

PRS 87.4%
glial cell CL0000125

CSI 3.5

rCSI 13.3%

PRS 75.3%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 3.6

rCSI 9.3%

PRS 79.6%
parietal epithelial cell CL1000452

CSI 3.6

rCSI 9.7%

PRS 76.2%
epithelial cell of lung CL0000082

CSI 3.6

rCSI 3.0%

PRS 84.8%
endocardial cell CL0002350

CSI 3.8

rCSI 18.0%

PRS 79.8%
renal beta-intercalated cell CL0002201

CSI 3.8

rCSI 9.0%

PRS 83.4%
cerebral cortex neuron CL0010012

CSI 3.9

rCSI 15.9%

PRS 75.7%
diffuse bipolar 2 cell CL4033028

CSI 4.1

rCSI 31.7%

PRS 77.5%
flat midget bipolar cell CL4033033

CSI 4.2

rCSI 29.8%

PRS 74.5%
contractile cell CL0000183

CSI 4.2

rCSI 12.4%

PRS 82.9%
epithelial cell of lower respiratory tract CL0002632

CSI 4.3

rCSI 3.3%

PRS 87.1%
ON parasol ganglion cell CL4033052

CSI 4.3

rCSI 60.8%

PRS 75.2%
mesothelial cell CL0000077

CSI 4.4

rCSI 17.0%

PRS 63.3%
diffuse bipolar 3a cell CL4033029

CSI 4.4

rCSI 29.8%

PRS 75.9%
retina horizontal cell CL0000745

CSI 4.5

rCSI 6.8%

PRS 80.6%
cardiac endothelial cell CL0010008

CSI 4.5

rCSI 18.2%

PRS 83.9%
diffuse bipolar 4 cell CL4033031

CSI 4.5

rCSI 51.6%

PRS 72.3%
fibroblast of cardiac tissue CL0002548

CSI 4.6

rCSI 22.1%

PRS 83.8%
tuft cell of colon CL0009041

CSI 4.6

rCSI 10.8%

PRS 88.0%
plasmacytoid dendritic cell, human CL0001058

CSI 4.7

rCSI 3.3%

PRS 87.0%
bronchus fibroblast of lung CL2000093

CSI 4.7

rCSI 3.8%

PRS 83.1%
pulmonary alveolar type 1 cell CL0002062

CSI 4.7

rCSI 26.9%

PRS 80.1%
transit amplifying cell of colon CL0009011

CSI 4.7

rCSI 5.5%

PRS 85.1%
GABAergic neuron CL0000617

CSI 4.7

rCSI 15.7%

PRS 68.0%
alveolar adventitial fibroblast CL4028006

CSI 4.7

rCSI 7.5%

PRS 85.0%
peripheral nervous system neuron CL2000032

CSI 4.8

rCSI 6.5%

PRS 75.8%
renal interstitial pericyte CL1001318

CSI 4.8

rCSI 13.2%

PRS 79.3%
cerebral cortex pyramidal neuron CL4023111

CSI 4.8

rCSI 29.6%

PRS 87.3%
cardiac neuron CL0010022

CSI 4.9

rCSI 15.5%

PRS 81.5%
Kupffer cell CL0000091

CSI 4.9

rCSI 11.3%

PRS 84.6%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 5.3

rCSI 7.5%

PRS 80.8%
lung neuroendocrine cell CL1000223

CSI 5.4

rCSI 7.9%

PRS 86.7%
megakaryocyte-erythroid progenitor cell CL0000050

CSI 5.4

rCSI 4.9%

PRS 82.2%
hepatic stellate cell CL0000632

CSI 5.5

rCSI 20.5%

PRS 76.8%
retinal cone cell CL0000573

CSI 5.8

rCSI 9.3%

PRS 74.4%
mature astrocyte CL0002627

CSI 6.0

rCSI 25.3%

PRS 76.1%
lung pericyte CL0009089

CSI 6.0

rCSI 15.8%

PRS 89.2%
enteric smooth muscle cell CL0002504

CSI 6.2

rCSI 8.8%

PRS 84.3%
mature T cell CL0002419

CSI 6.3

rCSI 4.9%

PRS 94.6%
ciliated epithelial cell CL0000067

CSI 6.4

rCSI 5.6%

PRS 73.5%
pulmonary ionocyte CL0017000

CSI 6.5

rCSI 7.9%

PRS 89.2%
Schwann cell CL0002573

CSI 6.6

rCSI 18.8%

PRS 79.5%
ON-bipolar cell CL0000749

CSI 6.9

rCSI 10.3%

PRS 83.2%
cerebral cortex GABAergic interneuron CL0010011

CSI 7.1

rCSI 21.0%

PRS 84.3%
alveolar type 1 fibroblast cell CL4028004

CSI 7.2

rCSI 7.9%

PRS 85.4%
pro-B cell CL0000826

CSI 7.2

rCSI 6.0%

PRS 85.9%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description

## Summary [TMEM161B DT](/details-gene/100505894) is a non-coding RNA (ncRNA) gene located on human chromosome 5q14.3. Expression data indicates that this gene is highly and specifically active within the central nervous system. Its significance is particularly pronounced across a diverse range of neuronal and glial cell types, most notably various subtypes of GABAergic cortical interneurons, including [pvalb](/details-cell/CL4023018), [VIP](/details-cell/CL4023016), and [sst](/details-cell/CL4023017) expressing cells. The high expression in these inhibitory [neurons](/details-cell/CL0000540) as well as in glial cells like [astrocytes](/details-cell/CL0002605) and [Bergmann glial cells](/details-cell/CL0000644), suggests a potential regulatory role in neural circuit function, glial support, and overall brain homeostasis. ## Cellular Roles and Expression Landscape The expression profile of [TMEM161B DT](/details-gene/100505894) demonstrates a profound enrichment within the central nervous system. **Overall**, the gene shows the highest significance in multiple, distinct classes of inhibitory interneurons, which are critical for regulating neural network activity. Top-ranking cell types include [pvalb GABAergic cortical interneurons](/details-cell/CL4023018) (CSI: 53.36), [VIP GABAergic cortical interneurons](/details-cell/CL4023016) (CSI: 51.47), and [sst GABAergic cortical interneurons](/details-cell/CL4023017) (CSI: 46.51). This pattern suggests a fundamental role for [TMEM161B DT](/details-gene/100505894) in the biology of cortical inhibitory circuits. Beyond interneurons, the gene is also significantly expressed in various glial populations. These include [Bergmann glial cells](/details-cell/CL0000644) (CSI: 39.76), [astrocytes of the cerebral cortex](/details-cell/CL0002605) (CSI: 31.99), and [differentiation-committed oligodendrocyte precursors](/details-cell/CL4023059) (CSI: 26.07), indicating a potential function in glial development, maintenance, or neuron-glia communication. Notably, [TMEM161B DT](/details-gene/100505894) also shows high significance in [glioblast](/details-cell/CL0000030) cells (CSI: 31.84), hinting at a possible involvement in the pathology of brain tumors. The gene's activity extends to other neuronal types as well, such as [cerebellar granule cells](/details-cell/CL0001031) and glutamatergic projecting [neurons](/details-cell/CL0000540), reinforcing its widespread importance in neural cell biology. ## Pathways and Molecular Function Detailed functional annotation for [TMEM161B DT](/details-gene/100505894) is not available in the provided dataset. As a non-coding RNA, its mechanism of action is likely regulatory. It may function by modulating the expression of adjacent or distal genes, acting as a scaffold for chromatin-modifying complexes, or influencing mRNA stability and translation. Elucidating its specific molecular interactions and downstream pathways is a key area for future investigation. ## Research Directions The highly specific expression pattern of [TMEM161B DT](/details-gene/100505894) in the central nervous system, particularly its dual significance in both healthy neural cells and malignant [glioblasts](/details-cell/CL0000030), opens several avenues for research. **Proposed Hypotheses:** 1. Given its high expression across multiple inhibitory interneuron subtypes, [TMEM161B DT](/details-gene/100505894) may be a master regulator of GABAergic neuron identity or function, essential for maintaining the excitatory/inhibitory balance in the cerebral cortex. 2. The significant expression of [TMEM161B DT](/details-gene/100505894) in [glioblast](/details-cell/CL0000030) cells suggests it may be co-opted during tumorigenesis, contributing to tumor cell proliferation, survival, or resistance to therapy. **Experimental Approach:** To test the hypothesis regarding its role in glioblastoma, one could perform a loss-of-function screen using CRISPR interference (CRISPRi) or antisense oligonucleotides (ASOs) to knockdown [TMEM161B DT](/details-gene/100505894) in patient-derived glioblastoma cell lines. The impact on cell viability, proliferation (e.g., via BrdU incorporation assays), and invasive potential (e.g., via Matrigel invasion assays) would be quantified. Subsequent RNA-sequencing of knockdown cells could identify the downstream pathways and target genes regulated by this ncRNA, potentially uncovering novel therapeutic targets. **Therapeutic Potential:** As a non-coding RNA with enriched expression in [glioblast](/details-cell/CL0000030) cells, [TMEM161B DT](/details-gene/100505894) presents a potential therapeutic target. An inhibitory strategy would be most appropriate. The development of brain-penetrant ASOs designed to specifically degrade the [TMEM161B DT](/details-gene/100505894) transcript could offer a novel therapeutic approach for glioblastoma, potentially slowing tumor growth or sensitizing cancer cells to existing chemotherapies. Its specificity to the CNS might limit peripheral toxicity, although on-target effects in healthy [neurons](/details-cell/CL0000540) and glia would need to be carefully evaluated.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood Healthy UBERON0000178_PATO0000461
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast cancer MONDO0007254
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Occipital cortex UBERON0016540
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	\|— Prefrontal cortex Healthy UBERON0000451_PATO0000461
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Right cardiac atrium UBERON0002078
	\|— Right cardiac atrium Healthy UBERON0002078_PATO0000461
	Schizophrenia MONDO0005090
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: TMEM161B DT

Cell Significance Landscape

Significant Cells

Network Configuration

Legend:

Other Information