Details for: GLCCI1
Gene ID: 113263
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: GLCCI1
Ensembl ID: ENSG00000106415
Description: glucocorticoid induced 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 31.05rCSI 52.12%PRS 45.94
-
CSI 29.74rCSI 37%PRS 44.12
-
CSI 23.13rCSI 56.23%PRS 44.43
-
CSI 20.28rCSI 32.62%PRS 47.88
-
CSI 19.78rCSI 23.18%PRS 80.48
-
CSI 17.32rCSI 38.1%PRS 46.98
-
CSI 16.88rCSI 43.62%PRS 59.48
-
CSI 16.86rCSI 40.32%PRS 51.55
-
CSI 16.53rCSI 62.47%PRS 46.62
-
CSI 16.07rCSI 20.72%PRS 47.22
-
CSI 15.76rCSI 29.52%PRS 52.66
-
CSI 14.59rCSI 14.33%PRS 80.08
-
CSI 14.55rCSI 15.6%PRS 64.32
-
CSI 13.69rCSI 42.8%PRS 50.03
-
CSI 13.52rCSI 11.59%PRS 72.09
-
CSI 12.46rCSI 27.04%PRS 52.16
-
CSI 11.8rCSI 36.89%PRS 47.6
-
CSI 11.26rCSI 10.64%PRS 63.88
-
CSI 11.23rCSI 8.83%PRS 71.22
-
CSI 11.07rCSI 39.82%PRS 44.26
-
CSI 10.92rCSI 13.04%PRS 45.76
-
CSI 10.57rCSI 9.84%PRS 65.13
-
CSI 10.51rCSI 8.3%PRS 51.34
-
CSI 10.48rCSI 61.73%PRS 47.07
-
CSI 10.39rCSI 35.6%PRS 53.01
-
CSI 10.09rCSI 20.48%PRS 43.48
-
CSI 10.08rCSI 52.98%PRS 58.55
-
CSI 9.4rCSI 7.59%PRS 75
-
CSI 9.15rCSI 16.63%PRS 56.19
-
CSI 9.07rCSI 16.29%PRS 57.72
-
CSI 8.93rCSI 9.14%PRS 77.96
-
CSI 8.92rCSI 11.45%PRS 61.48
-
CSI 8.69rCSI 6.11%PRS 82.14
-
CSI 8.42rCSI 6.3%PRS 79.53
-
CSI 8.21rCSI 13.1%PRS 56.84
-
CSI 8.2rCSI 36.05%PRS 60.85
-
CSI 8.14rCSI 58.2%PRS 57.24
-
CSI 7.93rCSI 5.69%PRS 78.61
-
CSI 7.76rCSI 17.14%PRS 50.5
-
CSI 7.73rCSI 10.95%PRS 60.87
-
CSI 7.54rCSI 50.05%PRS 61.31
-
CSI 7.43rCSI 33.03%PRS 64.38
-
CSI 7.38rCSI 9.86%PRS 73.35
-
CSI 7.23rCSI 14.53%PRS 53.5
-
CSI 7.06rCSI 41.72%PRS 58.89
-
CSI 7.02rCSI 8.11%PRS 57.38
-
CSI 6.86rCSI 10.59%PRS 62.95
-
CSI 6.69rCSI 11.81%PRS 45.03
-
CSI 6.68rCSI 15.24%PRS 60.62
-
CSI 6.53rCSI 17.03%PRS 64.22
-
CSI 6.47rCSI 14.77%PRS 56.08
-
CSI 6.38rCSI 10.34%PRS 60.96
-
CSI 6.32rCSI 4.75%PRS 70.19
-
CSI 6.3rCSI 15.02%PRS 65.07
-
CSI 6.17rCSI 6.15%PRS 57.9
-
CSI 6.15rCSI 15.01%PRS 57.62
-
CSI 5.84rCSI 8.26%PRS 68.65
-
CSI 5.79rCSI 15.08%PRS 61.42
-
CSI 5.78rCSI 8.03%PRS 62.98
-
CSI 5.73rCSI 27.44%PRS 62.69
-
CSI 5.69rCSI 42.77%PRS 57.64
-
CSI 5.64rCSI 14.96%PRS 75.03
-
CSI 5.55rCSI 7.27%PRS 87.32
-
CSI 5.45rCSI 4.78%PRS 73.65
-
CSI 5.43rCSI 17.84%PRS 51.34
-
CSI 5.42rCSI 4.2%PRS 66.95
-
CSI 5.39rCSI 15.16%PRS 60.97
-
CSI 5.33rCSI 9.34%PRS 56.51
-
CSI 5.33rCSI 6.62%PRS 66.14
-
CSI 5.29rCSI 27.11%PRS 69.35
-
CSI 5.09rCSI 34.62%PRS 59.44
-
CSI 5.01rCSI 8.66%PRS 54.59
-
CSI 4.98rCSI 13.27%PRS 53.71
-
CSI 4.86rCSI 7.15%PRS 57.77
-
CSI 4.69rCSI 4.08%PRS 75.22
-
CSI 4.66rCSI 34.28%PRS 50.95
-
CSI 4.63rCSI 11.75%PRS 58.57
-
CSI 4.45rCSI 7.84%PRS 61.09
-
CSI 4.43rCSI 16.72%PRS 50.14
-
CSI 4.4rCSI 8.77%PRS 81.1
-
CSI 4.33rCSI 5.28%PRS 71.95
-
CSI 4.32rCSI 10.68%PRS 63.03
-
CSI 4.3rCSI 7.04%PRS 53.6
-
CSI 4.29rCSI 5.5%PRS 56.74
-
CSI 4.15rCSI 15.53%PRS 56.4
-
CSI 4.02rCSI 34.6%PRS 51.54
-
CSI 3.96rCSI 6.38%PRS 54.05
-
CSI 3.9rCSI 9%PRS 53.14
-
CSI 3.87rCSI 4.64%PRS 80.11
-
CSI 3.87rCSI 12.59%PRS 64.59
-
CSI 3.81rCSI 2.97%PRS 81.8
-
CSI 3.72rCSI 32.16%PRS 61.12
-
CSI 3.63rCSI 18.07%PRS 61.47
-
CSI 3.59rCSI 10.3%PRS 83.8
-
CSI 3.58rCSI 7.89%PRS 68.49
-
CSI 3.5rCSI 5.02%PRS 54.07
-
CSI 3.42rCSI 15.07%PRS 54.66
-
CSI 3.36rCSI 15.81%PRS 58.94
-
CSI 3.35rCSI 2.66%PRS 84.94
-
CSI 3.19rCSI 4.36%PRS 70.71
-
CSI 0.2rCSI 3.3%PRS 77.7%
-
CSI 0.2rCSI 1.3%PRS 73.2%
-
CSI 0.3rCSI 3.2%PRS 78.4%
-
CSI 0.7rCSI 1.4%PRS 76.4%
-
CSI 0.7rCSI 6.5%PRS 73.6%
-
CSI 0.7rCSI 2.4%PRS 67.6%
-
CSI 0.8rCSI 4.7%PRS 56.2%
-
CSI 0.8rCSI 1.6%PRS 75.0%
-
CSI 0.9rCSI 3.6%PRS 63.3%
-
CSI 1.1rCSI 4.7%PRS 92.5%
-
CSI 1.1rCSI 4.9%PRS 48.6%
-
CSI 1.2rCSI 0.8%PRS 77.7%
-
CSI 1.2rCSI 2.9%PRS 71.6%
-
CSI 1.2rCSI 10.3%PRS 55.2%
-
CSI 1.3rCSI 11.3%PRS 51.4%
-
CSI 1.3rCSI 2.9%PRS 62.6%
-
CSI 1.3rCSI 5.1%PRS 78.4%
-
CSI 1.4rCSI 2.7%PRS 61.8%
-
CSI 1.4rCSI 1.3%PRS 61.5%
-
CSI 1.5rCSI 4.7%PRS 62.4%
-
CSI 1.6rCSI 1.8%PRS 54.9%
-
CSI 1.6rCSI 2.5%PRS 56.9%
-
CSI 1.6rCSI 2.6%PRS 67.0%
-
CSI 1.7rCSI 13.5%PRS 57.8%
-
CSI 1.7rCSI 2.1%PRS 75.0%
-
CSI 1.8rCSI 4.6%PRS 67.8%
-
CSI 1.8rCSI 6.0%PRS 49.3%
-
CSI 1.8rCSI 2.8%PRS 73.7%
-
CSI 1.9rCSI 38.0%PRS 55.0%
-
CSI 1.9rCSI 2.9%PRS 65.2%
-
CSI 1.9rCSI 7.6%PRS 63.4%
-
CSI 1.9rCSI 2.6%PRS 57.6%
-
CSI 1.9rCSI 30.5%PRS 69.0%
-
CSI 2.0rCSI 12.1%PRS 77.7%
-
CSI 2.0rCSI 4.4%PRS 72.3%
-
CSI 2.0rCSI 4.1%PRS 54.3%
-
CSI 2.1rCSI 4.4%PRS 81.0%
-
CSI 2.1rCSI 3.2%PRS 68.7%
-
CSI 2.1rCSI 29.5%PRS 55.4%
-
CSI 2.1rCSI 12.0%PRS 62.9%
-
CSI 2.1rCSI 22.2%PRS 62.6%
-
CSI 2.1rCSI 22.1%PRS 58.1%
-
CSI 2.2rCSI 14.0%PRS 73.5%
-
CSI 2.2rCSI 4.0%PRS 63.7%
-
CSI 2.2rCSI 3.3%PRS 69.7%
-
CSI 2.3rCSI 6.7%PRS 74.2%
-
CSI 2.3rCSI 8.6%PRS 55.1%
-
CSI 2.3rCSI 2.9%PRS 69.3%
-
CSI 2.3rCSI 26.3%PRS 55.1%
-
CSI 2.3rCSI 14.9%PRS 65.3%
-
CSI 2.3rCSI 5.3%PRS 46.6%
-
CSI 2.4rCSI 2.0%PRS 64.0%
-
CSI 2.4rCSI 3.7%PRS 71.6%
-
CSI 2.4rCSI 13.8%PRS 49.6%
-
CSI 2.5rCSI 7.1%PRS 54.0%
-
CSI 2.5rCSI 6.6%PRS 55.5%
-
CSI 2.5rCSI 2.4%PRS 84.8%
-
CSI 2.5rCSI 3.1%PRS 61.2%
-
CSI 2.6rCSI 18.8%PRS 64.3%
-
CSI 2.7rCSI 2.6%PRS 67.2%
-
CSI 2.7rCSI 54.6%PRS 56.6%
-
CSI 2.7rCSI 11.2%PRS 58.2%
-
CSI 2.8rCSI 66.3%PRS 45.8%
-
CSI 2.8rCSI 66.5%PRS 45.0%
-
CSI 2.8rCSI 3.4%PRS 62.6%
-
CSI 2.9rCSI 7.2%PRS 53.9%
-
CSI 2.9rCSI 2.6%PRS 52.4%
-
CSI 2.9rCSI 2.6%PRS 78.8%
-
CSI 3.1rCSI 8.4%PRS 59.8%
-
CSI 3.1rCSI 4.6%PRS 65.9%
-
CSI 3.1rCSI 24.2%PRS 60.8%
-
CSI 3.2rCSI 4.4%PRS 70.7%
-
CSI 3.4rCSI 2.7%PRS 84.9%
-
CSI 3.4rCSI 15.8%PRS 58.9%
-
CSI 3.4rCSI 15.1%PRS 54.7%
-
CSI 3.5rCSI 5.0%PRS 54.1%
-
CSI 3.6rCSI 7.9%PRS 68.5%
-
CSI 3.6rCSI 10.3%PRS 83.8%
-
CSI 3.6rCSI 18.1%PRS 61.5%
-
CSI 3.7rCSI 32.2%PRS 61.1%
-
CSI 3.8rCSI 3.0%PRS 81.8%
-
CSI 3.9rCSI 12.6%PRS 64.6%
-
CSI 3.9rCSI 4.6%PRS 80.1%
-
CSI 3.9rCSI 9.0%PRS 53.1%
-
CSI 4.0rCSI 6.4%PRS 54.1%
-
CSI 4.0rCSI 34.6%PRS 51.5%
-
CSI 4.2rCSI 15.5%PRS 56.4%
-
CSI 4.3rCSI 5.5%PRS 56.7%
-
CSI 4.3rCSI 7.0%PRS 53.6%
-
CSI 4.3rCSI 10.7%PRS 63.0%
-
CSI 4.3rCSI 5.3%PRS 72.0%
-
CSI 4.4rCSI 8.8%PRS 81.1%
-
CSI 4.4rCSI 16.7%PRS 50.1%
-
CSI 4.5rCSI 7.8%PRS 61.1%
-
CSI 4.6rCSI 11.8%PRS 58.6%
-
CSI 4.7rCSI 34.3%PRS 51.0%
-
CSI 4.7rCSI 4.1%PRS 75.2%
-
CSI 4.9rCSI 7.2%PRS 57.8%
-
CSI 5.0rCSI 13.3%PRS 53.7%
-
CSI 5.0rCSI 8.7%PRS 54.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2736695101
Symbol: GLCI1_HUMAN
Name: Glucocorticoid-induced transcript 1 protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12557054
Title: Two genes, three messengers: hybrid transcript between a gene expressed at specific stages of T-cell and sperm maturation and an unrelated adjacent gene.
PubMed ID: 12557054
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21991891
Title: Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.
PubMed ID: 21991891
PubMed ID: 22187997
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 547
- Mass: 58024
- Checksum: 51B6AF7788E8800D
- Sequence:
MSTASSSSSS SSSQTPHPPS QRMRRSAAGS PPAVAAAGSG NGAGGGGGVG CAPAAGAGRL LQPIRATVPY QLLRGSQHSP TRPPVAAAAA SLGSLPGPGA ARGPSPSSPT PPAAAAPAEQ APRAKGRPRR SPESHRRSSS PERRSPGSPV CRADKAKSQQ VRTSSTIRRT SSLDTITGPY LTGQWPRDPH VHYPSCMKDK ATQTPSCWAE EGAEKRSHQR SASWGSADQL KEQIAKLRQQ LQRSKQSSRH SKEKDRQSPL HGNHITISHT QATGSRSVPM PLSNISVPKS SVSRVPCNVE GISPELEKVF IKENNGKEEV SKPLDIPDGR RAPLPAHYRS SSTRSIDTQT PSVQERSSSC SSHSPCVSPF CPPESQDGSP CSTEDLLYDR DKDSGSSSPL PKYASSPKPN NSYMFKREPP EGCERVKVFE EMASRQPISA PLFSCPDKNK VNFIPTGSAF CPVKLLGPLL PASDLMLKNS PNSGQSSALA TLTVEQLSSR VSFTSLSDDT STAGSMEASV QQPSQQQQLL QELQGEDHIS AQNYVII