Details for: DIP2C

Gene ID: 22982

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: DIP2C

Ensembl ID: ENSG00000151240

Description: disco interacting protein 2 homolog C

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • VIP GABAergic cortical interneuron CL4023016
    CSI 50.39
    rCSI 60.19%
    PRS 64.65
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 48.64
    rCSI 60.51%
    PRS 62.34
  • sst GABAergic cortical interneuron CL4023017
    CSI 44.06
    rCSI 56.8%
    PRS 65.65
  • sncg GABAergic cortical interneuron CL4023015
    CSI 37.04
    rCSI 59.56%
    PRS 65.97
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 36.23
    rCSI 63.98%
    PRS 64
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 35.55
    rCSI 59.68%
    PRS 64.54
  • retinal ganglion cell CL0000740
    CSI 26.14
    rCSI 57.75%
    PRS 68.14
  • cardiac muscle cell CL0000746
    CSI 25.11
    rCSI 36.03%
    PRS 71.98
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 23.85
    rCSI 57.97%
    PRS 62.47
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 19.36
    rCSI 60.56%
    PRS 68.45
  • adipocyte CL0000136
    CSI 19.32
    rCSI 24.81%
    PRS 72.34
  • L6b glutamatergic cortical neuron CL4023038
    CSI 19.03
    rCSI 59.48%
    PRS 66.19
  • neuron CL0000540
    CSI 18.51
    rCSI 49.29%
    PRS 69.44
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 18.37
    rCSI 43.94%
    PRS 68.98
  • ON-bipolar cell CL0000749
    CSI 17.4
    rCSI 25.86%
    PRS 81.6
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 17.11
    rCSI 37.13%
    PRS 69.62
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 16.33
    rCSI 58.77%
    PRS 62.44
  • GABAergic amacrine cell CL4030027
    CSI 16.02
    rCSI 54.88%
    PRS 68.17
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 15.79
    rCSI 22.38%
    PRS 78.75
  • goblet cell CL0000160
    CSI 15.64
    rCSI 14.78%
    PRS 80.4
  • glioblast CL0000030
    CSI 15.56
    rCSI 24.83%
    PRS 73.57
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 15.39
    rCSI 58.16%
    PRS 65.06
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 15.26
    rCSI 27.72%
    PRS 73.73
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 15.14
    rCSI 17.48%
    PRS 74.18
  • progenitor cell CL0011026
    CSI 15.09
    rCSI 32.09%
    PRS 75.95
  • retinal bipolar neuron CL0000748
    CSI 14.86
    rCSI 27.83%
    PRS 70.63
  • radial glial cell CL0000681
    CSI 14.42
    rCSI 20.04%
    PRS 80.36
  • vascular leptomeningeal cell CL4023051
    CSI 14.27
    rCSI 25.03%
    PRS 76.19
  • retinal rod cell CL0000604
    CSI 14.2
    rCSI 25.03%
    PRS 77.26
  • renal principal cell CL0005009
    CSI 13.42
    rCSI 34.88%
    PRS 82.26
  • oligodendrocyte precursor cell CL0002453
    CSI 13.25
    rCSI 29.16%
    PRS 64.37
  • astrocyte of the cerebral cortex CL0002605
    CSI 13.25
    rCSI 29.71%
    PRS 65.34
  • neural crest cell CL0011012
    CSI 12.77
    rCSI 10.09%
    PRS 71.35
  • interneuron CL0000099
    CSI 12.71
    rCSI 25.51%
    PRS 72.72
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 12.7
    rCSI 41.73%
    PRS 67.87
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 12.4
    rCSI 32.33%
    PRS 83.01
  • hepatocyte CL0000182
    CSI 12
    rCSI 21.47%
    PRS 81.23
  • inhibitory interneuron CL0000498
    CSI 11.98
    rCSI 27.65%
    PRS 70.18
  • oligodendrocyte CL0000128
    CSI 11.89
    rCSI 35.13%
    PRS 73.15
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 11.33
    rCSI 14.53%
    PRS 78.06
  • rod bipolar cell CL0000751
    CSI 11.22
    rCSI 20.17%
    PRS 75.46
  • cerebral cortex neuron CL0010012
    CSI 11.06
    rCSI 45.07%
    PRS 73.97
  • epithelial cell of proximal tubule CL0002306
    CSI 10.92
    rCSI 26.66%
    PRS 74.4
  • ependymal cell CL0000065
    CSI 10.81
    rCSI 21.94%
    PRS 60.89
  • BEST4+ enteroycte CL4030026
    CSI 10.35
    rCSI 12.87%
    PRS 82.69
  • contractile cell CL0000183
    CSI 10.17
    rCSI 30.01%
    PRS 81.03
  • kidney collecting duct principal cell CL1001431
    CSI 10.02
    rCSI 50.46%
    PRS 79.43
  • blood vessel endothelial cell CL0000071
    CSI 9.98
    rCSI 20.7%
    PRS 78.81
  • neural cell CL0002319
    CSI 9.92
    rCSI 37.43%
    PRS 65.46
  • basophil CL0000767
    CSI 9.82
    rCSI 20.78%
    PRS 91.53
  • ionocyte CL0005006
    CSI 9.8
    rCSI 10.51%
    PRS 83.31
  • cerebellar granule cell CL0001031
    CSI 9.77
    rCSI 14.37%
    PRS 74.97
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 9.68
    rCSI 56.98%
    PRS 65.11
  • lung secretory cell CL1000272
    CSI 9.36
    rCSI 23.17%
    PRS 81.96
  • renal beta-intercalated cell CL0002201
    CSI 9.32
    rCSI 22.21%
    PRS 81.94
  • glycinergic amacrine cell CL4030028
    CSI 9.12
    rCSI 23.77%
    PRS 76.4
  • chondrocyte CL0000138
    CSI 9.04
    rCSI 14.38%
    PRS 75.26
  • parietal epithelial cell CL1000452
    CSI 8.73
    rCSI 23.32%
    PRS 74.08
  • peripheral nervous system neuron CL2000032
    CSI 8.45
    rCSI 11.52%
    PRS 73.81
  • central nervous system neuron CL2000029
    CSI 8.44
    rCSI 62.03%
    PRS 69.75
  • hepatic stellate cell CL0000632
    CSI 8.34
    rCSI 31.23%
    PRS 74.73
  • cardiac endothelial cell CL0010008
    CSI 8.3
    rCSI 33.5%
    PRS 81.94
  • cerebral cortex endothelial cell CL1001602
    CSI 8.2
    rCSI 14.18%
    PRS 73.94
  • choroid plexus epithelial cell CL0000706
    CSI 8.01
    rCSI 13.11%
    PRS 71.76
  • fibroblast of lung CL0002553
    CSI 7.91
    rCSI 7.36%
    PRS 82.78
  • ciliated cell CL0000064
    CSI 7.76
    rCSI 12.57%
    PRS 76.79
  • fibroblast of cardiac tissue CL0002548
    CSI 7.71
    rCSI 36.95%
    PRS 81.94
  • brush cell of tracheobronchial tree CL0002075
    CSI 7.55
    rCSI 22.4%
    PRS 89.81
  • Bergmann glial cell CL0000644
    CSI 7.53
    rCSI 10.31%
    PRS 73.31
  • enteric smooth muscle cell CL0002504
    CSI 7.51
    rCSI 10.72%
    PRS 82.71
  • small intestine goblet cell CL1000495
    CSI 7.44
    rCSI 16.3%
    PRS 86.75
  • perivascular cell CL4033054
    CSI 7.3
    rCSI 9.97%
    PRS 86.32
  • dopaminergic neuron CL0000700
    CSI 7.23
    rCSI 40.84%
    PRS 68.28
  • basal cell CL0000646
    CSI 7.21
    rCSI 9.64%
    PRS 80.27
  • amacrine cell CL0000561
    CSI 7.08
    rCSI 20.52%
    PRS 71.66
  • regular atrial cardiac myocyte CL0002129
    CSI 7.06
    rCSI 22.73%
    PRS 78.74
  • Schwann cell CL0002573
    CSI 6.94
    rCSI 19.71%
    PRS 77.55
  • epicardial adipocyte CL1000309
    CSI 6.81
    rCSI 22.16%
    PRS 79.69
  • enteroglial cell CL4040002
    CSI 6.75
    rCSI 35.5%
    PRS 83.18
  • retinal pigment epithelial cell CL0002586
    CSI 6.75
    rCSI 13.41%
    PRS 77.77
  • pulmonary alveolar type 2 cell CL0002063
    CSI 6.7
    rCSI 10.39%
    PRS 85.33
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 6.7
    rCSI 17.32%
    PRS 77.53
  • retinal cone cell CL0000573
    CSI 6.67
    rCSI 10.73%
    PRS 72.33
  • cardiac neuron CL0010022
    CSI 6.63
    rCSI 21.2%
    PRS 79.44
  • glutamatergic neuron CL0000679
    CSI 6.5
    rCSI 13.36%
    PRS 69.32
  • subcutaneous adipocyte CL0002521
    CSI 6.47
    rCSI 33.13%
    PRS 84.79
  • alveolar type 1 fibroblast cell CL4028004
    CSI 6.35
    rCSI 6.95%
    PRS 83.85
  • mesothelial cell CL0000077
    CSI 6.29
    rCSI 24.6%
    PRS 60.69
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 6.27
    rCSI 14.3%
    PRS 75.48
  • medial ganglionic eminence derived interneuron CL4023063
    CSI 6.1
    rCSI 60.97%
    PRS 41.38
  • periportal region hepatocyte CL0019026
    CSI 6.08
    rCSI 23.64%
    PRS 81.07
  • midzonal region hepatocyte CL0019028
    CSI 5.91
    rCSI 13.87%
    PRS 81.72
  • endocardial cell CL0002350
    CSI 5.79
    rCSI 27.71%
    PRS 78.38
  • kidney collecting duct intercalated cell CL1001432
    CSI 5.68
    rCSI 40.59%
    PRS 79.48
  • lung pericyte CL0009089
    CSI 5.65
    rCSI 14.9%
    PRS 88.02
  • neural progenitor cell CL0011020
    CSI 5.63
    rCSI 24.76%
    PRS 70.47
  • glial cell CL0000125
    CSI 5.5
    rCSI 20.93%
    PRS 73.26
  • enteroendocrine cell of small intestine CL0009006
    CSI 5.48
    rCSI 12.07%
    PRS 88.66
  • mature astrocyte CL0002627
    CSI 5.43
    rCSI 23.06%
    PRS 74.3
  • Mueller cell CL0000636
    CSI 5.37
    rCSI 12.27%
    PRS 73.57
  • mesenchymal stem cell CL0000134
    CSI 0.2
    rCSI 2.2%
    PRS 86.7%
  • diffuse bipolar 4 cell CL4033031
    CSI 0.8
    rCSI 9.6%
    PRS 70.0%
  • stromal cell of ovary CL0002132
    CSI 1.0
    rCSI 2.7%
    PRS 88.0%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.1
    rCSI 11.8%
    PRS 78.0%
  • pancreatic ductal cell CL0002079
    CSI 1.2
    rCSI 2.3%
    PRS 84.8%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 1.3
    rCSI 2.4%
    PRS 90.8%
  • corneal epithelial cell CL0000575
    CSI 1.4
    rCSI 4.0%
    PRS 87.5%
  • S cone cell CL0003050
    CSI 1.5
    rCSI 6.5%
    PRS 76.5%
  • neuroendocrine cell CL0000165
    CSI 1.5
    rCSI 5.7%
    PRS 89.5%
  • pancreatic A cell CL0000171
    CSI 1.6
    rCSI 1.7%
    PRS 85.0%
  • flat midget bipolar cell CL4033033
    CSI 1.7
    rCSI 11.8%
    PRS 72.7%
  • respiratory suprabasal cell CL4033048
    CSI 1.7
    rCSI 2.2%
    PRS 84.8%
  • mesangial cell CL0000650
    CSI 1.8
    rCSI 7.2%
    PRS 89.9%
  • diffuse bipolar 3b cell CL4033030
    CSI 1.8
    rCSI 11.8%
    PRS 76.4%
  • extravillous trophoblast CL0008036
    CSI 1.8
    rCSI 2.3%
    PRS 80.2%
  • type B pancreatic cell CL0000169
    CSI 1.8
    rCSI 4.0%
    PRS 81.4%
  • midbrain dopaminergic neuron CL2000097
    CSI 1.9
    rCSI 12.2%
    PRS 77.9%
  • mesodermal cell CL0000222
    CSI 1.9
    rCSI 2.3%
    PRS 80.0%
  • diffuse bipolar 2 cell CL4033028
    CSI 2.0
    rCSI 15.7%
    PRS 75.6%
  • pancreatic D cell CL0000173
    CSI 2.0
    rCSI 2.0%
    PRS 84.3%
  • alveolar adventitial fibroblast CL4028006
    CSI 2.1
    rCSI 3.3%
    PRS 83.4%
  • airway submucosal gland duct basal cell CL4033024
    CSI 2.1
    rCSI 13.4%
    PRS 86.6%
  • placental villous trophoblast CL2000060
    CSI 2.1
    rCSI 3.3%
    PRS 81.0%
  • pulmonary artery endothelial cell CL1001568
    CSI 2.2
    rCSI 3.0%
    PRS 89.7%
  • cerebral cortex pyramidal neuron CL4023111
    CSI 2.3
    rCSI 13.9%
    PRS 86.2%
  • invaginating midget bipolar cell CL4033034
    CSI 2.3
    rCSI 13.6%
    PRS 73.3%
  • OFFx cell CL4033036
    CSI 2.3
    rCSI 10.9%
    PRS 73.3%
  • intrahepatic cholangiocyte CL0002538
    CSI 2.4
    rCSI 5.7%
    PRS 85.1%
  • diffuse bipolar 1 cell CL4033027
    CSI 2.4
    rCSI 17.9%
    PRS 72.1%
  • myoepithelial cell CL0000185
    CSI 2.4
    rCSI 6.1%
    PRS 86.4%
  • lung ciliated cell CL1000271
    CSI 2.5
    rCSI 2.9%
    PRS 74.5%
  • tissue-resident macrophage CL0000864
    CSI 2.5
    rCSI 11.8%
    PRS 91.9%
  • podocyte CL0000653
    CSI 2.6
    rCSI 11.3%
    PRS 82.5%
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.6
    rCSI 61.6%
    PRS 63.1%
  • mesenchymal cell CL0008019
    CSI 2.6
    rCSI 6.5%
    PRS 75.6%
  • direct pathway medium spiny neuron CL4023026
    CSI 2.6
    rCSI 61.8%
    PRS 62.5%
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.6
    rCSI 16.2%
    PRS 73.9%
  • starburst amacrine cell CL0004232
    CSI 2.7
    rCSI 22.9%
    PRS 70.0%
  • diffuse bipolar 6 cell CL4033032
    CSI 2.7
    rCSI 14.3%
    PRS 72.6%
  • epithelial cell of lower respiratory tract CL0002632
    CSI 2.9
    rCSI 2.3%
    PRS 85.6%
  • endothelial cell of vascular tree CL0002139
    CSI 3.0
    rCSI 16.2%
    PRS 78.3%
  • stromal cell CL0000499
    CSI 3.0
    rCSI 8.4%
    PRS 77.1%
  • keratocyte CL0002363
    CSI 3.0
    rCSI 7.2%
    PRS 84.7%
  • neuroplacodal cell CL0000032
    CSI 3.1
    rCSI 28.4%
    PRS 82.4%
  • OFF midget ganglion cell CL4033047
    CSI 3.1
    rCSI 63.2%
    PRS 73.0%
  • macroglial cell CL0000126
    CSI 3.1
    rCSI 8.0%
    PRS 78.6%
  • ON midget ganglion cell CL4033046
    CSI 3.1
    rCSI 63.7%
    PRS 71.9%
  • blood vessel smooth muscle cell CL0019018
    CSI 3.2
    rCSI 26.0%
    PRS 76.6%
  • adventitial cell CL0002503
    CSI 3.2
    rCSI 7.7%
    PRS 85.6%
  • GABAergic interneuron CL0011005
    CSI 3.5
    rCSI 54.8%
    PRS 83.1%
  • paneth cell of epithelium of small intestine CL1000343
    CSI 3.6
    rCSI 9.9%
    PRS 88.1%
  • pulmonary alveolar type 1 cell CL0002062
    CSI 3.6
    rCSI 21.0%
    PRS 78.4%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 3.7
    rCSI 6.5%
    PRS 86.7%
  • mast cell CL0000097
    CSI 3.7
    rCSI 8.1%
    PRS 85.7%
  • conjunctival epithelial cell CL1000432
    CSI 3.8
    rCSI 5.9%
    PRS 81.9%
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 3.9
    rCSI 10.5%
    PRS 86.0%
  • lung neuroendocrine cell CL1000223
    CSI 3.9
    rCSI 5.8%
    PRS 85.5%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 4.2
    rCSI 36.1%
    PRS 76.4%
  • ON parasol ganglion cell CL4033052
    CSI 4.4
    rCSI 61.7%
    PRS 73.3%
  • melanocyte CL0000148
    CSI 4.5
    rCSI 3.3%
    PRS 75.7%
  • retinal blood vessel endothelial cell CL0002585
    CSI 4.6
    rCSI 7.4%
    PRS 85.4%
  • bronchus fibroblast of lung CL2000093
    CSI 4.7
    rCSI 3.8%
    PRS 81.4%
  • medium spiny neuron CL1001474
    CSI 4.7
    rCSI 40.6%
    PRS 70.2%
  • GABAergic neuron CL0000617
    CSI 4.7
    rCSI 15.9%
    PRS 66.0%
  • renal interstitial pericyte CL1001318
    CSI 5.0
    rCSI 13.8%
    PRS 77.3%
  • diffuse bipolar 3a cell CL4033029
    CSI 5.1
    rCSI 34.4%
    PRS 74.4%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 5.2
    rCSI 13.2%
    PRS 72.7%
  • Mueller cell CL0000636
    CSI 5.4
    rCSI 12.3%
    PRS 73.6%
  • mature astrocyte CL0002627
    CSI 5.4
    rCSI 23.1%
    PRS 74.3%
  • enteroendocrine cell of small intestine CL0009006
    CSI 5.5
    rCSI 12.1%
    PRS 88.7%
  • glial cell CL0000125
    CSI 5.5
    rCSI 20.9%
    PRS 73.3%
  • neural progenitor cell CL0011020
    CSI 5.6
    rCSI 24.8%
    PRS 70.5%
  • lung pericyte CL0009089
    CSI 5.7
    rCSI 14.9%
    PRS 88.0%
  • kidney collecting duct intercalated cell CL1001432
    CSI 5.7
    rCSI 40.6%
    PRS 79.5%
  • endocardial cell CL0002350
    CSI 5.8
    rCSI 27.7%
    PRS 78.4%
  • midzonal region hepatocyte CL0019028
    CSI 5.9
    rCSI 13.9%
    PRS 81.7%
  • periportal region hepatocyte CL0019026
    CSI 6.1
    rCSI 23.6%
    PRS 81.1%
  • medial ganglionic eminence derived interneuron CL4023063
    CSI 6.1
    rCSI 61.0%
    PRS 41.4%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 6.3
    rCSI 14.3%
    PRS 75.5%
  • mesothelial cell CL0000077
    CSI 6.3
    rCSI 24.6%
    PRS 60.7%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 6.4
    rCSI 7.0%
    PRS 83.9%
  • subcutaneous adipocyte CL0002521
    CSI 6.5
    rCSI 33.1%
    PRS 84.8%
  • glutamatergic neuron CL0000679
    CSI 6.5
    rCSI 13.4%
    PRS 69.3%
  • cardiac neuron CL0010022
    CSI 6.6
    rCSI 21.2%
    PRS 79.4%
  • retinal cone cell CL0000573
    CSI 6.7
    rCSI 10.7%
    PRS 72.3%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 6.7
    rCSI 17.3%
    PRS 77.5%
  • pulmonary alveolar type 2 cell CL0002063
    CSI 6.7
    rCSI 10.4%
    PRS 85.3%
  • retinal pigment epithelial cell CL0002586
    CSI 6.8
    rCSI 13.4%
    PRS 77.8%
  • enteroglial cell CL4040002
    CSI 6.8
    rCSI 35.5%
    PRS 83.2%
  • epicardial adipocyte CL1000309
    CSI 6.8
    rCSI 22.2%
    PRS 79.7%
  • Schwann cell CL0002573
    CSI 6.9
    rCSI 19.7%
    PRS 77.6%
  • regular atrial cardiac myocyte CL0002129
    CSI 7.1
    rCSI 22.7%
    PRS 78.7%
  • amacrine cell CL0000561
    CSI 7.1
    rCSI 20.5%
    PRS 71.7%
  • basal cell CL0000646
    CSI 7.2
    rCSI 9.6%
    PRS 80.3%
  • dopaminergic neuron CL0000700
    CSI 7.2
    rCSI 40.8%
    PRS 68.3%
  • perivascular cell CL4033054
    CSI 7.3
    rCSI 10.0%
    PRS 86.3%
  • small intestine goblet cell CL1000495
    CSI 7.4
    rCSI 16.3%
    PRS 86.8%
  • enteric smooth muscle cell CL0002504
    CSI 7.5
    rCSI 10.7%
    PRS 82.7%
  • Bergmann glial cell CL0000644
    CSI 7.5
    rCSI 10.3%
    PRS 73.3%
  • brush cell of tracheobronchial tree CL0002075
    CSI 7.6
    rCSI 22.4%
    PRS 89.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [DIP2C](/details-gene/22982) (Disco Interacting Protein 2 Homolog C) is a protein-coding gene located on human chromosome 10. While its precise molecular function remains largely uncharacterized, expression data strongly indicates a significant role in the central nervous system. **Overall**, [DIP2C](/details-gene/22982) displays its highest and most specific expression across a wide range of cortical interneurons, including [VIP GABAergic cortical interneuron](/details-cell/CL4023016), [pvalb GABAergic cortical interneuron](/details-cell/CL4023018), and [sst GABAergic cortical interneuron](/details-cell/CL4023017), suggesting it may be a key factor in the development, function, or maintenance of inhibitory circuits in the brain. Its discovery and initial characterization stem from large-scale cDNA sequencing projects aimed at identifying novel human genes ([Link](https://doi.org/10.1093/dnares/6.1.63), [Link](https://doi.org/10.1038/ng1285)). ## Cellular Roles and Expression Landscape The expression profile of [DIP2C](/details-gene/22982) reveals a profound enrichment within the nervous system, particularly in inhibitory neurons of the cerebral cortex. The **Overall** analysis identifies multiple subtypes of GABAergic interneurons as the top cell types expressing this gene, with the highest significance observed in [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 50.39), [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 48.64), [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 44.06), and [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064) (CSI: 36.23). This consistent high expression across functionally diverse interneuron classes suggests a fundamental role in inhibitory neuron biology rather than a function specific to a single subtype. Beyond cortical interneurons, [DIP2C](/details-gene/22982) also shows significant, albeit lower, expression in other neuronal populations such as the [retinal ganglion cell](/details-cell/CL0000740) and various glutamatergic neurons, including [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040). Interestingly, notable expression is also detected in select non-neuronal cell types, including [cardiac muscle cell](/details-cell/CL0000746) and [adipocyte](/details-cell/CL0000136). This pattern suggests that while [DIP2C](/details-gene/22982) is predominantly a neural gene, its function might be linked to a fundamental cellular process that is also important in these specific peripheral tissues. ## Pathways and Molecular Function The functional annotation for [DIP2C](/details-gene/22982) is currently limited to high-level, non-specific Gene Ontology terms, such as [biological process (GO:0008150)](https://www.ebi.ac.uk/QuickGO/term/GO:0008150) and [molecular function (GO:0003674)](https://www.ebi.ac.uk/QuickGO/term/GO:0003674). These root terms do not provide insight into its specific molecular activities or the pathways it participates in. The gene was identified as part of large-scale efforts to clone and sequence novel cDNAs from the human brain, but its function has not yet been experimentally defined ([Link](https://doi.org/10.1093/dnares/9.3.99)). Its strong and specific expression pattern in diverse neuronal subtypes provides the primary evidence for its putative role in the nervous system, but the molecular mechanisms through which it acts are yet to be determined. ## Research Directions The prominent and specific expression of [DIP2C](/details-gene/22982) in cortical interneurons, coupled with its uncharacterized function, presents several avenues for future investigation. **Testable Hypotheses:** 1. [DIP2C](/details-gene/22982) is essential for the terminal differentiation or maintenance of identity of cortical interneurons. Its high expression across multiple mature subtypes suggests it may regulate a core transcriptional program or cellular process common to these inhibitory cells. 2. Given its expression in metabolically active cells like neurons, [cardiac muscle cell](/details-cell/CL0000746), and [adipocyte](/details-cell/CL0000136), [DIP2C](/details-gene/22982) may function in a conserved pathway related to energy metabolism, protein trafficking, or cytoskeletal dynamics that is particularly critical in these high-demand cell types. **Proposed Experiment:** To test the hypothesis that [DIP2C](/details-gene/22982) is critical for interneuron function, a conditional knockout of the gene could be generated in mice using a Cre-lox system with a pan-GABAergic driver line (e.g., Gad2-Cre). The resulting knockout animals could be analyzed using a combination of techniques. *In vivo* two-photon calcium imaging would reveal potential deficits in neuronal activity in awake, behaving animals. Subsequently, patch-clamp electrophysiology on cortical slices would allow for detailed characterization of intrinsic firing properties, synaptic connectivity, and plasticity of [DIP2C](/details-gene/22982)-deficient interneurons. **Therapeutic Potential:** The therapeutic potential of [DIP2C](/details-gene/22982) is currently speculative due to its unknown function. However, its highly specific expression in cortical interneurons suggests it could be a future target for disorders characterized by an imbalance of excitatory/inhibitory signaling, such as certain forms of epilepsy or schizophrenia. Any therapeutic strategy would require a deep understanding of its function to determine whether inhibition or activation is desired. Furthermore, its expression in [cardiac muscle cell](/details-cell/CL0000746) raises a significant safety concern for systemic therapies, suggesting that any approach targeting [DIP2C](/details-gene/22982) would likely necessitate brain-specific delivery mechanisms to avoid cardiotoxicity.

Genular Protein ID: 925498918

Symbol: DIP2C_HUMAN

Name: Disco-interacting protein 2 homolog C

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1556
  • Mass: 170767
  • Checksum: E4CA7F0719C384EA
  • Sequence:
  • MADRSLEGMA LPLEVRARLA ELELELSEGD ITQKGYEKKR SKLIGAYLPQ PPRVDQALPQ 
    ERRAPVTPSS ASRYHRRRSS GSRDERYRSD VHTEAVQAAL AKHKERKMAV PMPSKRRSLV 
    VQTSMDAYTP PDTSSGSEDE GSVQGDSQGT PTSSQGSINM EHWISQAIHG STTSTTSSSS 
    TQSGGSGAAH RLADVMAQTH IENHSAPPDV TTYTSEHSIQ VERPQGSTGS RTAPKYGNAE 
    LMETGDGVPV SSRVSAKIQQ LVNTLKRPKR PPLREFFVDD FEELLEVQQP DPNQPKPEGA 
    QMLAMRGEQL GVVTNWPPSL EAALQRWGTI SPKAPCLTTM DTNGKPLYIL TYGKLWTRSM 
    KVAYSILHKL GTKQEPMVRP GDRVALVFPN NDPAAFMAAF YGCLLAEVVP VPIEVPLTRK 
    DAGSQQIGFL LGSCGVTVAL TSDACHKGLP KSPTGEIPQF KGWPKLLWFV TESKHLSKPP 
    RDWFPHIKDA NNDTAYIEYK TCKDGSVLGV TVTRTALLTH CQALTQACGY TEAETIVNVL 
    DFKKDVGLWH GILTSVMNMM HVISIPYSLM KVNPLSWIQK VCQYKAKVAC VKSRDMHWAL 
    VAHRDQRDIN LSSLRMLIVA DGANPWSISS CDAFLNVFQS KGLRQEVICP CASSPEALTV 
    AIRRPTDDSN QPPGRGVLSM HGLTYGVIRV DSEEKLSVLT VQDVGLVMPG AIMCSVKPDG 
    VPQLCRTDEI GELCVCAVAT GTSYYGLSGM TKNTFEVFPM TSSGAPISEY PFIRTGLLGF 
    VGPGGLVFVV GKMDGLMVVS GRRHNADDIV ATALAVEPMK FVYRGRIAVF SVTVLHDERI 
    VIVAEQRPDS TEEDSFQWMS RVLQAIDSIH QVGVYCLALV PANTLPKTPL GGIHLSETKQ 
    LFLEGSLHPC NVLMCPHTCV TNLPKPRQKQ PEIGPASVMV GNLVSGKRIA QASGRDLGQI 
    EDNDQARKFL FLSEVLQWRA QTTPDHILYT LLNCRGAIAN SLTCVQLHKR AEKIAVMLME 
    RGHLQDGDHV ALVYPPGIDL IAAFYGCLYA GCVPITVRPP HPQNIATTLP TVKMIVEVSR 
    SACLMTTQLI CKLLRSREAA AAVDVRTWPL ILDTDDLPKK RPAQICKPCN PDTLAYLDFS 
    VSTTGMLAGV KMSHAATSAF CRSIKLQCEL YPSREVAICL DPYCGLGFVL WCLCSVYSGH 
    QSILIPPSEL ETNPALWLLA VSQYKVRDTF CSYSVMELCT KGLGSQTESL KARGLDLSRV 
    RTCVVVAEER PRIALTQSFS KLFKDLGLHP RAVSTSFGCR VNLAICLQGT SGPDPTTVYV 
    DMRALRHDRV RLVERGSPHS LPLMESGKIL PGVRIIIANP ETKGPLGDSH LGEIWVHSAH 
    NASGYFTIYG DESLQSDHFN SRLSFGDTQT IWARTGYLGF LRRTELTDAN GERHDALYVV 
    GALDEAMELR GMRYHPIDIE TSVIRAHKSV TECAVFTWTN LLVVVVELDG SEQEALDLVP 
    LVTNVVLEEH YLIVGVVVVV DIGVIPINSR GEKQRMHLRD GFLADQLDPI YVAYNM

Genular Protein ID: 3107185043

Symbol: Q86XV3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 481
  • Mass: 53313
  • Checksum: 885422755C7A7621
  • Sequence:
  • VWVSRSACLM TTQLICKLLR SREAAAAVDV RTWPLILDTD DLPKKRPAQI CKPCNPDTLA 
    YLDFSVSTTG MLAGVKMSHA ATSAFCRSIK LQCELYPSRE VAICLDPYCG LGFVLWCLCS 
    VYSGHQSILI PPSELETNPA LWLLAVSQYK VRDTFCSYSV MELCTKGLGS QTESLKARGL 
    DLSRVRTCVV VAEERPRIAL TQSFSKLFKD LGLHPRAVST SFGCRVNLAI CLQGTSGPDP 
    TTVYVDMRAL RHDRVRLVER GSPHSLPLME SGKILPGVRI IIANPEIKGP LGDSHLGEIW 
    VHSAHNASGY FTIYGDESLQ SDHFNSRLSF GDTQTIWART GYLGFLRRTE LTDANGERHD 
    ALYVVGALDE AMELRGMRYH PIDIETSVIR AHKSVTECAV FTWTNLLVVV VELDGSEQEA 
    LDLVPLVTNV VLEEHYLIVG VVVVVDIGVI PINSRGEKQR MHLRDGFLAD QLDPIYVAYN 
    M

Genular Protein ID: 3588947339

Symbol: A0A0U1RQW6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1622
  • Mass: 178087
  • Checksum: B84949970DDAFBFF
  • Sequence:
  • MADRSLEGMA LPLEVRARLA ELELELSEGD ITQKGYEKKR SKLIGAYLPQ PPTANGAAVV 
    RCRLQHSEGA PRRTFRSAHI GVCDVREAAA RERVASTAGN RPLFYFRFGV DQALPQERRA 
    PVTPSSASRY HRRRSSGSRD ERYRSDVHTE AVQAALAKHK ERKMAVPMPS KRRSLVVQTS 
    MDAYTPPDTS SGSEDEGSVQ GDSQGTPTSS QGSINMEHWI SQAIHGSTTS TTSSSSTQSG 
    GSGAAHRLAD VMAQTHIENH SAPPDVTTYT SEHSIQVERP QGSTGSRTAP KYGNAELMET 
    GDGVPVSSRV SAKIQQLVNT LKRPKRPPLR EFFVDDFEEL LEVQQPDPNQ PKPEGAQMLA 
    MRGEQLGVVT NWPPSLEAAL QRWGTISPKA PCLTTMDTNG KPLYILTYGK LWTRSMKVAY 
    SILHKLGTKQ EPMVRPGDRV ALVFPNNDPA AFMAAFYGCL LAEVVPVPIE VPLTRKDAGS 
    QQIGFLLGSC GVTVALTSDA CHKGLPKSPT GEIPQFKGWP KLLWFVTESK HLSKPPRDWF 
    PHIKDANNDT AYIEYKTCKD GSVLGVTVTR TALLTHCQAL TQACGYTEAE TIVNVLDFKK 
    DVGLWHGILT SVMNMMHVIS IPYSLMKVNP LSWIQKVCQY KAKVACVKSR DMHWALVAHR 
    DQRDINLSSL RMLIVADGAN PWSISSCDAF LNVFQSKGLR QEVICPCASS PEALTVAIRR 
    PTDDSNQPPG RGVLSMHGLT YGVIRVDSEE KLSVLTVQDV GLVMPGAIMC SVKPDGVPQL 
    CRTDEIGELC VCAVATGTSY YGLSGMTKNT FEVFPMTSSG APISEYPFIR TGLLGFVGPG 
    GLVFVVGKMD GLMVVSGRRH NADDIVATAL AVEPMKFVYR GRIAVFSVTV LHDERIVIVA 
    EQRPDSTEED SFQWMSRVLQ AIDSIHQVGV YCLALVPANT LPKTPLGGIH LSETKQLFLE 
    GSLHPCNVLM CPHTCVTNLP KPRQKQPEIG PASVMVGNLV SGKRIAQASG RDLGQIEDND 
    QARKFLFLSE VLQWRAQTTP DHILYTLLNC RGAIANSLTC VQLHKRAEKI AVMLMERGHL 
    QDGDHVALVY PPGIDLIAAF YGCLYAGCVP ITVRPPHPQN IATTLPTVKM IVEVSRSACL 
    MTTQLICKLL RSREAAAAVD VRTWPLILDT DDLPKKRPAQ ICKPCNPDTL AYLDFSVSTT 
    GMLAGVKMSH AATSAFCRSI KLQCELYPSR EVAICLDPYC GLGFVLWCLC SVYSGHQSIL 
    IPPSELETNP ALWLLAVSQY KVRDTFCSYS VMELCTKGLG SQTESLKARG LDLSRVRTCV 
    VVAEERPRIA LTQSFSKLFK DLGLHPRAVS TSFGCRVNLA ICLQPHRLWT LAEQGTSGPD 
    PTTVYVDMRA LRHDRVRLVE RGSPHSLPLM ESGKILPGVR IIIANPETKG PLGDSHLGEI 
    WVHSAHNASG YFTIYGDESL QSDHFNSRLS FGDTQTIWAR TGYLGFLRRT ELTDANGERH 
    DALYVVGALD EAMELRGMRY HPIDIETSVI RAHKSVTECA VFTWTNLLVV VVELDGSEQE 
    ALDLVPLVTN VVLEEHYLIV GVVVVVDIGV IPINSRGEKQ RMHLRDGFLA DQLDPIYVAY 
    NM