Details for: SUN2
Gene ID: 25777
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: SUN2
Ensembl ID: ENSG00000100242
Description: Sad1 and UNC84 domain containing 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 34.66rCSI 23.1%PRS 69.21
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CSI 15.96rCSI 12.08%PRS 55.55
-
CSI 15.34rCSI 17.27%PRS 59.67
-
CSI 12rCSI 26.81%PRS 49.93
-
CSI 10.36rCSI 15.79%PRS 40.38
-
CSI 8.97rCSI 15.84%PRS 27.62
-
CSI 8.41rCSI 5.84%PRS 51.78
-
CSI 8.1rCSI 5.69%PRS 66.09
-
CSI 7.96rCSI 6.32%PRS 65.43
-
CSI 7.73rCSI 11.87%PRS 50.31
-
CSI 7.13rCSI 5.34%PRS 75.7
-
CSI 5.99rCSI 4.18%PRS 45.19
-
CSI 5.72rCSI 14.52%PRS 39.74
-
CSI 5.57rCSI 12.69%PRS 42.2
-
CSI 5.51rCSI 34.44%PRS 36.38
-
CSI 5.31rCSI 7.3%PRS 64.3
-
CSI 5.21rCSI 9.18%PRS 52.08
-
CSI 5.17rCSI 4.35%PRS 60.7
-
CSI 5.1rCSI 7.54%PRS 48.37
-
CSI 4.52rCSI 6.51%PRS 53.52
-
CSI 4.37rCSI 3.37%PRS 42.26
-
CSI 4.35rCSI 12.58%PRS 46.01
-
CSI 4.34rCSI 5.24%PRS 51.11
-
CSI 4.28rCSI 5.37%PRS 80.8
-
CSI 4.26rCSI 2.52%PRS 58.27
-
CSI 4.1rCSI 3.79%PRS 63.65
-
CSI 3.7rCSI 4.34%PRS 82.97
-
CSI 3.54rCSI 3.69%PRS 73.52
-
CSI 3.25rCSI 2.62%PRS 54.65
-
CSI 3.18rCSI 10.17%PRS 40.56
-
CSI 3.12rCSI 5.59%PRS 41.89
-
CSI 3.1rCSI 2.72%PRS 53.15
-
CSI 3.09rCSI 2.71%PRS 48.4
-
CSI 2.94rCSI 44.06%PRS 68.5
-
CSI 2.87rCSI 3.57%PRS 54.87
-
CSI 2.85rCSI 14.28%PRS 54.31
-
CSI 2.81rCSI 3.61%PRS 48.2
-
CSI 2.67rCSI 3.43%PRS 41.63
-
CSI 2.66rCSI 5.52%PRS 41.5
-
CSI 2.65rCSI 6.06%PRS 37.34
-
CSI 2.64rCSI 11.23%PRS 41.24
-
CSI 2.61rCSI 1.87%PRS 56.25
-
CSI 2.58rCSI 2.49%PRS 34.57
-
CSI 2.58rCSI 2.82%PRS 47.26
-
CSI 2.53rCSI 1.96%PRS 43.93
-
CSI 2.53rCSI 4.04%PRS 47.2
-
CSI 2.49rCSI 3.02%PRS 39.45
-
CSI 2.48rCSI 2.24%PRS 40.26
-
CSI 2.47rCSI 5.8%PRS 52.67
-
CSI 2.45rCSI 1.96%PRS 64.86
-
CSI 2.43rCSI 9.45%PRS 52.38
-
CSI 2.39rCSI 1.82%PRS 54.68
-
CSI 2.36rCSI 2.05%PRS 52.65
-
CSI 2.36rCSI 1.64%PRS 56.19
-
CSI 2.31rCSI 3.15%PRS 46.06
-
CSI 2.27rCSI 1.76%PRS 60.21
-
CSI 2.24rCSI 8.1%PRS 62.53
-
CSI 2.24rCSI 3.49%PRS 70.52
-
CSI 2.21rCSI 2.06%PRS 43.39
-
CSI 2.15rCSI 6.17%PRS 60.77
-
CSI 2.11rCSI 2.2%PRS 44.19
-
CSI 2.08rCSI 1.69%PRS 44.28
-
CSI 1.98rCSI 1.71%PRS 52.08
-
CSI 1.96rCSI 2.3%PRS 58.95
-
CSI 1.96rCSI 1.74%PRS 42.6
-
CSI 1.95rCSI 2.09%PRS 41.47
-
CSI 1.91rCSI 2.28%PRS 63.72
-
CSI 1.9rCSI 3.63%PRS 60.27
-
CSI 1.87rCSI 4.87%PRS 51.87
-
CSI 1.86rCSI 1.69%PRS 58.46
-
CSI 1.85rCSI 1.61%PRS 47.15
-
CSI 1.84rCSI 3.91%PRS 58.51
-
CSI 1.82rCSI 1.37%PRS 46.77
-
CSI 1.81rCSI 1.36%PRS 57.98
-
CSI 1.81rCSI 3.12%PRS 34.67
-
CSI 1.79rCSI 11.79%PRS 76.45
-
CSI 1.79rCSI 1.49%PRS 42.03
-
CSI 1.76rCSI 2.52%PRS 50.84
-
CSI 1.76rCSI 1.45%PRS 44.44
-
CSI 1.75rCSI 2.03%PRS 54.35
-
CSI 1.75rCSI 2.19%PRS 53.08
-
CSI 1.74rCSI 2.19%PRS 56.91
-
CSI 1.74rCSI 1.37%PRS 49.83
-
CSI 1.73rCSI 5.12%PRS 47.45
-
CSI 1.71rCSI 2.32%PRS 71.26
-
CSI 1.7rCSI 3.89%PRS 42.92
-
CSI 1.69rCSI 3.4%PRS 33.89
-
CSI 1.67rCSI 2.28%PRS 48.25
-
CSI 1.66rCSI 2.12%PRS 48.66
-
CSI 1.63rCSI 3.25%PRS 61.3
-
CSI 1.61rCSI 4.7%PRS 73.41
-
CSI 1.59rCSI 1.18%PRS 61.92
-
CSI 1.57rCSI 2.31%PRS 39.8
-
CSI 1.51rCSI 1.58%PRS 40.88
-
CSI 1.49rCSI 2.82%PRS 77.36
-
CSI 1.47rCSI 2.1%PRS 46.16
-
CSI 1.46rCSI 1.69%PRS 38.09
-
CSI 1.45rCSI 0.98%PRS 53.52
-
CSI 1.45rCSI 2.22%PRS 44.14
-
CSI 1.44rCSI 3.44%PRS 59.27
-
CSI 0.1rCSI 1.0%PRS 32.1%
-
CSI 0.2rCSI 1.9%PRS 59.9%
-
CSI 0.2rCSI 1.4%PRS 74.3%
-
CSI 0.3rCSI 2.8%PRS 83.3%
-
CSI 0.5rCSI 1.4%PRS 58.0%
-
CSI 0.5rCSI 3.0%PRS 68.2%
-
CSI 0.5rCSI 1.3%PRS 73.9%
-
CSI 0.6rCSI 1.3%PRS 27.8%
-
CSI 0.6rCSI 3.1%PRS 52.2%
-
CSI 0.7rCSI 1.2%PRS 27.0%
-
CSI 0.7rCSI 0.9%PRS 52.4%
-
CSI 0.7rCSI 1.6%PRS 55.7%
-
CSI 0.7rCSI 5.1%PRS 62.2%
-
CSI 0.7rCSI 4.7%PRS 61.9%
-
CSI 0.7rCSI 2.0%PRS 60.7%
-
CSI 0.7rCSI 9.8%PRS 81.7%
-
CSI 0.7rCSI 1.1%PRS 46.4%
-
CSI 0.7rCSI 1.4%PRS 73.4%
-
CSI 0.8rCSI 3.4%PRS 66.9%
-
CSI 0.8rCSI 1.7%PRS 50.2%
-
CSI 0.8rCSI 1.3%PRS 41.5%
-
CSI 0.8rCSI 1.3%PRS 44.4%
-
CSI 0.8rCSI 13.8%PRS 75.8%
-
CSI 0.8rCSI 1.1%PRS 56.4%
-
CSI 0.8rCSI 1.3%PRS 45.4%
-
CSI 0.8rCSI 1.5%PRS 70.2%
-
CSI 0.8rCSI 1.7%PRS 65.6%
-
CSI 0.9rCSI 2.3%PRS 50.9%
-
CSI 0.9rCSI 1.4%PRS 23.4%
-
CSI 0.9rCSI 2.9%PRS 75.9%
-
CSI 0.9rCSI 1.5%PRS 49.0%
-
CSI 0.9rCSI 1.8%PRS 45.4%
-
CSI 0.9rCSI 2.4%PRS 74.7%
-
CSI 0.9rCSI 2.4%PRS 39.8%
-
CSI 1.0rCSI 3.7%PRS 63.7%
-
CSI 1.0rCSI 1.3%PRS 39.5%
-
CSI 1.0rCSI 1.7%PRS 52.7%
-
CSI 1.0rCSI 1.0%PRS 58.6%
-
CSI 1.0rCSI 1.8%PRS 64.3%
-
CSI 1.0rCSI 2.7%PRS 67.0%
-
CSI 1.0rCSI 8.4%PRS 38.4%
-
CSI 1.1rCSI 1.4%PRS 56.5%
-
CSI 1.1rCSI 6.0%PRS 30.6%
-
CSI 1.1rCSI 12.5%PRS 78.8%
-
CSI 1.1rCSI 2.4%PRS 40.9%
-
CSI 1.1rCSI 3.7%PRS 46.4%
-
CSI 1.1rCSI 6.5%PRS 55.6%
-
CSI 1.2rCSI 1.1%PRS 50.7%
-
CSI 1.2rCSI 1.8%PRS 52.4%
-
CSI 1.2rCSI 1.3%PRS 66.2%
-
CSI 1.2rCSI 1.0%PRS 44.0%
-
CSI 1.2rCSI 1.8%PRS 59.6%
-
CSI 1.2rCSI 1.4%PRS 47.2%
-
CSI 1.2rCSI 3.6%PRS 34.8%
-
CSI 1.2rCSI 1.7%PRS 48.1%
-
CSI 1.2rCSI 3.1%PRS 41.6%
-
CSI 1.3rCSI 1.0%PRS 31.9%
-
CSI 1.3rCSI 5.2%PRS 41.3%
-
CSI 1.3rCSI 2.8%PRS 32.5%
-
CSI 1.3rCSI 7.2%PRS 61.9%
-
CSI 1.3rCSI 2.9%PRS 29.3%
-
CSI 1.3rCSI 3.3%PRS 51.7%
-
CSI 1.3rCSI 2.5%PRS 66.8%
-
CSI 1.3rCSI 1.8%PRS 65.8%
-
CSI 1.3rCSI 1.3%PRS 70.8%
-
CSI 1.3rCSI 3.2%PRS 59.3%
-
CSI 1.3rCSI 3.1%PRS 54.1%
-
CSI 1.3rCSI 1.6%PRS 51.1%
-
CSI 1.3rCSI 2.4%PRS 37.3%
-
CSI 1.3rCSI 3.0%PRS 47.5%
-
CSI 1.3rCSI 1.6%PRS 65.1%
-
CSI 1.4rCSI 3.2%PRS 49.4%
-
CSI 1.4rCSI 0.9%PRS 47.3%
-
CSI 1.4rCSI 3.4%PRS 53.6%
-
CSI 1.4rCSI 1.5%PRS 56.4%
-
CSI 1.4rCSI 1.1%PRS 56.4%
-
CSI 1.4rCSI 2.0%PRS 37.3%
-
CSI 1.4rCSI 3.4%PRS 59.3%
-
CSI 1.5rCSI 2.2%PRS 44.1%
-
CSI 1.5rCSI 1.0%PRS 53.5%
-
CSI 1.5rCSI 1.7%PRS 38.1%
-
CSI 1.5rCSI 2.1%PRS 46.2%
-
CSI 1.5rCSI 2.8%PRS 77.4%
-
CSI 1.5rCSI 1.6%PRS 40.9%
-
CSI 1.6rCSI 2.3%PRS 39.8%
-
CSI 1.6rCSI 1.2%PRS 61.9%
-
CSI 1.6rCSI 4.7%PRS 73.4%
-
CSI 1.6rCSI 3.3%PRS 61.3%
-
CSI 1.7rCSI 2.1%PRS 48.7%
-
CSI 1.7rCSI 2.3%PRS 48.3%
-
CSI 1.7rCSI 3.4%PRS 33.9%
-
CSI 1.7rCSI 3.9%PRS 42.9%
-
CSI 1.7rCSI 2.3%PRS 71.3%
-
CSI 1.7rCSI 5.1%PRS 47.5%
-
CSI 1.7rCSI 1.4%PRS 49.8%
-
CSI 1.7rCSI 2.2%PRS 56.9%
-
CSI 1.8rCSI 2.2%PRS 53.1%
-
CSI 1.8rCSI 2.0%PRS 54.4%
-
CSI 1.8rCSI 1.5%PRS 44.4%
-
CSI 1.8rCSI 2.5%PRS 50.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3175562925
Symbol: SUN2_HUMAN
Name: SUN domain-containing protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10818110
Title: A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion.
PubMed ID: 10818110
PubMed ID: 17132086
Title: Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome.
PubMed ID: 17132086
PubMed ID: 9734811
Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9734811
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10375507
Title: UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development.
PubMed ID: 10375507
PubMed ID: 12393179
Title: Isolation of differentially expressed genes in human heart tissues.
PubMed ID: 12393179
PubMed ID: 12239280
Title: A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies: identification of a novel protein, Frigg, as a protein kinase A substrate.
PubMed ID: 12239280
PubMed ID: 12958361
Title: Nuclear membrane proteins with potential disease links found by subtractive proteomics.
PubMed ID: 12958361
PubMed ID: 15082709
Title: Sun2 is a novel mammalian inner nuclear membrane protein.
PubMed ID: 15082709
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17724119
Title: Functional association of Sun1 with nuclear pore complexes.
PubMed ID: 17724119
PubMed ID: 18845190
Title: Sun1 forms immobile macromolecular assemblies at the nuclear envelope.
PubMed ID: 18845190
PubMed ID: 18396275
Title: Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.
PubMed ID: 18396275
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21391237
Title: TMEM43 mutations in Emery-Dreifuss muscular dystrophy-related myopathy.
PubMed ID: 21391237
DOI: 10.1002/ana.22338
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26244732
Title: A disulfide bond is required for the transmission of forces through SUN-KASH complexes.
PubMed ID: 26244732
PubMed ID: 22632968
Title: LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.
PubMed ID: 22632968
PubMed ID: 22945352
Title: Structural insights into SUN-KASH complexes across the nuclear envelope.
PubMed ID: 22945352
DOI: 10.1038/cr.2012.126
PubMed ID: 22170055
Title: Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope.
PubMed ID: 22170055
Sequence Information:
- Length: 717
- Mass: 80311
- Checksum: CCF43C118E935E84
- Sequence:
MSRRSQRLTR YSQGDDDGSS SSGGSSVAGS QSTLFKDSPL RTLKRKSSNM KRLSPAPQLG PSSDAHTSYY SESLVHESWF PPRSSLEELH GDANWGEDLR VRRRRGTGGS ESSRASGLVG RKATEDFLGS SSGYSSEDDY VGYSDVDQQS SSSRLRSAVS RAGSLLWMVA TSPGRLFRLL YWWAGTTWYR LTTAASLLDV FVLTRRFSSL KTFLWFLLPL LLLTCLTYGA WYFYPYGLQT FHPALVSWWA AKDSRRPDEG WEARDSSPHF QAEQRVMSRV HSLERRLEAL AAEFSSNWQK EAMRLERLEL RQGAPGQGGG GGLSHEDTLA LLEGLVSRRE AALKEDFRRE TAARIQEELS ALRAEHQQDS EDLFKKIVRA SQESEARIQQ LKSEWQSMTQ ESFQESSVKE LRRLEDQLAG LQQELAALAL KQSSVAEEVG LLPQQIQAVR DDVESQFPAW ISQFLARGGG GRVGLLQREE MQAQLRELES KILTHVAEMQ GKSAREAAAS LSLTLQKEGV IGVTEEQVHH IVKQALQRYS EDRIGLADYA LESGGASVIS TRCSETYETK TALLSLFGIP LWYHSQSPRV ILQPDVHPGN CWAFQGPQGF AVVRLSARIR PTAVTLEHVP KALSPNSTIS SAPKDFAIFG FDEDLQQEGT LLGKFTYDQD GEPIQTFHFQ APTMATYQVV ELRILTNWGH PEYTCIYRFR VHGEPAH
Genular Protein ID: 598384615
Symbol: B4E2A6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 752
- Mass: 83965
- Checksum: 10EEE401D14DA067
- Sequence:
MVSPPSAGQR LRGVPVWAAG AFRFSSGEES TSHLIMSRRS QRLTRYSQGD DDGSSSSGGS SVAGSQSTLF KDSPLRTLKR KSSNMKRLSP APQLGPSSDA HTSYYSESLV HESWFPPRSS LEELHGDANW GEDLRVRRRR GTGGSESSRA SGLVGRKATE DFLGSSSGYS SEDDYVGYSD VDQQSSSSRL RSAVSRAGSL LWMVATSPGR LFRLLYWWAG STWYRLTTAA SLLDVFVLTR RFSSLKTFLW FLLPLLLLTC LTYGAWYFYP YGLQTFHPAL VSWWAAKDSR RPDEGWEARD SSPHFQAEQR VMSRVHSLER RLEALAAEFS SNWQKEAMRL ERLELRQGAP GQGGGGGLSH EDTLALLEGL VSRREAALKE DFRRETAARI QEELSALRAE HQQDSEDLFK KIVRASQESE ARIQQLKSEW QSMTQESFQE SSVKELRRLE DQLAGLQQEL AALALKQSSV AEEVGLLPQQ IQAVRDDVES QFPAWISQFL ARGGGGRVGL LQREEMQAQL RELESKILTH VAEMQGKSAR EAAASLSLTL QKEGVIGVTE EQVHHIVKQA LQRYSEDRIG LADYALESGG ASVISTRCSE TYETKTALLS LFGIPLWYHS QSPRVILQPD VHPGNCWAFQ GPQGFAVVRL SARIRPTAVT LEHVPKALSP NSTISSAPKD FAIFGFDEDL QQEGTLLGKF TYDQDGEPIQ TFHFQAPTMA TYQVVELRIL TNWGHPEYTC IYRFRVHGEP AH