Details for: WWTR1
Gene ID: 25937
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: WWTR1
Ensembl ID: ENSG00000018408
Description: WW domain containing transcription regulator 1
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 22.4rCSI 27.14%PRS 61.43
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CSI 16.11rCSI 36.78%PRS 71.98
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CSI 15.51rCSI 31.47%PRS 59.05
-
CSI 15.4rCSI 28.84%PRS 68.94
-
CSI 14.14rCSI 22.58%PRS 83.95
-
CSI 13.25rCSI 21.62%PRS 47.64
-
CSI 13.13rCSI 64.7%PRS 87.62
-
CSI 13.06rCSI 22.59%PRS 72.13
-
CSI 12.61rCSI 25.03%PRS 76.14
-
CSI 12.13rCSI 28.28%PRS 90.5
-
CSI 12.06rCSI 19.54%PRS 75.31
-
CSI 11.62rCSI 30.19%PRS 81.09
-
CSI 11.28rCSI 8.74%PRS 83.99
-
CSI 10.1rCSI 25.63%PRS 70.96
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CSI 9.92rCSI 13.5%PRS 88.43
-
CSI 9.91rCSI 59.41%PRS 82.57
-
CSI 9.75rCSI 15.7%PRS 70.61
-
CSI 9.59rCSI 8.27%PRS 81.4
-
CSI 9.09rCSI 11.58%PRS 85.26
-
CSI 8.85rCSI 12.97%PRS 87
-
CSI 8.79rCSI 6.95%PRS 69.35
-
CSI 8.23rCSI 24.42%PRS 88.57
-
CSI 8.2rCSI 39.27%PRS 76.77
-
CSI 8.19rCSI 13.06%PRS 72
-
CSI 8.04rCSI 11.17%PRS 78.9
-
CSI 7.99rCSI 11.06%PRS 77.67
-
CSI 7.98rCSI 24.6%PRS 84.43
-
CSI 7.98rCSI 5.91%PRS 74.1
-
CSI 7.56rCSI 55.25%PRS 88.38
-
CSI 7.45rCSI 19.65%PRS 86.71
-
CSI 7.41rCSI 52.4%PRS 73.39
-
CSI 7.3rCSI 9.03%PRS 78.32
-
CSI 7.25rCSI 6.75%PRS 81.18
-
CSI 7.12rCSI 9.14%PRS 70.57
-
CSI 6.93rCSI 22.17%PRS 77.81
-
CSI 6.89rCSI 7.19%PRS 79.75
-
CSI 6.85rCSI 19.82%PRS 86.87
-
CSI 6.62rCSI 12.87%PRS 83.35
-
CSI 6.26rCSI 6.71%PRS 81.76
-
CSI 6.22rCSI 25.09%PRS 80.09
-
CSI 6.14rCSI 9.38%PRS 80.57
-
CSI 6.07rCSI 9.32%PRS 69.79
-
CSI 6.02rCSI 12.5%PRS 77.08
-
CSI 6.02rCSI 11.48%PRS 89.5
-
CSI 5.96rCSI 7.64%PRS 83.54
-
CSI 5.92rCSI 10.85%PRS 84.55
-
CSI 5.75rCSI 10.08%PRS 74.41
-
CSI 5.65rCSI 12.68%PRS 63.41
-
CSI 5.61rCSI 6.49%PRS 72.81
-
CSI 5.58rCSI 4.91%PRS 69.74
-
CSI 5.46rCSI 5.26%PRS 79.67
-
CSI 5.14rCSI 14.13%PRS 87
-
CSI 5.03rCSI 5.02%PRS 74.24
-
CSI 4.95rCSI 6.16%PRS 60.51
-
CSI 4.79rCSI 32.89%PRS 86.86
-
CSI 4.79rCSI 6.55%PRS 84.8
-
CSI 4.79rCSI 14.96%PRS 64.25
-
CSI 4.69rCSI 26.04%PRS 89.04
-
CSI 4.53rCSI 11.46%PRS 85.32
-
CSI 4.51rCSI 8.04%PRS 88.47
-
CSI 4.47rCSI 7.36%PRS 84.08
-
CSI 4.35rCSI 4.77%PRS 82.22
-
CSI 4.29rCSI 21.61%PRS 77.75
-
CSI 4.28rCSI 5.11%PRS 62.68
-
CSI 4.25rCSI 3.46%PRS 79.75
-
CSI 4.21rCSI 11.48%PRS 87.7
-
CSI 4.12rCSI 10.74%PRS 81.39
-
CSI 4.04rCSI 8%PRS 85.65
-
CSI 3.9rCSI 9.54%PRS 72.82
-
CSI 3.88rCSI 10.38%PRS 72.22
-
CSI 3.87rCSI 3.73%PRS 73.77
-
CSI 3.85rCSI 31.32%PRS 74.73
-
CSI 3.82rCSI 14.33%PRS 72.99
-
CSI 3.79rCSI 3.14%PRS 81.1
-
CSI 3.78rCSI 5.36%PRS 77.15
-
CSI 3.55rCSI 8.47%PRS 84.39
-
CSI 3.51rCSI 20.13%PRS 85.95
-
CSI 3.5rCSI 8.41%PRS 84.1
-
CSI 3.3rCSI 7.82%PRS 80.56
-
CSI 3.24rCSI 7.42%PRS 81.12
-
CSI 3.19rCSI 10.36%PRS 78.56
-
CSI 3.18rCSI 7.57%PRS 80.5
-
CSI 3.14rCSI 7.48%PRS 77.03
-
CSI 3.11rCSI 13.21%PRS 72.58
-
CSI 3.11rCSI 4.43%PRS 81.23
-
CSI 3.1rCSI 7.07%PRS 74.14
-
CSI 3.1rCSI 32.04%PRS 74.11
-
CSI 3.08rCSI 10.02%PRS 77.95
-
CSI 3.05rCSI 17.61%PRS 77.02
-
CSI 3rCSI 4.02%PRS 78.76
-
CSI 2.99rCSI 4.38%PRS 75.01
-
CSI 2.99rCSI 4.63%PRS 84.25
-
CSI 2.99rCSI 8.49%PRS 76.16
-
CSI 2.91rCSI 13.93%PRS 80.24
-
CSI 2.89rCSI 15.8%PRS 76.88
-
CSI 2.87rCSI 6.98%PRS 60.59
-
CSI 2.85rCSI 4.19%PRS 73.44
-
CSI 2.84rCSI 7.84%PRS 75.56
-
CSI 2.82rCSI 4.05%PRS 70.33
-
CSI 2.81rCSI 7.39%PRS 91.48
-
CSI 0.2rCSI 1.8%PRS 85.7%
-
CSI 0.2rCSI 4.6%PRS 87.9%
-
CSI 0.4rCSI 1.5%PRS 60.5%
-
CSI 0.5rCSI 3.4%PRS 72.2%
-
CSI 0.6rCSI 1.7%PRS 66.6%
-
CSI 0.6rCSI 3.7%PRS 84.2%
-
CSI 0.6rCSI 5.1%PRS 88.7%
-
CSI 0.9rCSI 5.4%PRS 88.9%
-
CSI 1.0rCSI 5.9%PRS 89.1%
-
CSI 1.0rCSI 1.7%PRS 62.6%
-
CSI 1.1rCSI 11.3%PRS 76.7%
-
CSI 1.1rCSI 7.0%PRS 85.7%
-
CSI 1.1rCSI 2.8%PRS 73.8%
-
CSI 1.1rCSI 5.9%PRS 87.9%
-
CSI 1.1rCSI 4.2%PRS 63.1%
-
CSI 1.1rCSI 3.6%PRS 77.2%
-
CSI 1.1rCSI 4.9%PRS 87.2%
-
CSI 1.2rCSI 26.7%PRS 91.6%
-
CSI 1.2rCSI 1.6%PRS 85.8%
-
CSI 1.2rCSI 2.3%PRS 90.1%
-
CSI 1.3rCSI 11.0%PRS 75.1%
-
CSI 1.3rCSI 3.5%PRS 85.0%
-
CSI 1.3rCSI 3.7%PRS 75.4%
-
CSI 1.3rCSI 2.1%PRS 81.9%
-
CSI 1.5rCSI 3.8%PRS 77.1%
-
CSI 1.6rCSI 2.3%PRS 89.3%
-
CSI 1.6rCSI 5.4%PRS 77.9%
-
CSI 1.6rCSI 3.1%PRS 90.5%
-
CSI 1.7rCSI 7.4%PRS 81.0%
-
CSI 1.7rCSI 4.4%PRS 87.3%
-
CSI 1.8rCSI 5.2%PRS 86.9%
-
CSI 1.8rCSI 4.4%PRS 83.4%
-
CSI 1.9rCSI 2.8%PRS 85.1%
-
CSI 1.9rCSI 10.1%PRS 81.6%
-
CSI 1.9rCSI 5.0%PRS 75.9%
-
CSI 2.0rCSI 8.7%PRS 89.6%
-
CSI 2.0rCSI 7.5%PRS 71.5%
-
CSI 2.0rCSI 5.8%PRS 79.9%
-
CSI 2.1rCSI 3.7%PRS 85.4%
-
CSI 2.1rCSI 40.6%PRS 88.0%
-
CSI 2.1rCSI 2.9%PRS 71.9%
-
CSI 2.2rCSI 3.4%PRS 88.7%
-
CSI 2.2rCSI 2.9%PRS 63.7%
-
CSI 2.2rCSI 2.7%PRS 78.3%
-
CSI 2.3rCSI 9.2%PRS 88.6%
-
CSI 2.3rCSI 13.3%PRS 63.3%
-
CSI 2.3rCSI 10.4%PRS 84.6%
-
CSI 2.3rCSI 4.1%PRS 79.6%
-
CSI 2.3rCSI 7.4%PRS 82.3%
-
CSI 2.3rCSI 10.4%PRS 88.0%
-
CSI 2.3rCSI 55.6%PRS 88.7%
-
CSI 2.3rCSI 6.8%PRS 91.6%
-
CSI 2.4rCSI 6.0%PRS 80.2%
-
CSI 2.5rCSI 4.3%PRS 49.7%
-
CSI 2.6rCSI 4.2%PRS 70.0%
-
CSI 2.6rCSI 10.9%PRS 85.7%
-
CSI 2.6rCSI 28.6%PRS 88.3%
-
CSI 2.7rCSI 9.5%PRS 84.2%
-
CSI 2.7rCSI 3.8%PRS 79.6%
-
CSI 2.7rCSI 2.8%PRS 84.3%
-
CSI 2.7rCSI 24.2%PRS 88.3%
-
CSI 2.8rCSI 4.4%PRS 73.6%
-
CSI 2.8rCSI 4.3%PRS 79.5%
-
CSI 2.8rCSI 7.4%PRS 91.5%
-
CSI 2.8rCSI 4.1%PRS 70.3%
-
CSI 2.8rCSI 7.8%PRS 75.6%
-
CSI 2.9rCSI 4.2%PRS 73.4%
-
CSI 2.9rCSI 7.0%PRS 60.6%
-
CSI 2.9rCSI 15.8%PRS 76.9%
-
CSI 2.9rCSI 13.9%PRS 80.2%
-
CSI 3.0rCSI 8.5%PRS 76.2%
-
CSI 3.0rCSI 4.6%PRS 84.3%
-
CSI 3.0rCSI 4.4%PRS 75.0%
-
CSI 3.0rCSI 4.0%PRS 78.8%
-
CSI 3.1rCSI 17.6%PRS 77.0%
-
CSI 3.1rCSI 10.0%PRS 78.0%
-
CSI 3.1rCSI 32.0%PRS 74.1%
-
CSI 3.1rCSI 7.1%PRS 74.1%
-
CSI 3.1rCSI 4.4%PRS 81.2%
-
CSI 3.1rCSI 13.2%PRS 72.6%
-
CSI 3.1rCSI 7.5%PRS 77.0%
-
CSI 3.2rCSI 7.6%PRS 80.5%
-
CSI 3.2rCSI 10.4%PRS 78.6%
-
CSI 3.2rCSI 7.4%PRS 81.1%
-
CSI 3.3rCSI 7.8%PRS 80.6%
-
CSI 3.5rCSI 8.4%PRS 84.1%
-
CSI 3.5rCSI 20.1%PRS 86.0%
-
CSI 3.6rCSI 8.5%PRS 84.4%
-
CSI 3.8rCSI 5.4%PRS 77.2%
-
CSI 3.8rCSI 3.1%PRS 81.1%
-
CSI 3.8rCSI 14.3%PRS 73.0%
-
CSI 3.9rCSI 31.3%PRS 74.7%
-
CSI 3.9rCSI 3.7%PRS 73.8%
-
CSI 3.9rCSI 10.4%PRS 72.2%
-
CSI 3.9rCSI 9.5%PRS 72.8%
-
CSI 4.0rCSI 8.0%PRS 85.7%
-
CSI 4.1rCSI 10.7%PRS 81.4%
-
CSI 4.2rCSI 11.5%PRS 87.7%
-
CSI 4.3rCSI 3.5%PRS 79.8%
-
CSI 4.3rCSI 5.1%PRS 62.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 317407180
Symbol: WWTR1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11118213
Title: TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
PubMed ID: 11118213
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18227151
Title: TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway.
PubMed ID: 18227151
DOI: 10.1128/mcb.01874-07
PubMed ID: 18568018
Title: TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
PubMed ID: 18568018
DOI: 10.1038/ncb1748
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19010321
Title: TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation.
PubMed ID: 19010321
PubMed ID: 19324877
Title: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.
PubMed ID: 19324877
PubMed ID: 21145499
Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.
PubMed ID: 21145499
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21205866
Title: Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.
PubMed ID: 21205866
DOI: 10.1101/gad.2000111
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23873930
Title: Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.
PubMed ID: 23873930
PubMed ID: 23911299
Title: AMOTL2 interaction with TAZ causes the inhibition of surfactant proteins expression in lung cells.
PubMed ID: 23911299
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25849865
Title: Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.
PubMed ID: 25849865
DOI: 10.1038/ncomms7781
PubMed ID: 29695716
Title: Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K.
PubMed ID: 29695716
Sequence Information:
- Length: 400
- Mass: 44101
- Checksum: 630B50F46FB74C60
- Sequence:
MNPASAPPPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA GAAGSPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT TWQDPRKAMN QPLNHMNLHP AVSSTPVPQR SMAVSQPNLV MNHQHQQQMA PSTLSQQNHP TQNPPAGLMS MPNALTTQQQ QQQKLRLQRI QMERERIRMR QEELMRQEAA LCRQLPMEAE TLAPVQAAVN PPTMTPDMRS ITNNSSDPFL NGGPYHSREQ STDSGLGLGC YSVPTTPEDF LSNVDEMDTG ENAGQTPMNI NPQQTRFPDF LDCLPGTNVD LGTLESEDLI PLFNDVESAL NKSEPFLTWL